CN112315839A - Brightening and anti-saccharification composition containing carnosine and ergothioneine and application thereof - Google Patents
Brightening and anti-saccharification composition containing carnosine and ergothioneine and application thereof Download PDFInfo
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- CN112315839A CN112315839A CN202011130862.8A CN202011130862A CN112315839A CN 112315839 A CN112315839 A CN 112315839A CN 202011130862 A CN202011130862 A CN 202011130862A CN 112315839 A CN112315839 A CN 112315839A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a brightening and anti-saccharification composition containing carnosine and ergothioneine, which comprises the following components in percentage by weight: 0.0001-20% of carnosine, 0.0001-5% of ergothioneine, 0.0001-2% of inositol and the balance of water. In the brightening and anti-saccharification composition, ergothioneine has good synergistic and antioxidant effects, so that the composition can not only exert a strong antioxidant effect, but also take effect in cooperation with other antioxidants, and can fully exert the effects of the composition. Carnosine Ergotine and skin have strong anti-saccharification, anti-oxidation, repair and brightening functions. The brightening and anti-saccharification composition is mild and non-irritant, can be used as an anti-saccharification and brightening skin active component, and is applied to various cosmetics.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a brightening and anti-saccharification composition containing carnosine and ergothioneine and application thereof in brightening and anti-saccharification.
Background
With the increase of age, environmental pollution and living pressure, the skin of people is more and more obvious. The common manifestations and causes of skin darkness are: first, the age begins to increase: the more active the free radicals in the body will be with age, the oxidation of the free radicals is aging, and problems such as wrinkles, sagging, color spots, darkness, etc. may be formed. Second, lack of motion at ordinary times: lack of daily exercise causes too slow metabolism, which causes excessive sugar to be dissociated in blood throughout the day, and the excessive sugar is attached to collagen, which breaks or disorganizes collagen, resulting in "skin saccharification". Thirdly, long-term sunlight solarization: long-term sunlight exposure is the cause of 90% of the human skin aging and tanning. Fourth, dietary nutritional imbalance: overeating and excessive intake of sugar will destroy the normal metabolism of skin and make skin saccharified and dull. Fifth, no skin cleansing is done: daily care should be taken to thoroughly cleanse the skin each day.
Disclosure of Invention
Aiming at the defects of the prior art, the brightening and anti-saccharification composition provided by the invention comprises the following components: the ergothioneine has good synergistic and antioxidant effects, not only can exert strong antioxidant effect, but also can act in synergy with other antioxidants, so that the composition can fully exert the effects. Carnosine Ergotine and skin have strong anti-saccharification, anti-oxidation, repair and brightening functions. Inositol has effects of keeping moisture and resisting wrinkle, and can also improve skin glossiness. The brightening and anti-saccharification composition is mild and non-irritant, and can be used as a brightening and anti-saccharification active component and applied to various cosmetics.
Specifically, the invention provides a brightening and anti-saccharification composition containing carnosine and ergothioneine, which comprises the following components in percentage by weight: 0.0001-20% of carnosine, 0.0001-5% of ergothioneine, 0.0001-2% of inositol and the balance of water.
In another preferred embodiment, the present invention provides a shine and anti-glycation composition comprising carnosine and ergothioneine, comprising the following components in weight percent: 0.0001-20% of carnosine, 0.0001-5% of ergothioneine, 0.0001-2% of inositol and the balance of water.
In another preferred embodiment, the invention provides a brightening and anti-glycation composition containing carnosine and ergothioneine, which comprises the following components, by weight, 1-20% of carnosine, 0.1-5% of ergothioneine, 0.1-2% of inositol and the balance water.
In another preferred embodiment, the present invention provides an anti-shine and anti-glycation composition comprising carnosine and ergothioneine, comprising the following components in percentage by weight: 5-15% of carnosine, 0.5-3% of ergothioneine, 0.5-1% of inositol and the balance of water.
Preferably, the Carnosine (L-Carnosine) is a dipeptide consisting of two amino acids, namely beta-alanine and L-histidine, and the purity of the Carnosine is 80-99.9%.
Preferably, the ergothioneine comprises ergothioneine and ergothioneine fermentation broth.
Preferably, the purity of the ergothioneine is 0.01-99.9%.
Preferably, the inositol is inositol, also known as inositol or inositol fibrates, which include D-chiro-inositol, L-quebrachol, myo-inositol and scyllo-inositol.
Preferably, the inositol has moisturizing and anti-wrinkle effects, and can also improve skin glossiness.
Preferably, the carnosine is a water-soluble dipeptide that occurs naturally in muscle tissue and in the brain with vigorous metabolism.
Preferably, the carnosine is capable of glycosylation with aldoses or ketoses, thereby protecting the protein and acting as an anti-glycation or glycation delay.
Preferably, the carnosine can also scavenge free radicals harmful to the skin and whiten and lighten skin color.
Preferably, the ergothioneine is a powerful hypochloride scavenger (HOCl) which protects red blood cells from neutrophils from normal functioning or diseased inflammatory sites.
Preferably, said ergothioneine also inhibits the oxidation of amino acids in the peroxynitroso anionic mediator, with an anti-inflammatory effect.
Preferably, the ergothioneine can minimize the formation of active oxygen and protect cells from radiation damage, and can be used as a skin protective agent added into certain cosmetics and used for developing outdoor skin care products and protective cosmetics.
Preferably, the ergothioneine can effectively remove high-concentration free radicals in a human body, remove color spots, whiten skin, delay aging and prevent various diseases.
The invention also provides a preparation method of the brightening and anti-saccharification composition containing carnosine and ergothioneine, which comprises the following steps:
at normal temperature, carnosine and ergothioneine are added into water and stirred to be dissolved uniformly, so that the brightening and anti-saccharification composition with the anti-saccharification and skin brightening effects is obtained.
The invention also provides a brightening and anti-saccharification cosmetic containing the carnosine and the ergothioneine, and the brightening and anti-saccharification cosmetic comprises a brightening and anti-saccharification composition containing the carnosine and the ergothioneine.
Preferably, the anti-glycation, shining cosmetic comprises 0.1-5% of shining and anti-glycation composition.
Preferably, the brightening and anti-saccharification cosmetic is a brightening and anti-saccharification mask, a brightening and anti-saccharification essence, a brightening and anti-saccharification cream.
The invention also provides application of the brightening and anti-saccharification composition containing the carnosine and the ergothioneine in preparing cosmetics for brightening and anti-saccharification.
Preferably, the carnosine is capable of glycosylation with aldoses or ketoses, thereby protecting the protein and acting as an anti-glycation or glycation delay.
Preferably, the carnosine can also scavenge free radicals harmful to the skin and whiten and lighten skin color.
Preferably, the ergothioneine is a powerful hypochloride scavenger (HOCl) which protects red blood cells from neutrophils from normal functioning or diseased inflammatory sites.
Preferably, said ergothioneine also inhibits the oxidation of amino acids in the peroxynitroso anionic mediator, with an anti-inflammatory effect.
Preferably, the ergothioneine can minimize the formation of active oxygen and protect cells from radiation damage, and can be used as a skin protective agent added into certain cosmetics and used for developing outdoor skin care products and protective cosmetics.
Preferably, the brightening and anti-glycation composition is mild and non-irritant, and can be used as an anti-glycation and brightening skin active component and applied to various cosmetics.
Drawings
FIG. 1 shows the results of anti-glycation in the control experiments of trial examples 4, 5 and 7.
Figure 2 is the facial speckle results of trial run 4.
Figure 3 is the facial speckle results of trial implementation 6.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Carnosine (carnosine) is a water-soluble dipeptide that occurs naturally in the skeletal muscles and in the metabolically active brain of a variety of vertebrates. This is the first representative bioactive peptide isolated from natural sources. Carnosine can effectively resist saccharification, resist oxidation, remove free radicals, prevent skin aging and whiten skin.
Inositol, i.e. inositol, is widely distributed in animals and plants, and is generally extracted from calcium phytate. Has effects of moisturizing and removing wrinkle, and can improve skin glossiness.
Ergothioneine is a natural amino acid which is abundant in a plurality of animals and plants, cannot be synthesized by the animal organism per se, and can only be taken from the outside. Ergothioneine is a natural antioxidant, has high protective effect on cells, is nontoxic, and can inhibit pigmentation and whiten skin. Ergothioneine absorbs certain wavelength in ultraviolet absorption range, and has sunscreen and antiinflammatory effects.
Example 1
At normal temperature, 0.5% of carnosine, 0.1% of ergothioneine and 0.1% of inositol are added into water, and stirred and dissolved uniformly to obtain the brightening and anti-saccharification composition with brightening and anti-saccharification skin effects.
Example 2
At normal temperature, 10% of carnosine, 0.1% of ergothioneine and 0.1% of inositol are added into water, and the mixture is stirred and dissolved uniformly to obtain the brightening and anti-saccharification composition with the brightening and anti-saccharification skin effect.
Example 3
At normal temperature, 0.5% of carnosine, 1% of ergothioneine and 1% of inositol are added into water, and the mixture is stirred and dissolved uniformly to obtain the brightening and anti-saccharification composition with brightening and anti-saccharification skin effects.
Example 4 preparation and use of brightening and anti-glycation essence
1. Raw materials
Phase A: water (95%), glycerin 4%, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer 0.10%, and EDTA disodium 0.01%;
phase B: 0.10 percent of triethanolamine;
and C phase: 0.5% of 1, 2-hexanediol and 0.25% of phenoxyethanol/ethylhexyl glycerin;
phase D: 1.2% of the shine and anti-glycation composition of example 1 of the invention;
phase E: 0.005% of essence and 0.02% of PEG-40 hydrogenated castor oil.
2. Preparation process of brightening and anti-saccharification essence
(1) Adding the phase A into an emulsifying pot, homogenizing for 3-5 minutes until the powder raw materials are well dispersed, heating to 85 ℃, keeping the temperature for 15 minutes, stirring and cooling the phase B (after adding the phase B, keeping the temperature again);
(2) cooling to below 45 deg.C, adding phase C, phase D and phase E (phase E is dissolved in advance), stirring, inspecting, filtering with 300 mesh sieve, and discharging. Obtaining the brightening and anti-saccharification essence.
Example 5 preparation and use of brightening and anti-glycation essence
1. Raw materials
Phase A: water (95%), glycerin 4%, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer 0.10%, and EDTA disodium 0.01%;
phase B: 0.10 percent of triethanolamine;
and C phase: 0.5% of 1, 2-hexanediol and 0.25% of phenoxyethanol/ethylhexyl glycerin;
phase D: 1.2% of the brightening and anti-glycation composition of example 2 of the invention;
phase E: 0.005% of essence and 0.02% of PEG-40 hydrogenated castor oil.
2. Preparation process of brightening and anti-saccharification essence
(1) Adding the phase A into an emulsifying pot, homogenizing for 3-5 minutes until the powder raw materials are well dispersed, heating to 85 ℃, keeping the temperature for 15 minutes, stirring and cooling the phase B (after adding the phase B, keeping the temperature again);
(2) cooling to below 45 deg.C, adding phase C, phase D and phase E (phase E is dissolved in advance), stirring, inspecting, filtering with 300 mesh sieve, and discharging. The anti-saccharification and brightening essence is obtained.
Example 6 preparation and use of brightening and anti-glycation essence
1. Raw materials
Phase A: water (95%), glycerin 4%, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer 0.10%, and EDTA disodium 0.01%;
phase B: 0.10 percent of triethanolamine;
and C phase: 0.5% of 1, 2-hexanediol and 0.25% of phenoxyethanol/ethylhexyl glycerin;
phase D: 1.2% of the shine and anti-glycation composition of example 3 of the invention;
phase E: 0.005% of essence and 0.02% of PEG-40 hydrogenated castor oil.
2. Preparation process of brightening and anti-saccharification essence
(1) Adding the phase A into an emulsifying pot, homogenizing for 3-5 minutes until the powder raw materials are well dispersed, heating to 85 ℃, keeping the temperature for 15 minutes, stirring and cooling the phase B (after adding the phase B, keeping the temperature again);
(2) cooling to below 45 deg.C, adding phase C, phase D and phase E (phase E is dissolved in advance), stirring, inspecting, filtering with 300 mesh sieve, and discharging. The anti-saccharification and brightening essence is obtained.
Example 7 preparation and use of brightening and anti-glycation essence
1. Raw materials
Phase A: water (95%), glycerin 4%, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer 0.10%, and EDTA disodium 0.01%;
phase B: 0.10 percent of triethanolamine;
and C phase: 0.5% of 1, 2-hexanediol and 0.25% of phenoxyethanol/ethylhexyl glycerin;
phase D: 1.2% of the brightening and anti-saccharification composition is replaced by water;
phase E: 0.005% of essence and 0.02% of PEG-40 hydrogenated castor oil.
2. Preparation process of brightening and anti-saccharification essence
(1) Adding the phase A into an emulsifying pot, homogenizing for 3-5 minutes until the powder raw materials are well dispersed, heating to 85 ℃, keeping the temperature for 15 minutes, stirring and cooling the phase B (after adding the phase B, keeping the temperature again);
(2) cooling to below 45 deg.C, adding phase C, phase D and phase E (phase E is dissolved in advance), stirring, inspecting, filtering with 300 mesh sieve, and discharging. The anti-saccharification and brightening essence is obtained.
In order to better illustrate the advantages of the invention, aiming at anti-saccharification skin-brightening series cosmetics, a specific cosmetic efficacy evaluation method is adopted to test and analyze the safety and efficacy of the composition obtained by the invention, and the detection results are as follows:
1. the shining of carnosine and the anti-glycation efficacy evaluation of the anti-glycation composition.
The experimental method comprises the following steps:
randomly extracting 3 eggs, uniformly mixing egg white in the eggs, uniformly pouring 30 g of egg white in each beaker into 3 beakers numbered from 1 to 3, adding 20 g of deionized water in each beaker, and uniformly mixing the mixture.
② No. 1 beaker is used as a control experiment, 5 g of example 5 is added and stirred evenly, and then 1 g of sugar is added and stirred evenly again; no. 2 beaker is used as a control experiment, 5 g of example 4 is added and stirred evenly, and then 1 g of sugar is added and stirred evenly again; no. 3 beaker is blank control experiment, add 5 g of example 7 and stir, then add 1 g of sugar and stir again.
Putting 3 beakers into a constant-temperature water bath kettle at 90 ℃ at the same time, and keeping the temperature for 2 hours.
And fourthly, taking out the protein after 2 hours to observe the yellowing degree of the protein after being saccharified.
The results are shown in fig. 1, where No. 3 beaker containing the shine and anti-glycation composition of the invention, clearly glycation-severe proteins turned yellow to brown. The protein in the No. 1 beaker and the No. 2 beaker is basically white, has low yellowing degree and has obvious anti-saccharification effect. The protein anti-glycation whiteness of the No. 1 beaker is obviously white compared with that of the No. 2 beaker, and the results prove that the anti-glycation and brightening capability of the anti-glycation and brightening composition on the protein can be improved because the concentration of ergothioneine is unchanged and the concentration of the carnosine is increased in the anti-glycation and brightening composition.
2. And (3) carrying out brightening on carnosine and evaluating the brightening and spot-fading effects of the anti-saccharification composition.
The experimental method comprises the following steps:
firstly, randomly extracting 20 testers, cleaning the face before testing, resting for 15 minutes at a fixed position, testing the facial spot value by using a skin tester VISIA machine, and recording the condition.
And secondly, applying the brightening essence of the embodiment 4 on the left face, applying the brightening essence of the embodiment 6 on the right face for 3 months, cleaning the face with clear water, testing the facial spot value by using a skin tester VISIA (visual inspection instrument), and recording the condition.
The results are shown in fig. 2-3, where the reduction in spots was significant after the application of the rejuvenating essence, but the reduction in spots was slightly lower for application example 4 than for application example 6. From this, it can be concluded that the skin lightening and spot lightening effect of the composition can be enhanced by increasing the concentration of ergothioneine without changing the concentration of carnosine in the lightening and anti-glycation composition containing carnosine and ergothioneine. The ergothioneine concentration is unchanged, the concentration of carnosine is increased, and the brightening and spot-lightening effect of the composition on skin can be improved. The carnosine and the ergothioneine are proved to have the functions of brightening and lightening spots.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. A brightening and anti-saccharification composition containing carnosine and ergothioneine is characterized by comprising the following components in percentage by weight: 0.0001-20% of carnosine, 0.0001-5% of ergothioneine, 0.0001-2% of inositol and the balance of water.
2. A brightening and anti-saccharification composition containing carnosine and ergothioneine is characterized by comprising the following components in percentage by weight: 0.0001-20% of carnosine, 0.0001-5% of ergothioneine, 0.0001-2% of inositol and the balance of water.
3. The shine and anti-glycation composition containing carnosine and ergothioneine according to claim 1, comprising the following components in percentage by weight: 1-20% of carnosine, 0.1-5% of ergothioneine, 0.1-2% of inositol and the balance of water.
4. The shine and anti-glycation composition comprising carnosine and ergothioneine according to claim 1, wherein the carnosine is a dipeptide consisting of β -alanine and L-histidine.
5. The shine and anti-glycation composition comprising carnosine and ergothioneine according to claim 1, wherein the purity of the carnosine is 80-99.9%.
6. The shine & anti-glycation composition comprising carnosine and ergothioneine according to claim 1, wherein the ergothioneine comprises ergothioneine and an ergothioneine fermentation broth.
7. The shine and anti-glycation composition comprising carnosine and ergothioneine according to claim 1, wherein the inositol comprises one or more of D-chiro-inositol, L-quebrachol, myo-inositol, and scyllo-inositol.
8. A brightening and anti-glycation cosmetic containing carnosine and ergothioneine, which is characterized by comprising the brightening and anti-glycation composition containing the carnosine and the ergothioneine according to any one of claims 1 to 7.
9. The shine and anti-glycation cosmetic containing carnosine and ergothioneine according to claim 8, wherein the shine and anti-glycation cosmetic comprises 0.1-5% of the shine and anti-glycation composition containing carnosine and ergothioneine.
10. Use of a shine and anti-glycation composition comprising carnosine and ergothioneine according to any of claims 1 to 7 in the preparation of an anti-glycation, shine cosmetic.
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| CN113181085A (en) * | 2021-04-29 | 2021-07-30 | 广州睿森生物科技有限公司 | Composition matrix for improving skin problems after makeup and application of composition matrix in cosmetics |
| CN114224779A (en) * | 2021-12-27 | 2022-03-25 | 广州睿森生物科技有限公司 | Eye repair composition and application thereof |
| CN114732754A (en) * | 2022-05-06 | 2022-07-12 | 宁波伯通伟达生物医药有限公司 | Composition with skin whole-link antioxidation and anti-aging functions and preparation method and application thereof |
| CN115006298A (en) * | 2022-07-04 | 2022-09-06 | 广州品赫生物科技有限公司 | Whitening and freckle-removing composition and preparation method and application thereof |
| CN115137661A (en) * | 2022-07-07 | 2022-10-04 | 广州品域美妆创新科技有限公司 | Anti-wrinkle composition containing beta-nicotinamide mononucleotide, preparation method of anti-wrinkle composition and cosmetics |
| CN115919673A (en) * | 2022-12-19 | 2023-04-07 | 华熙生物科技股份有限公司 | Composition with antioxidation effect and application thereof |
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