CN112791036A - Acarus-killing itching-relieving enhanced anti-dandruff shampoo preparation containing sweet wormwood herb - Google Patents
Acarus-killing itching-relieving enhanced anti-dandruff shampoo preparation containing sweet wormwood herb Download PDFInfo
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- CN112791036A CN112791036A CN202110219091.8A CN202110219091A CN112791036A CN 112791036 A CN112791036 A CN 112791036A CN 202110219091 A CN202110219091 A CN 202110219091A CN 112791036 A CN112791036 A CN 112791036A
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- extract
- parts
- itching
- relieving
- dandruff
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- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 5
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- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
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Abstract
The invention relates to an itching relieving shampoo, and aims to provide a mite-removing itching-relieving enhanced anti-dandruff shampoo preparation containing sweet wormwood. The shampoo preparation comprises a hair conditioner, and the hair conditioner comprises the following components in parts by weight: 0.05-0.2 part of allantoin, 0.10-0.50 part of guar hydroxypropyl trimethyl ammonium chloride, 0.10-0.50 part of dicetyl dimethyl ammonium chloride, 0.05-0.50 part of panthenol, 0.05-0.50 part of wild soybean oil and 0.01-1 part of purslane extract; and conventional surfactants, softeners, thickeners, and the like. The invention can achieve the purposes of lasting itching relieving, bacteriostasis and mite removal due to the addition of the southernwood extract for mite removal, and can play a role in enhancing dandruff removal together with the purslane extract.
Description
Technical Field
The invention belongs to the field of daily chemical articles, also relates to a biological extraction technology, and particularly relates to a mite-removing, itching-relieving, dandruff-removing and hair-washing preparation containing sweet wormwood herb.
Background
The shampoo preparation is also called shampoo or hair rinse, shampoo and shampoo, and is a cosmetic product for basic nursing of hair and scalp. The shampoo contains various components, and the combined action of the components can play a role in cleaning scalp and hair. The most effective component of shampoo is surfactant, i.e. short for "surface active component"; the surfactant has the effect of cleaning hair and scalp, and when the shampoo is mixed with water, it can generate foam to clean dirt.
With the accelerated social rhythm, the mental pressure of people is increased, the sub-health is increased and the environmental pollution is caused; the problems of itchy scalp and dandruff become more and more serious. In addition, the existing shampoo on the market generally has more research on the dandruff removing problem, but the problem of scalp itching is less concerned. In fact, the problem of scalp itching is far more influenced than dandruff on the life of a patient, and a plurality of patients with simple dandruff can not even perceive the dandruff, so that the scalp itching hardly influences the life; the itching of the scalp affects the comfort, mood, and night sleep of the human body.
At present, the dandruff removing shampoo on the market mainly adds Zinc Pyrithione (ZPT) to realize the dandruff removing function. ZPT is a bacteriostatic agent for fungi and bacteria, and can be added into shampoo for removing dandruff. However, the addition of chemical drugs can not cure the symptoms and root causes, and chemical preparations have great irritation and further aggravate the problem of scalp pruritus.
Disclosure of Invention
The invention aims to provide a mite-removing, itching-relieving, dandruff-removing and hair-washing preparation containing sweet wormwood.
In order to achieve the above object, the present invention firstly provides a compound additive for shampoo: the hair conditioner for the shampoo preparation comprises the following components in parts by weight: 0.05-0.2 part of allantoin, 0.10-0.50 part of guar hydroxypropyl trimethyl ammonium chloride, 0.10-0.50 part of dicetyl dimethyl ammonium chloride, 0.05-0.50 part of panthenol, 0.05-0.50 part of wild soybean oil and 0.01-1 part of Chinese medicinal plant extract.
Preferably, the traditional Chinese medicine extract is a tea seed extract or a burdock extract or a purslane extract or a ginger extract.
Correspondingly, the core technical scheme of the invention is as follows: a mite-removing itching-relieving enhanced anti-dandruff shampoo preparation containing sweet wormwood herb and utilizing the hair conditioner comprises the following components in parts by weight: 13.5-22 parts of surfactant, 2-10 parts of softener, 2.8-3.2 parts of thickener, 0.1-0.2 part of zinc sulfate, 1.5-3 parts of acrylic resin, 1.2-2.2 parts of glycerol, 0.05-2 parts of zinc pyrithione, 0.2-1.5 parts of essence, 0.05-0.2 part of ethoxy diglycol, 0.01-1 part of sweet wormwood herb extract, 0.36-3.2 parts of conditioner for hair, 0.06-0.3 part of preservative, 37.8-75.57 parts of purified water and pH value of a pH regulator system of 6-7; in the conditioner for hair, the traditional Chinese medicine plant extract is a purslane extract.
Preferably, the surfactant is at least one of sodium laureth sulfate, ammonium laureth sulfate, cocamidopropyl betaine and cocamide MEA;
and/or the preservative is at least one of methyl chloro isothiazolinone and methyl isothiazolinone;
and/or, the softener is at least one of polydimethylsiloxane and sodium methylcocoyl taurate;
and/or the thickening agent is at least one of dimethiconol, sodium chloride and cetearyl alcohol.
Preferably, the preparation method of the sweet wormwood herb extract comprises the following steps: cleaning fresh sweet wormwood, crushing and sieving with a 10-mesh sieve; then circularly freezing and unfreezing for a plurality of times, and finally crushing the frozen material again and sieving the crushed material with a 20-mesh sieve; extracting by steam extraction under negative pressure to obtain volatile oil-water separation oil layer as the herba Artemisiae Annuae extract, and extracting the residue as material for extracting artemisinin.
Preferably, the purslane extract is replaced by a tea seed extract or a burdock extract or a ginger extract.
Preferably, the weight ratio of: the surfactant is a combination of 12-18 parts of sodium laureth sulfate, 1.5-4 parts of ammonium laureth sulfate, 3-8 parts of cocamidopropyl betaine and 0.8-1.5 parts of cocamide MEA; the softener is a combination of 1-5 parts of polydimethylsiloxane and 1-5 parts of sodium methyl cocoyl taurate; the thickening agent is a combination of 0.8-2 parts of dimethiconol, 0.1-1 part of sodium chloride and 0.1-0.2 part of cetearyl alcohol; the preservative is a combination of 0.05-0.15 part of methyl chloroisothiazolinone and 0.01-0.15 part of methyl isothiazolinone.
The invention has the following beneficial effects:
1. the shampoo not only has the cleaning and washing functions of the conventional shampoo preparation, but also has the finished products of thickening agent, chelating agent, aromatic agent, preservative, suspending agent and the like. The main surfactant and the amino acid surfactant are matched according to a certain proportion, so that the good foaming degree and cleaning power are ensured, the irritation to the scalp is reduced to the maximum extent, the product is milder, and the washing and protecting effects are better.
2. According to the invention, the product has more stable properties and more excellent cleaning and maintenance effects through the optimization of specific components. And the sweet wormwood extract is added to play a role in removing mites and relieving itching. The itching of scalp and dandruff are caused by mites or some fungi and bacteria, and the purposes of lasting itching relieving, bacteriostasis and mite removal can be achieved by adding the artemisia apiacea extract to remove the mites and inhibit bacteria. And the sweet wormwood herb can clear heat and decompose malaria and expel wind and relieve itching, so the extract of the sweet wormwood herb also has the effect of relieving itching of the traditional Chinese medicine and plays a role in multiple itching relieving and dandruff removing.
3. The sweet wormwood herb extract, the tea seed oil and other substances can durably refresh the mind, and can directly act on the head of a human body to stimulate the immunity of the human body. The tea seed oil and the sweet wormwood herb extract also have the effects of killing and inhibiting bacteria, dehumidifying and the like in the aspect of traditional Chinese medicine, and the application of the artemisinin extracted from the sweet wormwood herb to the treatment of malaria mainly with fever is the best evidence. Therefore, the sweet wormwood herb and the effective components thereof can obviously improve the immunity of the human body and provide resistance to infectious diseases.
4. The invention also adds plant extracts except the sweet wormwood herb and the sweet wormwood herb extract to play a synergistic effect. The tea seed extract is generally called tea oil, has a lasting anti-withering effect, and the synergistic effect of the tea seed extract and the tea oil enables the shampoo preparation to have the effects of removing mites, inhibiting bacteria, relieving itching, reducing dandruff, moistening, brightening, preventing dry withering and the like, and is mild, healthy, hormone-free and lasting in efficacy. The sweet wormwood herb extract and the burdock extract can synergistically play the effects of removing mites, relieving itching and controlling oil; the purslane extractive can play a role in strengthening and removing dandruff together; the ginger extract can be used for removing mites, relieving itching, nourishing hair and growing hair.
Detailed Description
The following specific examples are provided to further clarify the technical solutions and effects of the present invention for those skilled in the art.
EXAMPLE A Artemisia annua extract preparation
Artemisia annua Linn, the scientific name of Artemisia annua, and the preparation method of the Artemisia annua extract comprises the following steps: cleaning fresh sweet wormwood, crushing and sieving with a 10-mesh sieve; then circularly freezing and unfreezing the wet material for a plurality of times, and crushing the frozen material and sieving the crushed material with a 20-mesh sieve during each unfreezing; the circulation frequency is 3-5 times, the freezing temperature is generally-10 to-4 ℃, the time is 3-10 hours, and the freezing is ensured to be completely frozen and to stay for a certain time; the thawing temperature is generally 15-25 ℃, and complete thawing is ensured. The plant cells can be fully broken in the whole low-temperature environment and by repeated freezing and thawing and crushing. Then extracting by a water vapor extraction method under the negative pressure of 0.2-0.1 MPa, and obtaining an oil layer which is a stand-by sweet wormwood herb extract and is obtained by separating volatile phase oil from water. During water vapor extraction, water vapor is introduced from the lower part of the material and overflows from the upper part of the material, and the lipophilic non-woven fabric is covered on the upper part of the material. The lipophilic nonwoven fabric such as unbleached raw cotton is lipophilic and can be made into oil-absorbing nonwoven fabric. The upper part is covered with lipophilic non-woven fabrics, which is beneficial to absorbing and adsorbing oil from the lower part to go upwards, and is more convenient to volatilize under hot gas. Meanwhile, the color of the non-woven fabric can be observed conveniently, and the extraction process of the volatile oil can be judged. The non-woven fabric can be reused, and the loss of adhered oil is almost negligible. Volatile oil can be overflowed more fully by performing steam distillation extraction on the wall-broken sweet wormwood herb, the boiling points of a plurality of substances are reduced by performing the steam distillation extraction under negative pressure, the volatilization temperature is lower, the active substances are prevented from being denatured by high temperature, the yield of the volatile oil and the content of active ingredients are higher, and the volatile oil is suitable for being used in the shampoo preparation. The extraction process is simple and is suitable for large-scale production.
Because the artemisinin is insoluble in water and has a melting point and a boiling point which are far higher than those of water, the artemisinin is completely remained in the residue, and the residue can be used as a raw material for extracting the artemisinin to extract the artemisinin. The residue of the invention can avoid the interference of the subsequent extraction of the artemisinin and simplify the artemisinin extraction process because most of volatile oil is separated, therefore, the process of the invention has good economic and environmental protection advantages and social benefits when being combined with the artemisinin extraction unit.
10 kg of fresh sweet wormwood raw materials produced in Sichuan in the same batch are respectively taken, groups 1-3 are extracted according to the method of the invention, and the fresh sweet wormwood plants or the dried sweet wormwood plants are directly extracted by comparison with the groups 1, 2 and 3 obtained by steam distillation after cutting the sweet wormwood in the conventional process, and the experimental results are as follows:
therefore, the yield of the volatile oil can be obviously improved by adopting the method of the invention, and the yield without adopting oleophylic non-woven fabrics is obviously better than that of the prior art, but the ideal extraction effect cannot be achieved. Although the yield of the dry sweet wormwood is obviously higher, 1 catty of dry sweet wormwood can be obtained basically by more than 4 catties of fresh sweet wormwood, and although the air-drying process has certain oil loss, the yield is several times of that of the fresh sweet wormwood, but the actual yield is not multiplied by the method, so that the extraction effect is better and the extraction efficiency is higher. In addition, the process of the invention does not need complex and precise process equipment, and the capacity is not limited.
The inhibition capability of the artemisia apiacea extract obtained by extracting the groups 1-3 on mites is detected according to the national standard GB/T24253-:
sample (I) | Time of action | Mite number in control plate | Number of mites in test group plate | Inhibition rate |
Extraction group 1 | 7 days | 154 | 0 | 100% |
Extraction group 2 | 7 days | 159 | 0 | 100% |
Extraction group 3 | 7 days | 144 | 0 | 100% |
The anti-mite effect of the sweet wormwood herb volatile oil is evaluated according to the national standard, namely that the sample has extremely strong anti-mite effect.
EXAMPLE two compositions of mite-killing and itching-relieving shampoo preparations
The mite-removing itching-relieving shampoo preparation comprises the following components in parts by weight:
remarking: acrylic resin, CAS number 25035-69-2; the wild soybean oil was purchased from Guangzhou Wuzhitang Biotech Co., Ltd; the tea seed extract is obtained from Mount Huangshan Huishan edible oil Co., Ltd, and is processed by physical squeezing process.
EXAMPLE three preparation of shampoo formulations
According to the formulation of example two, the shampoo preparation was prepared by the steps of:
A. purified water was added to the reaction kettle while turning on steam heating and stirring. The stirring speed is 25-40rpm, the slow stirring speed can cause long dissolving time, and the fast stirring speed can cause foam generation, which is not beneficial to the subsequent process. Adding sodium laureth sulfate, ammonium laureth sulfate and sodium methyl cocoyl taurate, heating to 80 deg.C, maintaining the temperature, and stirring for 30 min; the material is better dissolved.
Then adding allantoin, zinc sulfate, cetostearyl alcohol, wild soybean oil, cocamide MEA, guar hydroxypropyl trimethyl ammonium chloride, citric acid, and cocamidopropyl betaine, wherein pH is 6-6.5. And after stirring for another 20 minutes, closing the steam valve, and opening the cooling water valve to start cooling.
B. When the temperature is reduced to 65 ℃ (excessive temperature can cause partial material decomposition, and excessive temperature can cause insolubility), acrylic resin, sodium hydroxide, glycerol, dicetyl dimethyl ammonium chloride and zinc pyrithione are added, and the pH value is 6.5-7. Stirring at the temperature of 20-35rpm for 25 min, and stirring for 25 min to dissolve completely.
C. When the temperature is reduced to 48 ℃ (excessive temperature can cause partial material decomposition, and excessive temperature can cause insolubility), adding polydimethylsiloxane, dimethiconol, methylchloroisothiazolinone, methylisothiazolinone, ethoxy diglycol, panthenol, tea seed (CAMELLIA SINENSIS) extract, sweet wormwood (ARTEMISIA ANNUA) extract, essence and sodium chloride, increasing stirring speed to 25-40rpm, and stirring for 20 minutes to completely dissolve the material.
D. And when the temperature is reduced to 45 ℃, closing the cooling water valve, sampling and detecting, and after the temperature is qualified, extracting the material body for filling, wherein the pH value of the product is between 6 and 7.
EXAMPLE four shampoo preparations product Performance and Effect
The bacteriostatic properties of the products 1-4 obtained by processing the formula examples I to IV in the example II according to the method in the example III and the shampoos 1-3 containing the sweet wormwood herb extract in the market are tested in the formula examples I to IV in the example II. The strain is provided by Yunnan university of traditional Chinese medicine. The test method comprises the following steps: and (3) detecting the antibacterial effect by adopting an antibacterial ring method under the same condition, wherein the used strain is staphylococcus aureus, and the used culture medium is an agar culture medium. The test results are given in the following table:
sample (I) | Bacteriostatic diameter (mm) | Remarks for note |
Product 1 | 23.9 | |
Product 2 | 22.2 | |
Product 3 | 24.1 | |
Product 4 | 19.9 | |
Commercial example 1 | 10.5 | |
Commercial example 2 | 16.2 | |
Commercial example 3 | 6.5 |
As can be seen from the bacteriostatic effect of the table 1, the shampoo preparations of the embodiments 1 to 4 of the invention have better inhibitory effect on Staphylococcus aureus, and are obviously superior to the commercial products. The existing research proves that the specific gravity of staphylococcus aureus in microorganisms on dandruff is high, and staphylococcus aureus is a widely existing bacterium, so that the effect of the invention can prove that the invention has high inhibition effect on most of bacteria, and the antibacterial effect of the invention has inhibition effect on dandruff generation.
Human body using effect
350 volunteers with the problems of dandruff and scalp itching are selected, randomly divided into 7 groups, 50 of each group are respectively used with the shampoos of products 1-4 and commercial examples 1-3, and the dandruff-removing and itching-relieving effects of the shampoos are evaluated after use. Specifically, after the test subjects used the products for 1 week, the respective samples were tested for dandruff-removing and itching-relieving effects for 24 hours and 72 hours after shampooing. Subjective evaluation of the subjects is taken as a main evaluation, and the evaluation adopts a score of 5: the score of 5 is the highest score, and the score of 1 is the lowest score. And 5-1 points represent in turn: little head itch with no dandruff, somatosensory itching or visible dandruff, occasional head itch with little dandruff, improvement of dandruff or itching on the one hand, no improvement of both dandruff and head itch. Higher scores represent better results. The evaluation results are shown in the following table:
sample (I) | Anti-dandruff effect in 1 day | Antipruritic effect in 1 day | Anti-dandruff effect for 3 days | Antipruritic effect in 3 days |
Product 1 | 4.9 | 5.0 | 4.6 | 4.9 |
Product 2 | 5.0 | 5.0 | 4.4 | 4.6 |
Product 3 | 5.0 | 4.9 | 4.7 | 5.0 |
Product 4 | 4.8 | 5.0 | 4.2 | 4.7 |
Commercial example 1 | 4.7 | 4.3 | 2.7 | 3.3 |
Commercial example 2 | 4.9 | 4.2 | 3.9 | 3.5 |
Commercial example 3 | 4.6 | 3.5 | 2.6 | 1.9 |
As can be seen from the above results, the products 1 to 4 of the present invention have no significant advantage in the anti-dandruff and anti-itch effects one day after use, but the advantage is very significant after 3 days, compared to the commercial products. The product of the invention has strong capacity of removing dandruff and relieving itching for a long time. Radically improves the quality of hair and scalp, and does not adopt pure chemical drugs to remove dandruff and relieve itching.
Claims (7)
1. A hair conditioner for a shampoo preparation, characterized in that: the weight composition is as follows: 0.05-0.2 part of allantoin, 0.10-0.50 part of guar hydroxypropyl trimethyl ammonium chloride, 0.10-0.50 part of dicetyl dimethyl ammonium chloride, 0.05-0.50 part of panthenol, 0.05-0.50 part of wild soybean oil and 0.01-1 part of Chinese medicinal plant extract.
2. The hair conditioner for shampoo preparation as set forth in claim 1, characterized in that: the traditional Chinese medicine extract is a tea seed extract or a burdock extract or a purslane extract or a ginger extract.
3. A mite-removing itching-relieving enhanced dandruff-removing hair washing preparation containing Artemisia annua and using the hair conditioner of claim 1, which is characterized in that: comprises the following components by weight: 13.5-22 parts of surfactant, 2-10 parts of softener, 2.8-3.2 parts of thickener, 0.1-0.2 part of zinc sulfate, 1.5-3 parts of acrylic resin, 1.2-2.2 parts of glycerol, 0.05-2 parts of zinc pyrithione, 0.2-1.5 parts of essence, 0.05-0.2 part of ethoxy diglycol, 0.01-1 part of sweet wormwood herb extract, 0.36-3.2 parts of conditioner for hair, 0.06-0.3 part of preservative, 37.8-75.57 parts of purified water and pH value of a pH regulator system of 6-7; in the conditioner for hair, the traditional Chinese medicine plant extract is a purslane extract.
4. The mite-killing itching-relieving enhanced dandruff-removing hair washing preparation containing artemisia apiacea as claimed in claim 1, which is characterized in that: the surfactant is at least one of sodium laureth sulfate, ammonium laureth sulfate, cocamidopropyl betaine and cocamide MEA;
and/or the preservative is at least one of methyl chloro isothiazolinone and methyl isothiazolinone;
and/or, the softener is at least one of polydimethylsiloxane and sodium methylcocoyl taurate;
and/or the thickening agent is at least one of dimethiconol, sodium chloride and cetearyl alcohol.
5. The mite-killing itching-relieving enhanced dandruff-removing hair washing preparation containing artemisia apiacea as claimed in claim 3, wherein: the preparation method of the sweet wormwood herb extract comprises the following steps: cleaning fresh sweet wormwood, crushing and sieving with a 10-mesh sieve; then circularly freezing and unfreezing for a plurality of times, and finally crushing the frozen material again and sieving the crushed material with a 20-mesh sieve; extracting by steam extraction under negative pressure to obtain volatile oil-water separation oil layer as the herba Artemisiae Annuae extract, and extracting the residue as material for extracting artemisinin.
6. The shampoo preparation for removing mites and relieving itching as claimed in claim 3, wherein: the herba Portulacae extract is replaced by semen Camelliae sinensis extract or burdock extract or rhizoma Zingiberis recens extract.
7. The mite-killing itching-relieving enhanced dandruff-removing hair washing preparation containing artemisia apiacea as claimed in claim 3, wherein: according to the weight ratio:
the surfactant is a combination of 12-18 parts of sodium laureth sulfate, 1.5-4 parts of ammonium laureth sulfate, 3-8 parts of cocamidopropyl betaine and 0.8-1.5 parts of cocamide MEA;
the softener is a combination of 1-5 parts of polydimethylsiloxane and 1-5 parts of sodium methyl cocoyl taurate;
the thickening agent is a combination of 0.8-2 parts of dimethiconol, 0.1-1 part of sodium chloride and 0.1-0.2 part of cetearyl alcohol;
the preservative is a combination of 0.05-0.15 part of methyl chloroisothiazolinone and 0.01-0.15 part of methyl isothiazolinone.
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CN113018233A (en) * | 2021-03-10 | 2021-06-25 | 福州秋垄心田农业科技有限公司 | Bacteriostatic and itching-relieving plant composition and preparation method and application thereof |
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