CN112313216B - 作为axl/mer rtk和csf1r的抑制剂的喹啉衍生物 - Google Patents

作为axl/mer rtk和csf1r的抑制剂的喹啉衍生物 Download PDF

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CN112313216B
CN112313216B CN201980036560.3A CN201980036560A CN112313216B CN 112313216 B CN112313216 B CN 112313216B CN 201980036560 A CN201980036560 A CN 201980036560A CN 112313216 B CN112313216 B CN 112313216B
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CN112313216A (zh
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南凯寅
金载承
朴东实
全仪金
梁榮仁
姜焕奎
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Qurient Co Ltd
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
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  • Urology & Nephrology (AREA)
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CN201980036560.3A 2018-05-30 2019-05-31 作为axl/mer rtk和csf1r的抑制剂的喹啉衍生物 Active CN112313216B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862677902P 2018-05-30 2018-05-30
US62/677,902 2018-05-30
PCT/EP2019/064214 WO2019229251A1 (en) 2018-05-30 2019-05-31 Quinoline derivatives as inhibitors of axl/mer rtk and csf1r

Publications (2)

Publication Number Publication Date
CN112313216A CN112313216A (zh) 2021-02-02
CN112313216B true CN112313216B (zh) 2025-03-14

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US (1) US12162858B2 (https=)
EP (1) EP3774776A1 (https=)
JP (2) JP7390313B2 (https=)
KR (1) KR102901476B1 (https=)
CN (1) CN112313216B (https=)
AU (1) AU2019276359B2 (https=)
BR (1) BR112020021370A2 (https=)
CA (1) CA3097694A1 (https=)
IL (1) IL278960B2 (https=)
MX (1) MX2020011636A (https=)
PH (1) PH12020551806A1 (https=)
SG (1) SG11202009971QA (https=)
WO (1) WO2019229251A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
IL315474A (en) * 2022-03-30 2024-11-01 Qurient Co Ltd New forms of n-(5-((6,7-dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-1-propyl-4-(2,2,2-trifluoroethoxy)-1h-pyrazole-3 -carboxamide hydrochloride
KR102921178B1 (ko) * 2023-11-16 2026-02-02 (주)신테카바이오 헤테로아릴 유도체 화합물 및 이의 용도
CN117637185B (zh) * 2024-01-25 2024-04-23 首都医科大学宣武医院 一种基于影像的颅咽管瘤治疗辅助决策方法、系统及设备
CN118593494B (zh) * 2024-08-08 2024-11-01 四川大学华西医院 Nampt抑制剂在制备预防和/或治疗色素沉着绒毛结节性滑膜炎的药物中的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103124729A (zh) * 2010-08-28 2013-05-29 利德探索中心有限公司 作为Axl抑制剂的药物活性化合物
CN107667101A (zh) * 2015-04-14 2018-02-06 奎利恩特有限公司 作为tam rtk抑制剂的喹啉衍生物

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US6143764A (en) 1995-11-07 2000-11-07 Kirin Beer Kabushiki Kaisha Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same
EP2311809A1 (en) 2009-10-16 2011-04-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Quinolinyloxyphenylsulfonamides
WO2012118632A1 (en) 2011-02-28 2012-09-07 Ning Xi Substituted quinoline compounds and methods of use
CN102408411B (zh) * 2011-09-19 2014-10-22 北京康辰药业股份有限公司 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用
WO2016104617A1 (ja) 2014-12-25 2016-06-30 小野薬品工業株式会社 キノリン誘導体
CA3101983A1 (en) 2018-06-01 2019-12-05 Rigel Pharmaceuticals, Inc. Quinoline derivatives useful as tyrosine kinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103124729A (zh) * 2010-08-28 2013-05-29 利德探索中心有限公司 作为Axl抑制剂的药物活性化合物
CN107667101A (zh) * 2015-04-14 2018-02-06 奎利恩特有限公司 作为tam rtk抑制剂的喹啉衍生物

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Publication number Publication date
JP2023168629A (ja) 2023-11-24
US20210163448A1 (en) 2021-06-03
PH12020551806A1 (en) 2021-05-17
EP3774776A1 (en) 2021-02-17
IL278960A (en) 2021-01-31
KR20210020882A (ko) 2021-02-24
WO2019229251A1 (en) 2019-12-05
CA3097694A1 (en) 2019-12-05
NZ768747A (en) 2025-06-27
IL278960B2 (en) 2024-08-01
JP2021525270A (ja) 2021-09-24
US12162858B2 (en) 2024-12-10
IL278960B1 (en) 2024-04-01
BR112020021370A2 (pt) 2021-01-19
JP7390313B2 (ja) 2023-12-01
KR102901476B1 (ko) 2025-12-18
AU2019276359B2 (en) 2024-10-03
MX2020011636A (es) 2020-12-07
CN112313216A (zh) 2021-02-02
SG11202009971QA (en) 2020-11-27
AU2019276359A1 (en) 2020-10-29

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