AU2019286641A1 - Small molecule inhibitors of the JAK family of kinases - Google Patents
Small molecule inhibitors of the JAK family of kinases Download PDFInfo
- Publication number
- AU2019286641A1 AU2019286641A1 AU2019286641A AU2019286641A AU2019286641A1 AU 2019286641 A1 AU2019286641 A1 AU 2019286641A1 AU 2019286641 A AU2019286641 A AU 2019286641A AU 2019286641 A AU2019286641 A AU 2019286641A AU 2019286641 A1 AU2019286641 A1 AU 2019286641A1
- Authority
- AU
- Australia
- Prior art keywords
- yielded
- compound
- suspension
- diffractogram
- jak
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862685737P | 2018-06-15 | 2018-06-15 | |
| US62/685,737 | 2018-06-15 | ||
| US201962846290P | 2019-05-10 | 2019-05-10 | |
| US62/846,290 | 2019-05-10 | ||
| PCT/IB2019/055005 WO2019239387A1 (en) | 2018-06-15 | 2019-06-14 | Small molecule inhibitors of the jak family of kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2019286641A1 true AU2019286641A1 (en) | 2020-12-10 |
Family
ID=67766195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019286641A Abandoned AU2019286641A1 (en) | 2018-06-15 | 2019-06-14 | Small molecule inhibitors of the JAK family of kinases |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US20200017498A1 (https=) |
| EP (1) | EP3807277A1 (https=) |
| JP (1) | JP2021528391A (https=) |
| KR (1) | KR102768284B1 (https=) |
| CN (1) | CN112313233A (https=) |
| AU (1) | AU2019286641A1 (https=) |
| BR (1) | BR112020024744A2 (https=) |
| CA (1) | CA3101438A1 (https=) |
| CL (1) | CL2020003227A1 (https=) |
| CO (1) | CO2020015396A2 (https=) |
| CR (1) | CR20200603A (https=) |
| EC (1) | ECSP20080817A (https=) |
| IL (1) | IL279314A (https=) |
| JO (1) | JOP20200311A1 (https=) |
| MA (1) | MA52900A (https=) |
| MX (1) | MX2020013688A (https=) |
| NI (1) | NI202000100A (https=) |
| PE (1) | PE20212113A1 (https=) |
| PH (1) | PH12020551984A1 (https=) |
| SG (1) | SG11202011691PA (https=) |
| TW (1) | TW202016110A (https=) |
| UY (1) | UY38262A (https=) |
| WO (1) | WO2019239387A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3555097T (lt) | 2016-12-16 | 2022-08-25 | Janssen Pharmaceutica Nv | Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| BR112023018286A2 (pt) * | 2021-03-11 | 2023-10-31 | Janssen Pharmaceutica Nv | Lorpucitinib para uso no tratamento de distúrbios mediados por jak |
| CN113292561A (zh) * | 2021-05-22 | 2021-08-24 | 中国药科大学 | 一种二吡咯并吡啶结构的化合物、制备方法和医药用途 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080747A (en) | 1999-03-05 | 2000-06-27 | Hughes Institute | JAK-3 inhibitors for treating allergic disorders |
| UA67844C2 (uk) | 1999-04-23 | 2004-07-15 | Смітклайн Бічам Плс | Поліморф 5-[4-[2-(n-метил-n-(2-піридил)аміно)етокси]бензил]тіазолідин-2,4-діону солі малеїнової кислоти |
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| MXPA04011865A (es) | 2002-05-31 | 2005-03-31 | Schering Corp | Polimorfos inhibidores de xantina fosfodiesterasa v. |
| GB0319935D0 (en) | 2003-08-26 | 2003-09-24 | Cipla Ltd | Polymorphs |
| US7737279B2 (en) | 2005-05-10 | 2010-06-15 | Bristol-Myers Squibb Company | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same |
| EP1902029B2 (en) | 2005-07-01 | 2022-02-16 | Wyeth LLC | Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarb-onitrile and methods of preparing the same |
| EP2251341A1 (en) | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
| WO2007007919A2 (en) | 2005-07-14 | 2007-01-18 | Astellas Pharma Inc. | Heterocyclic janus kinase 3 inhibitors |
| JP5748659B2 (ja) | 2008-06-10 | 2015-07-15 | アッヴィ・インコーポレイテッド | 新規な三環式化合物 |
| JP5567137B2 (ja) | 2009-09-03 | 2014-08-06 | ブリストル−マイヤーズ スクイブ カンパニー | Ｊａｋ２阻害剤、ならびに骨髄増殖性疾患および癌の治療のためのそれらの使用 |
| KR20120102724A (ko) | 2009-12-01 | 2012-09-18 | 아보트 러보러터리즈 | 신규한 트리사이클릭 화합물 |
| PE20121336A1 (es) | 2009-12-01 | 2012-11-03 | Abbvie Inc | Nuevos compuestos triciclicos |
| EP2523957A1 (en) | 2010-01-12 | 2012-11-21 | F. Hoffmann-La Roche AG | Tricyclic heterocyclic compounds, compositions and methods of use thereof |
| EP2534258B1 (en) | 2010-02-10 | 2017-09-20 | Genon Biotechnologies OY | Dual activity kinase domains and uses thereof |
| WO2013007765A1 (en) * | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Fused tricyclic compounds for use as inhibitors of janus kinases |
| GB201212081D0 (en) | 2012-07-06 | 2012-08-22 | Kalvista Pharmaceuticals Ltd | New polymorph |
| JP6248948B2 (ja) | 2013-02-08 | 2017-12-20 | 日産化学工業株式会社 | ３環性ピロロピリジン化合物及びｊａｋ阻害剤 |
| EP2924026A1 (en) | 2014-03-28 | 2015-09-30 | Novartis Tiergesundheit AG | Aminosulfonylmethylcyclohexanes as JAK inhibitors |
| WO2015174376A1 (ja) | 2014-05-14 | 2015-11-19 | 日産化学工業株式会社 | ３環性化合物及びｊａｋ阻害剤 |
| JP6692836B2 (ja) | 2015-05-28 | 2020-05-13 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | Ｊａｋキナーゼ阻害剤としてのナフチリジン化合物 |
| EP3371332A4 (en) | 2015-11-04 | 2019-04-03 | Mayo Foundation for Medical Education and Research | METHOD AND MATERIALS FOR TREATING AUTOIMMUNE DISEASES |
| JOP20190053A1 (ar) | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
| TWI735681B (zh) | 2016-10-24 | 2021-08-11 | 瑞典商阿斯特捷利康公司 | 化合物 |
| EP3555064B9 (en) | 2016-12-16 | 2023-03-01 | Pfizer Inc. | Glp-1 receptor agonists and uses thereof |
| CA3045224A1 (en) | 2016-12-16 | 2018-06-21 | Basf Se | Pesticidal compounds |
| LT3555097T (lt) | 2016-12-16 | 2022-08-25 | Janssen Pharmaceutica Nv | Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai |
| KR102276022B1 (ko) | 2016-12-16 | 2021-07-13 | 일라이 릴리 앤드 캄파니 | 돌연변이체 idh1 및 idh2 억제제로서의 7-페닐에틸아미노-4h-피리미도[4,5-d][1,3]옥사진-2-온 화합물 |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| EP3528645A1 (en) | 2016-12-16 | 2019-08-28 | Société des Produits Nestlé S.A. | Oligosaccharides for flavour generation |
| PL3568396T3 (pl) | 2017-01-11 | 2021-05-31 | Leo Pharma A/S | Nowe pochodne aminoimidazopirydyny jako inhibitory kinaz janusowych i ich zastosowanie farmaceutyczne |
| PT3494116T (pt) | 2017-01-30 | 2020-01-28 | Astrazeneca Ab | Moduladores de recetores de estrogénio |
| WO2018195397A2 (en) | 2017-04-21 | 2018-10-25 | Kyn Therapeutics | Indole ahr inhibitors and uses thereof |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| WO2020216936A1 (en) | 2019-04-24 | 2020-10-29 | Janssen Pharmaceutica Nv | Non-clinical liquid formulations of pan-jak inhibitor |
-
2019
- 2019-06-13 TW TW108120432A patent/TW202016110A/zh unknown
- 2019-06-14 PE PE2020001995A patent/PE20212113A1/es unknown
- 2019-06-14 KR KR1020217000012A patent/KR102768284B1/ko active Active
- 2019-06-14 CA CA3101438A patent/CA3101438A1/en active Pending
- 2019-06-14 BR BR112020024744-8A patent/BR112020024744A2/pt not_active Application Discontinuation
- 2019-06-14 WO PCT/IB2019/055005 patent/WO2019239387A1/en not_active Ceased
- 2019-06-14 JP JP2020569049A patent/JP2021528391A/ja active Pending
- 2019-06-14 EP EP19759032.6A patent/EP3807277A1/en active Pending
- 2019-06-14 CN CN201980040198.7A patent/CN112313233A/zh active Pending
- 2019-06-14 CR CR20200603A patent/CR20200603A/es unknown
- 2019-06-14 UY UY0001038262A patent/UY38262A/es unknown
- 2019-06-14 MX MX2020013688A patent/MX2020013688A/es unknown
- 2019-06-14 SG SG11202011691PA patent/SG11202011691PA/en unknown
- 2019-06-14 AU AU2019286641A patent/AU2019286641A1/en not_active Abandoned
- 2019-06-14 JO JOP/2020/0311A patent/JOP20200311A1/ar unknown
- 2019-06-14 MA MA052900A patent/MA52900A/fr unknown
- 2019-09-24 US US16/581,081 patent/US20200017498A1/en not_active Abandoned
-
2020
- 2020-01-29 US US16/776,243 patent/US11066406B2/en active Active
- 2020-11-19 PH PH12020551984A patent/PH12020551984A1/en unknown
- 2020-12-09 CO CONC2020/0015396A patent/CO2020015396A2/es unknown
- 2020-12-09 IL IL279314A patent/IL279314A/en unknown
- 2020-12-11 CL CL2020003227A patent/CL2020003227A1/es unknown
- 2020-12-11 NI NI202000100A patent/NI202000100A/es unknown
- 2020-12-14 EC ECSENADI202080817A patent/ECSP20080817A/es unknown
-
2021
- 2021-07-15 US US17/377,249 patent/US11787807B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20200017498A1 (en) | 2020-01-16 |
| US11066406B2 (en) | 2021-07-20 |
| EP3807277A1 (en) | 2021-04-21 |
| US20210340144A1 (en) | 2021-11-04 |
| JP2021528391A (ja) | 2021-10-21 |
| CR20200603A (es) | 2021-01-20 |
| NI202000100A (es) | 2021-06-30 |
| BR112020024744A2 (pt) | 2021-03-23 |
| KR20210021342A (ko) | 2021-02-25 |
| PH12020551984A1 (en) | 2021-08-02 |
| UY38262A (es) | 2019-12-31 |
| US20200165250A1 (en) | 2020-05-28 |
| IL279314A (en) | 2021-01-31 |
| WO2019239387A1 (en) | 2019-12-19 |
| JOP20200311A1 (ar) | 2020-11-30 |
| MA52900A (fr) | 2021-04-21 |
| KR102768284B1 (ko) | 2025-02-13 |
| ECSP20080817A (es) | 2021-01-29 |
| CL2020003227A1 (es) | 2021-05-14 |
| TW202016110A (zh) | 2020-05-01 |
| CA3101438A1 (en) | 2019-12-19 |
| PE20212113A1 (es) | 2021-11-04 |
| MX2020013688A (es) | 2021-02-26 |
| CO2020015396A2 (es) | 2021-03-08 |
| US11787807B2 (en) | 2023-10-17 |
| SG11202011691PA (en) | 2020-12-30 |
| CN112313233A (zh) | 2021-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |