CN112402324B - Lavender hand cleaning solution and preparation method thereof - Google Patents
Lavender hand cleaning solution and preparation method thereof Download PDFInfo
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Abstract
The invention discloses lavender hand cleaning solution which is prepared from the following raw materials: disodium ethylene diamine tetraacetate, citric acid, pigment, DMDM hydantoin, rosemary extract, lavender extract, coconut oil fatty acid diethanolamide, sodium chloride, fatty alcohol-polyoxyethylene ether sodium sulfate and deionized water. The lavender hand cleaning solution disclosed by the invention has a good antibacterial effect and also has a good cleaning effect; the antibacterial effect is obviously improved by the lavender extract and the rosemary extract; the lavender extract with excellent antibacterial effect is obtained by extracting water-soluble parts of lavender stems and then performing vacuum freeze drying (prefreezing, freeze drying, sublimation drying and desorption drying); the rosemary extract with excellent antibacterial effect is obtained by crushing rosemary cell crushing materials, putting the crushed rosemary cell crushing materials into ethanol solution, extracting the crushed rosemary cell crushing materials by using a microwave extraction device, and adding macroporous adsorption resin.
Description
Technical Field
The invention relates to the field of hand cleaning liquid, and particularly relates to lavender hand cleaning liquid and a preparation method thereof.
Background
At present, hand cleaning liquid is mainly used for cleaning hands of people except for cleaning products such as perfumed soap and soap. The soap and soap have strong cleaning power, but have certain irritation, the hand skin is rough after long-term use, and consumers feel particularly dry hands and have strong irritation after using the soap due to the high alkalinity of the soap.
The hand sanitizer in the market is eight-door. On the one hand, most hand sanitizers have poor comfort. After washing, part of the product feels greasy, so that people feel not washed clean; after washing, part of the product has tight skin, and people feel uncomfortable. On the other hand, the sterilization and bacteriostasis components of the prior laundry detergent are mainly synthetic chemicals. Has certain irritation to skin, and is rough after long-term use.
Disclosure of Invention
The lavender hand cleaning solution has a good antibacterial effect and a good cleaning effect.
The invention adopts the following technical scheme for solving the technical problems:
the lavender hand cleaning solution is prepared from the following raw materials in parts by weight: 0.03-0.08 part of disodium ethylene diamine tetraacetate, 0.04-0.1 part of citric acid, 0.02-0.1 part of pigment, 0.2-0.6 part of DMDM hydantoin, 0.8-2 parts of rosemary extract, 0.8-2 parts of lavender extract, 1-3 parts of coconut oil fatty acid diethanolamide, 1.8-3 parts of sodium chloride, 16-20 parts of fatty alcohol polyoxyethylene ether sodium sulfate and 65-75 parts of deionized water.
As a preferable scheme, the lavender hand cleaning liquid is prepared from the following raw materials in parts by weight: 0.04-0.08 part of disodium ethylene diamine tetraacetate, 0.05-0.1 part of citric acid, 0.03-0.1 part of pigment, 0.2-0.5 part of DMDM hydantoin, 1-2 parts of rosemary extract, 1-2 parts of lavender extract, 1.5-3 parts of coconut oil fatty acid diethanolamide, 2-3 parts of sodium chloride, 16-19 parts of fatty alcohol polyoxyethylene ether sodium sulfate and 70-75 parts of deionized water.
As a most preferred scheme, the lavender hand cleaning solution is prepared from the following raw materials in parts by weight: 0.05 part of disodium ethylene diamine tetraacetate, 0.06 part of citric acid, 0.07 part of pigment, 0.4 part of DMDM hydantoin, 1.5 parts of rosemary extract, 1.5 parts of lavender extract, 2 parts of coconut oil fatty acid diethanolamide, 2.5 parts of sodium chloride, 18 parts of fatty alcohol-polyoxyethylene ether sodium sulfate and 73.92 parts of deionized water.
As a preferred scheme, the preparation method of the lavender extract comprises the following steps:
s1, washing lavender stems, drying, and crushing to 60-100 meshes to obtain lavender stem powder;
s2, adding lavender stem powder into deionized water, carrying out steam distillation to obtain an oil-water mixture, and separating a water phase;
s3, putting the water phase into a freezing box, quickly freezing, quickly reducing the temperature of the freezing box to-45 to-35 ℃, starting a vacuum pump, vacuumizing the freezing box to 40 to 50Pa, and keeping the temperature and the vacuum degree for 40 to 70min;
s4, adjusting the temperature of the freeze-drying box to-25 to-15 ℃, keeping the vacuum degree at 25 to 35Pa, and keeping the temperature for 40 to 70min; the temperature of the freeze-drying box is raised to-5 to 5 ℃, the vacuum degree is adjusted to 20 to 30Pa, and the freeze-drying box is kept for 40 to 70min; and then adjusting the temperature of the freeze-drying box to 10-20 ℃, adjusting the vacuum degree to 15-25 Pa, keeping the vacuum degree for 60-100 min, finally, finishing freeze-drying when the vacuum degree is restored to the atmospheric pressure, and crushing the mixture to 100-200 meshes to obtain the lavender extract.
The inventor of the invention surprisingly discovers in a large number of experiments that the lavender extract with excellent antibacterial effect is obtained by extracting the water-soluble part of the lavender stem and then performing vacuum freeze drying (prefreezing, freeze drying, sublimation drying and analysis drying).
As a preferable scheme, the weight ratio of the lavender stalk powder to the deionized water in the S2 is 1:6 to 10.
As a preferred embodiment, the preparation method of the rosemary extract comprises the following steps:
s11, cleaning rosemary, drying and crushing to obtain rosemary powder;
s12, mixing rosemary powder, a crushed material for crushing fine bubbles and deionized water according to a weight ratio of 100:1 to 3:300 to 600, reacting for 2 to 5 hours at a temperature of between 60 and 75 ℃ to obtain a mixture;
s13, adding the mixture into a microwave extraction device, adding 2-4 times of 60-80 wt% ethanol solution of the mixture, heating to 60-70 ℃, and extracting for 12-18 min under 500-800W of microwave power to obtain an extracting solution;
s14, concentrating the extracting solution until the water content is 10-20%, adjusting the pH value to 4.6-5, loading the extracting solution on macroporous adsorption resin at the rate of 0.8-1.2 BV/h, washing the extracting solution at the rate of 1.5-2.5 BV/h by deionized water, washing the extracting solution at the rate of 1.2-2BV by 60-80 wt% of ethanol solution at the rate of 1.5-3 BV, collecting ethanol washing solution, and drying to obtain the rosemary extract.
The inventor of the present invention has surprisingly found in a large number of experiments that a rosemary extract having an excellent antibacterial effect is obtained by crushing a rosemary cell fragment, placing the crushed rosemary cell fragment into an ethanol solution, extracting the crushed rosemary cell fragment with a microwave extraction device, and passing the crushed rosemary cell fragment through a macroporous adsorbent resin.
As a preferable scheme, the S11 is crushed to 50 to 80 meshes.
Preferably, the disrupted material for cell disruption is prepared from cellulase, pectinase and CTAB at a weight ratio of 1:0.8 to 2: 0.2-0.5.
As a preferable scheme, the macroporous absorption resin is HPD-600.
The invention also provides a preparation method of the lavender hand cleaning solution, which comprises the following steps:
(1) Heating deionized water to 80-90 ℃, adding fatty alcohol-polyoxyethylene ether sodium sulfate, disodium ethylene diamine tetraacetate and citric acid, and uniformly stirring;
(2) Adding coconut oil fatty acid diethanolamide, and stirring uniformly;
(3) Cooling to 40-50 ℃, adding citric acid, pigment, DMDM hydantoin, rosemary extract, lavender extract and sodium chloride, and uniformly stirring to obtain the lavender hand cleaning solution.
The invention has the beneficial effects that: (1) The lavender hand cleaning solution disclosed by the invention has a good antibacterial effect and also has a good cleaning effect; (2) According to the invention, the antibacterial effect is obviously improved through the lavender extract and the rosemary extract; (3) The lavender extract with excellent antibacterial effect is obtained by extracting water-soluble parts of lavender stems and then performing vacuum freeze drying (prefreezing, freeze drying, sublimation drying and resolution drying); the rosemary extract with excellent antibacterial effect is obtained by crushing cell crushing materials for rosemary, putting the crushed materials into ethanol solution, extracting the crushed materials by using a microwave extraction device, and then passing the crushed materials through macroporous adsorption resin.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the present invention, the "parts" are all parts by weight unless otherwise specified.
Example 1
The lavender hand cleaning solution is prepared from the following raw materials in parts by weight: 0.05 part of disodium ethylene diamine tetraacetate, 0.06 part of citric acid, 0.07 part of pigment, 0.4 part of DMDM hydantoin, 1.5 parts of rosemary extract, 1.5 parts of lavender extract, 2 parts of coconut oil fatty acid diethanolamide, 2.5 parts of sodium chloride, 18 parts of fatty alcohol polyoxyethylene ether sodium sulfate and 73.92 parts of deionized water.
The preparation method of the lavender extract comprises the following steps:
s1, washing lavender stems, drying, and crushing to 80 meshes to obtain lavender stem powder;
s2, adding lavender stem powder into deionized water, carrying out steam distillation to obtain an oil-water mixture, and separating a water phase;
s3, putting the water phase into a freezing box, quickly freezing, quickly reducing the temperature of the freezing box to-40 ℃, starting a vacuum pump, vacuumizing the freezing box to 48Pa, and keeping the temperature and the vacuum degree for 60min;
s4, adjusting the temperature of the freeze-drying box to-20 ℃, keeping the vacuum degree at 30Pa, and keeping for 55min; the temperature of the freeze-drying box is raised to 0 ℃, the vacuum degree is adjusted to 25Pa, and the freeze-drying box is kept for 50min; adjusting the temperature of the freeze drying box to 15 deg.C, vacuum degree to 20Pa, maintaining for 80min, recovering vacuum degree to atmospheric pressure, freeze drying, and pulverizing to 150 mesh to obtain Lavender extract.
In the S2, the weight ratio of the lavender stem powder to the deionized water is 1:9.
the preparation method of the rosemary extract comprises the following steps:
s11, cleaning rosemary, drying, and crushing to 60 meshes to obtain rosemary powder;
s12, mixing rosemary powder, a crushed material for fine soaking and crushing, and deionized water according to a weight ratio of 100:2:400, reacting for 4 hours at 70 ℃ to obtain a mixture;
s13, adding the mixture into a microwave extraction device, adding a 70wt% ethanol solution which is 3 times of the weight of the mixture, heating to 65 ℃, and extracting for 15min under the microwave power of 700W to obtain an extracting solution;
s14, concentrating the extracting solution until the water content is 12%, adjusting the pH value to 4.8, loading the macroporous adsorption resin at the rate of 1BV/h, washing the resin with deionized water at the rate of 2BV/h, washing the resin with 70wt% ethanol solution at the rate of 2BV/h, collecting ethanol washing liquid, and drying to obtain the rosemary extract.
The crushed material for cell crushing is prepared from cellulase, pectinase and CTAB according to the weight ratio of 1:1: 0.4.
The macroporous adsorption resin is HPD-600.
The preparation method of the lavender hand cleaning liquid comprises the following steps:
(1) Heating deionized water to 85 deg.C, adding sodium fatty alcohol-polyoxyethylene ether sulfate, disodium edetate and citric acid, and stirring;
(2) Adding coconut oil fatty acid diethanolamide, and stirring uniformly;
(3) Cooling to 45 deg.C, adding citric acid, pigment, DMDM hydantoin, herba Rosmarini officinalis extract, lavender extract, and sodium chloride, and stirring to obtain Lavender hand cleaning solution.
Example 2
The lavender hand cleaning solution is prepared from the following raw materials in parts by weight: 0.03 part of disodium ethylene diamine tetraacetate, 0.04 part of citric acid, 0.02 part of pigment, 0.2 part of DMDM hydantoin, 0.8 part of rosemary extract, 0.8 part of lavender extract, 1 part of coconut oil fatty acid diethanolamide, 1.8 parts of sodium chloride, 16 parts of fatty alcohol polyoxyethylene ether sodium sulfate and 65 parts of deionized water.
The preparation method of the lavender extract comprises the following steps:
s1, washing lavender stems, drying, and crushing to 80 meshes to obtain lavender stem powder;
s2, adding lavender stem powder into deionized water, carrying out steam distillation to obtain an oil-water mixture, and separating a water phase;
s3, putting the water phase into a freezing box, quickly freezing, quickly reducing the temperature of the freezing box to-40 ℃, starting a vacuum pump, vacuumizing the freezing box to 48Pa, and keeping the temperature and the vacuum degree for 60min;
s4, adjusting the temperature of the freeze-drying box to-20 ℃, keeping the vacuum degree at 30Pa, and keeping for 55min; the temperature of the freeze-drying box is raised to 0 ℃, the vacuum degree is adjusted to 25Pa, and the freeze-drying box is kept for 50min; adjusting the temperature of the freeze drying box to 15 deg.C, vacuum degree to 20Pa, maintaining for 80min, recovering vacuum degree to atmospheric pressure, freeze drying, and pulverizing to 150 mesh to obtain Lavender extract.
In the S2, the weight ratio of the lavender stem powder to the deionized water is 1:9.
the preparation method of the rosemary extract comprises the following steps:
s11, cleaning rosemary, drying, and crushing to 60 meshes to obtain rosemary powder;
s12, mixing rosemary powder, a crushed material for crushing fine bubbles and deionized water according to a weight ratio of 100:2:400, reacting for 4 hours at 70 ℃ to obtain a mixture;
s13, adding the mixture into a microwave extraction device, adding 70wt% ethanol solution which is 3 times the weight of the mixture, heating to 65 ℃, and extracting for 15min under the microwave power of 700W to obtain an extracting solution;
s14, concentrating the extracting solution until the water content is 12%, adjusting the pH value to 4.8, performing macroporous adsorption resin at the rate of 1BV/h and the elution speed of 2BV/h by using deionized water to wash 1.5BV and 70wt% ethanol solution to wash 2BV, collecting ethanol washing liquid, and drying to obtain the rosemary extract.
The crushed material for cell crushing is prepared from cellulase, pectinase and CTAB according to the weight ratio of 1:1: 0.4.
The macroporous adsorption resin is HPD-600.
The preparation method of the lavender hand cleaning liquid comprises the following steps:
(1) Heating deionized water to 85 ℃, adding fatty alcohol-polyoxyethylene ether sodium sulfate, disodium ethylene diamine tetraacetate and citric acid, and uniformly stirring;
(2) Adding coconut oil fatty acid diethanolamide, and stirring uniformly;
(3) Cooling to 45 deg.C, adding citric acid, pigment, DMDM hydantoin, herba Rosmarini officinalis extract, lavender extract, and sodium chloride, and stirring to obtain Lavender hand cleaning solution.
Example 3
The lavender hand cleaning solution is prepared from the following raw materials in parts by weight: 0.08 part of disodium ethylene diamine tetraacetate, 0.1 part of citric acid, 0.1 part of pigment, 0.6 part of DMDM hydantoin, 1.2 parts of rosemary extract, 1.2 parts of lavender extract, 3 parts of coconut oil fatty acid diethanolamide, 2 parts of sodium chloride, 20 parts of fatty alcohol-polyoxyethylene ether sodium sulfate and 75 parts of deionized water.
The preparation method of the lavender extract comprises the following steps:
s1, washing lavender stems, drying, and crushing to 80 meshes to obtain lavender stem powder;
s2, adding lavender stem powder into deionized water, carrying out steam distillation to obtain an oil-water mixture, and separating a water phase;
s3, putting the water phase into a freezing box, quickly freezing, quickly reducing the temperature of the freezing box to-40 ℃, starting a vacuum pump, vacuumizing the freezing box to 48Pa, and keeping the temperature and the vacuum degree for 60min;
s4, adjusting the temperature of the freeze-drying box to-20 ℃, keeping the vacuum degree at 30Pa, and keeping for 55min; the temperature of the freeze-drying box is raised to 0 ℃, the vacuum degree is adjusted to 25Pa, and the freeze-drying box is kept for 50min; adjusting the temperature of the freeze drying box to 15 deg.C, vacuum degree to 20Pa, maintaining for 80min, recovering vacuum degree to atmospheric pressure, freeze drying, and pulverizing to 150 mesh to obtain Lavender extract.
In the S2, the weight ratio of the lavender stem powder to the deionized water is 1:9.
the preparation method of the rosemary extract comprises the following steps:
s11, cleaning rosemary, drying, and crushing to 60 meshes to obtain rosemary powder;
s12, mixing rosemary powder, a crushed material for fine soaking and crushing, and deionized water according to a weight ratio of 100:2:400, reacting for 4 hours at 70 ℃ to obtain a mixture;
s13, adding the mixture into a microwave extraction device, adding 70wt% ethanol solution which is 3 times the weight of the mixture, heating to 65 ℃, and extracting for 15min under the microwave power of 700W to obtain an extracting solution;
s14, concentrating the extracting solution until the water content is 12%, adjusting the pH value to 4.8, loading the macroporous adsorption resin at the rate of 1BV/h, washing the resin with deionized water at the rate of 2BV/h, washing the resin with 70wt% ethanol solution at the rate of 2BV/h, collecting ethanol washing liquid, and drying to obtain the rosemary extract.
The crushed material for cell crushing is prepared from cellulase, pectinase and CTAB according to the weight ratio of 1:1: 0.4.
The macroporous adsorption resin is HPD-600.
The preparation method of the lavender hand cleaning liquid comprises the following steps:
(1) Heating deionized water to 85 ℃, adding fatty alcohol-polyoxyethylene ether sodium sulfate, disodium ethylene diamine tetraacetate and citric acid, and uniformly stirring;
(2) Adding coconut oil fatty acid diethanolamide, and stirring uniformly;
(3) Cooling to 45 deg.C, adding citric acid, pigment, DMDM hydantoin, herba Rosmarini officinalis extract, lavender extract, and sodium chloride, and stirring to obtain Lavender hand cleaning solution.
Example 4
The lavender hand cleaning solution is characterized by being prepared from the following raw materials in parts by weight: 0.06 part of disodium ethylene diamine tetraacetate, 0.05 part of citric acid, 0.08 part of pigment, 0.4 part of DMDM hydantoin, 1.6 parts of rosemary extract, 1.6 parts of lavender extract, 2.5 parts of coconut oil fatty acid diethanolamide, 2.4 parts of sodium chloride, 18 parts of fatty alcohol-polyoxyethylene ether sodium sulfate and 75 parts of deionized water.
The preparation method of the lavender extract comprises the following steps:
s1, washing lavender stems, drying, and crushing to 80 meshes to obtain lavender stem powder;
s2, adding lavender stem powder into deionized water, carrying out steam distillation to obtain an oil-water mixture, and separating a water phase;
s3, putting the water phase into a freezing box, quickly freezing, quickly reducing the temperature of the freezing box to-40 ℃, starting a vacuum pump, vacuumizing the freezing box to 48Pa, and keeping the temperature and the vacuum degree for 60min;
s4, adjusting the temperature of the freeze-drying box to-20 ℃, keeping the vacuum degree at 30Pa, and keeping for 55min; the temperature of the freeze-drying box is raised to 0 ℃, the vacuum degree is adjusted to 25Pa, and the freeze-drying box is kept for 50min; adjusting the temperature of the freeze drying box to 15 deg.C, vacuum degree to 20Pa, maintaining for 80min, recovering vacuum degree to atmospheric pressure, freeze drying, and pulverizing to 150 mesh to obtain Lavender extract.
In the S2, the weight ratio of the lavender stem powder to the deionized water is 1:9.
the preparation method of the rosemary extract comprises the following steps:
s11, cleaning rosemary, drying, and crushing to 60 meshes to obtain rosemary powder;
s12, mixing rosemary powder, a crushed material for crushing fine bubbles and deionized water according to a weight ratio of 100:2:400, reacting for 4 hours at 70 ℃ to obtain a mixture;
s13, adding the mixture into a microwave extraction device, adding a 70wt% ethanol solution which is 3 times of the weight of the mixture, heating to 65 ℃, and extracting for 15min under the microwave power of 700W to obtain an extracting solution;
s14, concentrating the extracting solution until the water content is 12%, adjusting the pH value to 4.8, loading the macroporous adsorption resin at the rate of 1BV/h, washing the resin with deionized water at the rate of 2BV/h, washing the resin with 70wt% ethanol solution at the rate of 2BV/h, collecting ethanol washing liquid, and drying to obtain the rosemary extract.
The crushed material for cell crushing is prepared from cellulase, pectinase and CTAB according to the weight ratio of 1:1: 0.4.
The macroporous adsorption resin is HPD-600.
The preparation method of the lavender hand cleaning liquid comprises the following steps:
(1) Heating deionized water to 85 ℃, adding fatty alcohol-polyoxyethylene ether sodium sulfate, disodium ethylene diamine tetraacetate and citric acid, and uniformly stirring;
(2) Adding coconut oil fatty acid diethanolamide, and stirring uniformly;
(3) Cooling to 45 deg.C, adding citric acid, pigment, DMDM hydantoin, herba Rosmarini officinalis extract, lavender extract, and sodium chloride, and stirring to obtain Lavender hand cleaning solution.
Comparative example 1
Comparative example 1 differs from example 1 in that comparative example 1 does not contain the lavender extract, the rest being the same.
Comparative example 2
Comparative example 2 is different from example 1 in that the lavender extract described in comparative example 2 is prepared by a method different from that of example 1, and the rest is the same.
The preparation method of the lavender extract comprises the following steps:
s1, washing lavender stems, drying, and crushing to 80 meshes to obtain lavender stem powder;
s2, adding lavender stem powder into deionized water, carrying out steam distillation to obtain an oil-water mixture, and separating a water phase;
and S3, drying the water phase in a drying oven at the constant temperature of 85 ℃ to obtain the lavender extract.
The weight ratio of the lavender stem powder to the deionized water in the S2 is 1:9.
comparative example 3
Comparative example 3 differs from example 1 in that the lavender extract of comparative example 3 is commercially available and the lavender extract of this comparative example is purchased from Yang Lingci, destiny biotech, inc, and is otherwise identical.
Comparative example 4
Comparative example 4 differs from example 1 in that comparative example 4 does not contain the rosemary extract, and is otherwise identical.
Comparative example 5
Comparative example 5 is different from example 1 in that the rosemary extract described in comparative example 5 was prepared by the same method as example 1.
The preparation method of the rosemary extract comprises the following steps:
s11, cleaning rosemary, drying and crushing to 60 meshes to obtain rosemary powder;
s12, mixing rosemary powder, a crushed material for crushing fine bubbles and deionized water according to a weight ratio of 100:2:400, reacting for 4 hours at 70 ℃ to obtain a mixture;
s13, adding the mixture into a microwave extraction device, adding a 70wt% ethanol solution which is 3 times of the weight of the mixture, heating to 65 ℃, and extracting for 15min under the microwave power of 700W to obtain an extracting solution;
s14, drying the extracting solution to obtain the rosemary extract.
The crushed material for cell crushing is prepared from cellulase, pectinase and CTAB according to the weight ratio of 1:1: 0.4.
Comparative example 6
Comparative example 6 is different from example 1 in that the rosemary extract described in comparative example 6 was prepared by the same method as example 1.
The preparation method of the rosemary extract comprises the following steps:
s11, cleaning rosemary, drying, and crushing to 60 meshes to obtain rosemary powder;
s12, mixing rosemary powder, a crushed material for fine soaking and crushing, and deionized water according to a weight ratio of 100:2:400, reacting for 4 hours at 70 ℃ to obtain a mixture;
s13, adding the mixture into a microwave extraction device, adding a 70wt% ethanol solution which is 3 times of the weight of the mixture, heating to 65 ℃, and extracting for 15min under the microwave power of 700W to obtain an extracting solution;
s14, concentrating the extracting solution until the water content is 12%, adjusting the pH value to 4.8, performing macroporous adsorption resin at the rate of 1BV/h and the elution speed of 2BV/h by using deionized water to wash 1.5BV and 70wt% ethanol solution to wash 2BV, collecting ethanol washing liquid, and drying to obtain the rosemary extract.
The crushed material for cell crushing is prepared from cellulase and pectinase according to the weight ratio of 1: 1.
The macroporous adsorbent resin is HPD-600.
To further demonstrate the effect of the present invention, the following test methods were provided:
1. according to the industrial standard QB/T2850-2007 antibacterial bacteriostatic detergent, bacteriostatic effect tests are carried out, the action concentration is 1wt%, the action time is 20 minutes, the test strains are Staphylococcus aureus (Staphylococcus aureus) ATCC 6538 and Escherichia coli (Escherichia coli) 8099, and the test results are shown in table 1.
TABLE 1 antimicrobial testing
As can be seen from Table 1, the lavender hand cleaning solution provided by the invention has a good antibacterial effect.
It can be known from comparative examples 1 to 4 that the antibacterial effect of the cleaning solution can be affected by the mixture ratio of different lavender hand cleaning solutions, wherein the best mixture ratio is adopted in example 1, and the best antibacterial effect is achieved.
Comparing example 1 with comparative example 1, it can be seen that the lavender extract of the present invention can significantly improve the antibacterial effect of the cleaning solution.
As can be seen from comparison of example 1 and comparative example 2, the antibacterial effect of the lavender extract prepared by the vacuum freeze-drying method of the present invention can be improved more than that of the lavender extract prepared by the vacuum freeze-drying method of the present invention.
As can be seen from comparison of example 1 and comparative example 3, the lavender extract prepared according to the present invention has an improved antibacterial effect as compared to commercially available lavender extracts.
Comparing example 1 with comparative example 4, it can be seen that the rosemary extract of the present invention can significantly improve the antibacterial effect.
Comparing example 1 with comparative examples 5 and 6, it can be seen that the antibacterial effect is significantly reduced when the rosemary extract is different from example 1.
In light of the foregoing description of the preferred embodiment of the present invention, it is to be understood that various changes and modifications may be made by those skilled in the art without departing from the scope and spirit of the invention. The technical scope of the present invention is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (7)
1. The lavender hand cleaning solution is characterized by being prepared from the following raw materials in parts by weight: 0.03-0.08 part of disodium ethylene diamine tetraacetate, 0.04-0.1 part of citric acid, 0.02-0.1 part of pigment, 0.2-0.6 part of DMDM hydantoin, 0.8-2 parts of rosemary extract, 0.8-2 parts of lavender extract, 1-3 parts of coconut oil fatty acid diethanolamide, 1.8-3 parts of sodium chloride, 16-20 parts of fatty alcohol polyoxyethylene ether sodium sulfate and 65-75 parts of deionized water;
the preparation method of the lavender extract comprises the following steps:
s1, washing lavender stems, drying, and crushing to 60-100 meshes to obtain lavender stem powder;
s2, adding lavender stem powder into deionized water, carrying out steam distillation to obtain an oil-water mixture, and separating a water phase;
s3, putting the water phase into a freeze-drying box, quickly freezing, quickly reducing the temperature of the freeze-drying box to-45 to-35 ℃, starting a vacuum pump, vacuumizing the freeze-drying box to 40 to 50Pa, and keeping the temperature and the vacuum degree for 40 to 70min;
s4, adjusting the temperature of the freeze-drying box to-25 to-15 ℃, keeping the vacuum degree at 25 to 35Pa, and keeping the temperature for 40 to 70min; the temperature of the freeze-drying box is raised to-5 to 5 ℃, the vacuum degree is adjusted to 20 to 30Pa, and the freeze-drying box is kept for 40 to 70min; and then adjusting the temperature of a freeze-drying box to be 10-20 ℃, adjusting the vacuum degree to be 15-25 Pa, keeping the vacuum degree for 60-100 min, finally, ending freeze-drying when the vacuum degree is restored to the atmospheric pressure, and crushing the mixture to be 100-200 meshes to obtain the lavender extract.
2. The lavender hand cleaning solution according to claim 1, wherein the lavender hand cleaning solution is prepared from the following raw materials in parts by weight: 0.04-0.08 part of disodium ethylene diamine tetraacetate, 0.05-0.1 part of citric acid, 0.03-0.1 part of pigment, 0.2-0.5 part of DMDM hydantoin, 1-2 parts of rosemary extract, 1-2 parts of lavender extract, 1.5-3 parts of coconut oil fatty acid diethanolamide, 2-3 parts of sodium chloride, 16-19 parts of fatty alcohol polyoxyethylene ether sodium sulfate and 70-75 parts of deionized water.
3. The lavender hand cleaning liquid according to claim 1, wherein the lavender hand cleaning liquid is prepared from the following raw materials in parts by weight: 0.05 part of disodium ethylene diamine tetraacetate, 0.06 part of citric acid, 0.07 part of pigment, 0.4 part of DMDM hydantoin, 1.5 parts of rosemary extract, 1.5 parts of lavender extract, 2 parts of coconut oil fatty acid diethanolamide, 2.5 parts of sodium chloride, 18 parts of fatty alcohol polyoxyethylene ether sodium sulfate and 73.92 parts of deionized water.
4. The lavender hand cleaning solution of claim 1, wherein the weight ratio of lavender stalk powder to deionized water in S2 is 1:6 to 10.
5. The lavender hand cleaning liquid of claim 1, wherein the rosemary extract is prepared by the method comprising:
s11, cleaning rosemary, drying and crushing to obtain rosemary powder;
s12, mixing rosemary powder, a crushed material for cell crushing and deionized water according to the weight ratio of 100:1 to 3:300 to 600, reacting for 2 to 5 hours at a temperature of between 60 and 75 ℃ to obtain a mixture;
s13, adding the mixture into a microwave extraction device, adding 2-4 times of 60-80 wt% ethanol solution of the mixture, heating to 60-70 ℃, and extracting for 12-18 min under the microwave power of 500-800W to obtain an extracting solution;
s14, concentrating the extracting solution until the water content is 10-20%, adjusting the pH value to 4.6-5, loading the extracting solution on macroporous adsorption resin at the rate of 0.8-1.2 BV/h, washing the extracting solution by deionized water at the rate of 1.5-2.5 BV/h, washing the extracting solution by 60-80 wt% ethanol solution at the rate of 1.5-3 BV, collecting ethanol washing solution, and drying to obtain rosemary extract;
the crushed material for cell crushing is prepared from cellulase, pectinase and CTAB according to the weight ratio of 1:0.8 to 2: 0.2-0.5.
6. The lavender hand cleansing liquid of claim 5, wherein S11 is pulverized to 50-80 mesh.
7. The lavender hand cleaning solution of claim 5, wherein the macroporous adsorbent resin is HPD-600.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102351701A (en) * | 2011-10-27 | 2012-02-15 | 广州汉方现代中药研究开发有限公司 | Method for separating and purifying rosmarinic acid from Tibetan radix salviae miltiorrhizae |
| CN108014042A (en) * | 2017-10-24 | 2018-05-11 | 泰合玺健康科技南京有限公司 | Releive and massage essential oil |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004123674A (en) * | 2002-10-07 | 2004-04-22 | Noevir Co Ltd | Skin care preparation for external use |
| CN103006742B (en) * | 2013-01-05 | 2014-07-09 | 邓钦伦 | Ultramicro mair-cona total-effect preparation and preparation method, dosage form and application thereof |
| CN104189335A (en) * | 2014-09-02 | 2014-12-10 | 张会英 | Lacrimal passage flushing fluid for caring infantile dacryocystitis and preparation method thereof |
| CN105287291A (en) * | 2015-11-18 | 2016-02-03 | 华文蔚 | Shampoo containing lavender extraction liquid |
| CN106221923A (en) * | 2016-08-26 | 2016-12-14 | 广西灏源盛世生物科技有限公司 | A kind of extracting method of Herba Lysimachiae foenum-graeci quintessence oil |
| CN106938006B (en) * | 2017-05-04 | 2020-09-08 | 广东武大珞珈健康科技有限公司 | Polygonatum sibiricum extract and preparation method and application thereof |
| EP3688128B1 (en) * | 2017-09-28 | 2021-05-26 | Lubrizol Advanced Materials, Inc. | Polymeric thickener for iridescent liquid hand soap compositions |
| CN108743423A (en) * | 2018-08-23 | 2018-11-06 | 安庆枝梅化工有限责任公司 | A kind of environmental protection disinfection hand cleanser |
| CN111214411A (en) * | 2020-03-27 | 2020-06-02 | 江苏瑞丰科技实业有限公司 | Antibacterial hand sanitizer |
-
2020
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102351701A (en) * | 2011-10-27 | 2012-02-15 | 广州汉方现代中药研究开发有限公司 | Method for separating and purifying rosmarinic acid from Tibetan radix salviae miltiorrhizae |
| CN108014042A (en) * | 2017-10-24 | 2018-05-11 | 泰合玺健康科技南京有限公司 | Releive and massage essential oil |
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Denomination of invention: A lavender hand cleaning solution and its preparation method Effective date of registration: 20230609 Granted publication date: 20221018 Pledgee: Guangdong Fogang Rural Commercial Bank Co.,Ltd. Pledgor: GUANGZHOU BAIFEI COSMETICS Co.,Ltd. Registration number: Y2023980043381 |
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