CN107281249A - A kind of honeysuckle bactericidal composition and its preparation method and application - Google Patents
A kind of honeysuckle bactericidal composition and its preparation method and application Download PDFInfo
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- CN107281249A CN107281249A CN201710630084.0A CN201710630084A CN107281249A CN 107281249 A CN107281249 A CN 107281249A CN 201710630084 A CN201710630084 A CN 201710630084A CN 107281249 A CN107281249 A CN 107281249A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention relates to a kind of honeysuckle bactericidal composition, the composition includes the Honegsukle flower P.E and its auxiliary material of effective dose, and the invention also discloses preparation method and use.The composition of the present invention, which can be killed effectively, controls pathogen, has good killing action, bacteriostasis rate >=60% to the germ such as pathogen such as staphylococcus aureus, Escherichia coli, Streptococcus hemolyticus of scytitis.Honeysuckle antibiotic preparation of the present invention has good biocompatibility, and cytotoxicity is small, safe；There is good anti-inflammatory, bactericidal action simultaneously, it is applied widely, it may also be used for baby and women breast-feeding their children.
Description
Technical field
The present invention relates to natural drug preparing technical field, more particularly to a kind of honeysuckle bactericidal composition and its preparation
Methods and applications.
Background technology
Honeysuckle is traditional Chinese herbal medicine, belongs to medical flower, nickname honeysuckle, because it is that Caprifoliaceae perennial half is evergreen
The bud of voluble shrub honeysuckle, is called honeysuckle flowers.It is pure white when just opening, turn yellow after a couple of days.Honeysuckle is heat-clearing and detoxifying drug, property
It is sweet, cold, enter lung, stomach, the heart channel of Hang-Shaoyin, be mainly used in heat toxin sore carbuncle, carbuncle is dissipated with removing toxic substances, clearing heat and cooling blood effect can also swell clearly bright
Mesh, expelling wind and cold pathogens.Pharmacologically, honeysuckle has antibacterial action：Experiment in vitro shows that flower and rattan are for example golden yellow to various pathogens
Color staphylococcus, hemolytic streptococcus, Escherichia coli, shigella dysenteriae, comma bacillus, typhoid bacillus, paratyphosum Bacterium etc. have
Certain inhibitory action is also effective to pneumococcus, diplococcus meningitidis, Pseudomonas aeruginosa, tubercle bacillus.
Honeysuckle preparation has " Lonicera and Forsythia ball ", " fructus forsythiae antidotal tablet ", " yin huang pian ", " YINHUANG ZHUSHEYE " etc. on the market at present.
It is that treatment is caught a cold, because of laryngitis, stomatitis and some dermopathic good if " Lonicera and Forsythia ball " is exactly preparation using honeysuckle as main ingredient
Medicine.Single honeysuckle preparation is not yet related in external use plaster or paste, and market is simultaneously immature.The present invention uses Honegsukle flower P.E
Novel antibacterial preparation is made, its preparation can be the external preparations such as bandage, medical dressing, gel, cream, cataplasm.
Honeysuckle belongs to natural Chinese medicinal herb, and its is safe, is usually used in pregnant woman, baby and women breast-feeding their children.The honeysuckle of the present invention resists
Bacteria preparation can be widely applied to wound, burn, skin donor site, bedsore, diabetic ulcer and other treatment of infection, and safety
Property it is high, it is wide using crowd.
The content of the invention
It is an object of the invention to provide a kind of honeysuckle bactericidal composition and preparation method thereof.
The composition includes Honegsukle flower P.E and its auxiliary material, and the Honegsukle flower P.E extraction step is：Take gold and silver
Flower is added water to cook 2 times, and 1 hour every time, collecting decoction was filtered, and the amount of doubling ethanol makes precipitation after filtrate concentration, stands 12-24
Hour, leaching supernatant, it is 1.20 to be concentrated into relative density, and the auxiliary material is selected from：Higher fatty acid ester, lanolin, honeybee
Wax, spermaceti, vaseline, paraffin, silicone oil, vegetable oil, rosin, esterase, hydrogenated rosin, stearic acid, tristerin,
Ethyl-para-hydroxybenzoate, ethylparaben, propylben, lauryl sodium sulfate, Tween-80, hard sorb be smooth, times
Half Span-80, cetanol, stearyl alcohol, glycerol monostearate alcohol, cholesterine, polyethylene glycol, triethanolamine, potassium carbonate,
Zinc oxide, superfine silica gel powder, calcium carbonate, kaolin, Arabic gum, sodium alginate, western tragacanth, gelatin, chitosan, starch, hydroxyl
It is third methylcellulose, first (second) base cellulose, carboxymethyl cellulose and its sodium salt, polyacrylic acid and its sodium salt, polyvinyl alcohol, poly-
Tie up ketone, glycerine, propane diols, ethanol, polyethylene glycol, sorbierite, azone, dimethyl sulfoxide (DMSO), urea, menthol, camphor, borneol,
Eucalyptus oil, carbomer, polyvinylpyrrolidone (PVP), one kind in polyvinyl alcohol (PVA) or its combination.
In the honeysuckle bactericidal composition, the Honegsukle flower P.E mass fraction is 0.1-50wt%, with the gold
The gross weight meter of honeysuckle flower bactericidal composition.
Present invention also offers a kind of described honeysuckle bactericidal composition answering in treatment antibacterial skin preparation is prepared
With.
The antibiotic preparation includes honeysuckle antibacterial ointment, honeysuckle antibacterial gel, honeysuckle antibacterial gel paste, gold
The dressing of honeysuckle flower antibacterial liquid, honeysuckle antibacterial film, honeysuckle antibacterial plaster, honeysuckle antibacterial emplastrum, honeysuckle antibacterial are applied
Various preparations including film.
The honeysuckle antibacterial ointment component is：Preparation per 100g is consisted of the following composition：Honegsukle flower P.E 0.1-
50g, stearic acid 10-15g, glycerin monostearate 1-5g, glycerine 5-15g, potassium carbonate 0.5-1.5g, triethanolamine 0.1-
0.5ml, surplus are pure water, and preparation method is：The matrix being made by emulsion process is taken, Honegsukle flower P.E is added, mixing produces gold
Honeysuckle flower antibacterial ointment, sterilization post package.
Preparation of the honeysuckle antibacterial gel per 100g is consisted of the following composition：Honegsukle flower P.E 1-50g, glycerine
1-15g, carbomer 1-5g, appropriate triethanolamine, surplus are pure water, gel preparation method：
1) glycerine is dissolved in pure water, obtains uniform glycerite；
2) extracting honeysuckle extract is added in glycerite, stirring while adding；
3) carbomer is dispersed in pure water, with 2) mixing after fully dissolving；
4) triethanolamine adjustment pH value 3) is being added, stirred, sterilization post package.
Preparation of the honeysuckle antibacterial gel paste per 100g is consisted of the following composition：It is Honegsukle flower P.E 1-50g, sweet
Oily 1-15g, carbomer 1-5g, PVP 5-10g, gelatin 0.1-1g, appropriate triethanolamine, surplus are pure water, and its preparation process is：
1) carbomer infiltration adds appropriate pure water and 2%-4% carbomer gels is made, pH is adjusted with triethanolamine in glycerine
Value about 7.0；
2) well-established law prepares glycerin gelatine；
3) appropriate pure water dissolving PVP is taken, the about 50%PVP aqueous solution is made；
4) extracting honeysuckle extract grinds in 1) mixing and uniformly, is then added to the preheating mixing in 60 DEG C of water-baths
2), 3) in mixture, grind and uniformly, make into homogeneous lotion.
5) 4) stir evenly even lotion paving by above-mentioned and be applied on non-woven fabrics backing, dry, cover polyethylene film, cut, go out
Bacterium sterilizes post package.
The advantage of the invention is that：
1. the honeysuckle bactericidal composition of the present invention can effectively solve Cutaneous infection, and good biocompatibility, safety
Property it is high；
2. the honeysuckle bactericidal composition of the present invention is to sterilization rate >=90% of inflammation bacterium；
3. the single honeysuckle antibiotic preparation of the present invention can fill up existing honeysuckle preparation in treatment skin infection field
External use plaster or paste market it is not enough.
Brief description of the drawings
Fig. 1 is the shaping figure of honeysuckle antibacterial ointment of the present invention.
Fig. 2 is the shaping figure of the honeysuckle antibacterial gel of the present invention.
Fig. 3 is the shaping figure of the honeysuckle antibacterial gel paste of the present invention.
Fig. 4 is Honegsukle flower P.E of the invention to staphylococcus aureus antibacterial effect figure.
Fig. 5 is honeysuckle antibacterial gel paste of the invention to Escherichia coli antibacterial effect figure.
Fig. 6 is honeysuckle antibacterial gel paste of the invention to staphylococcus aureus antibacterial effect figure.
Embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings.
Honeysuckle bactericidal composition includes Honegsukle flower P.E and its auxiliary material, and the Honegsukle flower P.E extraction step is：
Extracting honeysuckle is added water to cook 2 times, and 1 hour every time, collecting decoction was filtered, and the amount of doubling ethanol makes precipitation after filtrate concentration, stands
12-24 hours, leaching supernatant, it is 1.20 to be concentrated into relative density, and the auxiliary material is selected from：Higher fatty acid ester, wool
Fat, beeswax, spermaceti, vaseline, paraffin, silicone oil, vegetable oil, rosin, esterase, hydrogenated rosin, stearic acid, stearic acid are sweet
Grease, ethyl-para-hydroxybenzoate, ethylparaben, propylben, lauryl sodium sulfate, Tween-80, hard sorb
Smooth, sesquialter Span-80, cetanol, stearyl alcohol, glycerol monostearate alcohol, cholesterine, polyethylene glycol, triethanolamine, carbon
Sour potassium, zinc oxide, superfine silica gel powder, calcium carbonate, kaolin, Arabic gum, sodium alginate, western tragacanth, gelatin, chitosan, shallow lake
Powder, HPMC, first (second) base cellulose, carboxymethyl cellulose and its sodium salt, polyacrylic acid and its sodium salt, polyethylene
Alcohol, PVP, glycerine, propane diols, ethanol, polyethylene glycol, sorbierite, azone, dimethyl sulfoxide (DMSO), urea, menthol, camphor,
Borneol, eucalyptus oil, carbomer, polyvinylpyrrolidone (PVP), one kind in polyvinyl alcohol (PVA) or its combination.
In the honeysuckle bactericidal composition, the Honegsukle flower P.E mass fraction is 0.1-50wt%, with the gold
The gross weight meter of honeysuckle flower bactericidal composition.
Honeysuckle bactericidal composition is to sterilization rate >=60% of inflammation bacterium, and composition can be fabricated to anti-including honeysuckle
Bacterium ointment, honeysuckle antibacterial gel, honeysuckle antibacterial gel paste, the dressing of honeysuckle antibacterial liquid, honeysuckle antibacterial film,
Various preparations including honeysuckle antibacterial plaster, honeysuckle antibacterial emplastrum, honeysuckle antibacterial film coating agent.
Embodiment 1：The preparation of honeysuckle antibacterial ointment
Honegsukle flower P.E 10g, stearic acid 10g, glycerin monostearate 2.5g, glycerine 10g, potassium carbonate 0.9g, three second
Hydramine 0.3ml, surplus are pure water.
Preparation method is：The matrix being made by emulsion process is taken, Honegsukle flower P.E is added, it is soft that mixing produces honeysuckle antibacterial
Cream, sterilization post package.
Embodiment 2：The preparation of honeysuckle antibacterial gel
Honegsukle flower P.E 10g, glycerine 9g, Acritamer 940 3g, pure water 100ml, appropriate triethanolamine.
Preparation method is：By Honegsukle flower P.E, glycerine is successively dissolved in pure water, obtains homogeneous solution, take Acritamer 940 equal
It is even to be dispersed in above-mentioned solution, stir, plus triethanolamine adjusts pH 6.8-7.2, sterilization post package.
Embodiment 3：The preparation of honeysuckle antibacterial gel paste
Honegsukle flower P.E 10g, glycerine 7.7g, carbomer C-9342.4g, PVP 6g, gelatin 0.5g, triethanolamine are fitted
Amount, surplus are pure water.
Preparation method processed is：Carbomer is infiltrated with 3 times of amount glycerine, plus the carbomer gel of 3% concentration is made in pure water, with
Triethanolamine adjustment pH value 7.0 (I)；Well-established law prepares glycerin gelatine (II)；Appropriate pure water dissolving PVP is taken, 50%PVP is made water-soluble
Liquid (III)；By Honegsukle flower P.E in I mixing, grind and uniformly, be then added to and preheat II, the III of mixing in 60 DEG C of water-baths
In mixture, grind and uniformly, make into homogeneous lotion, stir evenly even lotion paving by above-mentioned and be applied on non-woven fabrics backing, it is appropriate plus
Pressure, makes into 0.25g/cm2, it is 0.10g/cm to put 45 DEG C of -50 DEG C of oven dryings to lotion weight2, take out, cover polyethylene film, cut out
Cut, sterilization post package.
Embodiment 4：Honegsukle flower P.E antibacterial effect
The Honegsukle flower P.E aqueous solution of the present invention is subjected to fungistatic effect experiment, the experimental results are shown inthe following table.
The antibacterial effect of table 1
| Project | Concentration | Sterilizing rate (%, >=) |
| Staphylococcus aureus S.a (ATCC6538) | 100mg/ml | 90.0 |
| Escherichia coli E.C (ATCC25922) | 100mg/ml | 90.0 |
The evaluation criterion according to as defined in GB15979-2002 appendix Cs 4, bacteriostasis rate >=50%-90%, product has antibacterial work
With bacteriostasis rate >=90%, product has stronger bacteriostasis.
Embodiment 5：Acute oral toxicity is tested
Acute oral toxicity LD50 ＞ of the Honegsukle flower P.E aqueous solution made from 1-3 of the embodiment of the present invention to rabbit
5000mg/kg BW, belong to actual nontoxic level.
All documents referred in the present invention are all incorporated as reference in this application, independent just as each document
It is incorporated as with reference to such.In addition, it is to be understood that after the above-mentioned instruction content of the present invention has been read, those skilled in the art can
To be made various changes or modifications to the present invention, these equivalent form of values equally fall within the model that the application appended claims are limited
Enclose.
The above-described embodiments merely illustrate the principles and effects of the present invention, and the embodiment that part is used, for
For one of ordinary skill in the art, without departing from the concept of the premise of the invention, can also make it is some deformation and
Improve, these belong to protection scope of the present invention.
Claims (7)
1. a kind of honeysuckle bactericidal composition, it is characterised in that the composition includes Honegsukle flower P.E and its auxiliary material, described
Honegsukle flower P.E extraction step is：Extracting honeysuckle is added water to cook 2 times, 1 hour every time, collecting decoction, filtration, after filtrate concentration
The amount of doubling ethanol makes precipitation, stands 12-24 hours, leaching supernatant, and it is 1.20 to be concentrated into relative density, the auxiliary material choosing
From：Higher fatty acid ester, lanolin, beeswax, spermaceti, vaseline, paraffin, silicone oil, vegetable oil, rosin, esterase,
Hydrogenated rosin, stearic acid, tristerin, ethyl-para-hydroxybenzoate, ethylparaben, propylben, dodecyl
Sodium sulphate, Tween-80, hard sorb are smooth, sesquialter Span-80, cetanol, stearyl alcohol, glycerol monostearate alcohol, courage
Sterol, polyethylene glycol, triethanolamine, potassium carbonate, zinc oxide, superfine silica gel powder, calcium carbonate, kaolin, Arabic gum, alginic acid
Sodium, western tragacanth, gelatin, chitosan, starch, HPMC, first (second) base cellulose, carboxymethyl cellulose and its sodium
Salt, polyacrylic acid and its sodium salt, polyvinyl alcohol, PVP, glycerine, propane diols, ethanol, polyethylene glycol, sorbierite, azone, two
Methyl sulfoxide, urea, menthol, camphor, borneol, eucalyptus oil, carbomer, polyvinylpyrrolidone (PVP), polyvinyl alcohol
(PVA) one kind or its combination in.
2. honeysuckle bactericidal composition according to claim 1, it is characterised in that in the honeysuckle bactericidal composition,
The Honegsukle flower P.E mass fraction is 0.1-50wt%, with the gross weight meter of the honeysuckle bactericidal composition.
3. application of the honeysuckle bactericidal composition according to claim 1 or 2 in treatment antibacterial skin preparation is prepared.
4. application according to claim 3, it is characterised in that the antibiotic preparation includes honeysuckle antibacterial ointment, gold and silver
Flower antibacterial gel, honeysuckle antibacterial gel paste, the dressing of honeysuckle antibacterial liquid, honeysuckle antibacterial film, honeysuckle antibacterial
Various preparations including plaster, honeysuckle antibacterial emplastrum, honeysuckle antibacterial film coating agent.
5. application according to claim 4, it is characterised in that honeysuckle ointment described in per 100g is consisted of the following composition：
Honegsukle flower P.E 0.1-50g, stearic acid 10-15g, glycerin monostearate 1-5g, glycerine 5-15g, potassium carbonate 0.5-1.5g,
Triethanolamine 0.1-0.5ml, surplus are pure water, and preparation method is：The matrix being made by emulsion process is taken, honeysuckle is added and extracts
Thing, mixing produces honeysuckle antibacterial ointment, sterilization post package.
6. application according to claim 4, it is characterised in that honeysuckle antibacterial gel is by following component described in per 100g
Composition：Honegsukle flower P.E 0.1-50g, glycerine 1-15g, carbomer 1-5g, appropriate triethanolamine, surplus are pure water, and it is prepared
Step is：
1) glycerine is dissolved in pure water, obtains uniform glycerite；
2) extracting honeysuckle extract is added in glycerite, stirring while adding；Stir and produce honeysuckle antibacterial gel；
3) carbomer is dispersed in pure water, with 5) mixing after fully dissolving；
4) triethanolamine adjustment pH value 3) is being added, stirred, sterilization post package.
7. application according to claim 4, it is characterised in that honeysuckle antibacterial gel paste described in per 100g by below into
It is grouped into：Honegsukle flower P.E 1-50g, glycerine 1-15g, carbomer 1-5g, PVP 5-10g, gelatin 0.1-1g, triethanolamine are fitted
Amount, surplus are pure water, and its preparation process is：
1) carbomer infiltration adds appropriate pure water and 2%-4% carbomer gels is made, pH value is adjusted about with triethanolamine in glycerine
For 7.0；
2) well-established law prepares glycerin gelatine；
3) appropriate pure water dissolving PVP is taken, the about 50%PVP aqueous solution is made；
4) extracting honeysuckle extract is ground and uniformly in 1) mixing, be then added to preheated in 60 DEG C of water-baths mixing 2), 3)
In mixture, grind and uniformly, make into homogeneous lotion.
5) 4) stir evenly even lotion paving by above-mentioned and be applied on non-woven fabrics backing, dry, cover polyethylene film, cut, sterilizing disappears
Malicious post package.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710630084.0A CN107281249A (en) | 2017-07-28 | 2017-07-28 | A kind of honeysuckle bactericidal composition and its preparation method and application |
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| CN201710630084.0A CN107281249A (en) | 2017-07-28 | 2017-07-28 | A kind of honeysuckle bactericidal composition and its preparation method and application |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107913233A (en) * | 2017-11-29 | 2018-04-17 | 桂林华诺威生物科技有限公司 | Antiseptic dressing |
| CN108904542A (en) * | 2018-09-06 | 2018-11-30 | 海安百优基质生物工程有限公司 | The preparation method of Chiral supermolecule hydrogel skin ointments for antibacterial reparation |
| CN109091296A (en) * | 2018-07-10 | 2018-12-28 | 常熟市亨利医疗器械有限公司 | A kind of postoperative quick healing adhesive plaster of foreskin |
| CN109091521A (en) * | 2018-10-22 | 2018-12-28 | 安徽亿人安股份有限公司 | A kind of Chinese medicine decontamination preparation and preparation method thereof |
| CN113122177A (en) * | 2021-04-19 | 2021-07-16 | 黑龙江省科学院石油化学研究院 | Composite antibacterial photo-curing adhesive composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039330A (en) * | 2016-06-16 | 2016-10-26 | 吉林医药学院 | Antibacterial medical ultrasonic coupling agent containing traditional Chinese medicine ingredients and preparation method thereof |
| CN106109451A (en) * | 2016-08-10 | 2016-11-16 | 武汉德仁科技开发有限公司 | A kind of antibiotic preparation and preparation method thereof |
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2017
- 2017-07-28 CN CN201710630084.0A patent/CN107281249A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039330A (en) * | 2016-06-16 | 2016-10-26 | 吉林医药学院 | Antibacterial medical ultrasonic coupling agent containing traditional Chinese medicine ingredients and preparation method thereof |
| CN106109451A (en) * | 2016-08-10 | 2016-11-16 | 武汉德仁科技开发有限公司 | A kind of antibiotic preparation and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107913233A (en) * | 2017-11-29 | 2018-04-17 | 桂林华诺威生物科技有限公司 | Antiseptic dressing |
| CN109091296A (en) * | 2018-07-10 | 2018-12-28 | 常熟市亨利医疗器械有限公司 | A kind of postoperative quick healing adhesive plaster of foreskin |
| CN108904542A (en) * | 2018-09-06 | 2018-11-30 | 海安百优基质生物工程有限公司 | The preparation method of Chiral supermolecule hydrogel skin ointments for antibacterial reparation |
| CN109091521A (en) * | 2018-10-22 | 2018-12-28 | 安徽亿人安股份有限公司 | A kind of Chinese medicine decontamination preparation and preparation method thereof |
| CN113122177A (en) * | 2021-04-19 | 2021-07-16 | 黑龙江省科学院石油化学研究院 | Composite antibacterial photo-curing adhesive composition and preparation method thereof |
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