CN108904542A - The preparation method of Chiral supermolecule hydrogel skin ointments for antibacterial reparation - Google Patents
The preparation method of Chiral supermolecule hydrogel skin ointments for antibacterial reparation Download PDFInfo
- Publication number
- CN108904542A CN108904542A CN201811039372.XA CN201811039372A CN108904542A CN 108904542 A CN108904542 A CN 108904542A CN 201811039372 A CN201811039372 A CN 201811039372A CN 108904542 A CN108904542 A CN 108904542A
- Authority
- CN
- China
- Prior art keywords
- chiral
- borneol
- supermolecule hydrogel
- maggot
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 27
- 239000002674 ointment Substances 0.000 title claims abstract description 24
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 17
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940116229 borneol Drugs 0.000 claims abstract description 17
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 17
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000243 solution Substances 0.000 claims abstract description 11
- 235000013871 bee wax Nutrition 0.000 claims abstract description 10
- 239000012166 beeswax Substances 0.000 claims abstract description 10
- 239000007864 aqueous solution Substances 0.000 claims abstract description 8
- 238000002844 melting Methods 0.000 claims abstract description 6
- 230000008018 melting Effects 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims description 5
- 235000021050 feed intake Nutrition 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 241000894006 Bacteria Species 0.000 abstract description 6
- 239000003814 drug Substances 0.000 abstract description 6
- 230000003628 erosive effect Effects 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 230000001050 lubricating effect Effects 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 238000009472 formulation Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000004513 sizing Methods 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 244000005714 skin microbiome Species 0.000 description 2
- 241001116389 Aloe Species 0.000 description 1
- 235000004256 Buglossoides arvense Nutrition 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000118841 Lithospermum incisum Species 0.000 description 1
- 239000006159 Sabouraud's agar Substances 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- KGEKLUUHTZCSIP-HOSYDEDBSA-N [(1s,4s,6r)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate Chemical compound C1C[C@]2(C)[C@H](OC(=O)C)C[C@H]1C2(C)C KGEKLUUHTZCSIP-HOSYDEDBSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- -1 ammonia Benzene sulfone Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
- 229960004171 hydroxychloroquine Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Insects & Arthropods (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses the preparation methods of the Chiral supermolecule hydrogel skin ointments for antibacterial reparation, belong to technical field of medicine, its preparation method is：Chiral supermolecule hydrogel, maggot extract and borneol are dissolved in pure water respectively, Chiral supermolecule hydrogel aqueous solution, maggot solution of extract and borneol aqueous solution are obtained respectively, after beeswax and atoleine heating and melting, Chiral supermolecule hydrogel solution, maggot solution of extract and borneol aqueous solution are mixed again, it is agitated to be extremely formed, obtain the Chiral supermolecule hydrogel skin ointments for being used for antibacterial reparation；This product is hormone-free without any side effects, can be applied and uses position extensive, can effectively inhibit bacterium to the erosion of skin and further reach repair, this product ingredient is mild smooth moist, long-acting while lubricating moisturizing can keep antibacterial repairing effect.
Description
Technical field
The invention belongs to technical field of medicine, and in particular to a kind of Chiral supermolecule hydrogel for antibacterial reparation
The preparation method of skin ointments.
Background technique
Bacteriostatic agent for skin has had a large amount of report, and has more commercialized product at present, such as hydroxychloroquine, ammonia
Benzene sulfone and reaction stop waiting the selection that can be used as skin bacteria inhibitor, have obtained the concern and research of many researchers, have applied
It number provides one kind for 201310338452.6 application for a patent for invention and is with oxalic acid borneol acetate saponification resultant borneol fenchanol
The skin bacteria inhibitor of main component, application No. is the patent of invention of 200810072492.X provide it is a kind of from plant with
Bacteriostatic agent based on aloe, Asian puccoon, pearl powder, honeycomb, medicine oil and matrix etc., but at present on the market be mostly only with it is antibacterial be main
The product of effect, action component curative effect are more single.
Chiral supermolecule hydrogel, number of patent application possess 10-80 um porous structure, spiral for 201310658697.7
For fibre diameter between 10-300 nanometers, the feature with bionical collagen structure possesses good biocompatibility.Physics and
Chemical characteristic and n cell growing environment high similarity, can be improved 20- using rear cell yield under the same conditions
40%, it can largely promote absorption and tissue growth.
Having a large amount of domestic and foreign literature report maggots can be added by many kinds of antibacterials of secretion and the factor of promoting healing
Fast infection wound healing.In recent years, getting worse with abuse of antibiotics situation, the wound of the severe infectious as caused by drug-fast bacteria
Face is gradually increased, and clinic lacks effective treatment means.Since the course of disease of such wound healing is long, complication is more, seriously affect
The Health and Living quality of patient, brings great burden to society.Maggot is China's traditional Chinese medicine, according to《Compendium of Materia Medica》Note
It carries：The worm is cold in nature nontoxic, can put deposited external application on the skin, can treat the surgical diseases such as ulcer on the shank.
Summary of the invention
It is an object of the invention to by a large amount of experiment in vitro, screening obtains a kind of with good fungistatic effect, energy
Wound healing does not have irritating pharmaceutical composition to skin, to provide a kind of chiral supermolecule for antibacterial reparation
The preparation method of hydrogel skin ointment.
The object of the present invention is achieved like this：
The Chiral supermolecule hydrogel, maggot extract, beeswax, atoleine and borneol account for ointment respectively and always feed intake quality
0.5%, 10%, 20%, 3% and 3%.
Ointment is made by the component of following parts by weight in the ointment：0.1-1 parts of Chiral supermolecule hydrogel, maggot
5-15 parts of extract, 10-30 parts of beeswax, 3-7 parts of atoleine, 3-5 parts of borneol, appropriate amount of water.
The technical scheme is that：Chiral supermolecule hydrogel, maggot extract and borneol are dissolved in pure water respectively,
Chiral supermolecule hydrogel aqueous solution, maggot solution of extract and borneol aqueous solution are obtained respectively, by beeswax and liquid stone
After wax heating and melting, then by the mixing of Chiral supermolecule hydrogel solution, maggot solution of extract and borneol aqueous solution, through stirring
It mixes to sizing, obtains the Chiral supermolecule hydrogel skin ointments for being used for antibacterial reparation.
Skin ointments are prepared using preparation method of the invention, manufacture craft is simple, at low cost and hormone-free, nontoxic pair
It acts on and antibacterial and repairing effect can be reached.Compared with other similar products in market, the present invention patented application number
201310658697.7 be action component, and maggot extract can promote wound reparation to have abundant theoretical foundation, in
Medicine maggot extraction process Patent No. 201810313013.2.This product is hormone-free without any side effects, smearable to make
It is extensive with position, it can effectively inhibit bacterium to the erosion of skin and further reach repair, this product ingredient is mildly smooth
It moistens, long-acting while lubricating moisturizing can keep antibacterial repairing effect.
Specific embodiment
Form is described in further detail above content of the invention again by the following examples, but should not manage this
For solution for the scope of the above subject matter of the present invention is limited to the following embodiments, all technologies realized based on above content of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1：
Ointment formulations：
Preparation process：It takes the Chiral supermolecule hydrogel factor to be placed in container and uses 80-90 DEG C of dissolution 5min of pure water；Separately take five cereals
After worm extract adds pure water stirring at normal temperature 10min to dissolve；Borneol is taken to add 60-80 DEG C of pure water stirring to being completely dissolved；It separately takes natural
Beeswax, atoleine are placed in another container, and 40-50 DEG C is heated to melting completely.Water phase liquid is slowly added in oil phase liquid afterwards
Mixing is stirred continuously to sizing and had both obtained.
Embodiment 2：
Ointment formulations：
Preparation process：It takes the Chiral supermolecule hydrogel factor to be placed in container and uses 80-90 DEG C of dissolution 5min of pure water；Separately take five cereals
After worm extract adds pure water stirring at normal temperature 10min to dissolve；Borneol is taken to add 60-80 DEG C of pure water stirring to being completely dissolved；It separately takes natural
Beeswax, atoleine are placed in another container, and 40-50 DEG C is heated to melting completely.Water phase liquid is slowly added in oil phase liquid afterwards
Mixing is stirred continuously to sizing and had both obtained.
Embodiment 3：
Ointment formulations：
Preparation process：It takes the Chiral supermolecule hydrogel factor to be placed in container and uses 80-90 DEG C of dissolution 5min of pure water；Separately take five cereals
After worm extract adds pure water stirring at normal temperature 10min to dissolve；Borneol is taken to add 60-80 DEG C of pure water stirring to being completely dissolved；It separately takes natural
Beeswax, atoleine are placed in another container, and 40-50 DEG C is heated to melting completely.Water phase liquid is slowly added in oil phase liquid afterwards
Mixing is stirred continuously to sizing and had both obtained.
Comparative example 1：
Ointment formulations：
Preparation process：With embodiment 2
Comparative example 2：
Ointment formulations：
Preparation process：With embodiment 2
Embodiment 4：Ointment bacteriostasis property test of the present invention
It tests using 2 ointment formulations of embodiment, nutrient agar, sabouraud's agar, LHH-150SD testing chamber for medicine stability is right
Staphylococcus aureus（ATCC6538）4th generation, Escherichia coli（8099）4th generation, Candida albicans（ATCC10231）4th generation
Carry out biocidal property test.
Test temperature is 25 DEG C ± 1 DEG C, is averaged to Escherichia coli within sample effect 2 minutes, 5 minutes, 10 minutes, 20 minutes
Sterilizing rate is respectively 99.4%, 99.6%, 99.8%, 99.9%, the sterilizing rate to staphylococcus aureus is respectively 99.5%,
99.7%, 99.8%, 99.9%, the sterilizing rate to Candida albicans is respectively 99.4%, 99.6%, 99.7%, 99.9%.
Bactericidal effect of the table 1 to test organisms
Note：Escherichia coli positive control bacterium amount is 3.0 × 104（2.2×104~3.8×104）Cfu/ piece, staphylococcus aureus
Positive control bacterium amount is 3.4 × 104（2.6×104~4.2×104）Cfu/ piece, Candida albicans positive control bacterium amount be 3.3 ×
104（2.3×104~5.0×104）Cfu/ piece.
Claims (3)
1. the preparation method of the Chiral supermolecule hydrogel skin ointments for antibacterial reparation, it is characterised in that：Its preparation side
Method is：Chiral supermolecule hydrogel, maggot extract and borneol are dissolved in pure water respectively, obtain chiral supermolecule water respectively
Gel solution, maggot solution of extract and borneol aqueous solution, after beeswax and atoleine heating and melting, then will be chiral
Supramolecular hydrogel sol solution, maggot solution of extract and the mixing of borneol aqueous solution, it is agitated to being formed, it obtains for antibacterial
The Chiral supermolecule hydrogel skin ointments of reparation.
2. the preparation method of the Chiral supermolecule hydrogel skin ointments according to claim 1 for antibacterial reparation, institute
It states Chiral supermolecule hydrogel, maggot extract, beeswax, atoleine and borneol and accounts for ointment respectively and always feed intake quality
0.5%, 10%, 20%, 3% and 3%.
3. being used for the Chiral supermolecule hydrogel skin ointments of antibacterial reparation, it is characterised in that：Including the group by following parts by weight
Divide and ointment is made：0.1-1 parts of Chiral supermolecule hydrogel, 5-15 parts of maggot extract, 10-30 parts of beeswax, atoleine
3-7 parts, 3-5 parts of borneol, appropriate amount of water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811039372.XA CN108904542A (en) | 2018-09-06 | 2018-09-06 | The preparation method of Chiral supermolecule hydrogel skin ointments for antibacterial reparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811039372.XA CN108904542A (en) | 2018-09-06 | 2018-09-06 | The preparation method of Chiral supermolecule hydrogel skin ointments for antibacterial reparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108904542A true CN108904542A (en) | 2018-11-30 |
Family
ID=64407823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811039372.XA Pending CN108904542A (en) | 2018-09-06 | 2018-09-06 | The preparation method of Chiral supermolecule hydrogel skin ointments for antibacterial reparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108904542A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109022342A (en) * | 2018-09-18 | 2018-12-18 | 海安百优基质生物工程有限公司 | The dimensional culture system cultivated using chiral hydrogel as attached cell |
| CN112641995A (en) * | 2020-12-21 | 2021-04-13 | 上海交通大学 | Chiral hydrogel dressing with antibacterial and repair promoting functions and preparation method and application thereof |
| CN113509493A (en) * | 2020-04-09 | 2021-10-19 | 大连麦琪克生物技术有限公司 | Bacteriostatic ointment for promoting wound healing and preparation method thereof |
| CN113599498A (en) * | 2021-08-13 | 2021-11-05 | 陈日和 | Composite antibacterial peptide and preparation method thereof, and bee venom conditioning cream capable of rapidly relieving pain and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103694131A (en) * | 2013-12-06 | 2014-04-02 | 上海交通大学 | Chiral supermolecule hydrogel and preparation method and application thereof |
| CN104610109A (en) * | 2009-11-12 | 2015-05-13 | 西格纳姆生物科学公司 | ANTI-BACTERIAL AGENTS and composites thereof |
| CN105833138A (en) * | 2016-03-25 | 2016-08-10 | 广西大学 | Anti-inflammation and itch-relieving ointment and preparation method thereof |
| CN105920047A (en) * | 2016-06-12 | 2016-09-07 | 赵海苹 | Traditional Chinese ointment for treating haemorrhoids, scald, anal eczema, anal fissure or herpes zoster |
| CN106390188A (en) * | 2016-04-01 | 2017-02-15 | 浙江理工大学 | Hydrogel having wound repair function and preparation method of hydrogel |
| CN106491856A (en) * | 2016-10-21 | 2017-03-15 | 济南豪瑞生物技术有限公司 | Hyaluronic acid bacteriostatic gel |
| CN107281249A (en) * | 2017-07-28 | 2017-10-24 | 蔡挺 | A kind of honeysuckle bactericidal composition and its preparation method and application |
| CN108186901A (en) * | 2018-03-08 | 2018-06-22 | 泰山医学院 | It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof |
| CN108392496A (en) * | 2018-04-09 | 2018-08-14 | 大连麦琪克生物技术有限公司 | A kind of Chinese medicine maggot fat acid-extraction |
-
2018
- 2018-09-06 CN CN201811039372.XA patent/CN108904542A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104610109A (en) * | 2009-11-12 | 2015-05-13 | 西格纳姆生物科学公司 | ANTI-BACTERIAL AGENTS and composites thereof |
| CN103694131A (en) * | 2013-12-06 | 2014-04-02 | 上海交通大学 | Chiral supermolecule hydrogel and preparation method and application thereof |
| CN105833138A (en) * | 2016-03-25 | 2016-08-10 | 广西大学 | Anti-inflammation and itch-relieving ointment and preparation method thereof |
| CN106390188A (en) * | 2016-04-01 | 2017-02-15 | 浙江理工大学 | Hydrogel having wound repair function and preparation method of hydrogel |
| CN105920047A (en) * | 2016-06-12 | 2016-09-07 | 赵海苹 | Traditional Chinese ointment for treating haemorrhoids, scald, anal eczema, anal fissure or herpes zoster |
| CN106491856A (en) * | 2016-10-21 | 2017-03-15 | 济南豪瑞生物技术有限公司 | Hyaluronic acid bacteriostatic gel |
| CN107281249A (en) * | 2017-07-28 | 2017-10-24 | 蔡挺 | A kind of honeysuckle bactericidal composition and its preparation method and application |
| CN108186901A (en) * | 2018-03-08 | 2018-06-22 | 泰山医学院 | It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof |
| CN108392496A (en) * | 2018-04-09 | 2018-08-14 | 大连麦琪克生物技术有限公司 | A kind of Chinese medicine maggot fat acid-extraction |
Non-Patent Citations (1)
| Title |
|---|
| 张丽娟等: "一种水凝胶敷料的制备及其对SD大鼠深Ⅱ度烧伤创面的愈合作用", 《中国药学杂志》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109022342A (en) * | 2018-09-18 | 2018-12-18 | 海安百优基质生物工程有限公司 | The dimensional culture system cultivated using chiral hydrogel as attached cell |
| CN113509493A (en) * | 2020-04-09 | 2021-10-19 | 大连麦琪克生物技术有限公司 | Bacteriostatic ointment for promoting wound healing and preparation method thereof |
| CN113509493B (en) * | 2020-04-09 | 2024-01-30 | 大连麦琪克生物技术有限公司 | Antibacterial ointment for promoting wound healing and preparation method thereof |
| CN112641995A (en) * | 2020-12-21 | 2021-04-13 | 上海交通大学 | Chiral hydrogel dressing with antibacterial and repair promoting functions and preparation method and application thereof |
| CN112641995B (en) * | 2020-12-21 | 2021-11-23 | 上海交通大学 | Chiral hydrogel dressing with antibacterial and repair promoting functions and preparation method and application thereof |
| CN113599498A (en) * | 2021-08-13 | 2021-11-05 | 陈日和 | Composite antibacterial peptide and preparation method thereof, and bee venom conditioning cream capable of rapidly relieving pain and preparation method thereof |
| CN113599498B (en) * | 2021-08-13 | 2023-09-26 | 广东日和堂医药科技有限公司 | Composite antibacterial peptide and preparation method thereof, and bee venom conditioning cream capable of quickly relieving pain and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108904542A (en) | The preparation method of Chiral supermolecule hydrogel skin ointments for antibacterial reparation | |
| CN101927029B (en) | Preparation method of chitosan/polyvinyl alcohol sponge dressing containing nano-silver | |
| CN101736584B (en) | Preparation method of anti-bacteria non-woven fabric and antibacterial agent | |
| EP2775838B1 (en) | Aqueous antimicrobial composition containing coniferous resin acids | |
| CN102302797B (en) | Medical colloid dressing and application thereof | |
| CN107998107A (en) | A kind of degerming gel of anti-inflammatory containing honey | |
| CN107982277B (en) | Composite antibacterial aerosol and preparation method and application thereof | |
| Maheshwari et al. | Green expertise: synthesis of silver nanoparticles for wound healing application an overview | |
| CN105326853A (en) | Composite chitosan material and preparation method and application thereof | |
| CN105854021B (en) | With analgesia, the external used medicine of antibacterial double effects, preparation and preparation method thereof | |
| CN103120642B (en) | Gel used for skin diseases and preparation method thereof | |
| CN110917120A (en) | Sticky antibacterial repairing material and preparation method and application thereof | |
| CN106421216A (en) | Anti-bacteria spraying agent and preparation method thereof | |
| CN1965650A (en) | Multiple metal ion chelated green antibacterial agent of chitosan | |
| CN107982509A (en) | A kind of liquid anti-inflammatory sterilized composition of the propolis containing honey | |
| CA2283314C (en) | Ointment for the treatment of burns and of other skin diseases | |
| CN108264235B (en) | Preparation method and application of bioactive glass powder for promoting wound healing | |
| CN108042654A (en) | A kind of preparation process of the anti-inflammatory degerming gel containing honey | |
| WO2009144711A1 (en) | Compositions comprising red microalgae polysaccharides and metals | |
| CN109793757B (en) | Composition for inhibiting growth of skin scar and preparation method and application thereof | |
| CN115068379A (en) | Long-acting oil control composition and preparation method thereof | |
| CN107595819A (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof | |
| CN102247490A (en) | Effective emulsified paste for treating skin wound inflammation and manufacturing method thereof | |
| CN102526121A (en) | Wound repair composition and preparation method and application thereof | |
| CN101310702B (en) | Emulsion type gel preparation containing chlorhexidine and alcohol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181130 |
|
| WD01 | Invention patent application deemed withdrawn after publication |