CN104800272A - Novel momordica saponin extraction technology - Google Patents
Novel momordica saponin extraction technology Download PDFInfo
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- CN104800272A CN104800272A CN201410044465.7A CN201410044465A CN104800272A CN 104800272 A CN104800272 A CN 104800272A CN 201410044465 A CN201410044465 A CN 201410044465A CN 104800272 A CN104800272 A CN 104800272A
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- momordica
- ethanol
- momordica saponins
- momordica saponin
- extraction
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Abstract
The invention discloses a novel momordica saponin extraction technology. The physical separation process for extraction of momordica saponin by water or ethanol as an extraction solvent does not produce harmful materials and realizes clean production. The water extraction agent saves a large amount of an organic solvent. The innocuous and unpoisonous water or ethanol extraction agent reduces damage to momordica saponin physiological activity, improves product quality and reduces environmental pollution. The novel momordica saponin extraction technology utilizes easily available raw materials and has a low manufacturing cost. The product can improve immunity, resist mutagenesis and viruses, reduce cholesterol and blood sugar and resist tumors and HIV. The momordica saponin product can be used as a raw material of many medical preparations. The momordica saponin product can be mainly used for adjusting human physiological functions, improving human immunity, inhibiting tumors, resisting oxidation and diminishing inflammation. The raw material formula of the technology comprises fresh momordica charantia, deionized water, ethanol with a concentration of 70% and petroleum ether.
Description
Technical field:
The invention belongs to extracted form natural plant pharmaceuticals technical field, particularly one utilizes momordica saponins to extract new technique.
Technical background:
Current people not consideration Fructus Momordicae charantiae plant extract medicine are used for cure diseases, but are directly taken as food by Fructus Momordicae charantiae.
Summary of the invention:
The present invention extracts natural health medicine to make full use of Fructus Momordicae charantiae, provides one Fructus Momordicae charantiae and extracts momordica saponins novel technique.This technology changes the single edible and wasting shortcoming of original Fructus Momordicae charantiae, is decomposed by Fructus Momordicae charantiae, and adopt with water or ethanol for extractant, the process therefrom extracting momordica saponins is physical separating process, does not generate harmful substance, and technical process can realize cleaner production; Using water as digestion agent, a large amount of organic solvents can be saved; Using nontoxic water or ethanol as extractant, decrease the destruction to momordica saponins physiologically active, improve the quality of product, decrease the pollution to environment.This products material is easy to get, cheap for manufacturing cost.The product that this technology is produced has raising immunity, antimutagenesis, antivirus action, reduction cholesterol, reduces the physiological functions such as blood glucose, antitumor and anti AIDS virus.Thus the raw material of many pharmaceutical preparation products is become.This product is mainly used as to regulate human physiological functions, strengthen body immunity, Tumor suppression, antioxidation, antiinflammatory.
Utilize Fructus Momordicae charantiae to extract its composition of raw materials of momordica saponins technology to be:
Fresh bitter-100 mass parts,
Deionized water-50 mass parts,
70% ethanol-1200 mass parts,
Petroleum ether-enough.
The present invention is achieved through the following technical solutions:
1. get the raw materials ready; Select free from admixture, work as annual output Fructus Momordicae charantiae, ion without what go mouldy, then air-dry, pulverized 20 mesh sieves choosings, stand-by.
2. water extraction; The raw material pulverized is dropped into hydrolysis and extracts the deionized water and stirring backflow adding 50% times amount in still, mix homogeneously, suitably heats, lixiviate 1 hours, filters, and collects filtering residue comprehensive utilization, obtains filtrate stand-by.
3. film from; Filtrate is put in membrane separator, under the condition of pressure (0.05-0.15) Mpa, making filtrate overload stay molecular weight to be greater than the hollow-fibre membrane of 6000, obtaining permeate, for extracting momordica saponins; Collect trapped concentrated solution, fully utilized, extract containing Fructus Momordicae charantiae crude polysaccharides.
4. chromatography; Macroporous resin column on permeate is adsorbed, to remove the impurity such as albumen, with the deionized water drip washing being equivalent to 20 times amount, then uses 70% ethanol elution, collect the eluent containing Saponin peak position with automatic segregator, stand-by.
5. concentrated; Eluent containing momordica saponins is put in vacuum concentrator, under decompression cryogenic conditions, reclaims ethanol to the greatest extent, obtain momordica saponins concentrate, stand-by.
6. cold dry; Momordica saponins concentrate is placed in freezer dryer, and lyophilization under decompression cryogenic conditions, then pulverizes, and crosses 80 mesh sieves, obtains momordica saponins product.
Claims (6)
1. extract a momordica saponins new technique with Fructus Momordicae charantiae, it is fresh bitter-100 mass parts with material formula, deionized water-50 mass parts, 70% ethanol-1200 mass parts, petroleum ether-enough.
2. it is characterized in that, it is select free from admixture that described this Fructus Momordicae charantiae extracts momordica saponins new technique preparation method, annual output Fructus Momordicae charantiae is worked as, ion without what go mouldy, then air-dry, pulverized 20 mesh sieve choosings, garbled raw material is dropped into the deionized water and stirring backflow adding 50% times amount in hydrolysis extraction still, mix homogeneously, suitably heats, lixiviate 1 hours, filter, collect filtering residue comprehensive utilization, obtain filtrate stand-by.
3. be further characterized in that, filtrate put in membrane separator, under the condition of pressure (0.05-0.15) Mpa, making filtrate overload stay molecular weight to be greater than the hollow-fibre membrane of 6000, obtaining permeate, for extracting momordica saponins; Collect trapped concentrated solution, fully utilized, extract containing Fructus Momordicae charantiae crude polysaccharides.
4. be further characterized in that, macroporous resin column on permeate is adsorbed, to remove the impurity such as albumen, with the deionized water drip washing being equivalent to 20 times amount, then use 70% ethanol elution, collect the eluent containing Saponin peak position with automatic segregator, stand-by.
5. be further characterized in that, the eluent containing momordica saponins is put in vacuum concentrator, under decompression cryogenic conditions, reclaim ethanol to the greatest extent, obtain momordica saponins concentrate, stand-by.
6. be further characterized in that, momordica saponins concentrate is placed in freezer dryer, lyophilization under decompression cryogenic conditions, then pulverizes, and crosses 80 mesh sieves, obtains momordica saponins product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410044465.7A CN104800272A (en) | 2014-01-23 | 2014-01-23 | Novel momordica saponin extraction technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410044465.7A CN104800272A (en) | 2014-01-23 | 2014-01-23 | Novel momordica saponin extraction technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104800272A true CN104800272A (en) | 2015-07-29 |
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ID=53685760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410044465.7A Pending CN104800272A (en) | 2014-01-23 | 2014-01-23 | Novel momordica saponin extraction technology |
Country Status (1)
| Country | Link |
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| CN (1) | CN104800272A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106008647A (en) * | 2016-07-05 | 2016-10-12 | 汕头大学 | Novel extraction method of momordica saponins |
| CN106905383A (en) * | 2017-03-31 | 2017-06-30 | 林婷 | A kind of hypoglycemic use glucoside extract and its manufacture method |
| CN110845633A (en) * | 2019-11-11 | 2020-02-28 | 江苏大学 | Normal-temperature method for extracting active polysaccharide from fresh bitter gourds |
-
2014
- 2014-01-23 CN CN201410044465.7A patent/CN104800272A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106008647A (en) * | 2016-07-05 | 2016-10-12 | 汕头大学 | Novel extraction method of momordica saponins |
| CN106008647B (en) * | 2016-07-05 | 2018-05-08 | 汕头大学 | A kind of extracting method of Momordica charantial |
| CN106905383A (en) * | 2017-03-31 | 2017-06-30 | 林婷 | A kind of hypoglycemic use glucoside extract and its manufacture method |
| CN110845633A (en) * | 2019-11-11 | 2020-02-28 | 江苏大学 | Normal-temperature method for extracting active polysaccharide from fresh bitter gourds |
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Application publication date: 20150729 |
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| WD01 | Invention patent application deemed withdrawn after publication |