CN109568219A - A kind of biology anti-dandruff and itching-relieving complexing agent and its application - Google Patents
A kind of biology anti-dandruff and itching-relieving complexing agent and its application Download PDFInfo
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- CN109568219A CN109568219A CN201910114345.2A CN201910114345A CN109568219A CN 109568219 A CN109568219 A CN 109568219A CN 201910114345 A CN201910114345 A CN 201910114345A CN 109568219 A CN109568219 A CN 109568219A
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- dandruff
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Abstract
The present invention relates to amenities technical fields, more particularly to a kind of biological anti-dandruff and itching-relieving complexing agent and its application, biological anti-dandruff and itching-relieving complexing agent includes the component of following mass percent: Artemisinin 2-4%, Radix Notoginseng root extract 2-4%, windproof root extract 2-3%, Folium Artemisiae Argyi extract 2-3%, common cnidium fruit P.E 2-3%, stephania tetrandra extract 1-3%, kuh-seng root extract 1-3%, Phenoxyethanol 0.6%, surplus is water.Wherein, the mass ratio of Artemisinin and Radix Notoginseng root extract is 1:1, and the mass ratio of stephania tetrandra extract and kuh-seng root extract is 1:1, and anti-dandruff and itching-relieving complexing agent of the invention can be used as functional raw material, for making shampoo, hair conditioner, hair gel.Biological anti-dandruff and itching-relieving complexing agent of the invention is rich in a variety of natural composite plant polyphenols, has and adjusts hormonal readiness and sebum metabolism, efficient anti-inflammatory sterilization, anti-dandruff and itching-relieving efficacies.
Description
Technical field
The present invention relates to amenities technical field more particularly to a kind of biological anti-dandruff and itching-relieving complexing agent and its applications.
Background technique
Dandruff is a kind of common physiological phenomenon of the mankind, is a kind of repeatability multiple cutaneous problem.The generation of dandruff
It is, once metabolism is not normal, just to have excessive scalp cells because scalp is ceaselessly carrying out metabolism and peel off, become
Seedless, abiotic cuticula, so as to cause dandruff problem.Traditional anti-dandruff and itching-relieving theory thinks that the generation of dandruff is because of two
Caused by the lipid metabolic waste of kind fungi, i.e., restricted chlosma and Malassezia cilobosa.Restricted chlosma and ball
The feature of shape chlosma has thermophilic lipid, they have disappeared using the fatty material secreted in people's scalp hair follicles as food by some
The fat of change stays on scalp, becomes the stimulus for causing dandruff.
Therefore, the assorted miscellaneous anti-dandruff and itching-relieving ingredient with bactericidal effect of each shape is applied to anti-dandruff and itching-relieving hair washing
In aquatic products, these shampoo products with anti-dandruff and itching-relieving function, only unilaterally in view of chlosma etc. on formula
Fungus-caused dandruff and itching of the scalp problem, are added in shampoo formula: the synthesis such as climbazole, ZPT, OTC are killed
The plants fungicide such as microbial inoculum or honeysuckle, lemongrass, tea oil, kuh-seng.
It has been generally acknowledged that dandruff is a kind of scalp affections of clinical inflammatory, there is periodical, recurrent or persistence, and
With different degrees of itch, shampoo, anti-dandruff and itching-relieving agent used in hair conditioner at present, whether Z.P.T, ketoconazole, still
Active climbazole etc. is chemically synthesized sterilization.Due to the variation of drug resistance of microorganism, effect cannot be lasting.In fact, from
Further reason sees that the metabolism of the generation of dandruff and hormonal readiness, sebum is related, and microorganism infection is external factor
One of.Therefore, anti-dandruff and itching-relieving wants integrated control could be effectively.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of biological anti-dandruff and itching-relieving complexing agent and its application, the biology are anti-dandruff
Antipruritic complexing agent is rich in a variety of natural composite plant polyphenols, has and adjusts hormonal readiness and sebum metabolism, and efficiently anti-inflammatory sterilization is gone
Consider itching-relieving efficacies to be worth doing.
The present invention solves above-mentioned technical problem by following technological means:
A kind of biology anti-dandruff and itching-relieving complexing agent, including Artemisinin, Radix Notoginseng root extract, windproof root extract, folium artemisiae argyi
Extract, common cnidium fruit P.E, stephania tetrandra extract, kuh-seng root extract.
Further, the anti-dandruff and itching-relieving complexing agent includes the component of following mass percent: Artemisinin 2-4%, three
Seven root extract 2-4%, windproof root extract 2-3%, Folium Artemisiae Argyi extract 2-3%, common cnidium fruit P.E 2-3%, Fourstamen Stephania Root mention
Object 1-3%, kuh-seng root extract 1-3%, Phenoxyethanol 0.6% are taken, surplus is water.
Further, the mass ratio of the Artemisinin and Radix Notoginseng root extract is 1:1, the stephania tetrandra extract and hardship
The mass ratio for joining root extract is 1:1.
Further, the anti-dandruff and itching-relieving complexing agent includes the component of following mass percent: Artemisinin 3%, Radix Notoginseng
Root extract 3%, windproof root extract 2%, Folium Artemisiae Argyi extract 3%, common cnidium fruit P.E 2.5%, stephania tetrandra extract 2%,
Kuh-seng root extract 2%, Phenoxyethanol 0.6%, surplus are water.
Further, the Radix Notoginseng root extract prepare it is as follows: the Roots of Panax Notoginseng after clean dry is pulverized to mistake
1300~1500 meshes Roots of Panax Notoginseng powder are added in deionized water according to solid-to-liquid ratio 400:1g/L, 55~60 DEG C of Yu Wendu, frequency
Ultrasonic oscillation 1h under the conditions of 28~33KHz, the filtrate being obtained by filtration carry out rotary evaporation concentration and extract to get to Roots of Panax Notoginseng
Object.
Further, the stephania tetrandra extract prepare it is as follows: dry Fourstamen Stephania Root is crushed to 500~800 meshes, in
50~55 DEG C of temperature, 7~10MPa of pressure, 5~6MPa of separating pressure, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction,
Obtained extract liquor i.e. stephania tetrandra extract.
The invention also discloses the applications of above-mentioned biological anti-dandruff and itching-relieving complexing agent, and the anti-dandruff and itching-relieving complexing agent being capable of conduct
Functional raw material, for making shampoo, hair conditioner, hair gel.
Further, dosage of the anti-dandruff and itching-relieving complexing agent in shampoo, hair conditioner, hair gel is 0.5-5%.
Further, dosage of the anti-dandruff and itching-relieving complexing agent in shampoo, hair conditioner, hair gel is 1.0%.
Biological anti-dandruff and itching-relieving complexing agent of the invention using the natural plants such as sweet wormwood, Radix Notoginseng, radix saposhnikoviae, folium artemisiae argyi, frutus cnidii as
Raw material obtains the natural components of its anti-inflammatory sterilization, the anti-dandruff hair care nursing scalp of the antipruritic plant herbal that desensitizes, rich in a variety of natural
Composite plant polyphenol has and adjusts hormonal readiness and sebum metabolism, and efficient anti-inflammatory sterilization, anti-dandruff and itching-relieving efficacies are a kind of novel
Biological anti-dandruff and itching-relieving complexing agent, there is good water solubility, compatibility is good, and dosage is few, the long advantage of aftereffect.Biology of the invention is gone
It considers antipruritic complexing agent to be worth doing to be added in eruption water with 0.5%~5% amount, there is effect antipruritic immediately after spraying, after a few days is used continuously,
Dandruff significantly reduces.
Detailed description of the invention
Fig. 1 is the effect picture after the biological anti-dandruff and itching-relieving complexing agent using the example IV containing 1%；
Fig. 2 is the fungistatic effect figure using the biological anti-dandruff and itching-relieving complexing agent of the example IV containing 1%；
Fig. 3 is the self-appraisal of dandruff improvement degree after the biological anti-dandruff and itching-relieving complexing agent using the example IV containing 1%
Result figure；
Fig. 4 is the self-appraisal knot of scalp grease degree after the biological anti-dandruff and itching-relieving complexing agent using the example IV containing 1%
Fruit figure.
Specific embodiment
Below with reference to the drawings and specific embodiments, the present invention is described in detail:
A kind of biological anti-dandruff and itching-relieving complexing agent of the invention includes the component of following mass percent: Artemisinin 2-
4%, Radix Notoginseng root extract 2-4%, windproof root extract 2-3%, Folium Artemisiae Argyi extract 2-3%, common cnidium fruit P.E 2-3%, powder
Radix Stephaniae Tetrandrae extract 1-3%, kuh-seng root extract 1-3%, Phenoxyethanol 0.6%, surplus is water.Wherein, Artemisinin and three
The mass ratio of seven root extracts is 1:1, and the mass ratio of stephania tetrandra extract and kuh-seng root extract is 1:1.
Preparing for the Radix Notoginseng root extract that the present invention uses is as follows: the Roots of Panax Notoginseng after clean dry is pulverized to mistake
1300~1500 meshes Roots of Panax Notoginseng powder are added in deionized water according to solid-to-liquid ratio 400:1g/L, 55~60 DEG C of Yu Wendu, frequency
Ultrasonic oscillation 1h under the conditions of 28~33KHz, the filtrate being obtained by filtration carry out rotary evaporation concentration and extract to get to Roots of Panax Notoginseng
Object.
Preparing for stephania tetrandra extract is as follows: dry Fourstamen Stephania Root is crushed to 500~800 meshes, Yu Wendu 50~55
DEG C, 7~10MPa of pressure, 5~6MPa of separating pressure, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extraction
Liquid, that is, stephania tetrandra extract.
Anti-dandruff and itching-relieving complexing agent of the invention can be used as functional raw material, for making shampoo, hair conditioner, gel
Water, and dosage of the anti-dandruff and itching-relieving complexing agent in shampoo, hair conditioner, hair gel is 0.5-5%.
Embodiment one
Preparing for the Radix Notoginseng root extract that the present embodiment uses is as follows: the Roots of Panax Notoginseng after clean dry is pulverized to mistake
1300 meshes Roots of Panax Notoginseng powder are added in deionized water according to solid-to-liquid ratio 400:1g/L, 55~60 DEG C of Yu Wendu, frequency 32KHz
Under the conditions of ultrasonic oscillation 1h, the filtrate that is obtained by filtration carries out rotary evaporation concentration to get to Radix Notoginseng root extract.
Preparing for the stephania tetrandra extract that the present embodiment uses is as follows: dry Fourstamen Stephania Root is crushed to 500 meshes, Yu Wen
Spend 50~55 DEG C, pressure 9MPa, separating pressure 5MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extraction
Take liquid i.e. stephania tetrandra extract.
The anti-dandruff and itching-relieving complexing agent of the present embodiment includes the component of following mass percent: Artemisinin 2%, Roots of Panax Notoginseng
Extract 2%, windproof root extract 3%, Folium Artemisiae Argyi extract 3%, common cnidium fruit P.E 2%, stephania tetrandra extract 1%, kuh-seng
Root extract 1%, Phenoxyethanol 0.6%, surplus are water.
Embodiment two
Preparing for the Radix Notoginseng root extract that the present embodiment uses is as follows: the Roots of Panax Notoginseng after clean dry is pulverized to mistake
1500 meshes Roots of Panax Notoginseng powder are added in deionized water according to solid-to-liquid ratio 400:1g/L, 55~60 DEG C of Yu Wendu, frequency 33KHz
Under the conditions of ultrasonic oscillation 1h, the filtrate that is obtained by filtration carries out rotary evaporation concentration to get to Radix Notoginseng root extract.
Preparing for the stephania tetrandra extract that the present embodiment uses is as follows: dry Fourstamen Stephania Root is crushed to 800 meshes, Yu Wen
Spend 50~55 DEG C, pressure 10MPa, separating pressure 6MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extraction
Take liquid i.e. stephania tetrandra extract.
The anti-dandruff and itching-relieving complexing agent of the present embodiment includes the component of following mass percent: Artemisinin 4%, Roots of Panax Notoginseng
Extract 4%, windproof root extract 2%, Folium Artemisiae Argyi extract 2%, common cnidium fruit P.E 3%, stephania tetrandra extract 3%, kuh-seng
Root extract 3%, Phenoxyethanol 0.6%, surplus are water.
Embodiment three
Preparing for the Radix Notoginseng root extract that the present embodiment uses is as follows: the Roots of Panax Notoginseng after clean dry is pulverized to mistake
1400 meshes Roots of Panax Notoginseng powder are added in deionized water according to solid-to-liquid ratio 400:1g/L, 55~60 DEG C of Yu Wendu, frequency 28KHz
Under the conditions of ultrasonic oscillation 1h, the filtrate that is obtained by filtration carries out rotary evaporation concentration to get to Radix Notoginseng root extract.
Preparing for the stephania tetrandra extract that the present embodiment uses is as follows: dry Fourstamen Stephania Root is crushed to 600 meshes, Yu Wen
Spend 50~55 DEG C, pressure 7MPa, separating pressure 5.5MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtains
Extract liquor, that is, stephania tetrandra extract.
The anti-dandruff and itching-relieving complexing agent of the present embodiment includes the component of following mass percent: Artemisinin 3.5%, Radix Notoginseng
Root extract 3.5%, windproof root extract 2.8%, Folium Artemisiae Argyi extract 2.8%, common cnidium fruit P.E 2.8%, Fourstamen Stephania Root extract
Object 1.8%, kuh-seng root extract 1.8%, Phenoxyethanol 0.6%, surplus are water.
Example IV
Preparing for the Radix Notoginseng root extract that the present embodiment uses is as follows: the Roots of Panax Notoginseng after clean dry is pulverized to mistake
1500 meshes Roots of Panax Notoginseng powder are added in deionized water according to solid-to-liquid ratio 400:1g/L, 55~60 DEG C of Yu Wendu, frequency 30KHz
Under the conditions of ultrasonic oscillation 1h, the filtrate that is obtained by filtration carries out rotary evaporation concentration to get to Radix Notoginseng root extract.
Preparing for the stephania tetrandra extract that the present embodiment uses is as follows: dry Fourstamen Stephania Root is crushed to 700 meshes, Yu Wen
Spend 50~55 DEG C, pressure 8MPa, separating pressure 6MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extraction
Take liquid i.e. stephania tetrandra extract.
The anti-dandruff and itching-relieving complexing agent of the present embodiment includes the component of following mass percent: Artemisinin 3%, Roots of Panax Notoginseng
Extract 3%, windproof root extract 2%, Folium Artemisiae Argyi extract 3%, common cnidium fruit P.E 2.5%, stephania tetrandra extract 2%, hardship
Join root extract 2%, Phenoxyethanol 0.6%, surplus is water.
Coherent detection:
1, antimicrobial and anti-inflammation efficacy is tested
Seborrhea volunteer scalp is being suffered from, the biological anti-dandruff and itching-relieving complexing agent containing 1.0% example IV is smeared
Aqueous solution determines the correlated condition of different times skin by volunteer main suit's itch degree, as shown in Figure 1.
The results showed that volunteer's scalp is because seborrheica after smearing the aqueous solution containing biological anti-dandruff and itching-relieving complexing agent
Itch pain phenomenon caused by dermatitis is mitigated, it was demonstrated that has good anti-inflammatory anti-itch effect.
2, bacteriostasis efficacy
Known according to the evaluation method of daily chemical products antibacterial bacteriostatic effect, with the type of anti-dandruff agent and the difference of dosage,
The diameter of antibacterial ring size also can be different.Debris removing agent effect is better, and inhibition zone diameter is bigger.
This test uses the shampoo containing 1% biological anti-dandruff and itching-relieving complexing agent, shampoo containing 1%ZPT, without debris removing ingredient
Shampoo carries out antibacterial ring test respectively, as shown in Figure 2.
The effect that can be seen that polyphenol dandruff-removing itching-relieve agent by the test is suitable compared with ZPT, has good debris removing effect.
3, subject's self-assessment
Questionnaire survey mode is taken in this test, and subject's self-assessment two sides dandruff quantity, scalp oil quantity is allowed to change
It is kind, and 0~3 member record is pressed, as a result as shown in Figure 3 and Figure 4.0 point=without improvement, 1 point ,=slightly improvement, 2 points=significantly changes
It is apt to, 3 points=improve completely.
Investigation is as can be seen that subject's self-appraisal dandruff improves and grease improves test side and is significantly better than control sides.
The above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to preferred embodiment to this hair
It is bright to be described in detail, those skilled in the art should understand that, it can modify to technical solution of the present invention
Or equivalent replacement should all cover without departing from the objective and range of technical solution of the present invention in claim of the invention
In range.Technology not described in detail in the present invention, shape, construction portion are well-known technique.
Claims (9)
1. a kind of biology anti-dandruff and itching-relieving complexing agent, which is characterized in that mentioned including Artemisinin, Radix Notoginseng root extract, opoponax
Take object, Folium Artemisiae Argyi extract, common cnidium fruit P.E, stephania tetrandra extract, kuh-seng root extract.
2. a kind of biological anti-dandruff and itching-relieving complexing agent according to claim 1, which is characterized in that the anti-dandruff and itching-relieving complexing agent
Component including following mass percent: Artemisinin 2-4%, Radix Notoginseng root extract 2-4%, windproof root extract 2-3%,
Folium Artemisiae Argyi extract 2-3%, common cnidium fruit P.E 2-3%, stephania tetrandra extract 1-3%, kuh-seng root extract 1-3%, benzene oxygen second
Alcohol 0.6%, surplus are water.
3. a kind of biological anti-dandruff and itching-relieving complexing agent according to claim 2, which is characterized in that the Artemisinin and three
The mass ratio of seven root extracts is 1:1, and the mass ratio of the stephania tetrandra extract and kuh-seng root extract is 1:1.
4. a kind of biological anti-dandruff and itching-relieving complexing agent according to claim 3, which is characterized in that the anti-dandruff and itching-relieving complexing agent
Component including following mass percent: Artemisinin 3%, Radix Notoginseng root extract 3%, windproof root extract 2%, folium artemisiae argyi mention
Take object 3%, common cnidium fruit P.E 2.5%, stephania tetrandra extract 2%, kuh-seng root extract 2%, Phenoxyethanol 0.6%, surplus
For water.
5. a kind of biological anti-dandruff and itching-relieving complexing agent according to claim 4, which is characterized in that the Radix Notoginseng root extract
It prepares as follows: the Roots of Panax Notoginseng after clean dry is pulverized to 1300~1500 meshes are crossed, it will according to solid-to-liquid ratio 400:1g/L
Roots of Panax Notoginseng powder is added in deionized water, and ultrasonic oscillation 1h under the conditions of 55~60 DEG C of Yu Wendu, 28~33KHz of frequency is filtered
The filtrate arrived carries out rotary evaporation concentration to get Radix Notoginseng root extract is arrived.
6. a kind of biological anti-dandruff and itching-relieving complexing agent according to claim 5, which is characterized in that the stephania tetrandra extract
It prepares as follows: dry Fourstamen Stephania Root is crushed to 500~800 meshes, 50~55 DEG C of Yu Wendu, 7~10MPa of pressure, separation pressure
5~6MPa of power, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extract liquor i.e. stephania tetrandra extract.
7. the application of -6 any a kind of biological anti-dandruff and itching-relieving complexing agents according to claim 1, which is characterized in that described to go
Considering antipruritic complexing agent to be worth doing can be as functional raw material, for making shampoo, hair conditioner, hair gel.
8. a kind of application of biological anti-dandruff and itching-relieving complexing agent according to claim 7, which is characterized in that the anti-dandruff and itching-relieving
Dosage of the complexing agent in shampoo, hair conditioner, hair gel is 0.5-5%.
9. a kind of application of biological anti-dandruff and itching-relieving complexing agent according to claim 8, which is characterized in that the anti-dandruff and itching-relieving
Dosage of the complexing agent in shampoo, hair conditioner, hair gel is 1.0%.
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| CN111096940A (en) * | 2020-02-19 | 2020-05-05 | 云南群优生物科技有限公司 | Mite-removing itching-relieving hair washing preparation containing sweet wormwood |
| CN111789793A (en) * | 2020-08-28 | 2020-10-20 | 广州市妆妍生物技术有限公司 | Care composition and method of making same |
| CN112274469A (en) * | 2020-11-10 | 2021-01-29 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition and application thereof |
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| CN111096940A (en) * | 2020-02-19 | 2020-05-05 | 云南群优生物科技有限公司 | Mite-removing itching-relieving hair washing preparation containing sweet wormwood |
| CN111096940B (en) * | 2020-02-19 | 2021-02-05 | 云南群优生物科技有限公司 | Mite-removing itching-relieving hair washing preparation containing sweet wormwood |
| CN111789793A (en) * | 2020-08-28 | 2020-10-20 | 广州市妆妍生物技术有限公司 | Care composition and method of making same |
| CN112274469A (en) * | 2020-11-10 | 2021-01-29 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition and application thereof |
| CN112274469B (en) * | 2020-11-10 | 2022-09-06 | 广州环亚化妆品科技股份有限公司 | Traditional Chinese medicine composition and application thereof |
| CN113081935A (en) * | 2021-04-28 | 2021-07-09 | 惠州市肌缘生物科技股份有限公司 | Amino acid oil-control fluffy moisturizing hair conditioner and preparation process thereof |
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