CN112534065B - Trbc使用的分子评估 - Google Patents

Trbc使用的分子评估

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Publication number
CN112534065B
CN112534065B CN201980051847.3A CN201980051847A CN112534065B CN 112534065 B CN112534065 B CN 112534065B CN 201980051847 A CN201980051847 A CN 201980051847A CN 112534065 B CN112534065 B CN 112534065B
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China
Prior art keywords
gene
cell
seq
region
cells
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CN201980051847.3A
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English (en)
Chinese (zh)
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CN112534065A (zh
Inventor
S.奥诺哈
M.查皮加
B.马
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Autolus Ltd
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Autolus Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201980051847.3A 2018-08-03 2019-07-18 Trbc使用的分子评估 Active CN112534065B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1812650.8A GB201812650D0 (en) 2018-08-03 2018-08-03 Molecular assessment of TRBC usage
GB1812650.8 2018-08-03
PCT/GB2019/052011 WO2020025928A1 (en) 2018-08-03 2019-07-18 Molecular assessment of trbc usage

Publications (2)

Publication Number Publication Date
CN112534065A CN112534065A (zh) 2021-03-19
CN112534065B true CN112534065B (zh) 2025-08-26

Family

ID=63518375

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980051847.3A Active CN112534065B (zh) 2018-08-03 2019-07-18 Trbc使用的分子评估

Country Status (8)

Country Link
US (1) US12241124B2 (https=)
EP (1) EP3830297A1 (https=)
JP (2) JP7606958B2 (https=)
CN (1) CN112534065B (https=)
AU (1) AU2019312877B2 (https=)
CA (1) CA3108000A1 (https=)
GB (1) GB201812650D0 (https=)
WO (1) WO2020025928A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11385233B2 (en) 2015-03-05 2022-07-12 Autolus Limited Methods of depleting malignant T-cells
US11982673B2 (en) 2014-03-05 2024-05-14 Autolus Limited Methods
GB201709203D0 (en) 2017-06-09 2017-07-26 Autolus Ltd Antigen-binding domain
US12247060B2 (en) 2018-01-09 2025-03-11 Marengo Therapeutics, Inc. Calreticulin binding constructs and engineered T cells for the treatment of diseases
EP3765517A1 (en) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
CA3105448A1 (en) 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
GB201817172D0 (en) 2018-10-22 2018-12-05 Autolus Ltd Antibody
GB201817822D0 (en) 2018-10-31 2018-12-19 Autolus Ltd Binding domain
GB2599228B (en) 2019-02-21 2024-02-07 Marengo Therapeutics Inc Multifunctional molecules that bind to T cell related cancer cells and uses thereof
CN119039441A (zh) 2019-02-21 2024-11-29 马伦戈治疗公司 与nkp30结合的抗体分子及其用途
AU2020416273A1 (en) 2020-01-03 2022-07-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
WO2023236189A1 (zh) * 2022-06-10 2023-12-14 刘宗霖 利用非完整重组的t细胞受体核苷酸序列诊断t细胞淋巴瘤的方法及试剂盒

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102443624A (zh) * 2010-10-11 2012-05-09 遵义医学院 一种高通量同时测序多样本cdr3受体库的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103205420B (zh) 2012-01-13 2015-04-01 深圳华大基因科技有限公司 用于扩增T细胞受体β链CDR3编码序列的引物组合物及其用途
US11385233B2 (en) 2015-03-05 2022-07-12 Autolus Limited Methods of depleting malignant T-cells
DK3241561T3 (da) 2014-03-05 2025-06-30 Autolus Ltd Konjugeret antistof eller bispecifik t-celle-engager, som selektivt binder enten tcr-beta konstant region 1 (trbc1) eller trbc2
WO2016051205A1 (en) 2014-10-03 2016-04-07 Isis Innovation Limited Analysis of t-cell monotypia
EP3211003A1 (en) * 2016-02-24 2017-08-30 Institut Pasteur T cell receptors from the hiv-specific repertoire, means for their production and therapeutic uses thereof
CN110168105B (zh) 2016-12-09 2024-05-24 瑞泽恩制药公司 用于对t细胞受体进行测序的系统和方法及其用途
GB201709203D0 (en) 2017-06-09 2017-07-26 Autolus Ltd Antigen-binding domain
GB201800298D0 (en) 2018-01-09 2018-02-21 Autolus Ltd Method
GB201817172D0 (en) 2018-10-22 2018-12-05 Autolus Ltd Antibody
GB201817822D0 (en) 2018-10-31 2018-12-19 Autolus Ltd Binding domain

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102443624A (zh) * 2010-10-11 2012-05-09 遵义医学院 一种高通量同时测序多样本cdr3受体库的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Paul M Maciocia等.Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.Nature medicine.第23卷第1416–1423页. *
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies;Paul M Maciocia等;Nature medicine;第23卷;第1416–1423页 *

Also Published As

Publication number Publication date
CA3108000A1 (en) 2020-02-06
US12241124B2 (en) 2025-03-04
JP7606958B2 (ja) 2024-12-26
JP2024023671A (ja) 2024-02-21
JP2021532792A (ja) 2021-12-02
CN112534065A (zh) 2021-03-19
US20220010377A1 (en) 2022-01-13
WO2020025928A1 (en) 2020-02-06
EP3830297A1 (en) 2021-06-09
GB201812650D0 (en) 2018-09-19
AU2019312877B2 (en) 2025-12-18
AU2019312877A1 (en) 2021-01-28

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