CN112472753A - 一种保护肝脏的组合物、中药制剂及用途 - Google Patents
一种保护肝脏的组合物、中药制剂及用途 Download PDFInfo
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Abstract
本发明涉及一种保护肝脏的组合物、中药制剂及用途，所述保护肝脏的组合物按照重量份由以下组分组成：葛根提取物130‑170重量份，蒲公英提取物80‑120重量份，茶多酚30‑70重量份，白扁豆提取物105‑145重量份，枳椇子提取物55‑95重量份。本发明所述保护肝脏的组合物的主要功效有：清肝利胆，健脾和胃，降压降脂，强效抗氧化，预防肝损伤，保肝解毒(如：酒精，尼古丁，重金属，农药等)，减淡色斑。适用人群：烟酒人群；熬夜人群；脂肪肝人群；工作压力大人群；用眼过度人群；皮肤敏感人群。
Description
技术领域
本发明涉及中药制剂领域，尤其是一种保护肝脏的组合物、中药制剂及用途。
背景技术
肝属木，主疏泻、主藏血，肝藏魂，为谋略所出，开窍于目，肝主筋，其华在爪，在志为怒，在声为呼，在液为泪。
现代人最常见的问题就是肝气郁结，导致肝的疏泄功能异常。情志抑郁，脂肪肝，胆结石、肝炎等都会导致肝气郁结。肝气郁结以后，就会有肋痛、胸闷、脘胀、嗳气等表现，就好比肾→肝→心→胃→胆→小肠这个轮子上的“肝”这个点卡住了。肝气郁结没有及时的治疗，气郁时间久了，就会化火，即肝郁化火，患者就会出现心情烦躁，脾气急躁，失眠等问题。同时，肝郁化火迁延日久，就会伤及肝阴，导致肝脏阴血不足，患者除了心情烦躁外，还会双目干涩，视物模糊、胁肋作痛等症状。如果继续失养，病情加重，除了肝阴受损外，会出现肝叶枯槁，硬化，萎缩，甚至是肝癌。所以早期的肝气郁结，会导致肝郁化火→邪火伤阴→肝叶枯槁→肝硬化→肝癌。肝脏的早期调理和保健至关重要。
肝主疏泄，凡一身之中，当疏而未疏，当通而未通的情况，均应该从肝入手进行调理。比如，肾结石，乳腺增生，性功能减退，肿瘤的调理均离不开疏肝理气。年轻的女性，好强争胜，稍有不顺就会怒火中烧，或抑郁寡欢。郁怒伤肝，木伤则不能疏土，时间长了脾胃气机就会郁滞，乳头属肝，乳房属胃，肝胃气滞不疏，气血周流失度，蕴结于乳房胃络，经脉阻塞不通，不通则痛，因此乳房疼痛。而肝郁化火，伤及肾水，火无水制，其炎更盛。所以，治疗乳腺增生，必须疏肝。
现代人生活压力大，导致男性性功能减退的人特别的多。大多数人都认为是肾虚，反复补肾，大量的补肾产品上市，但是效果却很一般。其实，性欲的问题不单单涉及到肾，而是与心、肝、肾息息相关，三个功能一个也不能差。心肝肾如同性之三部曲。心为性欲之“苗”；肝为性欲之“茎”；肾为性欲之“根”。心主欲，心血充足的人自然性欲望比较强烈，但有欲望未必能勃起。肝主筋，阴茎为肝筋所主，同时肝藏血，肝脏对血液的调节也是阴茎勃起的关键。所以，重度脂肪肝、肝硬化、酒精肝炎等肝血不足之人，纵然有欲望，也无法正常勃起。强弱与否，与肾密切相关，同房时间短的人，是肾精亏虚，这样的人才是真正的要补肾了。
专利申请CN111758873A公开了一种黄精人参补气保肝健脾胃增强免疫力的固体饮料，主要成分由食用葡萄糖、葛根、人参(人工种植)、茯苓、黄精、枸杞子组成；其配方比例为：食用葡萄糖20-35％、葛根16-29％、人参(人工种植)5-13％、茯苓9-20％、黄精3-9.5％、枸杞子13-25％，合并2次煎煮提取液浓缩干燥粉碎，再按颗粒剂制备方法制成颗粒。上述方案中采用黄精、人参等补药，不利于疏导肝郁，且不适合长期饮用。
发明内容
本发明的目的是提供一种保护肝脏的组合物，采用药食同源的葛根，白扁豆，枳椇子，蒲公英四种原料的提取物与茶多酚进行混合，具有解酒，保肝和护肝的功效。
发明人认为，上述女性、男性两个病症的例子表明，疾病的起因源于肝，治疗方案要从肝入手。人体的心血来源于肝，肝藏血，为心脏提供阴血。肝所藏之血来源肾，肾阴是肝血补充的关键。肾阴来源于胃，食物精微通过脾胃的消化，吸收，转化而来。由此可见，肝是中间通道，是“茎”，交通心肾，肝主疏泻气机，调节人体气机的升降对流，使寒与热、虚与实得到实时调整，有助于疾病的治疗。肝疏泻二便，及时排出人体内的废物和毒素。肝升胃降，使心肾相交，阴阳平衡，人才会白天精力充沛，晚上睡眠香甜，更不会出现现代病。
本发明中，蒲公英清肝降胃，抗氧化，保肝解毒，一剂蒲公英相当于“小柴胡汤”。调理肝胆脾胃四个点。使肝气上升条畅，胆气下降顺畅，脾胃中焦运转正常。现代医学研究表明，蒲公英还有抗肿瘤的功效。从中医理论来讲，蒲公英使肝气疏泄正常，不会郁结，自然也就祛除了形成肿瘤的先决条件。
白扁豆具有健胃化湿、清肝明目、利尿消肿，抗氧化，降血脂。调理脾胃中焦，胃气下降，也更容易使肝气上升，条达。
茶多酚抗氧化，能明显降低ALT血清、肝匀浆MDA含量,提高肝脏谷胱甘肽过氧化物酶活性,保肝护肝，防止酒精性肝损伤。另外，茶多酚可以清除过多的过氧化脂质及降低内毒素水平有关，有效抗肝纤维化。还能够调节胆固醇和甘油三酯的代谢，加速脂肪的燃烧，防止脂肪肝的形成。另外还能够促进肝脏内重金属的排除，比如，茶多酚可以显著降低血铅含量，增加尿铅排除。
葛根具有发表解肌、升阳透疹、解热生津等功效,据《本经》《药性论》《本草拾遗》《千金方》等著作记载葛根能“解酒毒”“治酒醉不醒”“开胃下食……止烦渴”。经现代科学研究表明,葛根中含有葛根素和类黄酮等化合物,该类物质对人体有多种保健作用,可促进心脑血管、视网膜血流的作用舒张平滑肌解痉挛作用，抗癌及诱导癌细胞分化作用，抗氧化作用，降血糖、降血脂和解热作用，降低血醇浓度解醉酒作用，提高学习记忆功能及增强机体免疫力的作用等。葛根解酒的机理：①葛根的主要有效成分葛根素在急性酒精中毒的情况下,可以改善内脏循环,增加组织的供氧量。②葛根素可以通过扩张血管,改善肾小管的痉挛状态而增加肾血流量,尿量增加,排泄增强。③葛根素可以通过清除氧自由基和抗脂质过氧化而使酒精中毒所致的血清黏度异常变化恢复到正常状态。④葛根素可以通过改善脑组织氧供及兴奋脑细胞作用,达到醒脑之作用。乙醇摄入后,使肝脏产生与醛类亲合力大的酶数量减少,致使乙醛在体内堆积,刺激脂质过氧化,而服用葛根后拟制活性氧减少脂质过氧化,从而起到保护细胞的作用。
枳椇子有清热利尿，解酒毒之功效，主治酒毒、烦热、口渴、呕吐、二便不利等症。民间素有“千杯不醉枳椇子”的说法。现代医学研究也证明，枳椇子提取物可加快乙醇代谢，降低酒后血醇浓度，增强肝脏乙醇脱氢酶活性，降低肝脏脂质过氧化风险，减少乙醇所致肝损伤。另外，其提取物还具有抗氧化、抗衰老、抗肿瘤和镇静、镇痛等作用。
整个配方从肝胆脾胃入手，葛根升阳升清；白扁豆健脾降浊；蒲公英，枳椇子，茶多酚清肝降浊，该升则升，该降则降，配伍合理，缺一不可，是一个有机整体，顺应脏腑的特性，使肝脏疏泄畅通，推动人体气血的正常运行，能够激发人体的自愈能力。
具体方案如下：
一种保护肝脏的组合物，按照重量份由以下组分组成：葛根提取物130-170重量份，蒲公英提取物80-120重量份，茶多酚30-70重量份，白扁豆提取物105-145重量份，枳椇子提取物55-95重量份。
进一步的，按照重量份由以下组分组成：葛根提取物140-160重量份，蒲公英提取物90-110重量份，茶多酚40-60重量份，白扁豆提取物115-135重量份，枳椇子提取物65-85重量份。
进一步的，按照重量份由以下组分组成：葛根提取物150重量份，蒲公英提取物100重量份，茶多酚50重量份，白扁豆提取物125重量份，枳椇子提取物75重量份。
进一步的，所述保护肝脏的组合物是将葛根，蒲公英，白扁豆，枳椇子四种原料的提取物与茶多酚混合制备得到，所述提取物是将葛根，蒲公英，白扁豆，枳椇子四种原料加水煎煮得到的水提液。
本发明还提供一种保护肝脏的中药制剂，所述保护肝脏的中药制剂包含所述保护肝脏的组合物，和药学上可接受的辅料，制成颗粒剂、片剂、膏剂、胶囊剂、口服液、丸剂或粉剂中的至少一种。
进一步的，将所述保护肝脏的组合物添加辅料制成片剂，辅料包括山梨糖醇，麦芽糊精或硬脂酸镁中至少一种。
进一步的，所述片剂按照重量份由以下组分组成：葛根提取物130-170重量份，蒲公英提取物80-120重量份，茶多酚30-70重量份，白扁豆提取物105-145重量份，枳椇子提取物55-95重量份，山梨糖醇140-160重量份，麦芽糊精40-60重量份，硬脂酸镁10-20重量份。
本发明还保护所述保护肝脏的组合物在制备解酒、保护肝脏，或者预防肝损伤的药物或者保健品上的用途。
有益效果：本发明所述保护肝脏的组合物的主要功效有：清肝利胆，健脾和胃，降压降脂，强效抗氧化，预防肝损伤，保肝解毒(如：酒精，尼古丁，重金属，农药等)，减淡色斑。适用人群：烟酒人群；熬夜人群；脂肪肝人群；工作压力大人群；用眼过度人群；皮肤敏感人群。
具体实施方式
下面将更详细地描述本发明的优选实施方式。虽然以下描述了本发明的优选实施方式，然而应该理解，可以以各种形式实现本发明而不应被这里阐述的实施方式所限制。实施例中未注明具体技术或条件者，按照本领域内的文献所描述的技术或条件或者按照产品说明书进行。所用试剂或仪器未注明生产厂商者，均为可以通过市购获得的常规产品。在下面的实施例中，如未明确说明，“％”均指重量百分比。
实施例1
将葛根提取物150g，蒲公英提取物100g，茶多酚50g，白扁豆提取物125g，枳椇子提取物75g，山梨糖醇150g，麦芽糊精50g，硬脂酸镁15g，混合均匀，过筛，压片，制成1000粒。
其中，各原料的提取物是将葛根，蒲公英，白扁豆，枳椇子四种原料分别加水煎煮得到的水提液，加水量为原料重量的5倍，煎煮30分钟。
实施例2
将葛根提取物160g，蒲公英提取物110g，茶多酚60g，白扁豆提取物135g，枳椇子提取物85g，山梨糖醇160g，麦芽糊精60g，硬脂酸镁20g，混合均匀，过筛，压片，制成1000粒。
其中，各原料的提取物是将葛根，蒲公英，白扁豆，枳椇子四种原料分别加水煎煮得到的水提液，加水量为原料重量的5倍，煎煮30分钟。
实施例3
将葛根提取物130g，蒲公英提取物80g，茶多酚30g，白扁豆提取物105g，枳椇子提取物55g，山梨糖醇140g，麦芽糊精40g，硬脂酸镁10g，混合均匀，过筛，压片，制成1000粒。
其中，各原料的提取物是将葛根，蒲公英，白扁豆，枳椇子四种原料分别加水煎煮得到的水提液，加水量为原料重量的5倍，煎煮30分钟。
实施例4
将葛根提取物170g，蒲公英提取物120g，茶多酚70g，白扁豆提取物145g，枳椇子提取物95g，山梨糖醇160g，麦芽糊精60g，硬脂酸镁20g，混合均匀，过筛，压片，制成1000粒。
其中，各原料的提取物是将葛根，蒲公英，白扁豆，枳椇子四种原料分别加水煎煮得到的水提液，加水量为原料重量的5倍，煎煮30分钟。
实施例5
将葛根提取物150g，蒲公英提取物100g，茶多酚50g，白扁豆提取物125g，枳椇子提取物75g，混合均匀装入密封体内制成胶囊。
其中，各原料的提取物是将葛根，蒲公英，白扁豆，枳椇子四种原料分别加水煎煮得到的水提液，加水量为原料重量的5倍，煎煮30分钟。
实施例6
将葛根提取物150g，蒲公英提取物100g，茶多酚50g，白扁豆提取物125g，枳椇子提取物75g，混合均匀后装成胶囊剂，或者制成粉剂，颗粒剂、膏剂、口服液、丸剂等形式。
其中，各原料的提取物是将葛根，蒲公英，白扁豆，枳椇子四种原料分别加水煎煮得到的水提液，加水量为原料重量的5倍，煎煮30分钟。
以上详细描述了本发明的优选实施方式，但是，本发明并不限于上述实施方式中的具体细节，在本发明的技术构思范围内，可以对本发明的技术方案进行多种简单变型，这些简单变型均属于本发明的保护范围。
另外需要说明的是，在上述具体实施方式中所描述的各个具体技术特征，在不矛盾的情况下，可以通过任何合适的方式进行组合。为了避免不必要的重复，本发明对各种可能的组合方式不再另行说明。
此外，本发明的各种不同的实施方式之间也可以进行任意组合，只要其不违背本发明的思想，其同样应当视为本发明所公开的内容。
Claims (8)
1.一种保护肝脏的组合物，其特征在于：按照重量份由以下组分组成：葛根提取物130-170重量份，蒲公英提取物80-120重量份，茶多酚30-70重量份，白扁豆提取物105-145重量份，枳椇子提取物55-95重量份。
2.根据权利要求1所述保护肝脏的组合物，其特征在于：按照重量份由以下组分组成：葛根提取物140-160重量份，蒲公英提取物90-110重量份，茶多酚40-60重量份，白扁豆提取物115-135重量份，枳椇子提取物65-85重量份。
3.根据权利要求2所述保护肝脏的组合物，其特征在于：按照重量份由以下组分组成：葛根提取物150重量份，蒲公英提取物100重量份，茶多酚50重量份，白扁豆提取物125重量份，枳椇子提取物75重量份。
4.根据权利要求1-3任一项所述保护肝脏的组合物，其特征在于：所述保护肝脏的组合物是将葛根，蒲公英，白扁豆，枳椇子四种原料的提取物与茶多酚混合制备得到，所述提取物是将葛根，蒲公英，白扁豆，枳椇子四种原料加水煎煮得到的水提液。
5.一种保护肝脏的中药制剂，其特征在于：所述保护肝脏的中药制剂包含权利要求1-4任一项所述保护肝脏的组合物，和药学上可接受的辅料，制成颗粒剂、片剂、膏剂、胶囊剂、口服液、丸剂或粉剂中的至少一种。
6.根据权利要求5所述保护肝脏的中药制剂，其特征在于：将所述保护肝脏的组合物添加辅料制成片剂，辅料包括山梨糖醇，麦芽糊精或硬脂酸镁中至少一种。
7.根据权利要求6所述保护肝脏的中药制剂，其特征在于：所述片剂按照重量份由以下组分组成：葛根提取物130-170重量份，蒲公英提取物80-120重量份，茶多酚30-70重量份，白扁豆提取物105-145重量份，枳椇子提取物55-95重量份，山梨糖醇140-160重量份，麦芽糊精40-60重量份，硬脂酸镁10-20重量份。
8.一种权利要求1-4任一项所述保护肝脏的组合物在制备解酒、保护肝脏，或者预防肝损伤的药物或者保健品上的用途。
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