JP2003119151A - Cosmetic composition, or food and drink - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a lipase activity inhibitor, an active oxygen scavenger, a cosmetic composition or a food and drink, which are new and safe. SOLUTION: The lipase activity inhibitor, active oxygen scavenger, cosmetic composition, or food and drink contains an extract of Clematis vitalba L. The lipase activity inhibitor suppresses lipase activity, and effectively removes and suppresses activated oxygen. Further, it improves eczema, pimples and rough skin, and imparts tenseness and gloss to the skin, and it is effective for preventing the aging of the skin and the scalp. Further, it is safe when administered orally, or externally to a human or an animal. It can be used in any form of preparation (medicines, quasi-drugs, cosmetics, and foods and drinks).

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an application to a lipase activity inhibitor, an active oxygen scavenger, a cosmetic composition, or a food or drink containing a Kobotsudzu extract.

[Prior art]

Today, deterioration of environmental conditions and changes in lifestyle,
Acne vulgaris (acne), which can be especially abundant from adolescence to adolescence due to the increase in stress accompanying the complication of social life, has become one of the major worries of the skin in recent years regardless of gender or age.

The process of development of acne vulgaris (acne) is roughly divided into two stages. First, sebaceous follicles are clogged with keratin plugs (keratinized substances and sebum lumps), and comed ( Comes with). At this time, comedo (comes) is non-inflammatory, but then changes to papules, pustules, and inflammatory rashes that are difficult to treat, such as cysts.

[0004] The causes of this occurrence are three factors: endocrine factor (enhancement of sebaceous gland function), bacterial factor (proliferation of Propionibacterium acnes), and keratinizing factor (keratinizing damage of hair funnel part). It is said that the suppression of lipase activity is largely related to one factor (bacterial factor).

That is, as the initial stage of acne development,
When sebum secretion is activated / increased, Propionibacterium acnes produces enzymes such as hyaluronidase and protease in addition to lipase. In addition, lipase hydrolyzes triglyceride in sebum to produce free fatty acid. This free fatty acid stimulates the hair follicle wall, promotes keratinization, and promotes the formation of comedones (comedones). Furthermore, hyaluronidase and protease stimulate and destroy the hair follicle wall of comedo (comedones) to form inflammatory acne such as papules and pustules. However, by suppressing the activity of lipase, the suppression of free fatty acid production, the suppression of keratinization damage, and eventually the formation of comedo (comedones) are suppressed, and the secretion of sebum is rapidly secreted into the epidermis. Become.

[0006] In recent years, production of active oxygen in the living body and various effects (diseases) caused thereby have been reported. Generally, these active oxygens are also called Activated oxygens, and are roughly classified into 4 types of O ²⁻ , H ₂ O ₂ , · OH, and chemiluminescence. When it is caught as an important substance involved in defense and, for example, bacteria, viruses, foreign substances such as foreign substances (those that become antigens) invade the body, first phagocytic cells in blood, neutrophils, monocytes, macrophages are phagocytosed. Active oxygen is produced to initiate the action and then lyse the phagocytic foreign substances in the endoplasmic reticulum of phagocytes, and this produced active oxygen is responsible for the lysis of phagocytic food, while , Directly exerts a bactericidal action against external enemies such as bacteria and foreign substances, and plays a role of protecting from external enemies. In other words, it has the function of eliminating the antigenic substance before activating the immune function.

However, when the active oxygen for self-defense is excessively produced and secreted, even normal cells are lysed and stimulated, resulting in various disorder reactions. Recently, many active oxygen-induced diseases and diseases have been reported. For example, cholesterol and other oils and fats in blood are oxidized by active oxygen, resulting in vascular disorders due to arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.). It is said that, during cerebral trauma, blood flow disorder due to thrombus or the like, and ischemic state in blood vessel due to rapid transient atrophy, resulting in oxygen deficiency state. Therefore, in this state,
It is said that xanthine dehydrogenase in blood vessels is converted to xanthine oxidase, and a large amount of active oxygen is generated in blood in blood vessels, causing damage to blood vessel walls and causing fatal damage.

Further, regarding the relationship between the skin and the active oxygen, for example, since the skin is an organ which is in direct contact with the outside world, the active oxygen is excessively applied to the skin by ultraviolet rays or radiation while being susceptible to environmental factors. If the state continues, it reacts with unsaturated fatty acids and the like of the biomembrane phospholipid, and lipid peroxide is produced. This lipid peroxide causes arteriosclerosis, carcinogenesis, aging, membrane destruction, protein denaturation, etc.,
It also causes skin inflammation, edema, wrinkles and the like. Furthermore, as a disease caused by excess active oxygen, from a cosmetic point of view, for example, herpes dermatitis, roentgen dermatitis,
It is said to cause burns, trauma, sunlight dermatitis, contact dermatitis, eczema, atopic dermatitis, etc., and reduce skin tension and gloss.

[0009]

However, the above-mentioned lipase activity-inhibiting component or active oxygen scavenging substance has poor stability and solubility in the formulation system, causing offensive odor and coloring due to precipitation and decomposition, and The effect at the level of the living body was not sufficient, and there were problems in safety such as skin irritation, which was not satisfactory.

Further, as an external preparation having a therapeutic effect on acne,
Keratolytic agents (resorcin, salicylic acid, lactic acid, etc.), antiseborrheic agents (pyridoxine or its derivatives, sulfur, vitamin B6, etc.), antibacterial agents, anti-inflammatory agents, etc., but substances with lipase activity suppressing action Is currently unknown.

[0011]

In view of the above circumstances, the present inventors have developed various plants useful as lipase activity inhibitors and active oxygen scavengers, and as a result, as a result, lipases have been added to Kobodzu vine extract. It is confirmed that it has an activity suppressing action and an active oxygen scavenging (SOD) action, and therefore, it should be used as a lipase activity inhibitor and an active oxygen scavenger. Also, improve eczema, acne, and rough skin. Further, the present invention has been completed by providing a safe lipase activity inhibitor, an active oxygen scavenger, a cosmetic composition, or a food or drink that can impart tension and gloss to the skin.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, "Kobotan Crane (alias: Clematis, Clematis)" means a plant of the family Rannclaceae, Clematis: Kobotan Crane "Clematis vitalba L. (= C .brevicauda
ta DC.) '' flowers, spikes, pericarps, fruits, stems, leaves, branches, foliage,
The trunk, bark, rhizome, root bark, roots, seeds or whole plants are used,
In addition, the same species, C. apiifolia DC., C. chinensis Osbeck, and Japanese calyx, C. hexapetal
a Pall.), Ogi Dori (C.armandi Fr.), Pillar-fed wire lotus (C.unci
nata Champ.ex Benth.), hairy iron wire lotus (C. meyeniana Wal
p.), monoplane iron lotus (C.henryi Oliv.), Yamaki Dori (C.finetiana)
Level.et Vant.), Tohoku Iron Line Lotus (C.manshurica Rupr.),
Tessen (C. florida Thunb.)
(C.japonica Thunb.), (C.lanuginosa Lindl.), Cazagurma (C.patens Morr.et Decne), Kusa Button (C.stans S
ieb.et Zucc. Senninsou (C. terniflora D)
C.), safflower (C. texensis Buchl.),
(C. viticella L.) and the like can also be used.

[0013] The extract of Kobodzu crane used in the present invention means various parts of a plant (flower, spike, pericarp, fruit, stem,
(Leaves, branches, branches, stems, bark, rhizomes, root bark, roots, seeds or whole plants) as they are or after crushing and squeezing. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the Kotanduzu extract may be selected in consideration of the purpose of use, the type of product to be provided, the processing to be performed later, etc.
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, etc. or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, polyhydric alcohols such as glycerin, or hydrous polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the content of the organic solvent is not preferable depending on the purpose of use, water alone may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water. You can use the extracted one.
Furthermore, it can be used in a state where each solvent extract is combined.

[0015] In addition to hydrolytic extraction by enzymatic decomposition of Kobodzu crane, a product obtained by hydrolyzing with acid / alkali can also be used.

The production method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure. After extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected. It is also possible to add an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol or the like, or an arbitrary mixture thereof to the extract after extraction. The obtained extract can be used as it is, but can also be used as a paste or powder by concentrating and drying.

The Kobodzu vine extract of the present invention can be contained in a lipase activity inhibitor, an active oxygen scavenger, a cosmetic composition or a food or drink, and the content thereof is not particularly specified, but a lipase activity inhibitor, Slightly different depending on the type, quality, and expected degree of action of the active oxygen scavenger, cosmetic composition or food and drink. Expressed), preferably 0.01 to 50.0%. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so that the concentration is about the same.

Further, the lipase activity inhibitor, active oxygen scavenger, cosmetic composition or food / beverage product of the present invention may have any dosage form / form, including capsules, powders, granules, solids, liquids, gels, bubbles and emulsions. , Cream, ointment, sheet and the like can be mixed and used.

The fields of application thereof are, for example, all kinds of internal and external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules. , Solids, liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) pharmaceuticals, 2) quasi drugs, 3) topical or systemic skin cosmetics ( For example, lotions, emulsions, creams, ointments, lotions, oils, basic cosmetics such as packs, facial cleansers and skin cleansers, massage agents, cleansing agents,
Makeup cosmetics such as hair remover, depilatory, shaving treatment, after shave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail polish, beauty Nail enamel, beauty nail enamel remover, poultice, plaster, tape, sheet, patch, aerosol, etc.), 4) Medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoo) Agent, rinse agent,
Hair treatment agent, pre-hair treatment agent, permanent liquid, hair dye, hair styling agent, hair styling agent, hair growth agent, hair nourishing agent, patch agent, plaster agent, tape agent, sheet agent, patch agent, aerosol agent, etc.), 5) bath Bath agents to be used by pouring in hot water, 6) Others, armpit deodorant and deodorant,
Examples include deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpaste, mouthwash, mouthwash, and 7) food and drink.

Further, as foods and beverages, oral composition (gum, candy, etc.), processed fish paste products such as kamaboko and chikuwa, livestock products such as sausage and ham, western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles. , Noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy,
Seasonings such as starch syrup, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, greens, sprinkles, or processed vegetables and fruits such as canned and bottled vegetables and fruits, Dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice,
It can be used for general food and drink such as vegetable juice, whey beverage, soft drink, beverage such as alcoholic beverage, health food and the like.

The lipase activity inhibitor, active oxygen scavenger, cosmetic composition or food and drink of the present invention is, in addition to the above-mentioned essential components, if necessary, within the range not impairing the effect of the present invention, The components and additives exemplified above can be arbitrarily selected and used in combination, and the content in the preparation is not particularly limited, but usually 0.0001 to 50% is preferable.

(1) Various oils and fats Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide. Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant- or animal-based raw materials These are processes (for example, crushing, milling, washing, hydrolysis, etc.) which are conventionally carried out depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, etc., but usually, water, methanol, ethanol, propyl alcohol, isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

In addition, in foods and drinks, nutritional supplementation, recovery from fatigue, tonicity, healthy and cosmetic effects such as cell activation (prevention of cell aging), improvement of taste, imparting of color tone, aroma and luster, stabilization, It can be used for the purpose of thickening and preserving. In addition to this, expect various various cosmetic and pharmaceutical effects of each raw material known so far, and aim to enhance the desired effect by combining these.
Alternatively, the product can be expected to have a multi-functional effect.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Goji paulownia), Aotsutsurafuji (Kibo), Aotenma, Acacia, Red capsicum (Akasoma), Redcurrant `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red algae (Red bud), Red pine or Red madder or Red madder (Akane) (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Gua Su, Aguahe (Omi Tenguyashi), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (sweet tea), Amachatsuru, Amadokoro (Tamatake), Amana (Kokoji), Amaranthus (Hiyu, Hagatetow, Himegateto, Senninkoku, Sugimorigateto,
Hosoaogatetou, Aogatetou, Haribiyu, Aozulan, Amaranthus hippocondriacus), Amigasa lily or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), aloe (蘆 薆), aloe vera, angelica, apricot or hon apricot (apricot kernel), ansokkou (benzoin), yellow sapote, igakoukousrina (geijutsu), sardine or chinensis (indian cabbage), rush
(Wicked grass), Japanese knotweed (Kojo root), yew (first place), strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir Ogashira, Argentine (Rawberry), Unshu Mikan (Chenhide), Umboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibareniku, Echinashi), Enishi Mushrooms), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry "fruit",
Elemi, Eryngii or Pre-Lotus erynge, Enju (Sophorae, Sophorae rice), Pea, Ougi or Kibanana
(Yellow radish), Naruco lily or Kagi Kurumabanaruko Yuri (Yellow), Ohihisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Houken, Ookarasuri (Calocon),
Plantain (Civil engineering incense), Giant tsuboji (Self-defense), Plantain
(Carmaco, Carophyllum), Milk thistle (Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Ochera (White Sprout), Obana Sarsberg (Banaba), Ooba Yashaboshi "Fruit", "Fruit" Grains), Oomiacatetsu, Omihawthorn or Hawthorn
(Yamashiko), Omiyashi, Barley (barley), Oka, Okazeri (Heiwako), Okra "fruit", Oguruma (overturning), Oklurihigotai (Banzhou Leopard, Indigo Spin), Panax ginseng or Panax ginseng (carrot) , Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (younger brother cut grass), Odorikosou (intermittent), Onami (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninogagara
(Tianma), Oniyuri or Sasayuri or Hakatayuri (yuri),
Onoelan, Ononis, halibut, Ominaeshi
(Soy sauce), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch millet, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, peel",
Kaikaizou (ripe ground yellow), cacao "fruit, peel, seed", oyster (persimmon "leaf"), oyster vine (fishing hook), oyster or citrus root (rensenzo), oyster, hydrangea, cassia, casino ki ( (Fruit `` fruit ''), banyan tree (pepper), oak (camellia tree, camellia leaf), cascarilla, cascara sagrada, gypsophila, kasenso, cypress (Kinshato), kaniwa, carnation, valerian root, hippo,
Birch or weeping birch (white birch), gerbera, pumpkin, kapok cypress `` seed '', kahokusansho (shusho),
Cattail, chamomile or Roman chamomile, chamomile
(Grass), camu camu (duck), color, larva, mantle or crow cucumber (sea melon), crow bischak (half summer), oats, guarana "seed", callahoo
(Koboku), Karaya, Gallu, Karin (Cucurbita), Garcinia, Kawamidori, Kawara Psycho (Koryosai, White-floured grass), Kawajisha, Kawaratake, Kawara-nadeshiko (stone bamboo) or Ezokawaranadeshiko (barley, tannin), Kawaraninjin (Kawaraninjin) (Blue ginger),
Kawamoyogi (Chinese cabbage), Kansui (Asaito), Kanzo
(Licorice), cantara, candelilla, canto, canna, canlan, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry,
European raspberries), kiwi "fruits, leaves", cichlids (melon roots), kyokyo (bellflowers, bellflowers), chrysanthemums (chrysanthemums,
Cicada daisies, Astragalus vulgaris, Amaranthaceae, Catalpa (Azusa), Rumex (Yotei), Kizitsu (Apricot), Kizuta, Kidachiaroe, Kidachiha, Kina, Kinaoki (Shinkona, Akakinanoki), Quinua (quinoa), Kakiha (yellow oak). Kimame, Gymnema sylvestre, Kimenkak, cabbage, cabbage "immature fruit", caraway, cucumber, goryu (Nishikawayanagi, Teyanagi), Kiraja saponaria, Kiraya, Kiranso (Kenshi Kobayashi), Kumquat "fruit", Kinkiju, Ginsekai, Kimbusen, betel,
Kinmizuhiki (Sensakurusu), Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruits", Guayule, Quercus Infectria (Gall), Kukui Nuts, Kugenumaran, Cuco (Glitters, Lances of the Barrels) Black-headed whale (Tenmon winter), kudzu
(Kakkon), camphor tree, gooseberry `` fruit '', carrot (yellow flower), kutiti river, gardenia (yamashiko), kunugi (brassica sol), cupua, cubebaba, kumazasa, tsuchidura (horse whiskers), clara (bittersweet) ), Cranberry “fruit”, chestnut “seed, fruit, astringent skin”, curculigo latifolia “fruit”, grapefruit “fruit / leaves”, buckthorn, black ganemochi (necessity of rescue), turtle beetle or black beetle or hikikoshiki (prolonged life grass), clove.
(Cloves, cloves), Gumbai nazuna (Sekimei, Sekimeishi), Keigai (Mature beetle, Magewort), Keitou (crown flower, corolla), geckavidin, bay (ken laurel), kenashi sartoriibara (earthen 苓苓, mountain return genus), gentiana, genchiana. (Old bird), Kemponashi (Kyugushi), Koukisekekoku, Citrus unshiu (Koji, Tachibana, Ovenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara)
(Tachibana skin)), Kousimbara (Monthly flower), Kousui mint, Kozo `` fruit '', Kocha (black tea), Kouhone (river bone), Kouhon (Straw book, Karamoto book), Kouryan, Kori Ryokyo
(Kara Ginger), cilantro “fruit”, Kouren (Kuroren),
Scutellaria (yellow gon), cowberry (over Tachibana), coconut `` fruit '', goshuyu (gojutsu), gosho strawberry (covered bonito), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaf '', kobushi or magnolia ( Spicy), burdock (burdock, burdock root), sesame (sesame), sesame nohagusa (genus), trash (schisandra), rapeseed or binankazura or pine beetle, wheat (wheat), rice or rice bran "red bran, white bran", rice oil , Cola Acuminata "Seeds", Cola Bella "Seeds", Colony Lya, Fenugreek "Fruits", Colombo, Conslango, Combs, Konjac, Comfrey (final grass),
Sisal (Sisal), Saihairan, Sakaneran
(Ezo cherry tree), cherry tree (Oshima cherry tree, Yama cherry tree, Oyama cherry tree, Ed Higashi, Mame cherry tree, Miya cherry tree, Yoshino cherry tree, Takane cherry tree, Kasumi cherry tree,
Kohigan, Satozakura, Kanzakura "leaves, flowers, fruits, bark (cherry bark)"), cherry, pomegranate, sasa, sasabaginran, sasanqua, sadomodaka (sawaki), sweet potato, sugarcane, sugar beet, rapeseed jujube (saccharin),
Saffron (Safflower, West safflower), Sapodilla, Sapote amariyo, Pomelo "fruit", Savonso, salmon berry "fruit", Saladina zebra (Roma hemp), Saranshito (sand indigo pin), Salvia (sage), Sawagikyo (mountain garden vegetable) ), Soiled walnut (mountain walnut), Sankaku cactus, Sangre Degrad (Croton), Hydrangea communis, Sanshi carrot
(37 ginseng), Sanshuyu (Yamatake mushroom), Sansho (Japanese pepper),
Sandscon (wild bean root), shea (carite), cyanoki `` fruit '', shiitake (shiitake mushroom), zion (purple garden), shikakumame, digitalis, shikunshi (messenger), perilla or blue-throated foxtail, or chimenjiso or katamenjizo (shiso leaf, shiso-ko) ), Rosewood, linden, cypress, syringa (ream),
Shimeji (Hinjimeji, Shakamejime, Hatake Shimeji, Oshiroijimeji, Beech Shimeji, Honjimeshi, Shimotake Mushroom), Shimokuren (Spicy), Apiaceae, Potato,
Peonies (peony), shajin (samseng), jasmine (matsuryka), january beard (barley winter), juvenile cowpea, gypsophila, shukshamitsu (sand kernel, curd sand), juzdama, palm "fruit", shunlan, Palm oil palm, ginger (ginger), hydrangea hydrangea (tsuneyama), ginger (iris, iris root), shozuku "fruit", white oak "seed", silane (butterfly), white-billed butterfly "seed",
White clover (white clover), White Azuki (chicken bone grass),
White squirrel (Small squirrel), White vine, "Flower",
White lupine, Shirominanten (southern Tenmi), Cinchona Succibula, Jinchoge (Mizuka, Mizukaka, Shichohana),
Cinnamon, Cinnamomum cassia, watermelon
(Watermelon), honeysuckle (gold and silver flower, Shinobi winter), sorrel (acidic), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', Suzuko (Lord Xu), horsetail (question), purslane (horse toothpaste,) Horse tooth Kenko), plum "fruit", sulgalan (orang), red pine "cone", Japanese larch, western quintet, walnut, hawthorn, hornbill, dandelion, horse chestnut (malonie), pear "fruit" ], Natsumiyukiso, Sambucus nigra
(Elder), Pacific jelly (Juniper, Juniper), Yarrow (Millfoil), Rose, Astragalus vulgaris, Mistletoe, Peppermint or Peppermint, Horseradish, Budgerigar
(Ishikon), Ginkgo (Cherry Blossom, Kouki Ginkgo, Oanabashi Ginkgo, Okinawa Ginkgo, Hon Ginkgo, Ginkgo Ginkgo, Shikaku Ginkgo, Kibanano Ginkgo) (Dendrobium, Ishibuchi), Cedron (Boshishuboku), Henasei, Henosei, Henosei, Henosei, Heisei Oise, Hire Celery, senkyu (river kyu), senshinren (shinshinren), sendan, sennin cactus, senna "fruit, leaf", senburi (our drug), senboku, souka (grass), elephantial chow,
Soshinsoubai, buckwheat "seed fruit", some potatoes, broad bean, rhubarb (daikon), radish, soybean, daidai (orange peel, drought), takasago rurihigotai (south indigo spine), takasaburo (drown lotus grass), takatodai (daisaku) , Takawarabi (in Japanese),
Dark sweet cherry "fruit", hollyhocks, pearl oysters (thyme, lily of the valley), tadikoro (hikai), willow, tamarind "seed", onion, tamshiba
(Spicy), Taranoki `` fruit, leaf, root bark '', tarayo (Oba winter blue, one leaf tea, bitcho tea, bitter lantern tea), dahlia (tenjiku button), tarui, tanchi lima bean, tanchiuchiwa, tanjin (danshen), dandelion ( Gankouei) or white dandelion or moco dandelion, dammar, cherry "fruit", chigaya "fruit, roots, buds", chixetetsu ginseng (Chicken ginseng), chicory, chanka piedra (Kidachi citrus), tulip, choconostay, dactylum thistle. (Artichoke), Korean daisies (daikon), Korean ginseng
(Mushrooms), Korean Wormwood (Moleleaf), Choreimaitake
(Boar), Chorogi, Tsukisou, Tsukushisakaneran, Tsukuritake (Mushroom), Tsuchiakebi, Camellia, Centella asiatica, Tsumekusa (lacquer grass), Tsuyakusa (Duck rush), Tsuzukiazuki (Red adzuki bean), Tsurutsuchiakemitsu, Tsurudaku, Tsurudaku, Tsurudaku, Tsurudaku, Tsurudaku, Tsurudaku
Tsuruna (Japanese apricot), Japanese ginseng (Folia ginseng), Glycine soja, Tsuwabuki, Deico, Walnut, Duberry "fruit", Agar-apricot, Tencha (Japanese tea), Tendaiyaku (crow), Toga (winter melon), Tokagi vine, Capsicum Pepper), Touki (Tokiki), Toru Calendula (marigold), Gleditsia sinensis, Touna Bena (river cut), Maize or maize hair (nanban hair), Tone mouse peach (maid Sadako), Ginseng or Datura japonica (dragon gall), Horsetail (Tree bandits), Dokudami (10 medicines), Tokon (Vegetable roots), Toshishi or Maedaoshi or Nenshikazura, Eucommia (Munaka "bark, leaves, roots"), Ash (Hata peel), tomato, tragacanth, Triacanthus "seed", Turkish kyoto , Tormentilla, Delonoki, Porphyra angustifolium, Kingfish, Nigeria berry "fruit", Chinese yam or yam (mountain), na Raft (Butcher Bloom), elsholtzia ciliata, shepherd's purse, rape, sword bean or Tatehaki (Katanamame), natsudaidai, jujube (Dainatsume),
Naniwaibara (Kinzako), Navena (interrupted), Nameko, Peanut (peanut), Nanten (Namitenmi), Nanban Karamushi
(Cara hemp), iosum violet, nigaki (Bitterwood), sagebrush (Bitterwood), nutmeg, Kei or Nikkei or Ceylon Nikkei or Yabunikei (cinnamon bark) or Keishi (Keishi), Nyohakudo, Chinese chive (Nishiko), Elderberry (bone skeleton) Tree "fruit, flower,
Stems, leaves "), garlic (garlic), nurude (quintile), leeks,
Nemoki or Nebu or Nebi or Nemuriki or Jigokubana (Joint reception), Thistle (Oyagi), Noibara (Fruit), Nosyllium chinensis (Ryoshu), Nogetou, Yarrow, Nodoke
(Foreground Hu), Novara, Peach, Pineapple "fruit", Hibiscus (Bussouge, Furinbussouge, Roselle), Hyringou, Hauchiwa, Pau Doce, Hakamauraboshi (Hypercutting), Hakukayumato, Hakusanchidori,
Hakusen (tinea bark), Huckleberry "fruit", chickweed (prosperous), Hazel (Haruko), Hashirodokoro (roth root), basil, lotus (lotus, lotus meat, lotus root), parsley (Netherlands jelly), hadakamugi, batata, hachiku Or madake (boiled bamboo), patchouli, peppermint (light load, light load), hazelnut, pearl barley
(Yokuinin), Hanasuge (knowledge mother), banana, Hana mint,
Hanabishi (Shitsuri, Shishitsuri), Vanilla Bins, Papaya, Yellow-footed squirrel (mouse koji), Pahalobobo, Hub "Whole grass,
`` Stems, leaves '', paprika, oyster oysters, sesame or honeywort (vine vine), pipiens (kabushi), yamabishi (shitsuriko), hamanasu (maikai flower), hamaboufu (hama windbreak), hamamelis, palm, rose (rose) , Balata, balata gum, agaricus (agaricus, white-bellied agaricus, Uskimorinokasa), harlan, paliurus (Haimamatsume), parietalia, harukanran, balsamina (vine pickles, bitter melon), harunire (wooden bark, bark bark, mubari bar) Harlin Do, Handai Kai
(Katsu Omi), Panoki, Hyogi (Sho-ho), Leek Carrot (Party Participant), Pecan Nut, Higanbana (Ishigaru, Urusu Sasa), Higulmadaria, Higotai, Hishi (Hishimi), Pistachio, Beet, Hittsuba (Stone) Reed), Aedes aegypti,
Daisies (daisies), Hinako no Kozuchi (cows), Hydrangea cypress, cypress, hiba, castor, sunflower, peppers,
Himeuzu (Aoi), Himegama (Agaricus), Himematsutake (Kawariharatake, Hiromatsutake), Himemu Orchid, Pimenta "fruit", juniper, juniper, juniper "fruit",
Chickpeas, lentils, velvet aoi, pearl oysters (Bald oak), loquat "fruits, leaves, stems", betel nut (dairy skin, calyx), puerh tea (Fu-cha), futokazura
(South rattan), butterbur, butterbur dandelion (submarine winter flower, subterranean winter leaf), wisteria kama (Orchid grass), wisteria beans (flat bean), wisteria wisteria (chocolate, seeds, leaves), grape "fruit, fruit skin, seeds, leaves", beech, fuyu mucinsk Bamboo shoots (caterpillar), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "fruit", Blackberry,
Branjeen, Plum "fruits", Fluceraria, Blueberries (Hemaceae), Prune, Floral Blanca, Blonde Psyllium, Bungou (mung bean), Hazelnuts, Loofah, Hetukaran, Safflowers (Hanaken), Henneken, Belladonna, Berries "fruits", Persear , Peruvian Berg, Pereschia grandifolia, red quince or duckweed (Keiten), Boysenberry "fruit",
Houki, Elderweed, Nendoza, or Hahakiki Kochia (ground silk), Hosairan, Housenka (Housen, Acute child, Bone grass), Pouteria sapota, Pouteria rukuma, Honoki, Bowhuu (windbreak), Spinach, Hozuki (Torone root) ), Japanese holly (Japanese magnolia, magnolia), bokeh (wood melon), Hosoba Abragiku (Bitter Yoku), Hosoba Ogura, Hosobanaokera (Sokyu), Hosobanokirinso (Keiten Sanshichi), Hosobabarengiku, Bodaiju (Bodhi tree), button Peony "Flowers, leaves,
Stem, bark "), button pie (peony skin), hop, jojoba, bourgei (Ruricha), Bordeaux, white berry" fruit ", Hongonik (Meat Juyo, Daiei), Hongsekoku (Sekiseki Suzu, Suzuyama Ishihasu) , Maizuru Tennan Show (Tiannansei), Maitake (Maitake), Maou (Mako), Maca, Macadamia nuts, Margaret (Mokshungiku), Makuri (Seagrass), Magwa (Mulberry bark "bark, leaf"), Magnolia・ Sprengheri, Masarunzuba, Masalanzuuba de Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matatabi (Matsukasa), Matsukasa, pine "leaf, bark, root", Matta Orho, Matsuhodo (boiled peony), Matico (Cordon sillo), Mayoram (Hanajaca), Marvanojazin (Ginseng), Mulberry "fruit", quince, Malein (Bilroadmou) Zuica), mango, mangosteen, mansagna (Andes chamomile), manshugurumi, mandarin "fruit",
Ganoderma lucidum (Ganoderma lucidum), Pheasant (Gourmet `` Fruit ''), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossus),
Mizokukushi (Half-sided lotus), Misohagi (Senkyaku), Michiyanagi or Niwayanagi (Henji), Mitsugashiwa, Mitsuba, Midori Zapote, Midorihakka, Mimosa, Myoga, Miracle Fruit "fruits", Myrrh, Myrobalan, Mugiwaragiku, Mukuge , Mukunoki, Mukuroji (prolonged skin), Munya, purple (purple root), purple syrup or purple syrup
(Purple), purple corn, purple fuji (Kunmei chicken blood wisteria), megakansa opuntica, swordfish (prosperous herb), mebourgi, evening primrose (evening primrose), melaloca, melissa, melilote, melon "fruit", sorghum, moss worm, mokurin. , Moje (pepper), holly, mokko (wood incense), maple,
Peach (peaches "leaves, seeds, flowers, fruits"), bean sprouts, morelo cherry "fruits", Moroheiya (burlap), Yakuwamurasaki yam, Yakuchi (Machi), cornflower (cornflower), cornflower, yakon, yashabushi ( Yarrow) or Himeyashabushi or Oyabayashabushi "fruit, fruit skin, fruit ear", willow willow, stinking (octagonal metal plate), mistletoe (willow parasite), willow (cow willow, weeping willow, willowia unagi, willow unagi, willow unagi, willow tree, willow tree, willow tree, willow tree, willow , Miyayanagi, palm, yamayanagi, willow, willow, willow, willow), willow tree "leaves, stems", yabs, yabukoji (purple gold beef), yab tobacco (crane, Tenmeisei),
Pokeweed (Shokuryoku), Yamanoki (Yamaharu), bayberry (Yangume skin), wormwood, eucalyptus, Yukinoshita (tiger ear grass),
Yucca or flavifolia, yuzu "fruit", lily, yellow dragonfly, mugwort (mage leaf), rygan (thunder circle), lime "fruit", rye, lakanka "fruit", raspberry "leaf,"
`` Fruits '', Latania (Clameria), Rakkyo or Shallot (white meat), Lavender, Longan (dragon eye meat), Agave (Aonoguretsuran, Fukurin agave), Ryoccha (green tea), Apple "fruit, seeds,"
Leaves, roots ", gentian, rubus or Suabisimus,
Ruritama thistle (Vladivostigo, Shinji indigo stab), litchi (lichi, lichi kernel), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or chinese forsythia (consecutive), Astragalus, Rhizoma, Rumeshi, Locon (Reed, Rhizome),
Logan berry "fruit", rosemary (mannen wax), rose hips (novara), wasabi, cotton wisteria
(Dimenghua), Waremoko (earthen worm), etc.

As the seaweed, there are seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (Austenium australis, Sujiaoonori, Hiraaonoori, Bouahonori, Hosoedahonori), Anahaosa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Qualmomim: Quanomimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao midori, Genus Tsurugimido, Genus Himidoro: Hibimidoro, Genus Aosa: Anaaosa, Amiosa, Nagaaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Cyanobacteria (genus Suizenjinori: genus Suizenjinori, genus Water-bloom, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraela, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa genus: Ichimegasa, Keyari genus: Keyari, Umibosu genus: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus Boschnori: Physcomitrella patens, Funorinousichoke, Genus Amanori: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Algae (genus Chara, genus Shiratama,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived raw materials include chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposed products thereof, cow or pig. Brain tissue extract, hydrolyzed collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle, pigs or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin of beef or pig or elastin hydrolyzate (acid , Alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or bovine blood cell protein degradation product (globin peptide), to cow or pig Degradation products of hemoglobin (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As a material derived from a plant or animal raw material, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, seawater dried product, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, etc.

(15) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, fungus or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, duckweed, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankaishi, hamarisu, yamagwa, extended life grass, bellflower, horsetail, succulent, yellow-dried, hemp dry, hemp. Senkyu, dokkatsu, psycho, bow hu, hama boufu, sardine, peony skin, peony, genosho, kakkon, licorice, quintuplet, aloe, shouma, safflower, green tea, black tea, assen drug) etc.

(21) Melanin dye reducing / decomposing substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odori Koso, Assemblies, Touki, Daffodil, Amacha, Hypericum, Cucumber, Prickly Pear,
Rosemary, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or its salt, stearic acid ester, vitamin E or its derivative, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame cultured cells, armature,
Hypericum perforatum, Hamamelis, Clove, Melissa, Trillium birch, Salvia, Rosemary, South Tenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / sterilizing / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Humectant Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its Salt, sodium lactate, mini-sasaniki extract, Bacillus natto metabolite, natto extract, loofah water, birch (white birch) or sap of red pine

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, hypericum, clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pie), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castari tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral blood flow promoter Vitamin E or a derivative thereof, cucumber extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing Agent Hydrogen Peroxide, Sodium Persulfate, Ammonium Persulfate, Sodium Perborate, Urea Peroxide, Sodium Percarbonate, Sodium Tripolyphosphate Peroxide, Sodium Bromate, Potassium Bromate, Pyroline Peroxide Sodium acid salt, sodium peroxyorthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal fragrances such as musk, civet, castorium and ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, Choji essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood essential oil, petitgrain essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, Peruvian balsam essential oil, boad rose essential oil, scented essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable oils such as essential oils and Japanese peppermint oil, and other synthetic flavors.

(43) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, enju dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Sweetener Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monerin, licorice extract and the like.

(45) Nutrient enhancer shell-baked calcium, cyanocholamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(46) Dairy products Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk and the like.

(47) Other hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetics
Vegetable protein and its degradation product, animal / vegetable polysaccharide and its degradation product, animal / vegetable glycoprotein and its degradation product, blood flow promoter, anti-inflammatory / anti-inflammatory / anti-allergic agent, wound healing agent, Foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorizing / deodorizing agents, bitters, seasonings, etc. are listed. An additive or synergistic improvement of the invention effect or other cosmetic effect can be expected.

Regarding the method for adding the lipase activity inhibitor, active oxygen scavenger, cosmetic composition or food and drink of the present invention, it may be added in advance or during production. It may be selected appropriately in consideration of the characteristics.

[0082]

EXAMPLES Hereinafter, production examples, test examples and prescription examples will be described, but the present invention is not limited thereto.

(Production Example 1) 100 g of a dried product of Kobotsuduru was warmed and extracted with purified water (about 80 ° C.) for about 5 hours and filtered to obtain an extract (dry solid content: about 0.1 to 2.0% by mass). You get 1.0kg.

(Production Example 2) 100 g of a dried product of Kobotan Tsuru
Soak in 50% ethanol solution, extract for 5 days at room temperature, and then filter to extract (dry solids: about 0.1-2.0 mass%)
About 1.0 kg.

(Manufacturing Example 3) 100 g of dried kobotantsuru
Soak in 70% ethanol solution, 70% 1,3-butylene glycol solution, 60% propylene glycol solution, or purified water (about 30 ° C), extract at room temperature for 5 days and then extract (dry) Solid content: about 0.1 to 2.5 mass%) about 1.0k
get g.

(Test 1) Lipase activity inhibition test The lipase activity inhibition activity was evaluated based on the lipase activity value using the quantitative reaction of human blood lipase as an index.

"Test Method and Evaluation Method" a. Sample Note that the sample of the lipase activity inhibition test is the production example 2 of the present invention.
The extract (solid content concentration: adjusted to 0.3%) obtained in 1 was used for the test. b. Enzyme lipase Enzyme lipase (from porcine pancreas / manufactured by Sigma) contains 0.2 units
I adjusted it to be. c. Measurement of lipase activity Using a mixture of 40% sample, 0.2 units lipase 50%, and purified water 10% as a sample, a test was carried out according to the test method of Lipase Kit S (Dainippon Pharmaceutical Co., Ltd.). As a control, the extraction solvent concentration of the sample was used in place of the sample, and the control was set to 100% based on the difference in color between each sample and the control and the blind test in which the substrate was added after the reaction was stopped. The lipase activity inhibitory rate (= lipase activity inhibitory effect) was obtained by
It was shown to.

[Equation 1] Lipase activity inhibition rate (%) = {1- (sample BALB unit /
Control BALB unit)} × 100

(Test Results) As shown in FIG. 1, it was confirmed that the Kobotsudzu extract of the present invention has a lipase activity inhibitory action, and can be used as a lipase activity inhibitor.

(Test 2) Active oxygen elimination (SOD-like activity)
Test In recent years, many diseases / illnesses induced by active oxygen have been reported, and it is pointed out that removal / elimination of active oxygen (SOD activity) leads to prevention of tissue damage. In this test, the extract obtained in Production Example 2 was tested for its ability to eliminate active oxygen generated by the xanthine-xanthine oxidase system by the NBT method (Imperial Lipid Peroxide Experimental Method, P.144, Ito Dental Publishing). Co., Ltd.).

“Test method and evaluation method” 0.05 for small test tubes
0.75 mM nitroblue tetrazolium (NBT), 0.15 W / V% bovine serum albumin in 2.6 mL of a substrate solution in which xanthine and ethylenediaminetetraacetic acid were dissolved in M sodium carbonate buffer (pH 10.2) to a concentration of 3.0 mM Then, add 0.1 mL of the sample solution (the solvent for the control) and leave at 25 ° C for 10 minutes. An aqueous solution of xanthine oxidase 0.1m, which was adjusted in advance so that the change in absorbance was about 0.3 / 20 minutes
After adding L and leaving it at 25 ℃ for 20 minutes, 6.0mM CuCl solution 0.1m
The reaction was stopped by adding L and the absorbance at 560 nm was measured. In addition, as a control, the one in which the solvent of the sample solution was added instead of the sample was used as a control, and the group in which the reaction stop solution was added before adding the xanthine oxidase was used as a blank for the sample and the control. The oxygen scavenging action) was determined and the results are shown in FIG. "Sample" The sample of the active oxygen elimination (SOD-like activity) test is the extract obtained in Production Example 2 of the present invention (solid content concentration:
(Adjusted to 0.1%) was used for the test. As a comparative sample, a Tochu extract (manufactured by Ichimaru Falcos) known to have an active oxygen scavenging effect was prepared under the same conditions,
Used for the test.

[Equation 2] Active oxygen scavenging rate (%) = {1- (sample OD value−blank (sample)
OD value) / (control OD value-blank (control) OD value)} × 100

(Test Results) As shown in FIG. 2, it was confirmed that the Kobotsudzu extract of the present invention significantly suppressed the production of active oxygen and had an active oxygen scavenging action. Further, it can be confirmed that the extract has a strong active oxygen scavenging effect as compared with Tochu extract, and therefore it can be used as an active oxygen scavenger.

(Test 3) Safety test (1) Primary skin irritation test The Kobo-dzu extract obtained in Production Examples 1 to 3 was prepared so that the solid content concentration was about 1.0%, and the back was shaved. Hartley guinea pig (female, 3 per group, weight 300)
˜350 g) of skin was applied in an amount of 0.03 ml per 2 × 2 cm ² square. Judgment was performed 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indexes. As a result, in all animals, no erythema or edema was observed, and it was determined to be negative.

(Test 4) Safety test (2) Cumulative skin irritation test The Kobodzu vine extract obtained in Production Examples 1 to 3 was prepared so that the solid content concentration was about 1.0%, and this was applied to the flank. 0.5m on the skin of shaved (2 × 4cm ² ) Hartley guinea pigs (female, 3 animals per group, weight 320g) once a day, 5 times a week
l / per animal was applied. Application for 2 weeks,
Shaving was done on the last application day of each week. Judgment was performed on the day after each application day and the day after the last application day, using erythema and edema as indexes by the primary irritation scoring method. As a result, all the animals were judged to be negative because no erythema or edema was observed for 2 weeks after application.

(Test 5) Safety Test (3) Single-dose Toxicity Test The Kobodzu vine extract obtained in Production Examples 1 to 3 was adjusted to 12.5% concentration with purified water, and 16 mL / kg per animal. Before the test, the amount was orally administered to a ddy mouse (male and female, 5 mice per group, 5 weeks old) that had been fasted for 16 hours, and the onset and degree of toxic symptoms were observed over time. . As a result, no abnormality was observed in all mice for 14 days, and the results of autopsy were also abnormal. Therefore, LD ₅₀ is 2,
The substance content was 000 mg / kg or more, and the substance was judged to be safe.

(Formulation example) Production of lipase activity inhibitor, active oxygen scavenger, cosmetic composition or food and drink The formulation example is shown below according to the above-mentioned evaluation results. Each formulation example is used in the production of each product. Those prepared by a conventional method may be used, and only the blending amount is shown. Further, the present invention is not limited to these.

[0098] (Prescription example 1) Emulsion mass%     1. Squalane 5.0     2. Olive oil 5.0     3. Jojoba oil 5.0     4. Cetyl alcohol 1.5     5. Glycerin monostearate 2.0     6. Polyoxyethylene (20) cetyl ether 3.0     7. Polyoxyethylene (20) soorbitan monooleate 2.0     8.1,3-butylene glycol 1.0     9. Glycerin 2.0    10. Kobo-duzu extract from Production Example 5.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0099] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12.1,2-Pentanediol 3.0    13. Kobodzu leaf or stem 70% ethanol extract 3.0    14. Scots pine cones 70% ethanol extract 3.0    15. Silk protein enzymatic degradation solution 5.0    16. Pork placenta water extract 1.0    17. Preservative (paraoxybenzoate) Suitable amount    18. Residue to make purified water 100

[0100] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Hot water extract of Kobotsuduru bark 3.0     6. Choji bud hot water extract 1.0     7. Grapefruit fruit or leaf hot water extract 3.0     8. Tochu leaf hot water extract 3.0     9. Soybean seed hot water extract 1.0    10. Olive oil 1.0    11. Shea butter 1.0    12.Butyl hydroxyanisole 0.1    13. Vitamin E derivative 0.1    14. Preservative (benzalkonium chloride) Suitable amount    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0101] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Kobodzu leaf or stem 30% ethanol extract 3.0     6. Bodaiju flower or fruit 50% 1,3-butylene glycol extract 5.0     7. Yuzu fruit 30% ethanol extract 1.0     8. Chickweed whole plant 30% ethanol extract 1.0     9. Grape stem or leaf 30% ethanol extract 1.0    10. Sansho peel or fruit 30% 1,2-pentanediol extract 1.0    11. Kiwi fruit 50% ethanol extract 1.0    12. White birch sap 1.0    13. Antibacterial (lactoferrin solution) appropriate amount    14. Preservative (paraoxybenzoate) Suitable amount    15. Perfume (Western light water) Appropriate amount    16. Residue to make purified water 100

[0102] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4.1,2-Pentanediol 3.0     5. 50% 1,3-butylene glycol extract of Kobodzu crane 3.0     6. Soaproot leaves 50% 1,3-butylene glycol extract 2.0     7. Gentian whole plant 50% ethanol extract 2.0     8. Hamamelis leaf or bark 50% 1,3-butylene glycol extract 1.0     9. Green tea leaf or stem 50% 1,3-butylene glycol extract 1.0    10. Yeast 50% 1,3-butylene glycol extract 1.0    11. Allantoin 0.2    12. Astringent (zinc sulfocarbonate) 0.2    13. Antibacterial and antiseptic (thiamin lauryl sulfate)    14. Perfume (Lavender water) Suitable amount    15. Residue to make purified water 100

[0103] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Solbit 1.0     4. Ethanol 15.0     5. Kobotsutsuru Fruit 50% Propylene Glycol Extract 2.0     6. Red radish rhizome or root bark 50% propylene glycol extract 2.0     7. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0     8. Whole assembly 50% 1,3-butylene glycol extract 2.0     9. Sage whole plant 50% ethanol extract 1.0    10. Bodaiju flower or fruit 30% ethanol extract 1.0    11. Ascorbic acid 0.2    12. Astringent (calamine) 0.1    13. Preservative (phenoxyethanol) Appropriate amount    14. Perfume (apple water)    15. Residue to make purified water 100

[0104] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Kobodzu leaf or stem 50% propylene glycol extract 2.0     8. Astragalus flower 50% propylene glycol extract 2.0     9. Peony root 50% propylene glycol extract 2.0    10. Water mallow flower or leaf 50% propylene glycol extract 2.0    11. Chamomile flower 50% propylene glycol extract 2.0    12. Comfrey leaf and stem 50% ethanol extract 1.0    13. Pig placenta enzyme decomposition solution 1.0    14. Silk protein alkaline solution 2.0    15. Camphor 0.2    16. Phenol 0.03    17. Preservative (photosensitive element 201 & 401) Suitable amount    18. Perfume (bodhi water) Suitable amount    19. Residue to make purified water 100

[0105] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5. 50% glycerin extract from the leaves or rhizomes of Kobotsunazu 1.0     6. Rubus fruit 50% diglycerin extract 1.0     7. Toji bud 50% diglycerin extract 1.0     8.Wenzhou mandarin orange peel 50% 1,3-butylene glycol extract 1.0     9. Green tea leaf hot water extract 1.0    10. Peach leaf hot water extract 2.0    11. Pork placenta hot water extract 1.0    12. Preservative (paraoxybenzoate) Suitable amount    13. Fragrance (rose water)    14. Purified water 100 residue

[0106] (Prescription example 9) Peel-off pack mass%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Kobodzu flowers or spikes 50% glycerin extract 2.0     8. Safflower whole plant 50% ethanol extract 2.0     9. Dutch jelly (parsley) leaf or stem 50% ethanol extract 2.0    10. Eucalyptus leaf or stem 30% ethanol extract 2.0    11. Royal Jelly 50% Ethanol Extract 1.0    12. Trehalose solution 1.0    13. Preservative (paraoxybenzoate) Suitable amount    14. Perfume (Chamomile water) Suitable amount    15. Residue to make purified water 100

[0107] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8. Kobodzu Crane Seed Extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)     9. Achillea millefolium extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Panax ginseng root 50% propylene glycol extract 2.0    12. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    13. Soybean seed water extract 1.0    14. Liquid shea fat 1.0    15. Dipotassium glycyrrhizinate 0.1    16. Preservative (acrinol) 0.1    17. Fragrance (lavender water) Suitable amount    18. Residue to make purified water 100

[0108] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 2.0     9.1,2-Pentanediol 2.0    10. Hot-water extract of Kobodzu crane leaf or stem 3.0    11. Dodami leaf hot water extract 3.0    12. Shiso leaf 50% propylene glycol extract 2.0    13. Purple root 50% propylene glycol extract 2.0    14. Soybean seed fermented soybeans 1.0    15. Glycyrrhetinic acid 0.1    16. Pig placenta enzyme decomposition solution 1.0    17. Preservative (paraben) proper amount    18. Perfume (clove water) appropriate amount    19. Residue to make purified water 100

[0109] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Kobotsudzu rhizome 50% glycerin extract 1.0     8. Apple fruit 20% 1,3-butylene glycol extract 2.0     9. Kawara Artemisia leaf 20% 1,3-butylene glycol extract 2.0    10. Rosehip fruit 30% ethanol extract 1.0    11. Kakkon hot water extract 2.0    12. Glycyrrhizic acid 1.0    13. Apricot kernel 0.1    14. Preservative (salicylic acid) 0.1    15. Perfume (oncoming water) Appropriate amount    16. Residue to make purified water 100

[0110] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Glycerin 18.0     6. Sodium dl-pyrrolidonecarboxylate 1.0     7. Dioctyl adipate 1.0     8. Cetostearyl alcohol 3.0     9. Triethanolamine 3.0    10. Ergocalciferol 1.0    11. Oleyl alcohol 1.5    12. Lanolin derivative (EO adduct) 1.0    13. Potassium hydroxide 6.0    14. Kobotsudzu extract from Production Example 5.0    15. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    16. Oil-soluble chamomile flower or leaf extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    17. Oil-soluble licorice root or rhizome extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    18. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    19. Edetate 2.0    20. Glycyrrheteric acid 1.0    21. Preservative (salicylic acid) 0.1    22. Perfume (Mugwort water)    23. Residue to make purified water 100

[0111] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Kobodzu leaf or stem 70% 1,3-butylene glycol extract 1.0     5. Oolong tea leaf 70% 1,3-butylene glycol extract 1.0     6. Toki rhizome 70% 2,3-butylene glycol extract 0.5     7. Seaweed 70% 1,3-butylene glycol extract 0.5     8. Meliroth flower or leaf 70% 1,3-butylene glycol extract 0.5     9. Armature leaf or stem 70% 1,3-butylene glycol extract 0.5    10. Soybean seed fermented soybeans 0.5    11. Aloe pulp 70% ethanol extract 2.0    12. Polyethylene powder 0.5    13. Hydroxypropyl chitosan solution 0.5    14. Amino acids (arginine, glycine, glutamine, etc.) 0.5    15. Monoammonium glycyrrhizinate 0.1    16. Preservatives (undecylenic acid, phenol) Suitable amount    17. pH adjuster    18. Perfume (lavender water) Suitable amount    19. Residue to make purified water 100

[0112] (Prescription example 15) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3.Dihydroxymethoxybenzophenone 0.2     4. Squalane 10.0     5. Vaseline 5.0     6. Stearyl alcohol 3.0     7. Stearic acid 3.0     8. Glyceryl monostearate 2.0     9. Polyethyl acrylate 1.0    10.1,3-butylene glycol 6.0    11. Disodium edetate 0.1    12. Triethanolamine 1.0    13. Titanium dioxide 5.0    14. Kobotsudzu fruit or peel 50% dipropylene glycol extract 0.5    15. White birch bark 70% dipropylene glycol extract 1.5    16. Cornflower leaf 50% propylene glycol extract 0.5    17.Kakkon 50% propylene glycol extract 0.5    18. Yuzu fruit 50% dipropylene glycol extract 0.5    19. Preservative (benzyl paraoxybenzoate) Suitable amount    20. Fragrance (jasmine water) Suitable amount    21. Residue to make purified water 100

[0113] (Prescription example 16) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 70.0     2. Tetrahydroxybenzophenone 1.0     3. Cetyl octanoate 23.8     4. Kobodzu leaf or stem 30% 1,3-butylene glycol extract 1.0     5. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0     6. Burdock root hot water extract 0.5     7. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5     8. Mallow flower or leaf 50% propyl alcohol extract 0.5     9. Whole pearl barley 50% 1,3-butylene glycol extract 0.5    10. Incense fruit 30% butanol extract 0.5    11. Peony root or leaf hot water extract 0.5    12.Ethyl paraaminobenzoate 0.2    13. Antioxidant (Butylhydroxytoluene) Suitable amount    14. Perfume (cornflower water) Suitable amount

[0114] (Prescription example 17) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Kobotsudzu root bark or rhizome hot water extract dry powder 0.2    16. Dokudami leaf hot water extract dry powder 0.2    17. Wenzhou tangerine peel or fruit hot water extract dry powder 0.2    18. Yukinoshita whole grass hot water extract dry powder 0.2    19. Preservative (phenoxyethanol) 0.1    20. Perfume (Rose water) Suitable amount    21. Residue to make purified water 100

[0115] (Prescription example 18) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6. Kobodzu crane whole plant 20% 2,3-butylene glycol extract 2.0     7. Hamamelis bark hot water extract 2.0     8. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0     9. Toki root 30% 1,4-butylene glycol extract 1.0    10. Hydroxypropyl chitosan solution 1.0    11. Mucopolysaccharide solution 1.0    12. Dipotassium glycyrrhizinate 0.1    13. Antibacterial and antiseptic (photosensitive element 101)    14. pH adjusting agent    15. Perfume (sandalwood water)    16. Purified water

[0116] (Prescription example 19) Rinse mass%     1. Stearyl trimethyl ammonium chloride 3.0     2. cetostearyl alcohol 3.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5.1,2-Pentanediol 2.0     6. Kobodzu leaf or stem 50% 2,3-butylene glycol extract 5.0     7. Scented flower 50% 1,3-butylene glycol extract 1.0     8. Astragalus leaf 50% 2,3-butylene glycol extract 2.0     9. Mackerel fruit 30% 1,2-butylene glycol extract 2.0    10. Yellow rhizome 50% 1,3-butylene glycol extract 1.0    11. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0    12. Soybean seed natto fermented liquid 0.5    13. Hydroxyethyl chitosan solution 0.5    14. Trehalose solution 0.5    15. Hydrolyzed silk solution 0.5    16. Antibacterial / antiseptic (benzalkonium chloride)    17. Perfume (grape water) Suitable amount    18. Residue to make purified water 100

[0117] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Kobodzu crane leaf or stem 50% 1,3-butylene glycol extract 1.0     7. Western Bodhi bark or fruit 50% 1,4-butylene glycol extract 1.0     8. Olive leaf 50% 1,2-butylene glycol extract 1.0     9. Loquat leaf 50% ethanol extract 1.0    10. Centipede fruit or flower 50% 1,3-butylene glycol extract 1.0    11. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    12. Trehalose solution 1.0    13. Hydrolyzed keratin solution 1.0    14. Antibacterial / antiseptic (benzalkonium chloride)    15. Perfume (Chamomile water) Suitable amount    16. Residue to make purified water 100

[0118] (Formulation example 21) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Kobodzu crane leaf 50% 1,3-butylene glycol extract 1.0     6. Tormentilla root or rhizome 50% 1,3-butylene glycol extract 1.0     7. Hop female spike 50% ethanol extract 1.0     8. Melissa whole plant 50% ethanol extract 1.0     9. Usubasaicin rhizome 30% ethanol extract 1.0    10. White birch sap 1.0    11. Carpronium chloride 0.3    12. Hinokitiol 0.5    13. Keratin decomposition solution 0.5    14. Stearyl glycyrrhetinate 0.1    15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    16. Perfume (Rosehip water) Suitable amount    17. Residue to make purified water 100

[0119] (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Trimethylene glycol 5.0     6. Kobodzu crane bark 50% 1,3-butylene glycol extract 1.0     7. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0     8. Panax ginseng root hot water extract 1.0     9. Lemon fruit 50% 1,3-butylene glycol extract 0.5    10. Apple fruit 30% ethanol extract 1.0    11. White birch sap 1.0    12. Azulene 1.0    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (orange water) Suitable amount    15. Residue to make purified water 100

[0120] (Formulation Example 23) Hair liquid mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4. Kobodzu crane extract of Production Example 1 5.0     5. Comfrey leaf or stem 50% ethanol extract 3.0     6. Yuzu leaf or fruit 50% ethanol extract 3.0     7. Soybean seed natto fermented liquid 1.0     8. Hamamelis leaf or bark hot water extract 1.0     9. Comfrey leaf or stem 50% ethanol extract 3.0    10. Loquat leaf 30% ethanol extract 1.0    11. Carpronium chloride 0.3    12. Pantethine solution 0.3    13. Amino acids or their derivatives 3.0     (Lysine, alanine, pyrrolidone carboxylic acid, etc.)    14. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0121] (Prescription example 24) Hair artic mass%           1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4. Kotanduzu crane extract of Production Example 2 5.0     5. Preservative (paraben) appropriate amount     6. Residue to make purified water 100

[0122] (Prescription example 25) Heartonic mass%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6. Hot-water extract of Kobo-dzu fruit or peel 2.0     7. Lavender flowers or spikes hot water extract 1.0     8. Bildo Aoi rhizome or root bark 50% ethanol extract 1.0     9. Scutellariae rhizome or root bark 50% ethanol extract 1.0    10. Pleurotus rhizome or root bark 50% ethanol extract 1.0    11. Soybean seed hot water extract 1.0    12. Carboxymethyl chitin solution 1.0    13. Chicken wicker extraction solution 0.2    14. Vitamin E derivative 0.2    15. Pantethine solution 0.2    16. Preservative (phenoxyethanol) Appropriate amount    17. Fragrance (sage water) appropriate amount    18. Residue to make purified water 100

[0123] (Prescription example 26) Hair growth and hair nourishing agent mass%     1.Ethanol 60.0     2. 50% glycerin extract of whole kobodzu crane 2.0     3. 50% Propylene Glycol Extract Liquid     4. Vitamin E derivative 0.5     5. Capsicum tincture 0.5     6. Resorcin 0.5     7.Dipotassium glycyrrhizinate 0.5     8. Carboxymethyl chitin solution 0.5     9. Collagen protein enzymatic degradation solution 2.0    10. Pig hematin solution 0.5    11. Pork mucin solution 0.5    12. Amino acids (arginine, glycine, glutamine, etc.) 0.5    13. Antibacterial and antiseptic (paraben) 0.1    14. Perfume (rosemary water) Suitable amount    15. Residue to make purified water 100

[0124] (Prescription example 27) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2. 50% glycerin extract from Kobodzu crane leaf or stem 1.0     3. Whole assembly 60% ethanol extract 1.0     4. Peony rhizome or root bark 60% ethanol extract 1.0     5. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0     6. Soybean seed fermented soybeans 1.0     7. Cantharis tincture 0.5     8. Pantothenic acid derivative 0.2     9.β-glycyrrhetinic acid 0.2    10. Resorcin 0.2    11. Salicylic acid 0.2    12. Hydroxyethyl chitosan solution 0.2    13. Elastin hydrolyzate 0.2    14.Keratin protein enzymatic degradation solution 0.2    15. Antibacterial / antiseptic (paraben) 0.1    16. Perfume (lavender water) Suitable amount    17. Residue to make purified water 100

[0125] (Prescription example 28) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 6.0     4. Kobodzu leaf or stem hot water extract dry powder 3.0     5. Eucalyptus hot water extract dry powder 1.0     6. Peach leaf 70% ethanol extract dry powder 1.0     7. Silk protein enzymatic degradation solution dry powder 1.0     8. Dye (Gunjo green)

[0126] (Prescription example 29) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 3.0     4. Kobotsudzu whole plant hot water extract liquid dry powder 3.0     5. Sambucus nigra flower or berries hot water extract dry powder 1.0     6. Kawamura Artemisia leaf or stem hot water extract dry powder 1.0     7. Wenzhou mandarin orange peel or fruit 50% ethanol extract dry powder 1.0     8. Peach leaf 70% ethanol extract dry powder 1.0     9. Iris leaf or root 70% ethanol extract dry powder 1.0    10. Apple juice powder 1.0    11. Dye (Gunjou, Chromium hydroxide) Appropriate amount    12. Perfume (grape water) Suitable amount

(Prescription Example 30) A coating protective agent gauze or liniment cloth is impregnated with a prescription liquid in which an appropriate amount of a kotubuzunur fruit or leaf hot water extract, an antibiotic, an anti-inflammatory agent, etc. is impregnated and attached to the wound. Alternatively, the hot-water extract of Kobotsudzu fruit or leaf may be directly sprayed locally and covered with gauze or the like.

[0128] (Prescription example 31) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6. Kobodzu leaf or stem hot water extract dry powder 0.1     7. Almond seed hot water extract dry powder 0.1     8. Green tea leaf hot water extract dry powder 0.1     9. Dye (Gunzhou Green) Appropriate amount    10. Residue to make purified water 100

[0129] (Prescription example 32) Detergent for tableware Mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5. Dried powder of hot-water extract of citrus fruit or peel 1.5     6. Soybean seed hot water extract dry powder 3.0     7. Rubus pericarp or fruit hot water extract dry powder 2.0     8. Residue to make purified water 100

[0130] (Prescription example 33) Mentsuyu mass%     1. Soy sauce 80.0     2. Black vinegar 2.0     3. Glucose 13.0     4. Sodium glutamate 2.0     5. Kotanduzu leaf hot water extract dry powder 1.5     6. Rakanka hot water extract dry powder 1.5

[0131] (Prescription example 34) Udon or buckwheat mass%     1. Wheat flour or buckwheat flour 90.0     2. Salt 1.0     3. Kobotsudzu whole plant hot water extract dry powder 4.0     4. Bodaiju hot water extract dry powder 4.0     5. Dried powder of hot water extract of Renshen whole plant 1.0

[0132] (Prescription example 35) Beverage mass%     1. Glucose liquid sugar 30.0     2. Grapefruit juice 50.0     3. Kobodzu leaf or stem hot water extract dry powder 9.0     4. Mucopolysaccharide solution 4.0     5. Iyokan juice 7.0     6. Perfume suitable amount     7. Suitable amount of acidulant

[0133] (Prescription example 36) Bread mass%     1.flour 80.0     2. Salt 1.0     3. Glucose 8.0     4. Kotanduzu fruit or pericarp hot water extract dry powder 3.0     5. Salvia whole grass hot water extract dry powder 2.0     6. Perilla leaf hot water extract dry powder 2.0     7. Carboxymethyl chitin solution 2.0     8. Vitamin E 1.0     9. Heme iron 1.0

[0134] (Prescription example 37) Sausage mass%     1. Ground meat 85.0     2. Chicken egg 5.0     3. Spice 1.0     4. Seasoning 1.0     5. Kobodzu leaf or bark hot water extract dry powder 4.0     6. Capsicum extract 4.0

[0135] (Formulation Example 38) gum mass%     1.Menthol Micron 30.0     2. Grapefruit flavor 60.0     3. Kobotsudzu rhizome hot water extract dry powder 4.0     4. Crassulaceae whole plant extract dry powder 2.0     5. Artemisia leaf or stem hot water extract dry powder 2.0     6. Tannin 2.0

[0136] (Prescription example 39) Miso soup mass%     1. Tofu 30.0     2. Deep fried 5.0     3. carrot 5.0     4. Burdock 5.0     5. Chinese cabbage 5.0     6. Red miso 20.0     7. Kotanduzu leaf hot water extract dry powder 5.0     8. Skipjack dashi     9. Residue to make purified water 100

[0137] (Formulation example 40) Cookie mass%     1.milk 62.0     2. Whole egg 14.5     3. Sugar 12.0     4. Constarch 5.0     5. Salt 0.5     6. Dried powder of Kobotsudzu extract from Production Example 6.0     7. Fragrance suitable amount

(Test 6) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. Use test is for adult women who suffer from acne, eczema, rough skin or skin tension, and lack of gloss 20-40
Each 10 year-old was used as a panelist, and twice a day in the morning and at night, after washing the face, the emulsion (preferred amount) of Prescription Example 1 was applied to the face for 3 months. As a control, an emulsion obtained by removing the Kobodzu crane extract of the present invention from the emulsion and formulated by the same method was used. The evaluation method was carried out according to the following criteria, and the results are shown in Tables 1 and 2, and the numerical values in the table represent the number of people.
No one complained of skin abnormality during the period of use.

[Effect of improving skin diseases] Effective: Acne, eczema, and rough skin were improved. Slightly effective: Acne, eczema, and rough skin were slightly improved. Ineffective: No change from before use.

[Effect of improving skin feel] Effective: Increased skin tension and gloss. Slightly effective: Skin tension and luster slightly increased. Ineffective: No change from before use.

[0141]

[Table 1]

[0142]

[Table 2]

(Test Results) As shown in Tables 1 and 2, the cosmetic composition containing the Kobotsudzu extract of the present invention was:
It was confirmed that it improves acne, eczema, and rough skin, and that it gives the skin firmness and gloss.

(Test 7) Use effect test The effect of actually using the food or drink of the present invention was examined. The use test was conducted by 10 adult panelists, each aged 20 to 40 years old, who suffers from acne, eczema, rough skin or rough skin, and lack of gloss, and is given twice daily in the morning and at night.
I had a cup of miso soup (about 150cc) and took it for 3 months. As a control, a miso soup obtained by removing the kobodzu crane extract of the present invention and formulated by the same method was used. The evaluation method was carried out according to the following criteria, and the results are shown in Tables 3 to 4, and the numerical values in the table represent the number of people. No one complained of any abnormality during the period of use.

[Effect of improving skin diseases] Effective: Acne, eczema, and rough skin were improved. Slightly effective: Acne, eczema, and rough skin were slightly improved. Ineffective: No change from before use.

[Effect of improving skin feel] Effective: Increased skin tension and gloss. Slightly effective: Skin tension and luster slightly increased. Ineffective: No change from before use.

[0147]

[Table 3]

[0148]

[Table 4]

(Test Results) As shown in Tables 3 and 4, the foods and drinks containing the extract of Kobotsudzu of the present invention of the present invention can improve acne, eczema, and rough skin, and can give the skin tension and gloss. confirmed.

[0150]

INDUSTRIAL APPLICABILITY The lipase activity inhibitor, active oxygen scavenger, cosmetic composition, or food and drink containing the Kobotsudzu extract of the present invention inhibits lipase activity and significantly eliminates or suppresses active oxygen. It is also effective in preventing aging of the skin and scalp, since it can improve eczema, acne, and rough skin, and can give the skin tension and gloss. Further, it is safe to be used internally or externally for humans or animals, and can be applied to preparations in any form (medicines, quasi drugs, cosmetics, foods).

[Brief description of drawings]

FIG. 1 is a graph showing the lipase activity inhibitory action of the Kobotsudzu extract of the present invention.

FIG. 2 is a view showing the active oxygen scavenging action of the Kobotsudzu crane extract of the present invention.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A23L 1/22 A23L 1/22 D 4B042 1/30 1/30 B 4B046 1/317 1/317 A 4B047 1 / 39 1/39 4C083 2/38 2/38 C 4C088 2/52 A61K 7/00 K 4H003 A61K 7/00 M N U 7/021 7/021 7/06 7/06 7/075 7/075 7 / 08 7/08 7/42 7/42 7/50 7/50 A61P 17/10 A61P 17/10 39/06 39/06 43/00 111 43/00 111 C11D 3/38 C11D 3/38 A23L 2/00 FF term (reference) 4B014 GB13 GK12 GL03 4B017 LC03 LG15 LL09 LP01 4B018 LB01 LB02 LB06 LB08 LB09 MD61 ME06 ME14 MF01 4B032 DB01 DB21 DK29 DL20 DP80 4B036 LF01 4B046 LB03 LAB0446 AC03 AD03 4B0447 AC03 AD03 AD03 LE01 LF08 LG37 LG65 LP01 4C083 AA08 AA111 AA112 AA122 AB03 AB15 AB212 AB232 AB24 AB442 AC022 AC072 AC112 AC122 AC172 AC182 AC21 AC24 AC352 AC422 AC442 AC482 AC53 AC54 AC58 AC662 AD042 AD09 AD112 AD272 AD43 AD53 AD642 AD662 CC01 CC04 CC05 CC07 CC12 CC19 CC23 CC32 DD33 DD27 DD27 DD27 DD27 DD27 DD27 DD27 DD27 AB32 AC01 CA03 NA14 ZA89 ZC20 ZC37 ZC41 4H003 AB27 AB31 AC05 AC13 DA02 DA17 EB04 EB05 EB16 EB41 EB43 ED02 FA21 FA33

Claims (4)

[Claims] 1. A lipase activity inhibitor, which comprises an extract of Kobotsudzu. 2. An active oxygen scavenger, which contains an extract of Kobotsudzu. 3. A cosmetic composition comprising any one or more of the lipase activity inhibitor and the active oxygen scavenger according to claim 1 or 2. 4. A food or drink containing one or more of the lipase activity inhibitor and the active oxygen scavenger according to any one of claims 1 to 2.