CN112313233A - Jak家族激酶的小分子抑制剂 - Google Patents

Jak家族激酶的小分子抑制剂 Download PDF

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Publication number
CN112313233A
CN112313233A CN201980040198.7A CN201980040198A CN112313233A CN 112313233 A CN112313233 A CN 112313233A CN 201980040198 A CN201980040198 A CN 201980040198A CN 112313233 A CN112313233 A CN 112313233A
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CN
China
Prior art keywords
compound
suspension
diffractogram
jak
compounds
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Pending
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CN201980040198.7A
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English (en)
Chinese (zh)
Inventor
P·J·克劳祖克
P·费尔南德斯
M·S·蒂谢诺
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN112313233A publication Critical patent/CN112313233A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
CN201980040198.7A 2018-06-15 2019-06-14 Jak家族激酶的小分子抑制剂 Pending CN112313233A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862685737P 2018-06-15 2018-06-15
US62/685737 2018-06-15
US201962846290P 2019-05-10 2019-05-10
US62/846290 2019-05-10
PCT/IB2019/055005 WO2019239387A1 (en) 2018-06-15 2019-06-14 Small molecule inhibitors of the jak family of kinases

Publications (1)

Publication Number Publication Date
CN112313233A true CN112313233A (zh) 2021-02-02

Family

ID=67766195

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980040198.7A Pending CN112313233A (zh) 2018-06-15 2019-06-14 Jak家族激酶的小分子抑制剂

Country Status (23)

Country Link
US (3) US20200017498A1 (https=)
EP (1) EP3807277A1 (https=)
JP (1) JP2021528391A (https=)
KR (1) KR102768284B1 (https=)
CN (1) CN112313233A (https=)
AU (1) AU2019286641A1 (https=)
BR (1) BR112020024744A2 (https=)
CA (1) CA3101438A1 (https=)
CL (1) CL2020003227A1 (https=)
CO (1) CO2020015396A2 (https=)
CR (1) CR20200603A (https=)
EC (1) ECSP20080817A (https=)
IL (1) IL279314A (https=)
JO (1) JOP20200311A1 (https=)
MA (1) MA52900A (https=)
MX (1) MX2020013688A (https=)
NI (1) NI202000100A (https=)
PE (1) PE20212113A1 (https=)
PH (1) PH12020551984A1 (https=)
SG (1) SG11202011691PA (https=)
TW (1) TW202016110A (https=)
UY (1) UY38262A (https=)
WO (1) WO2019239387A1 (https=)

Cited By (1)

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LT3555097T (lt) 2016-12-16 2022-08-25 Janssen Pharmaceutica Nv Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
BR112023018286A2 (pt) * 2021-03-11 2023-10-31 Janssen Pharmaceutica Nv Lorpucitinib para uso no tratamento de distúrbios mediados por jak

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CN110312719A (zh) * 2016-12-16 2019-10-08 詹森药业有限公司 作为jak家族激酶抑制剂的咪唑并吡咯并吡啶

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TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011086053A1 (en) * 2010-01-12 2011-07-21 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof
WO2013007765A1 (en) * 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases
CN110088105A (zh) * 2016-12-16 2019-08-02 詹森药业有限公司 Jak家族激酶的小分子抑制剂
CN110312719A (zh) * 2016-12-16 2019-10-08 詹森药业有限公司 作为jak家族激酶抑制剂的咪唑并吡咯并吡啶

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115385911A (zh) * 2021-05-22 2022-11-25 南京康屹生物医药中心(有限合伙) 一种二吡咯并吡啶结构的化合物、制备方法和医药用途

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US20200017498A1 (en) 2020-01-16
US11066406B2 (en) 2021-07-20
EP3807277A1 (en) 2021-04-21
US20210340144A1 (en) 2021-11-04
JP2021528391A (ja) 2021-10-21
CR20200603A (es) 2021-01-20
NI202000100A (es) 2021-06-30
BR112020024744A2 (pt) 2021-03-23
KR20210021342A (ko) 2021-02-25
PH12020551984A1 (en) 2021-08-02
UY38262A (es) 2019-12-31
US20200165250A1 (en) 2020-05-28
IL279314A (en) 2021-01-31
WO2019239387A1 (en) 2019-12-19
JOP20200311A1 (ar) 2020-11-30
MA52900A (fr) 2021-04-21
KR102768284B1 (ko) 2025-02-13
ECSP20080817A (es) 2021-01-29
CL2020003227A1 (es) 2021-05-14
TW202016110A (zh) 2020-05-01
CA3101438A1 (en) 2019-12-19
PE20212113A1 (es) 2021-11-04
MX2020013688A (es) 2021-02-26
CO2020015396A2 (es) 2021-03-08
US11787807B2 (en) 2023-10-17
AU2019286641A1 (en) 2020-12-10
SG11202011691PA (en) 2020-12-30

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Application publication date: 20210202