CN112516214A - Antibacterial and anti-inflammatory composition and preparation method and application thereof - Google Patents

Antibacterial and anti-inflammatory composition and preparation method and application thereof Download PDF

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Publication number
CN112516214A
CN112516214A CN202011513095.9A CN202011513095A CN112516214A CN 112516214 A CN112516214 A CN 112516214A CN 202011513095 A CN202011513095 A CN 202011513095A CN 112516214 A CN112516214 A CN 112516214A
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parts
weight
propylene glycol
skin
honeysuckle
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胡才忠
胡小峰
胡伟
常群
曹德华
何国忠
张庆
肖凌
李辉敏
胡适愿
胡婉清
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Jiangxi Jianjitang Agriculture Development Co ltd
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Jiangxi Jianjitang Agriculture Development Co ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention provides a bacteriostatic and anti-inflammatory composition, a preparation method and application thereof, and relates to the field of medicines. The present invention provides a composition comprising: flos Lonicerae, cortex Phellodendri, radix Sophorae Flavescentis, Spirulina, inulin, alpha-glucose oligosaccharide, sodium carboxymethylcellulose, menthol, propylene glycol, etc. According to the invention, the moisture-keeping effect is obviously improved by adjusting the ratio of the honeysuckle to the propylene glycol. The composition provided by the invention quickly solves the skin problem caused by skin microecological imbalance from two ways of traditional Chinese medicine components with antibacterial and anti-inflammatory effects and prebiotics capable of regulating skin microecology, has good antibacterial effect and moisturizing effect, enhances skin barrier repair, is completely nontoxic, has a simple preparation process, and is suitable for large-scale mass production.

Description

Antibacterial and anti-inflammatory composition and preparation method and application thereof
The technical field is as follows:
the invention relates to the field of medicines, and particularly relates to a bacteriostatic and anti-inflammatory composition as well as a preparation method and application thereof.
Background art:
it is known that the skin is the largest organ of the human body, and common skin diseases include chapped skin, dermatitis eczema and the like, wherein the chapped skin is often seen in cold weather and dry winter, secretion of subcutaneous sweat glands is reduced, the skin is dry, cutin is thickened, the skin loses elasticity, and the chapped skin is easily caused by the traction effect of labor or activity. It is often characterized by rough and cracked skin, severe bleeding and pain, and susceptibility to bacterial infection. Dermatitis eczema is mainly manifested by severe pruritus, skin lesions with multiformity, symmetrical distribution, exudation tendency, chronic course and easy recurrent attacks. The clinical manifestations of the medicine are characterized by symmetry, exudation, pruritic dermatosis, polymorphism and recurrence. The disease usually recurs or aggravates in winter, tends to exudate, has a chronic course and is easy to recur.
Under normal conditions, a large number of microorganisms exist on the surface of human skin, including bacteria, fungi, viruses, chlamydia and the like, microbial flora forms a microecological system similar to an ecosphere, and different strains are mutually dependent and restricted to form a unique ecological structure, namely the normal microbial flora of the skin. However, if the long-term, repeated and excessive internal and external environmental stimulation acts on the skin and exceeds the compensation capacity of the skin, the ecological balance of the skin is broken, thereby causing various skin diseases. "microbiome new science" holds that: many skin problems, such as dryness, desquamation, itching, acne, allergic dermatitis, psoriasis, erythema, and weak resistance to germs and viruses, are directly and closely related to the imbalance of skin flora.
The existing external bacteriostatic preparation in the market has a good bacteriostatic effect, but does not have a good regulating effect on the skin microecological balance and the skin state, and cannot well solve the skin problem caused by the skin microecological imbalance. And the bacteriostatic component mostly contains pure chemical bactericide components of alcohol, halogen and quaternary ammonium salts, such as triclosan, benzoyl peroxide, ketoconazole, miconazole nitrate, parachloroxylenol, hydrocortisone and the like, and the bactericide components belong to either dangerous chemicals or strict control products with antibiotic property which can generate harmful bacterial and viral tolerance hazards. With the increasing concern of people on safety and health, scientific technology is continuously developed. It is recognized that protection against harmful bacteria cannot be achieved by merely inhibiting (anti-) bacteria or killing a pathway, but can also be achieved by balancing "harmful" pathways with "beneficial bacteria".
Prebiotics generally refer to organic substances that are not digested and absorbed by the host but selectively promote the growth and reproduction of beneficial bacteria such as bifidobacteria in the body, thereby improving the health of the host. The prebiotics can promote the growth and reproduction of beneficial bacteria in intestinal tracts in vivo, form microecological competitive advantages, optimize the microecological balance of the intestinal tracts, and further improve the immunity so as to keep the body healthy. Meanwhile, the intestinal micro-ecology can be improved. Also, we can apply prebiotics to regulate skin micro-ecology, thereby solving skin problems due to imbalance in skin micro-ecology. The commonly used prebiotics include oligosaccharides, including fructo-oligosaccharide, galacto-oligosaccharide, xylo-oligosaccharide, isomalto-oligosaccharide, soybean oligosaccharide, inulin, etc., some microalgae can also be used as prebiotics, such as spirulina, arthrospira, etc., and polysaccharides, protein hydrolysate, and vegetables, Chinese herbal medicines, wild plants, etc. in natural plants can also be used as prebiotics.
The flos Lonicerae is dried bud or flower with initial blossom of Lonicera Japonica of Caprifoliaceae. Sweet taste and cold nature, enters lung, heart and stomach channels, has the effects of clearing away heat and toxic materials and dispelling wind and heat, and can be used for treating carbuncle, furuncle, pharyngitis, erysipelas, toxic heat, dysentery, wind-heat type common cold, epidemic febrile disease, and fever. Flos Lonicerae mainly contains flavonoids, volatile oils, organic acids, triterpenoid saponins, iridoid, etc., such as luteolin, chlorogenic acid, and isochlorogenic acid. Modern pharmacological and clinical researches show that the honeysuckle has the pharmacological effects of bacteriostasis, antivirus, anti-inflammation, antipyresis, immunity enhancement, blood fat reduction, endotoxin resistance, cholagogue, liver protection, tumor resistance and the like. Wherein the antibacterial effective components mainly comprise chlorogenic acid, isochlorogenic acid and flavonoids. Modern researches prove that the honeysuckle has strong broad-spectrum antibacterial action and strong antibacterial action on various germs, and the extract of the honeysuckle has strong inhibiting action on bacillus pumilus, bacillus subtilis, diplococcus pneumoniae, staphylococcus epidermidis, escherichia coli, streptococcus B and the like.
The invention provides a bacteriostatic and anti-inflammatory composition and a preparation method and application thereof, which can quickly solve the skin problem caused by the unbalance of skin micro-ecology by using traditional Chinese medicine components with bacteriostatic and anti-inflammatory effects and prebiotics capable of adjusting the skin micro-ecology in a bidirectional way.
The invention content is as follows:
the invention aims to provide a bacteriostatic and anti-inflammatory composition, and a preparation method and application thereof. The composition provided by the invention can quickly solve the skin problem caused by skin microecological imbalance, has good antibacterial effect and moisturizing effect, is completely nontoxic, has a simple preparation process, and is suitable for large-scale batch production.
The invention provides a bacteriostatic and anti-inflammatory composition, which comprises the following components in parts by weight: 8-20 parts of honeysuckle, 3-10 parts of golden cypress, 4-12 parts of radix sophorae flavescentis, 1-5 parts of spirulina, 0.5-3 parts of inulin, 0.2-2 parts of alpha-glucose oligosaccharide, 10-30 parts of sodium carboxymethylcellulose, 6-15 parts of menthol and 20-50 parts of propylene glycol.
Preferably, the composition comprises the following components in parts by weight: 12-20 parts of honeysuckle, 5-10 parts of golden cypress, 6-12 parts of radix sophorae flavescentis, 2-5 parts of spirulina, 1-3 parts of inulin, 0.8-2 parts of alpha-glucose oligosaccharide, 16-30 parts of sodium carboxymethylcellulose, 8-15 parts of menthol and 30-50 parts of propylene glycol.
Preferably, the weight ratio of the honeysuckle to the propylene glycol is 2-4: 1; further preferably, the weight ratio of the honeysuckle to the propylene glycol is 3: 1.
More preferably, the composition comprises, in parts by weight: 15 parts of honeysuckle, 6 parts of phellodendron, 8 parts of radix sophorae flavescentis, 3 parts of spirulina, 1.5 parts of inulin, 1.5 parts of alpha-glucose oligosaccharide, 20 parts of sodium carboxymethylcellulose, 12 parts of menthol and 45 parts of propylene glycol.
The invention also provides a preparation method of the antibacterial and anti-inflammatory composition, which comprises the following steps:
(1) taking honeysuckle, phellodendron and radix sophorae flavescentis according to the weight ratio, adding purified water for decocting twice, adding 10 times of purified water for the first time, adding spirulina for the second time, adding 6 times of purified water for the second time, combining filtrates, filtering again, concentrating into solution volume: 1:1 of the weight of the medicinal materials;
(2) taking inulin, alpha-glucose oligosaccharide, sodium carboxymethylcellulose, 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol according to the weight ratio, and uniformly stirring at room temperature to obtain a mixed solution A;
(3) and (3) mixing the medicine extract obtained in the step (1) with the mixed liquid A obtained in the step (2), heating and stirring at 40-50 ℃ for 20-40min, cooling to 20-30 ℃, adding the remaining 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol, stirring for 30-50min, and filtering to obtain the antibacterial and anti-inflammatory composition.
Preferably, the decoction time in the step (1) is 2 h.
Preferably, the heating and stirring conditions in the step (3) are 40-50 ℃ for 20-40 min; the temperature reduction in the step (3) is to be 20-30 ℃; the stirring time in the step (3) is 30-50 min.
Specifically, the preparation method of the antibacterial and anti-inflammatory composition comprises the following steps:
(1) taking honeysuckle, phellodendron and radix sophorae flavescentis according to the weight ratio, adding purified water, decocting for two times, each time for 2 hours, adding 10 times of purified water for the first time, adding spirulina for the second time, adding 6 times of purified water, combining filtrates, filtering again, concentrating into a solution volume: 1:1 of the weight of the medicinal materials;
(2) taking inulin, alpha-glucose oligosaccharide, sodium carboxymethylcellulose, 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol according to the weight ratio, and uniformly stirring at room temperature to obtain a mixed solution A;
(3) and (3) mixing the medicine extract obtained in the step (1) with the mixed liquid A obtained in the step (2), heating and stirring at 40-50 ℃ for 20-40min, cooling to 20-30 ℃, adding the remaining 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol, stirring for 30-50min, and filtering to obtain the antibacterial and anti-inflammatory composition.
The invention also provides application of the antibacterial and anti-inflammatory composition, and the composition can be used for preparing aqua, cream, ointment, tincture and liniment.
The invention has the beneficial effects that:
the invention provides a bacteriostatic and anti-inflammatory composition, a preparation method and application thereof, the composition mainly comprises traditional Chinese medicines and prebiotics, is safe and has no toxic or side effect, and the skin problem caused by skin micro-ecological imbalance is quickly solved from two ways of traditional Chinese medicine components with bacteriostatic and anti-inflammatory effects and prebiotics capable of adjusting skin micro-ecology, the bacteriostatic effect and the moisturizing effect are good, and the skin barrier repair is enhanced. The invention also finds that the effects of moisturizing and repairing skin barriers can be obviously improved by adjusting the ratio of the honeysuckle to the propylene glycol. In addition, the preparation method of the composition has simple process and is suitable for large-scale batch production.
Detailed Description
In order to make the technical means, the original characteristics, the achieved purposes and the effects of the invention easily understood, the invention is further explained with the following embodiments, but the following embodiments are only the preferred embodiments of the invention, and not all embodiments. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention.
The experimental methods in the following examples are conventional methods unless otherwise specified, and materials, reagents and the like used in the following examples are commercially available unless otherwise specified.
Example 1
The antibacterial and anti-inflammatory composition comprises the following components in parts by weight: 8 parts of honeysuckle, 3 parts of phellodendron, 4 parts of radix sophorae flavescentis, 1 part of spirulina, 0.5 part of inulin, 0.2 part of alpha-glucose oligosaccharide, 10 parts of sodium carboxymethylcellulose, 6 parts of menthol and 20 parts of propylene glycol.
The preparation method of the composition comprises the following steps:
(1) taking honeysuckle, phellodendron and radix sophorae flavescentis according to the weight ratio, adding purified water, decocting for two times, each time for 2 hours, adding 10 times of purified water for the first time, adding spirulina for the second time, adding 6 times of purified water, combining filtrates, filtering again, concentrating into a solution volume: 1:1 of the weight of the medicinal materials;
(2) taking inulin, alpha-glucose oligosaccharide, sodium carboxymethylcellulose, 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol according to the weight ratio, and uniformly stirring at room temperature to obtain a mixed solution A;
(3) and (3) mixing the medicine extract obtained in the step (1) with the mixed liquid A obtained in the step (2), heating and stirring at 40 ℃ for 20min, cooling to 20 ℃, adding the remaining 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol, stirring for 30min, and filtering to obtain the antibacterial and anti-inflammatory composition.
The composition can be made into aqua, cream, ointment, tincture and liniment by conventional method.
Example 2
The antibacterial and anti-inflammatory composition comprises the following components in parts by weight: 12 parts of honeysuckle, 5 parts of phellodendron, 6 parts of radix sophorae flavescentis, 2 parts of spirulina, 1 part of inulin, 0.8 part of alpha-glucose oligosaccharide, 16 parts of sodium carboxymethylcellulose, 8 parts of menthol and 30 parts of propylene glycol.
The preparation method of the composition comprises the following steps:
(1) taking honeysuckle, phellodendron and radix sophorae flavescentis according to the weight ratio, adding purified water, decocting for two times, each time for 2 hours, adding 10 times of purified water for the first time, adding spirulina for the second time, adding 6 times of purified water, combining filtrates, filtering again, concentrating into a solution volume: 1:1 of the weight of the medicinal materials;
(2) taking inulin, alpha-glucose oligosaccharide, sodium carboxymethylcellulose, 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol according to the weight ratio, and uniformly stirring at room temperature to obtain a mixed solution A;
(3) and (3) mixing the medicine extract obtained in the step (1) with the mixed liquid A obtained in the step (2), heating and stirring at 40 ℃ for 30min, cooling to 25 ℃, adding the remaining 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol, stirring for 35min, and filtering to obtain the antibacterial and anti-inflammatory composition.
The composition can be made into aqua, cream, ointment, tincture and liniment by conventional method.
Example 3
The antibacterial and anti-inflammatory composition comprises the following components in parts by weight: 15 parts of honeysuckle, 6 parts of phellodendron, 8 parts of radix sophorae flavescentis, 3 parts of spirulina, 1.5 parts of inulin, 1.5 parts of alpha-glucose oligosaccharide, 20 parts of sodium carboxymethylcellulose, 12 parts of menthol and 45 parts of propylene glycol. Namely, the weight ratio of the honeysuckle to the propylene glycol is 1: 3.
The preparation method of the composition comprises the following steps:
(1) taking honeysuckle, phellodendron and radix sophorae flavescentis according to the weight ratio, adding purified water, decocting for two times, each time for 2 hours, adding 10 times of purified water for the first time, adding spirulina for the second time, adding 6 times of purified water, combining filtrates, filtering again, concentrating into a solution volume: 1:1 of the weight of the medicinal materials;
(2) taking inulin, alpha-glucose oligosaccharide, sodium carboxymethylcellulose, 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol according to the weight ratio, and uniformly stirring at room temperature to obtain a mixed solution A;
(3) and (3) mixing the medicine extract obtained in the step (1) with the mixed liquid A obtained in the step (2), heating and stirring at 45 ℃ for 30min, cooling to 24 ℃, adding the remaining 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol, stirring for 40min, and filtering to obtain the antibacterial and anti-inflammatory composition.
The composition can be made into aqua, cream, ointment, tincture and liniment by conventional method.
Example 4
The antibacterial and anti-inflammatory composition comprises the following components in parts by weight: 20 parts of honeysuckle, 10 parts of golden cypress, 12 parts of radix sophorae flavescentis, 5 parts of spirulina, 3 parts of inulin, 2 parts of alpha-glucose oligosaccharide, 30 parts of sodium carboxymethyl cellulose, 15 parts of menthol and 50 parts of propylene glycol.
The preparation method of the composition comprises the following steps:
(1) taking honeysuckle, phellodendron and radix sophorae flavescentis according to the weight ratio, adding purified water, decocting for two times, each time for 2 hours, adding 10 times of purified water for the first time, adding spirulina for the second time, adding 6 times of purified water, combining filtrates, filtering again, concentrating into a solution volume: 1:1 of the weight of the medicinal materials;
(2) taking inulin, alpha-glucose oligosaccharide, sodium carboxymethylcellulose, 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol according to the weight ratio, and uniformly stirring at room temperature to obtain a mixed solution A;
(3) and (3) mixing the medicine extract obtained in the step (1) with the mixed liquid A obtained in the step (2), heating and stirring at 50 ℃ for 40min, cooling to 30 ℃, adding the remaining 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol, stirring for 50min, and filtering to obtain the antibacterial and anti-inflammatory composition.
The composition can be made into aqua, cream, ointment, tincture and liniment by conventional method.
Example 5
A bacteriostatic and anti-inflammatory composition is different from the composition in example 3 only in 16 parts of honeysuckle and 32 parts of propylene glycol. Namely, the weight ratio of the honeysuckle to the propylene glycol is 1: 2.
The preparation of the above composition was the same as in example 3.
Example 6
A bacteriostatic and anti-inflammatory composition is different from the composition in example 3 only in 12 parts of honeysuckle and 48 parts of propylene glycol. Namely, the weight ratio of the honeysuckle to the propylene glycol is 1: 4.
The preparation of the above composition was the same as in example 3.
Comparative example 1
A bacteriostatic and anti-inflammatory composition is different from that in example 3 only in that honeysuckle is not added.
The preparation of the above composition was the same as in example 3.
Comparative example 2
A bacteriostatic anti-inflammatory composition differing from example 3 only in that no propylene glycol was added.
The preparation of the above composition was the same as in example 3.
Experimental example 1
Detection of the modulation of skin microorganisms
The experimental method comprises the following steps: respectively inoculating staphylococcus epidermidis, bifidobacterium adolescentis, staphylococcus aureus and escherichia coli by adopting a glass culture dish and a conventional culture medium, wherein the inoculation amount is 1 multiplied by 105Subsequently, the bacteriostatic and anti-inflammatory compositions of examples 1 to 6 and comparative examples 1 to 2 were applied to the inoculated surface, and the number of colonies was measured after 24 hours. Staphylococcus aureus and escherichia coli are harmful flora of skin, staphylococcus epidermidis and bifidobacterium adolescentis are beneficial flora, and the detection results are shown in table 1:
table 1: results of testing the Regulation of skin microorganisms
Group of Staphylococcus epidermidis Bifidobacterium adolescentis Staphylococcus aureus Escherichia coli
Example 1 3.9×107 6.2×107 2.5×103 3.8×103
Example 2 4.8×107 7.4×107 1.6×103 2.8×103
Example 3 5.6×107 8.3×107 0.6×103 1.1×103
Example 4 4.3×107 6.8×107 2.1×103 3.4×103
Example 5 5.4×107 8.1×107 0.8×103 1.7×103
Example 6 5.1×107 7.7×107 1.1×103 2.1×103
Comparative example 1 2.2×107 3.3×107 7.8×104 1.3×105
Comparative example 2 1.8×107 2.9×107 8.6×104 2.2×105
As shown in the table 1, the compositions prepared in the examples 1 to 6 of the present invention can effectively promote the proliferation of Staphylococcus epidermidis and Bifidobacterium which are normal flora on the skin, and have obvious inhibiting effect on Staphylococcus aureus and Escherichia coli which are pathogenic bacteria on the skin.
Experimental example 2
Moisturizing Performance and skin Barrier repair test
The moisture retention performance and the skin barrier repair function of the antibacterial and anti-inflammatory compositions of examples 1-6 and comparative examples 1-2 are detected through a human skin water content experiment and a human percutaneous water loss experiment.
The method for detecting the water content of the human skin comprises the following steps: the Moisture retention was measured by a skin Moisture content tester (meter CM825, CK, germany), and the Moisture content of the skin was measured by a degree Measurement Value (MMV Value), and the Moisture content of the horny layer of human skin, the MMV Value of the Moisture content of the skin were measured by a capacitance method: the MMV value characterizes skin moisture, the greater the MMV value, the higher the stratum corneum moisture content.
The human body percutaneous water loss detection method comprises the following steps: the skin barrier is detected by a percutaneous water loss tester (Tewameter TM 300; German CK) and is measured by a TEWL value index, the water vapor pressure gradient of different points formed by the water loss of an angle layer of the epidermis is measured by two groups of sensors with different temperatures and humidities, the water content evaporated by the epidermis is measured, the TEWL value is used for evaluating the skin barrier function, the important parameter for inspecting the skin repair after the product is used, and the smaller the value is, the better the skin barrier is, and the better the repair is.
40 volunteers were recruited and divided into 8 groups of 5, 8 groups were each coated with 0.02g of the bacteriostatic and anti-inflammatory compositions of examples 1-6 and comparative examples 1-2, respectively. Testing at 20 deg.C and 50% relative humidity, cleaning the inner side of arm with cleaning product, marking test area on the inner side of arm, each test area is 5 × 5cm2Standing for 20min, collecting initial skin data for the first time, then smearing the antibacterial and anti-inflammatory compositions of examples 1-6 and comparative examples 1-2, smearing uniformly in the same direction, collecting data at 2h, and calculating the average value of the detection results, wherein the specific detection results are shown in the following table 2.
Table 2: moisturizing performance and skin barrier repair test results
Figure BDA0002847017990000071
As can be seen from table 2, after the bacteriostatic anti-inflammatory compositions of examples 1 to 6 of the present invention are used, the moisture content and the percutaneous water loss of human skin are both significantly improved, which indicates that the bacteriostatic anti-inflammatory composition of the present invention has the effects of moisturizing and repairing skin barrier; comparing example 3 with examples 5 and 6 and comparative examples 1 and 2, it is found that the effects of moisturizing and repairing skin barrier can be obviously improved by adjusting the ratio of honeysuckle to propylene glycol.
It should be understood that the above examples are only for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. It is intended that the present invention be understood and implemented by those skilled in the art, and not limited thereto. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims (8)

1. The bacteriostatic and anti-inflammatory composition is characterized by comprising the following components in parts by weight: 8-20 parts of honeysuckle, 3-10 parts of golden cypress, 4-12 parts of radix sophorae flavescentis, 1-5 parts of spirulina, 0.5-3 parts of inulin, 0.2-2 parts of alpha-glucose oligosaccharide, 10-30 parts of sodium carboxymethylcellulose, 6-15 parts of menthol and 20-50 parts of propylene glycol.
2. The bacteriostatic and anti-inflammatory composition according to claim 1, which comprises the following components in parts by weight: 12-20 parts of honeysuckle, 5-10 parts of golden cypress, 6-12 parts of radix sophorae flavescentis, 2-5 parts of spirulina, 1-3 parts of inulin, 0.8-2 parts of alpha-glucose oligosaccharide, 16-30 parts of sodium carboxymethylcellulose, 8-15 parts of menthol and 30-50 parts of propylene glycol.
3. The bacteriostatic and anti-inflammatory composition according to claim 2, wherein the weight ratio of the honeysuckle to the propylene glycol is 2-4: 1.
4. The bacteriostatic and anti-inflammatory composition according to claim 3, wherein the composition comprises the following components in parts by weight: 15 parts of honeysuckle, 6 parts of phellodendron, 8 parts of radix sophorae flavescentis, 3 parts of spirulina, 1.5 parts of inulin, 1.5 parts of alpha-glucose oligosaccharide, 20 parts of sodium carboxymethylcellulose, 12 parts of menthol and 45 parts of propylene glycol.
5. A method for preparing the bacteriostatic and anti-inflammatory composition according to claim 1, wherein the method comprises the following steps:
(1) taking honeysuckle, phellodendron and radix sophorae flavescentis according to the weight ratio, adding purified water for decocting twice, adding 10 times of purified water for the first time, adding spirulina for the second time, adding 6 times of purified water for the second time, combining filtrates, filtering again, concentrating into solution volume: 1:1 of the weight of the medicinal materials;
(2) taking inulin, alpha-glucose oligosaccharide, sodium carboxymethylcellulose, 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol according to the weight ratio, and uniformly stirring at room temperature to obtain a mixed solution A;
(3) and (3) mixing the medicine extract obtained in the step (1) with the mixed liquid A obtained in the step (2), heating and stirring at 40-50 ℃ for 20-40min, cooling to 20-30 ℃, adding the remaining 1/2 parts by weight of menthol and 1/2 parts by weight of propylene glycol, stirring for 30-50min, and filtering to obtain the antibacterial and anti-inflammatory composition.
6. The method according to claim 5, wherein the decoction in step (1) is carried out for 2 hours.
7. The method according to claim 6, wherein the heating and stirring conditions in the step (3) are 40 to 50 ℃ for 20 to 40 min; the temperature reduction in the step (3) is to be 20-30 ℃; the stirring time in the step (3) is 30-50 min.
8. The antibacterial and anti-inflammatory composition for use according to any one of claims 1 to 4, wherein the composition can be used for preparing aqua, cream, ointment, tincture and liniment.
CN202011513095.9A 2020-12-20 2020-12-20 Antibacterial and anti-inflammatory composition and preparation method and application thereof Pending CN112516214A (en)

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