CN106421216A - Anti-bacteria spraying agent and preparation method thereof - Google Patents
Anti-bacteria spraying agent and preparation method thereof Download PDFInfo
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- CN106421216A CN106421216A CN201611011722.2A CN201611011722A CN106421216A CN 106421216 A CN106421216 A CN 106421216A CN 201611011722 A CN201611011722 A CN 201611011722A CN 106421216 A CN106421216 A CN 106421216A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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Abstract
The invention provides an anti-bacterial spraying agent and a preparation method thereof. The anti-bacterial spraying agent is prepared from the following components in parts by weight: 5 to 6 parts of water soluble chitosan, 3 to 5 parts of carnosic acid, 1 to 2 parts of nano-titanium dioxide, 4 to 5 parts of medical glycerine, 1 to 2 parts of aloe powder, 1 to 5 parts of ethyl alcohol, 0.5 to 2 parts of an emulsifying agent, 1 to 3 parts of amount increasing agent and 95 to 99 parts of purified water. According to the anti-bacterial spraying agent and the preparation method thereof, by adding the carnosic acid and the nano-titanium dioxide and utilizing a synergistic effect of the water soluble chitosan and the carnosic acid, under the helping role of the nano-titanium dioxide,the prepared anti-bacterial spraying agent has a good sterilizing effect, and meanwhile, the film-forming persistence is high, and the requirement on long-acting sterilizing can be met.
Description
Technical field
The present invention relates to medical preparation field, more particularly, to a kind of antimicrobial spray and preparation method thereof.
Background technology
Shitosan is chitin through a kind of deacetylated prepared macromolecule glycosaminoglycan, at present in the world unique carry sun from
The macromolecule alkalescence polysaccharide polymer of son.Shitosan is water insoluble, can only be dissolved in weak acid, but its modified product, such as carboxylic first
The modified carboxymethyl chitosan obtaining of baseization can be directly dissolved in water, considerably increases its range of application.Enrich on strand
Hydroxyl and amino make it easily occur chemical reaction to possess several functions, have hemostasis, pain relieving, promote wound healing, reduce scar
The excellent performances such as trace, antibacterial, good physiological compatibility and biodegradability.The antibacterial action of shitosan is mainly manifested in
The bacterial strains such as MRSE, staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa, Candida albicans are all had
There is inhibitory action.The antibacterial principle of shitosan mainly includes following several respects：One be polycation due to shitosan it is easy to
The negatively charged group effect of fungal cell surface, thus change mobility and the permeability of pathogen cell membrane；Two is interference
The duplication of DNA and transcription；Three is to block pathogen metabolism.Chitosan-phospholipid complex has following function：(1) shitosan is permissible
Promote the growth of epithelial cell and normal fibroblast, accelerating wound healing；(2) glycan red blood cell is had obvious and direct
Adhesion and agglutination, can promote platelet adhesion reaction and gathering, quick-acting haemostatic powder；(3) shitosan is sprayed onto surface of a wound film forming, for wound
Face creates micro- acid, anaerobic or hypoxemia, appropriateness moistens, the preferable healing environment of relative closure, and shitosan can absorb wound simultaneously
Lead to the Inflammatory substances-blood bradykinin of pain in mouthful, play analgesic activity.
Ethyl-para-hydroxybenzoate is that the Antimicrobial preservative effect obtaining after P-hydroxybenzoic acid (phenolic acid) carboxyl esterification is better than
The material of phenolic acid.The chain carrier of this material has α, and beta-unsaturated carbonyl structure, by ketonic oxygen and α-carbon group in molecule
Become the electronic relay system at a distance of about 0.25 ran, formed between carbonyl p electronics and adjacent ethylene linkage pi-electron grips effect altogether,
There is strong electronics buffer capacity, thus there is stronger antibacterial activity；Ester compounds are existed with molecular forms simultaneously, in electricity
Property, penetrate readily through the cell membrane of microorganism and produce bacteriostasis.
At present, the illness rate of gynecological disease is higher, and such as vaginitis, cervicitis, cervical erosion etc. are all that women is common many
Morbidity, now in ascendant trend year by year, and the phenomenon such as clinically common light degree Ⅱ burn and scald, canker sore, trauma surface infestation
Also increase year by year.The treatment surface of a wound occurring on market and the antiseptic of gynecological disease are substantially all and there is problems with：(1) select
Shitosan be only dissolve in weak acid it is impossible to be directly dissolved in water, most of with acetic acid as solvent, such chitosan anti-bacteria
Effectiveness comparison is good, but shitosan is placed in weak acid for a long time, so that the main chain of chitosan molecule is degraded, leads to molecule matter
Amount declines；(2) using single shitosan as the main component of antiseptic although shitosan is as externally used antimicrobial agent and surface of a wound shield
Reason agent has preferable effect, but Shortcomings in terms of killing intractable pathogenic bacteria；(3) most of product in the treatment surface of a wound and
During some gynecological diseases, because RT is short, greatly reduce the performance of dressing function；(4) most of shitosan class antibacterial
After the sterilizing of agent product, with the increase of resting period, the stability of product property declines.(5) most of antiseptic is that Chinese medicine carries
Thing configuration is taken to form, these products have formula components complexity, product no repairs conditioning functions.
CN 104740141 A discloses a kind of antimicrobial spray and preparation method thereof, and meter includes by weight：Water-soluble
0.2～1 part of shitosan, 0.05～0.1 part of ethyl-para-hydroxybenzoate, 0.5～3 part of medicinal glycerin, Alose 0.1～0.5
Part, 1～5 part of ethanol, 95～99 parts of purified water.Although described antimicrobial spray has preferable bactericidal effect, its film forming is lasting
Property need to be improved it is impossible to meet long-acting degerming needs.
Content of the invention
For above-mentioned problems of the prior art, the present invention provides a kind of antimicrobial spray and preparation method thereof.This
Bright logical interpolation carnosic acid and nano titanium oxide, using the synergy of water soluble chitosan and carnosic acid, in nanometer two
Under the booster action of titanium oxide, make obtained antimicrobial spray not only have good bactericidal effect, there is film forming lasting simultaneously
Property is long, can meet long-acting degerming demand.
For solving above-mentioned technical problem, the technical solution used in the present invention is：
In a first aspect, the invention provides a kind of antimicrobial spray, by weight meter include：
5～6 parts of water soluble chitosan, 3～5 parts of carnosic acid, 1～2 part of nano titanium oxide, 4～5 parts of medicinal glycerin,
1～2 part of Alose, 1～5 part of ethanol, 0.5～2 part of emulsifying agent, 1～3 part of agent of amount and 95～99 parts of purified water.
Wherein, the weight portion of water soluble chitosan can be 5 parts, 5.2 parts, 5.4 parts, 5.6 parts, 5.8 parts or 6 parts etc.；Rat-tail
The weight portion of oxalic acid can be 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts etc.；The weight portion of nano titanium oxide can for 1 part, 1.2 parts,
1.4 parts, 1.6 parts, 1.8 parts or 2 parts etc.；The weight portion of medicinal glycerin can be 4 parts, 4.3 parts, 4.5 parts, 4.7 parts or 5 parts etc.；Reed
The weight portion of luxuriant growth powder can be 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts or 2 parts etc.；The weight portion of ethanol can for 1 part, 2 parts,
3 parts, 4 parts or 5 parts etc.；The weight portion of emulsifying agent can be 0.5 part, 1 part, 1.5 parts or 2 parts etc.；The weight portion of emulsifying agent can be 0.5
Part, 1 part, 1.5 parts or 2 parts etc.；The weight portion of extender can be 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts etc.；The weight of purified water
Part can be 95 parts, 96 parts, 97 parts, 98 parts or 99 parts etc..
Following as currently preferred technical scheme, but the restriction of the technical scheme providing not as the present invention, pass through
Technical scheme below, can preferably reach and realize technical purpose and the beneficial effect of the present invention.
As currently preferred technical scheme, described water soluble chitosan is carboxymethyl chitosan.
As currently preferred technical scheme, the purity of described medicinal glycerin is more than 99.8%.
As currently preferred technical scheme, described antimicrobial spray count by weight including：Water soluble chitosan 5
Part, 4 parts of carnosic acid, 1 part of nano titanium oxide, 4 parts of medicinal glycerin, 2 parts of Alose, 3 parts of ethanol, 1 part of emulsifying agent, amount
2 parts of agent and 96 parts of purified water.
As currently preferred technical scheme, described emulsifying agent is polyglyceryl laurate, polyglycereol myristinate, poly-
In palmitin or polyglycerol stearate any one or at least two combination, described combination typical case but unrestricted
Example has：Polyglyceryl laurate and the combination of polyglycereol myristinate, POGE-A and polyglycerol stearate
Combination, polyglyceryl laurate, the combination of polyglycereol myristinate, POGE-A and polyglycerol stearate.
Preferably, described extender be producing starch, in sucrose or lactose any one or at least two combination, described
Combination is typical but non-limiting example has：Producing starch and the combination of sucrose, the combination of sucrose and lactose.
As currently preferred technical scheme, the concentration of described ethanol is 95%.
Second aspect, the invention provides the preparation method of above-mentioned antimicrobial spray, comprises the following steps：
S1. take water soluble chitosan, carnosic acid, emulsifying agent, amount agent and the purified water of formula ratio, be mixed and stirred for
10min is to uniform；
S2. the nano titanium oxide, medicinal glycerin, Alose and the ethanol that take formula ratio mix, and stirring 5min is extremely
Uniformly；
S3. solution S1 prepared solution and S2 being obtained is mixed under 0.3～0.5MPa and carries out at 120～150 DEG C
Reaction, natural cooling, adjust the pH value of mixed solution to 5～7 with ammoniacal liquor, be then sub-packed in spray bottle, after radiation sterilization i.e.
Obtain described antimicrobial spray.
Wherein, the reaction pressure in S3 can be 0.3MPa, 0.4MPa or 0.5MPa etc.；Reaction temperature can for 120 DEG C, 125
DEG C, 130 DEG C, 135 DEG C, 140 DEG C, 145 DEG C or 150 DEG C etc..
As currently preferred technical scheme, described water soluble chitosan is carboxymethyl chitosan.
Preferably, the purity of described medicinal glycerin is more than 99.8%.
Preferably, the concentration of described ethanol is 95%.
As currently preferred technical scheme, described emulsifying agent is polyglyceryl laurate, polyglycereol myristinate, poly-
In palmitin or polyglycerol stearate any one or at least two combination, described combination typical case but unrestricted
Example has：Polyglyceryl laurate and the combination of polyglycereol myristinate, POGE-A and polyglycerol stearate
Combination, polyglyceryl laurate, the combination of polyglycereol myristinate, POGE-A and polyglycerol stearate.
Preferably, described extender be producing starch, in sucrose or lactose any one or at least two combination, described
Combination is typical but non-limiting example has：Producing starch and the combination of sucrose, the combination of sucrose and lactose.
The present invention compared with prior art, has the advantages that：
The present invention leads to interpolation carnosic acid and nano titanium oxide, using the collaborative effect of water soluble chitosan and carnosic acid
Really, under the booster action of nano titanium oxide, make obtained antimicrobial spray not only have good bactericidal effect, have simultaneously
There is into film persistence long, it becomes film persistence ＞ 48h, can meet long-acting degerming demand.
Specific embodiment
With reference to embodiment, further detailed description is done to the concrete preparation method of the present invention, but the enforcement of the present invention
Mode not limited to this.
Embodiment 1：
Present embodiments provide a kind of antimicrobial spray and preparation method thereof, described antimicrobial spray count by weight including：
5 parts of water soluble chitosan, 4 parts of carnosic acid, 1 part of nano titanium oxide, 4 parts of medicinal glycerin, 2 parts of Alose, 3 parts of ethanol,
1 part of emulsifying agent, 2 parts of agent of amount and 96 parts of purified water.
Its preparation method is as follows：
S1. take water soluble chitosan, carnosic acid, emulsifying agent, amount agent and the purified water of formula ratio, be mixed and stirred for
10min is to uniform；
S2. the nano titanium oxide, medicinal glycerin, Alose and the ethanol that take formula ratio mix, and stirring 5min is extremely
Uniformly；
S3. solution S1 prepared solution and S2 being obtained is mixed under 0.4MPa and is reacted at 130 DEG C, naturally cold
But, adjust the pH value of mixed solution to 6 with ammoniacal liquor, be then sub-packed in spray bottle, after radiation sterilization, obtain described antibacterial spray
Agent.
The performance of the antimicrobial spray obtained by the present embodiment is as shown in table 1.
Embodiment 2：
Present embodiments provide a kind of antimicrobial spray and preparation method thereof, described antimicrobial spray count by weight including：
5.5 parts of water soluble chitosan, 3 parts of carnosic acid, 1.5 parts of nano titanium oxide, 4.5 parts of medicinal glycerin, 1.5 parts of Alose,
1 part of ethanol, 0.5 part of emulsifying agent, 1 part of agent of amount and 95 parts of purified water.
Its preparation method is as follows：
S1. take water soluble chitosan, carnosic acid, emulsifying agent, amount agent and the purified water of formula ratio, be mixed and stirred for
10min is to uniform；
S2. the nano titanium oxide, medicinal glycerin, Alose and the ethanol that take formula ratio mix, and stirring 5min is extremely
Uniformly；
S3. solution S1 prepared solution and S2 being obtained is mixed under 0.3MPa and is reacted at 120 DEG C, naturally cold
But, adjust the pH value of mixed solution to 5 with ammoniacal liquor, be then sub-packed in spray bottle, after radiation sterilization, obtain described antibacterial spray
Agent.
The performance of the antimicrobial spray obtained by the present embodiment is as shown in table 1.
Embodiment 3：
Present embodiments provide a kind of antimicrobial spray and preparation method thereof, described antimicrobial spray count by weight including：
6 parts of water soluble chitosan, 5 parts of carnosic acid, 2 parts of nano titanium oxide, 5 parts of medicinal glycerin, 2 parts of Alose, 5 parts of ethanol,
2 parts of emulsifying agent, 3 parts of agent of amount and 99 parts of purified water.
Its preparation method is as follows：
S1. take water soluble chitosan, carnosic acid, emulsifying agent, amount agent and the purified water of formula ratio, be mixed and stirred for
10min is to uniform；
S2. the nano titanium oxide, medicinal glycerin, Alose and the ethanol that take formula ratio mix, and stirring 5min is extremely
Uniformly；
S3. solution S1 prepared solution and S2 being obtained is mixed under 0.5MPa and is reacted at 150 DEG C, naturally cold
But, adjust the pH value of mixed solution to 7 with ammoniacal liquor, be then sub-packed in spray bottle, after radiation sterilization, obtain described antibacterial spray
Agent.
The performance of the antimicrobial spray obtained by the present embodiment is as shown in table 1.
Comparative example 1：
Embodiment 1 in CN 104740141 A.
Comparative example 2：
This comparative example provides a kind of antimicrobial spray, except without carnosic acid in the preparing raw material of described antimicrobial spray
Outward, unclassified stores consumption is all in the same manner as in Example 1 with preparation method.
The performance of the antimicrobial spray that this comparative example is obtained is as shown in table 1.
Comparative example 3：
This comparative example provides a kind of antimicrobial spray, except without nanometer titanium dioxide in the preparing raw material of described antimicrobial spray
Outside titanium, unclassified stores consumption is all in the same manner as in Example 1 with preparation method.
The performance of the antimicrobial spray that this comparative example is obtained is as shown in table 1.
Table 1：The performance table of the antimicrobial spray being obtained in embodiment 1-3 and comparative example 1-3
The result of integrated embodiment 1-3 and comparative example 1-3 can be seen that the present invention and leads to interpolation carnosic acid and nano-silica
Change titanium, using the synergy of water soluble chitosan and carnosic acid, under the booster action of nano titanium oxide, make obtained
Antimicrobial spray not only there is good bactericidal effect, to have into a film persistence long simultaneously, and it becomes film persistence ＞ 48h, permissible
Meet long-acting degerming demand.
Applicant states, the present invention illustrates the method detailed of the present invention by above-described embodiment, but the present invention not office
It is limited to above-mentioned method detailed, that is, do not mean that the present invention has to rely on above-mentioned method detailed and could implement.Art
Technical staff is it will be clearly understood that any improvement in the present invention, the equivalence replacement to each raw material of product of the present invention and auxiliary element
Interpolation, selection of concrete mode etc., within the scope of all falling within protection scope of the present invention and disclosure.
Claims (10)
1. a kind of antimicrobial spray it is characterised in that described antimicrobial spray count by weight including：Water soluble chitosan 5～6
Part, 3～5 parts of carnosic acid, 1～2 part of nano titanium oxide, 4～5 parts of medicinal glycerin, 1～2 part of Alose, ethanol 1～5
Part, 0.5～2 part of emulsifying agent, 1～3 part of agent of amount and 95～99 parts of purified water.
2. antimicrobial spray according to claim 1 is it is characterised in that described water soluble chitosan is carboxymethyl chitosan.
3. antimicrobial spray according to claim 1 and 2 is it is characterised in that the purity of described medicinal glycerin is more than 99.8%.
4. antimicrobial spray according to claim 1 and 2 it is characterised in that described antimicrobial spray count by weight including：
5 parts of water soluble chitosan, 4 parts of carnosic acid, 1 part of nano titanium oxide, 4 parts of medicinal glycerin, 2 parts of Alose, 3 parts of ethanol,
1 part of emulsifying agent, 2 parts of agent of amount and 96 parts of purified water.
5. antimicrobial spray according to claim 1 and 2 is it is characterised in that described emulsifying agent is polyglyceryl laurate, gathers
In Myristin, POGE-A or polyglycerol stearate any one or at least two combination；Preferably
Ground, described extender is producing starch, in sucrose or lactose any one or at least two combination.
6. the antimicrobial spray according to any one of claim 1-5 is it is characterised in that the concentration of described ethanol is 95%.
7. a kind of preparation method of the antimicrobial spray as described in any one as claim 1-6 is it is characterised in that methods described includes
Following steps：
S1. take water soluble chitosan, carnosic acid, emulsifying agent, amount agent and the purified water of formula ratio, be mixed and stirred for 10min
To uniform；
S2. the nano titanium oxide, medicinal glycerin, Alose and the ethanol that take formula ratio mix, and 5min is to uniform for stirring；
S3. solution S1 prepared solution and S2 being obtained is mixed under 0.3～0.5MPa and is reacted at 120～150 DEG C,
Natural cooling, adjusts the pH value of mixed solution to 5～7 with ammoniacal liquor, is then sub-packed in spray bottle, obtains institute after radiation sterilization
State antimicrobial spray.
8. preparation method according to claim 7 is it is characterised in that described water soluble chitosan is carboxymethyl chitosan；
Preferably, the purity of described medicinal glycerin is more than 99.8%；
Preferably, the concentration of described ethanol is 95%.
9. the preparation method according to claim 7 or 8 is it is characterised in that described emulsifying agent is polyglyceryl laurate, gathers
In Myristin, POGE-A or polyglycerol stearate any one or at least two combination；
Preferably, described extender be producing starch, in sucrose or lactose any one or at least two combination.
10. the preparation method according to any one of claim 7-9 is it is characterised in that the reaction time described in step S3 is 1
～3h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201611011722.2A CN106421216A (en) | 2016-11-17 | 2016-11-17 | Anti-bacteria spraying agent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611011722.2A CN106421216A (en) | 2016-11-17 | 2016-11-17 | Anti-bacteria spraying agent and preparation method thereof |
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| CN106421216A true CN106421216A (en) | 2017-02-22 |
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| CN201611011722.2A Pending CN106421216A (en) | 2016-11-17 | 2016-11-17 | Anti-bacteria spraying agent and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106978137A (en) * | 2017-03-28 | 2017-07-25 | 张文新 | A kind of fog-proof eraser spray for resin lens |
| CN114631590A (en) * | 2022-03-28 | 2022-06-17 | 桂林市农业科学研究中心 | Processing technology of dried sweet potatoes |
| CN114891482A (en) * | 2022-02-24 | 2022-08-12 | 张文新 | Anti-fog wiping spray for resin lenses |
| CN115380916A (en) * | 2022-08-15 | 2022-11-25 | 四川大学华西医院 | Sprayable nano antibacterial aqueous solution spray and preparation method thereof |
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| CN104740141A (en) * | 2015-04-16 | 2015-07-01 | 广东泰宝医疗科技股份有限公司 | Antibacterialp spray and preparation method thereof |
| CN105696195A (en) * | 2016-04-05 | 2016-06-22 | 东华大学 | Preparation method of carnosol and chitosan composite nanometer fiber mat |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106978137A (en) * | 2017-03-28 | 2017-07-25 | 张文新 | A kind of fog-proof eraser spray for resin lens |
| CN114891482A (en) * | 2022-02-24 | 2022-08-12 | 张文新 | Anti-fog wiping spray for resin lenses |
| CN114631590A (en) * | 2022-03-28 | 2022-06-17 | 桂林市农业科学研究中心 | Processing technology of dried sweet potatoes |
| CN115380916A (en) * | 2022-08-15 | 2022-11-25 | 四川大学华西医院 | Sprayable nano antibacterial aqueous solution spray and preparation method thereof |
| CN115380916B (en) * | 2022-08-15 | 2023-05-26 | 四川大学华西医院 | Spray-type nano antibacterial aqueous solution spray and preparation method thereof |
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Application publication date: 20170222 |