CN109091521A - A kind of Chinese medicine decontamination preparation and preparation method thereof - Google Patents
A kind of Chinese medicine decontamination preparation and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine decontamination preparations and preparation method thereof, are related to the field of Chinese medicines.The preparation method of the Chinese medicine decontamination preparation obtains decoction liquor the following steps are included: decoct honeysuckle, is cooled to 40 DEG C hereinafter, mix with ethyl alcohol, stands, collect supernatant, removing ethyl alcohol obtains Flos Lonicerae extractive solution.Menthol, borneol and polyethylene glycol are mixed, is then mixed with Flos Lonicerae extractive solution.The preparation method is simple, and time-consuming short, process is easily-controllable.It is reasonable to prepare resulting Chinese medicine decontamination pharmaceutical formulation, antibacterial range is wide, speed is fast, and it is nontoxic, non-stimulated, without side-effects, pseudomonas aeruginosa, staphylococcus aureus and Candida albicans etc. can be killed, to the significant in efficacy of the various infectious dermatosis for the treatment of.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine decontamination preparation and preparation method thereof.
Background technique
With the development of economic society and the progress of modern science and technology, huge change is had occurred in environment for human survival, living standard
Change.Great variety, understanding of the mankind to health also just occur for adaptable human diseases spectrum, medical model and medical model therewith
It is continuously improved, the pursuit of health is increasingly enhanced, the international market of traditional medicine is continuously increased.The doctor growing in face of various countries
Health care expense is treated, modern medicine cannot sufficiently meet worldwide disease preventing and treating, sanatory great demand, international
Society has appreciated that the knot of the health care theory of traditional medicine, especially traditional Chinese medicine, the validity of medical practice and modern medicine
Conjunction will likely provide medical and health care new model for the mankind.
Summary of the invention
One of the objects of the present invention is to provide a kind of preparation methods of Chinese medicine decontamination preparation, and the preparation method is simple, consumption
When it is short, process is easily-controllable.
Another object of the present invention is to provide a kind of Chinese medicine decontamination preparations being prepared by above-mentioned preparation method.
The present invention solves its technical problem and adopts the following technical solutions to realize.
The invention proposes a kind of preparation methods of Chinese medicine decontamination preparation, comprising the following steps:
Honeysuckle is decocted, decoction liquor is obtained, is cooled to 40 DEG C hereinafter, mixing with ethyl alcohol, standing collects supernatant, removes second
Alcohol obtains Flos Lonicerae extractive solution.
Menthol, borneol and polyethylene glycol are mixed, is then mixed with Flos Lonicerae extractive solution.
The invention also provides a kind of Chinese medicine decontamination preparations being prepared by above-mentioned preparation method.
The beneficial effect for the Chinese medicine decontamination preparation and preparation method thereof that present pre-ferred embodiments provide includes:
The preparation method for the Chinese medicine decontamination preparation that present pre-ferred embodiments provide is simple, and time-consuming short, process is easily-controllable.Preparation
Resulting Chinese medicine decontamination pharmaceutical formulation is reasonable, and antibacterial range is wide, speed is fast and nontoxic, non-stimulated, without side-effects, can kill
Pseudomonas aeruginosa, staphylococcus aureus and Candida albicans etc., to the significant in efficacy of the various infectious dermatosis for the treatment of.
Specific embodiment
Chinese medicine decontamination preparation provided in an embodiment of the present invention and preparation method thereof is specifically described below.
The application provides a kind of preparation method of Chinese medicine decontamination preparation, can comprise the following steps that
Honeysuckle is decocted, decoction liquor is obtained, is cooled to 40 DEG C hereinafter, mixing with ethyl alcohol, standing collects supernatant, removes second
Alcohol obtains Flos Lonicerae extractive solution.Menthol, borneol and polyethylene glycol are mixed, is then mixed with Flos Lonicerae extractive solution.
In some embodiments, the weight ratio of honeysuckle, menthol, borneol and polyethylene glycol can be followed successively by 80-100:
0.1-2:0.1-2:5-20.Preferably 85-95:0.2-1:0.2-1:8-15.More preferably 90:0.5:0.5:10.
Honeysuckle comes from Compendium of Material Medica, and just entitled honeysuckle (Lonicera japonica Thunb.) is known as from ancient times
Clearing heat and detoxicating good medicine.The sweet cold air fragrance of its property, enters lung, stomach meridian, and for clear heat with drugs of sweet flavour and cold nature without injuring one's stomach, fragrance reaches thoroughly again can eliminating evil.Gold
Honeysuckle flower can dispelling wind-heat, also kind removing summer-heat blood poison is used for various febrile diseases, and such as body heat, dermexanthesis, macular eruption, heat toxin sore carbuncle, throat swell
The diseases such as pain, equal significant effect.To hemolytic streptococcus, staphylococcus aureus, Escherichia coli, shigella dysenteriae, comma bacillus, wound
Cold bacillus, paratyphosum Bacterium etc. have certain inhibiting effect, to pneumococcus, diplococcus meningitidis, Pseudomonas aeruginosa, tubercle bacillus
Also the various pathogens such as effective and infection of the upper respiratory tract Causative virus etc. have stronger inhibitory or killing effect.
Menthol to be extracted in the leaf and stem by peppermint, have refrigerant antipruritic, expelling mosquito, anti-inflammatory and antalgic, antibacterium,
Antimycotic and antiviral effect can contact skin directly to play antipruritic part, analgesic, refrigerant and slight local anaesthesia and other effects.
In addition, menthol is in this application, additionally it is possible to promote honeysuckle to pass through keratoderma barrier, improve its transdermal
Rate, to reach preferable treatment concentration.
Borneol has the effects that clearing away heat to and alleviating pain, myogenic, anti-inflammatory and antalgic, antibacterial and antiviral, and can after honeysuckle cooperation
Improve the inhibitory or killing effect of the bacteriums such as Chinese medicine decontamination formulation against S staphylococcus, I herpes simplex virus type.In addition, borneol with
Menthol cooperates the permeability and utilization rate that can be further improved honeysuckle, to improve the effect effect of Chinese medicine decontamination preparation
Fruit.
Polyethylene glycol dissolves menthol and borneol mainly as solvent.
It holds, using honeysuckle as monarch drug in a prescription in the Chinese medicine decontamination preparation of the application, there is clearing heat and detoxicating, anti-inflammatory and qi-restoratives to treat
The effects of wind.Menthol heat-clearing and damp-drying drug, wind dispelling insecticide are antipruritic.Borneol is that adjutant master dissipates stagnated fire, can deep heat, control frightened epilepsy, phlegm confusing heart,
Sore throat, hot eyes float screen, acne poison invagination, desinsection, promote infiltration, improve the biological utilisation etc. of drug.All medicines share is played heat-clearing altogether and is stopped
Bitterly, the effect of desinsection is antipruritic, very to curative effects such as infectious dermatosis, eczema, papule, bleb, itch, Bacteria skin infection infection
It is good.
In this application, it decocts and is carried out under conditions of 80-100 DEG C.Decoction also can be only 1 time, or repeatedly, example
It is rear primary resulting after decocting object and being preceding primary decoction when decoction number is multiple such as 2 times, 3 times or 3 times or more
The dregs of a decoction are decocted, are the mixed liquor of the resulting decoction medical fluid after decocting every time eventually for the total decoction liquor mixed with ethyl alcohol.
In some embodiments, decocting number is 2 times, including decocts decoct with second for the first time.It decocts for the first time
It is to mix honeysuckle for 1:3.5-4.5 with weight ratio with water, then cooks 30-40min for the first time, obtain and cook liquid for the first time.
With 100 meshes, filtering cooks liquid for the first time for the first time, obtains the first filtrate and the first filter residue.
It is to cook 30- second after mixing above-mentioned first filter residue for 1:3.5-4.5 with weight ratio with water that second, which decocts,
40min obtains second of cooking liquid.Second is filtered with second of 100 meshes and cooks liquid, obtains the second filtrate and the second filter residue.
It in these cases, is the mixing of the first filtrate Yu the second filtrate eventually for the total decoction liquor mixed with ethyl alcohol
Liquid.If decocting number to be greater than 2 times, operation, which can refer to, decocts the step that number is 2 times.
In this application, before cooking for the first time and before cooking for second, the pH value for adjusting system to be cooked respectively is
4-5.It preferably, further include directly impregnating 30-40min after mixing honeysuckle with water in water before cooking for the first time.
In this application, before standing, decoction liquor is first cooled to 40 DEG C hereinafter, then mixing decoction liquor under stirring condition
With ethyl alcohol, mixed liquor is obtained, the pH value for adjusting mixed liquor is 4-5, stirs 8-12min.
It can refer to ground, time of repose can be 20-24h, after standing, collect supernatant with organic filter membrane and carry out refined filtration, have
The filter diameter of machine filter film for example can be 0.45 μm.After refined filtration, the ethyl alcohol in (recycling) supernatant is removed, then single-action energy conservation is dense
Contracting.
Further, menthol and borneol are dissolved in polyethylene glycol according to the ratio, then with single-action energy conservation concentration after
Flos Lonicerae extractive solution mixing, stirs and evenly mixs, Chinese medicine decontamination preparation can be obtained.
In some embodiments, also containing double-chain quaternary ammonium salt or between chlorine in Chinese medicine decontamination preparation provided herein
Dimethlbenzene (PCMX) or excipient.It during the preparation process, can be by menthol, borneol, polyethylene glycol and Flos Lonicerae extractive solution
Mixed mixture is mixed with double-chain quaternary ammonium salt or parachlorometaxylenol or excipient.
Antimicrobial form Chinese medicine decontamination preparation is formed after double-chain quaternary ammonium salt or parachlorometaxylenol is added in Chinese medicine decontamination preparation.
The additional amount of double-chain quaternary ammonium salt can be the 0.1-0.2wt% of Chinese medicine decontamination preparation.Parachlorometaxylenol is in Chinese medicine decontamination system
Content in agent need to meet safety standard.
Optionally, double-chain quaternary ammonium salt for example can be using double decyl dimethyl ammonium bromides or double decyl dimethyl chlorinations
Ammonium.Double-chain quaternary ammonium salt can not only be adsorbed in microorganism division on electronegative each quasi-microorganism, is inhibited, it is made to lose breeding
Ability, and film blocking microbial respiratory channel can also be formed, accelerate the death of microorganism.Parachlorometaxylenol is blue to leather
Family name's positive bacteria, Gram-negative bacteria and mould all have preferable killing effect.
The application can make former Chinese medicine by the way that double-chain quaternary ammonium salt or parachlorometaxylenol are added in Chinese medicine decontamination preparation
The antibacterial effect of decontamination preparation is more rapidly and efficiently.
Gel-type or solid type Chinese medicine decontamination preparation are formed after excipient is added in Chinese medicine decontamination preparation.The addition of excipient
Amount can be the 0.3-0.4wt% of Chinese medicine decontamination preparation.It is worth noting that during the preparation process, it can be according to final products institute
Different categories of excipients need to be added.
The application method of Chinese medicine decontamination preparation provided herein includes being used for dipping bath or flushing, can be prevented a variety of
The invasion of pathogenic bacteria in 3-5 minutes, can kill pseudomonas aeruginosa, staphylococcus aureus and Candida albicans etc., right
Various infectious dermatosis are treated, especially to infectious dermatosis, eczema, papule, bleb and the itch etc. caused by sarcoptic mite
It is significant in efficacy.In practical applications, can be applied to various public places, family room, personal hygiene, medical institutions and
Human body hand, foot, oral area and other area skins resist antibacterial nursing.
Feature and performance of the invention are described in further detail with reference to embodiments.
Embodiment 1
The honeysuckle of 90 parts by weight is mixed with the water of 360 parts by weight, the pH value for adjusting mixed system is 4.5, is impregnated
Then 35min cooks 35min under conditions of 90 DEG C for the first time, obtain and cook liquid for the first time.Sieve with 100 mesh sieve, obtain the first filtrate and
First filter residue.
First filter residue is mixed with water with weight ratio for 1:4, adjusting pH value is 4.5, then second under conditions of 90 DEG C
Secondary cooking 35min obtains second of cooking liquid.It sieves with 100 mesh sieve, obtains the second filtrate and the second filter residue.
Above-mentioned first filtrate and the second filtrate are mixed, decoction liquor is obtained.Decoction liquor is cooled to 30 DEG C, under agitation with
Ethyl alcohol is 1:1.5 mixing with volume ratio, obtains mixed liquor, and the pH value for adjusting mixed liquor is 4.5, stands 22h after stirring 10min, receives
Collection supernatant crosses 0.45 μm of organic filter membrane, then recycles ethyl alcohol and single-action energy conservation concentration, obtains Flos Lonicerae extractive solution.
The menthol of 0.5 parts by weight and the borneol of 0.5 parts by weight are dissolved in the polyethylene glycol of 10 parts by weight according to the ratio
In, it is then mixed with the Flos Lonicerae extractive solution after above-mentioned single-action energy conservation concentration, stirs and evenly mixs, obtain Chinese medicine decontamination preparation.
Embodiment 2
The honeysuckle of 80 parts by weight is mixed with the water of 280 parts by weight, the pH value for adjusting mixed system is 4, is impregnated
Then 30min cooks 40min under conditions of 80 DEG C for the first time, obtain and cook liquid for the first time.Sieve with 100 mesh sieve, obtain the first filtrate and
First filter residue.
First filter residue is mixed with water with weight ratio for 1:3.5, adjusting pH value is 4, then second under conditions of 80 DEG C
Secondary cooking 40min obtains second of cooking liquid.It sieves with 100 mesh sieve, obtains the second filtrate and the second filter residue.
Above-mentioned first filtrate and the second filtrate are mixed, decoction liquor is obtained.Decoction liquor is cooled to 25 DEG C, under agitation with
Ethyl alcohol is 1:2 mixing with volume ratio, obtains mixed liquor, and the pH value for adjusting mixed liquor is 4, stands 20h after stirring 8min, collects supernatant
Liquid crosses 0.45 μm of organic filter membrane, then recycles ethyl alcohol and single-action energy conservation concentration, obtains Flos Lonicerae extractive solution.
The menthol of 0.1 parts by weight and the borneol of 0.1 parts by weight are dissolved in the polyethylene glycol of 5 parts by weight according to the ratio
In, it is then mixed with the Flos Lonicerae extractive solution after above-mentioned single-action energy conservation concentration, stirs and evenly mixs, obtain Chinese medicine decontamination preparation.
Embodiment 3
The honeysuckle of 100 parts by weight is mixed with the water of 450 parts by weight, the pH value for adjusting mixed system is 5, is impregnated
Then 40min cooks 30min under conditions of 100 DEG C for the first time, obtain and cook liquid for the first time.It sieves with 100 mesh sieve, obtains the first filtrate
With the first filter residue.
First filter residue is mixed with water with weight ratio for 1:4.5, adjusting pH value is 5, then second under conditions of 100 DEG C
Secondary cooking 30min obtains second of cooking liquid.It sieves with 100 mesh sieve, obtains the second filtrate and the second filter residue.
Above-mentioned first filtrate and the second filtrate are mixed, decoction liquor is obtained.Decoction liquor is cooled to 38 DEG C, under agitation with
Ethyl alcohol is 1:1 mixing with volume ratio, obtains mixed liquor, and the pH value for adjusting mixed liquor is 5, is stood for 24 hours after stirring 12min, in collection
Clear liquid crosses 0.45 μm of organic filter membrane, then recycles ethyl alcohol and single-action energy conservation concentration, obtains Flos Lonicerae extractive solution.
The menthol of 2 parts by weight and the borneol of 2 parts by weight are dissolved according to the ratio in the polyethylene glycol of 20 parts by weight, so
It is mixed afterwards with the Flos Lonicerae extractive solution after above-mentioned single-action energy conservation concentration, stirs and evenly mixs, obtain Chinese medicine decontamination preparation.
Embodiment 4
The present embodiment the difference from embodiment 1 is that: raw materials used honeysuckle is 85 parts by weight, thin in Chinese medicine decontamination preparation
Lotus brain is 1 parts by weight, borneol is 0.2 parts by weight and polyethylene glycol is 15 parts by weight.
Embodiment 5
The present embodiment the difference from embodiment 1 is that: raw materials used honeysuckle is 95 parts by weight, thin in Chinese medicine decontamination preparation
Lotus brain is 0.2 parts by weight, borneol is 1 parts by weight and polyethylene glycol is 8 parts by weight.
Embodiment 6
The present embodiment the difference from embodiment 1 is that: decoct number be only 1 time.
Embodiment 7
The present embodiment the difference from embodiment 1 is that: decocting number is 3 times, and total decoction liquor for mixing with ethyl alcohol is
Decoction for the first time distinguishes resulting first filtrate, the second filtrate and third filtrate after decocting and decoct for the third time for second
Mixed liquor.
Embodiment 8
It is in the resulting Chinese medicine decontamination preparation of embodiment 1 the present embodiment provides a kind of antimicrobial form Chinese medicine decontamination preparation
Double decyl dimethyl ammonium bromides of 0.1wt% are added.
Embodiment 9
It is in the resulting Chinese medicine decontamination preparation of embodiment 1 the present embodiment provides a kind of antimicrobial form Chinese medicine decontamination preparation
The double-track suspended self-propelled conveyor of 0.2wt% is added.
Embodiment 10
It is in the resulting Chinese medicine decontamination preparation of embodiment 1 the present embodiment provides a kind of antimicrobial form Chinese medicine decontamination preparation
The parachlorometaxylenol of 0.05wt% is added.
Embodiment 11
It is in the resulting Chinese medicine decontamination preparation of embodiment 1 the present embodiment provides a kind of gel-type Chinese medicine decontamination preparation
The excipient of 0.3wt% is added.
Embodiment 12
It is in the resulting Chinese medicine decontamination preparation of embodiment 1 the present embodiment provides a kind of solid type Chinese medicine decontamination preparation
The excipient of 0.4wt% is added.
Test example 1
Embodiment above-described embodiment 1-7 is repeated, enough Chinese medicine decontamination preparations are obtained, and carries out following detection.
(1), suppression microbicide effect monitoring:
In microbiological analysis inspection center of Guangdong Province and Anhui Institute of Medical Sciences according to " disinfection technology standard
(version in 2002) " it is detected, it is as shown in Table 1 and Table 2 to kill microbial test results.
Table 1 kills microbial test results
2 microbial test results of table
| Serial number | Detection project | Testing result |
| 1 | Total number of bacterial colonies cfu/ml | It is not detected |
| 2 | Coliform | It is not detected |
| 3 | Pathogenic pyogenic baeceria | It is not detected |
| 4 | Fungus colony sum | It is not detected |
Chinese medicine decontamination formulations on P pseudomonad provided herein, golden yellow Portugal it can be seen from Tables 1 and 2
Grape coccus and Candida albicans all have preferable killing effect.
(2), multiple skin irritation test:
1. tested substance: Chinese medicine decontamination preparation.
2. experimental animal:
2.1 regular grade animal houses, experimental animal use credit number: SYXK (Guangdong) 2017-0264.
2.2 animal species strains: regular grade new zealand rabbit, animal certificate number: 44411600003671.
2.3 animal origins: experimental animal by Guangdong Medical Lab Animal Center (experimental animal production licence number:
SCXK (Guangdong) 2013-0002) it provides.
3. method:
3.1 detection methods: " disinfection technology standard " 2002 editions, second part, 2.3.3.3.3 " multiple skin thorn in 2.3.3
Swash property test ".
3.2 testing conditions: 22-25 DEG C of environment temperature, relative humidity 40-70%.
4. experimental procedure:
Contamination method: before experiment for 24 hours, experimental animal backbone two sides dorsal body setae is subtracted or is shaved off, epidermis, unhairing can not be damaged
Each 3cm × 3cm of range or so.Tested material 0.5mL is taken directly to be applied on the skin of side, with two layers of gauze (2.5cm × 2.5cm)
With one layer of glassine paper or the like covering, then fixed with nonirritant adhesive tape or bandage.Other side skin is right as itself
According to using enclosed experiment, the application time is 4h, after the test, removes residual tested material with warm water.It smears daily once, even
It is continuous to smear 10 days.It is observed for the ease of the smearing and result of tested material, answers cropping when necessary.
5. evaluation of result:
The recipient site of observation for 24 hours dermoreaction after smearing every time is as a result, anti-by skin wound repair scoring progress skin
It should score.According to each point of observation top mean value of 1-10d, by skin irritatin strength grading standard determination skin irritatin intensity.
The determination of observing time should meet the overall process to observe reversible and irreversible stimulation, and experimental result is as shown in table 3.
3 skin irritation test result of table
Top mean value: sample: 0, reference substance: 0.
Hold, testing result show Chinese medicine decontamination preparation provided herein under this experiment condition, tested material pair
The multiple skin irritation test of new zealand rabbit, according to " disinfection technology standard " standards of grading, total mark average value is 0, skin thorn
Swash 0 < 0.5 of index, stimulus intensity result is nonirritant.
In conclusion the preparation method of Chinese medicine decontamination preparation provided by the present application is simple, time-consuming short, process is easily-controllable.Preparation
Resulting Chinese medicine decontamination pharmaceutical formulation is reasonable, and antibacterial range is wide, speed is fast and nontoxic, non-stimulated, without side-effects, can kill
Pseudomonas aeruginosa, staphylococcus aureus and Candida albicans etc., to the significant in efficacy of the various infectious dermatosis for the treatment of.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of preparation method of Chinese medicine decontamination preparation, which comprises the following steps:
Honeysuckle is decocted, decoction liquor is obtained, is cooled to 40 DEG C hereinafter, mixing with ethyl alcohol, standing collects supernatant, removes the second
Alcohol obtains Flos Lonicerae extractive solution；
Menthol, borneol and polyethylene glycol are mixed, is then mixed with the Flos Lonicerae extractive solution.
2. preparation method according to claim 1, which is characterized in that the honeysuckle, the menthol, the borneol with
The weight ratio of the polyethylene glycol is followed successively by 80-100:0.1-2:0.1-2:5-20.
3. preparation method according to claim 1, which is characterized in that decoction carries out under conditions of 80-100 DEG C.
4. preparation method according to claim 1, which is characterized in that decocting includes decocting to decoct with second for the first time；
Decocting for the first time is to cook 30-40min for the first time after mixing the honeysuckle for 1:3.5-4.5 with weight ratio with water,
It obtains and cooks liquid for the first time, filter for the first time, obtain the first filtrate and the first filter residue；
It is to cook 30- second after mixing first filter residue for 1:3.5-4.5 with weight ratio with water that second, which decocts,
40min obtains second of cooking liquid, and second of filtering obtains the second filtrate and the second filter residue；
The decoction liquor is the mixed liquor of first filtrate and second filtrate.
5. the preparation method according to claim 4, which is characterized in that before cooking for the first time and before cooking for second, adjust
The pH value for saving system to be cooked is 4-5.
6. the preparation method according to claim 4, which is characterized in that further include by the honeysuckle before cooking for the first time
Yu Shuizhong impregnates 30-40min.
7. preparation method according to claim 1, which is characterized in that before standing, the decoction is mixed under stirring condition
Liquid and the ethyl alcohol, obtain mixed liquor, and the pH value for adjusting mixed liquor is 4-5.
8. preparation method according to claim 1, which is characterized in that time of repose 20-24h.
9. preparation method according to claim 1, which is characterized in that further include by the menthol, borneol, described
Polyethylene glycol and the mixed mixture of the Flos Lonicerae extractive solution and double-chain quaternary ammonium salt or parachlorometaxylenol or excipient
Mixing.
10. a kind of Chinese medicine decontamination preparation, which is characterized in that the Chinese medicine decontamination preparation is as described in claim any one of 1-9
Preparation method be prepared.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112516214A (en) * | 2020-12-20 | 2021-03-19 | 江西兼济堂农业开发有限公司 | Antibacterial and anti-inflammatory composition and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491240A (en) * | 2014-11-27 | 2015-04-08 | 周可幸 | Chinese herbal medicine bactericide |
| CN107281249A (en) * | 2017-07-28 | 2017-10-24 | 蔡挺 | A kind of honeysuckle bactericidal composition and its preparation method and application |
-
2018
- 2018-10-22 CN CN201811237583.4A patent/CN109091521A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491240A (en) * | 2014-11-27 | 2015-04-08 | 周可幸 | Chinese herbal medicine bactericide |
| CN107281249A (en) * | 2017-07-28 | 2017-10-24 | 蔡挺 | A kind of honeysuckle bactericidal composition and its preparation method and application |
Non-Patent Citations (1)
| Title |
|---|
| 吕海燕: "金银花茶冰块含服预防放射性口腔黏膜炎的效果观察", 《全科医学临床与教育》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112516214A (en) * | 2020-12-20 | 2021-03-19 | 江西兼济堂农业开发有限公司 | Antibacterial and anti-inflammatory composition and preparation method and application thereof |
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