CN112313501A - 检测方法、检测用器具和检测装置 - Google Patents

检测方法、检测用器具和检测装置 Download PDF

Info

Publication number
CN112313501A
CN112313501A CN201980042281.8A CN201980042281A CN112313501A CN 112313501 A CN112313501 A CN 112313501A CN 201980042281 A CN201980042281 A CN 201980042281A CN 112313501 A CN112313501 A CN 112313501A
Authority
CN
China
Prior art keywords
substance
refractive index
detected
detection
periodic structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980042281.8A
Other languages
English (en)
Chinese (zh)
Inventor
赤木良教
浅野元彦
土居淳
远藤达郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Public University Legal Person Osaka
Sekisui Chemical Co Ltd
University Public Corporation Osaka
Original Assignee
Public University Legal Person Osaka
Sekisui Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Public University Legal Person Osaka, Sekisui Chemical Co Ltd filed Critical Public University Legal Person Osaka
Publication of CN112313501A publication Critical patent/CN112313501A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N2021/4126—Index of thin films
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N2021/4166—Methods effecting a waveguide mode enhancement through the property being measured
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7776—Index
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Optical Measuring Cells (AREA)
CN201980042281.8A 2018-07-31 2019-07-31 检测方法、检测用器具和检测装置 Pending CN112313501A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2018-143726 2018-07-31
JP2018143726 2018-07-31
JP2019-052598 2019-03-20
JP2019052598 2019-03-20
PCT/JP2019/030010 WO2020027197A1 (fr) 2018-07-31 2019-07-31 Procédé d'inspection, instrument d'inspection et dispositif d'inspection

Publications (1)

Publication Number Publication Date
CN112313501A true CN112313501A (zh) 2021-02-02

Family

ID=69231821

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980042281.8A Pending CN112313501A (zh) 2018-07-31 2019-07-31 检测方法、检测用器具和检测装置

Country Status (5)

Country Link
US (1) US20210310945A1 (fr)
EP (1) EP3832292B1 (fr)
JP (1) JP7345782B2 (fr)
CN (1) CN112313501A (fr)
WO (1) WO2020027197A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2021193589A1 (fr) * 2020-03-23 2021-09-30

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005516210A (ja) * 2002-01-28 2005-06-02 エス アール ユー バイオシステムス，エル エル シー 線形光学表面構造を用いた導波モード共鳴フィルターバイオセンサー
US20090079976A1 (en) * 2006-11-09 2009-03-26 The Board Of Trustees Of The University Of Illinois Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis
CN101978173A (zh) * 2008-03-11 2011-02-16 积水化学工业株式会社 光响应性气体发生材料、微泵及微流体设备
CN102112866A (zh) * 2008-07-30 2011-06-29 兴和株式会社 用于测定来自生物体的生理活性物质的方法和测定装置
CN104359874A (zh) * 2008-06-06 2015-02-18 博纳基因技术有限公司 集成分析装置及相关制造方法和分析技术
WO2017138595A1 (fr) * 2016-02-09 2017-08-17 積水化学工業株式会社 Instrument de contrôle, dispositif de contrôle et procédé de contrôle

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04152249A (ja) * 1990-10-16 1992-05-26 Kiminori Ito 光導波路回折格子バイオケミカルセンサー
EP1126278B1 (fr) * 1992-07-31 2007-05-23 Inverness Medical - BioStar Inc. Dispositifs et méthodes de détection d'un analyte basés sur l'interférence de lumière
WO2000042233A1 (fr) * 1999-01-13 2000-07-20 Cornell Research Foundation, Inc. Fabrication de structures fluidiques monolithiques
EP1190236A1 (fr) * 1999-06-05 2002-03-27 Zeptosens AG Plate-forme de capteurs et procede permettant de determiner plusieurs substances a analyser
US7167615B1 (en) * 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
JP2001308352A (ja) * 2000-04-18 2001-11-02 Canon Inc 光起電力素子、該光起電力素子を用いた太陽電池モジュール及び該太陽電池モジュールの製造方法
US7615339B2 (en) * 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US20020164824A1 (en) * 2001-02-16 2002-11-07 Jianming Xiao Method and apparatus based on bundled capillaries for high throughput screening
JP4533044B2 (ja) * 2003-08-27 2010-08-25 キヤノン株式会社 センサ
JP4360265B2 (ja) * 2004-05-06 2009-11-11 株式会社日立製作所 生化学測定チップおよび測定装置
NZ565682A (en) * 2005-07-08 2009-11-27 Univ Illinois Photonic crystal biosensor fabrication method
US7790406B2 (en) * 2005-08-11 2010-09-07 Sru Biosystems, Inc Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
JP2007327946A (ja) 2006-05-09 2007-12-20 Tokyo Univ Of Agriculture & Technology 標的酵素の活性を測定する方法、標的酵素の活性を測定するためのキット、および標的酵素の活性を測定するためのバイオセンサ
JP2008002948A (ja) * 2006-06-22 2008-01-10 Olympus Corp 標的核酸の検出方法及び該検出方法に用いる容器
NZ576760A (en) * 2006-11-09 2011-10-28 Univ Illinois Photonic crystal based biosensor based on a microfluidic device
US20080240543A1 (en) * 2007-03-30 2008-10-02 Wolfgang Ernst Gustav Budach Calibration and normalization method for biosensors
US7852468B2 (en) * 2007-12-14 2010-12-14 Baker Hughes Incorporated Fiber optic refractometer
US20150268237A1 (en) * 2014-03-24 2015-09-24 Josef Kerimo Bioassay system and method for detecting analytes in body fluids
IL260323B1 (en) * 2015-12-30 2024-09-01 Kodiak Sciences Inc Antibodies and their conjugates
FR3046879B1 (fr) * 2016-01-20 2022-07-15 Ulis Procede de fabrication d'un detecteur de rayonnement electromagnetique a micro-encapsulation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005516210A (ja) * 2002-01-28 2005-06-02 エス アール ユー バイオシステムス，エル エル シー 線形光学表面構造を用いた導波モード共鳴フィルターバイオセンサー
US20090079976A1 (en) * 2006-11-09 2009-03-26 The Board Of Trustees Of The University Of Illinois Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis
CN101978173A (zh) * 2008-03-11 2011-02-16 积水化学工业株式会社 光响应性气体发生材料、微泵及微流体设备
CN104359874A (zh) * 2008-06-06 2015-02-18 博纳基因技术有限公司 集成分析装置及相关制造方法和分析技术
CN102112866A (zh) * 2008-07-30 2011-06-29 兴和株式会社 用于测定来自生物体的生理活性物质的方法和测定装置
WO2017138595A1 (fr) * 2016-02-09 2017-08-17 積水化学工業株式会社 Instrument de contrôle, dispositif de contrôle et procédé de contrôle

Also Published As

Publication number Publication date
JP7345782B2 (ja) 2023-09-19
EP3832292A4 (fr) 2022-04-06
WO2020027197A1 (fr) 2020-02-06
EP3832292A1 (fr) 2021-06-09
EP3832292B1 (fr) 2023-08-30
JPWO2020027197A1 (ja) 2021-09-24
US20210310945A1 (en) 2021-10-07

Similar Documents

Publication Publication Date Title
JP5397577B2 (ja) 表面プラズモン共鳴センサ及び当該センサ用チップ
KR101879794B1 (ko) 나노구조를 가지는 표면 플라스몬 공명(ｓｐｒ) 센서 장치
US8314935B2 (en) Target substance-detecting apparatus and target substance-detecting method
US20050026346A1 (en) Device for the manipulation of limited quantities of liquids
CN1971267B (zh) 波导耦合表面等离子体共振生物传感器
CN104203808A (zh) 具有纳米结构电极的生物传感器
EP1553400B1 (fr) Procédé pour la détection de corps d'essai
CN104220862A (zh) 靶物质捕捉装置
JP2007218900A (ja) 標的物質検出用の素子
JP4840588B2 (ja) 分析用チップ及びその製造方法、分析装置並びに分析方法
US20210239690A1 (en) Implement for inspection, inspecting device and inspecting method
CN112313501A (zh) 检测方法、检测用器具和检测装置
US6870237B1 (en) Repeated structure of nanometer thin films with symmetric or asymmetric configuration for SPR signal modulation
JP6926731B2 (ja) 検出チップ、検出キット、検出システムおよび被検出物質の検出方法
JP5016958B2 (ja) 光学素子の製造方法
WO2021193589A1 (fr) Procédé, kit et système de test
JP5831230B2 (ja) 表面プラズモン増強蛍光測定装置
US20160282342A1 (en) Method for determining interaction kinetics with rapid dissociation
Weng et al. Optical disc technology-enabled analytical devices: from hardware modification to digitized molecular detection
CN107076671B (zh) 光学传感器表面上的质量传输性质的归一化
Male Thermally Enhanced Paper Microfluidics for Photonic Crystal Biosensors in Amorphous Silicon
Terao et al. Size-exclusion SPR sensor chip: application to detection of aggregation and disaggregation of biological particles
JP2011169609A (ja) プラズモン励起センサを用いたアッセイ法
WO2024086923A1 (fr) Dispositif d'interrogation optique et procédé associé
CN112275333A (zh) 基于fp激光器和金属阵列结构的传感芯片及其制备方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination