CN112206187B - Skin care compositions - Google Patents

Skin care compositions Download PDF

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Publication number
CN112206187B
CN112206187B CN201910630710.5A CN201910630710A CN112206187B CN 112206187 B CN112206187 B CN 112206187B CN 201910630710 A CN201910630710 A CN 201910630710A CN 112206187 B CN112206187 B CN 112206187B
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skin care
skin
care composition
stirring
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CN112206187A (en
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郭笑笑
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Xi'an Bohong Biotechnology Co ltd
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Xi'an Bohong Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A61K2800/72—Hypo-allergenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention provides a skin care composition comprising: VP/hexadecene copolymer, polyquaternium-7, moringa pterospiana seed extract, nicotinamide, and Dischizosaccharomyces cerevisiae fermentation product lysate. The skin care composition disclosed by the invention can resist environmental pollution, improves the self-repairing capability of skin and has a better skin repairing effect.

Description

Skin care compositions
Technical Field
The invention relates to the field of skin care products, and in particular relates to a skin care composition and application thereof.
Background
Modern people have fast pace of life, poor sleep, lack of skin maintenance, increasingly serious environmental pollution, ultraviolet rays, radioactive rays, computer electric appliance radiation, smoking and drinking, excessive exercise, tension pressure, excessive intake of processed food and grease which are eaten too much, and the like, which cause a plurality of skin problems.
With the continuous bad environment and the continuous increase of human pollution sources, the skin becomes more sensitive due to the bad environment. Human skin is a barrier between the body and the environment, and is the organ which has the longest contact time with the external environment and the largest area exposed in the air, so that environmental air pollution is an important risk factor for skin diseases.
Environmental pollution can cause a series of problems to skin, and related researches find that the environmental pollution can cause the problems of atopic dermatitis, eczema, urticaria, skin aging, skin color spots and the like. In addition to improving the environment, for example by reducing the emission of fine particles in the air, personal protection, for example by skin care products, can also be enhanced to eliminate or reduce the risk of pollutants on the skin.
Patent CN103735458B discloses a skin anti-allergy repairing composition, which comprises, by weight: 5 to 12 percent of humectant, 0.1 to 3.0 percent of thickening agent, 1 to 4 percent of skin repairing agent, 0.1 to 1.5 percent of preservative and the balance of water. The anti-allergy skin repair composition has strong effects of clearing heat, removing toxicity, anti-allergy repair, diminishing inflammation, astringing and the like; the other auxiliary additive components are selected from moisturizers, preservatives, thickeners and the like which can make the skin tender, smooth and moist and are mild and non-irritant to the skin, are convenient to use, achieve the purposes of moisturizing, diminishing inflammation, relieving itching and repairing damaged skin, and are suitable for sensitive skin and the phenomena of skin allergy, pruritus, desquamation, redness and the like caused by improper use of cosmetics. However, the existing skin care compositions mainly aim at people who suffer from environmental pollution and generate sensitive skin, and are not compositions for preventing environmental pollution.
Therefore, in the field of skin care products, there is a strong need for a skin care composition that can protect the skin from environmental pollution, improve the self-healing ability of the skin, and allow the skin to self-heal in a healthier environment.
Disclosure of Invention
In view of this, the present invention aims to provide a skin care composition for resisting environmental pollution and improving the self-healing ability of skin, which has a good skin-healing effect.
Therefore, the invention provides the following technical scheme.
In a first aspect, the present invention provides a skin care composition, wherein the composition comprises: VP/hexadecene copolymer, polyquaternium-7, moringa pterospolia seed extract, nicotinamide and Saccharomyces bifidus fermentation product lysate.
In a preferred embodiment, the composition further comprises: emulsifiers, humectants, antioxidants and preservatives;
wherein,
the emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, polysorbate-20, PEG-100 distearate, sorbitan olivil oleate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
the humectant is selected from one or more of glycerol, diglycerol, propylene glycol, 1, 3-butylene glycol, 1, 2-pentanediol, polyethylene glycol-8, polyethylene glycol-32, glyceryl polyether-7, sodium hyaluronate, glyceryl polyether-26, glyceryl glucoside, sucrose, rhamnose, mannose, raffinose, betaine, erythritol, xylitol, biogum-2, urea, glyceryl polyether-5 lactate, sodium polyglutamate, hydrolyzed sclerotium rolfsii gum, pullulan, tremella polysaccharide and sour bean seed polysaccharide;
the antioxidant is selected from one or more of tocopherol, tert-butyl hydroxy cumin, tert-butyl hydroxy toluene and propyl gallate;
the preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
In a more preferred embodiment, the composition may further comprise water.
In a preferred embodiment, wherein, in parts by weight, the composition comprises:
0.2 to 3 parts of VP hexadecene copolymer, for example, the parts by weight of VP hexadecene copolymer may be 0.2, 0.3, 0.4, 0.5, 0.7, 1, 1.2, 1.3, 1.5, 1.7, 2, 2.3, 2.5, 2.7, 2.9 or 3;
0.2 to 2 parts of polyquaternium-7, for example, the weight part of polyquaternium-7 may be 0.2, 0.3, 0.4, 0.5, 0.7, 1, 1.2, 1.3, 1.5, 1.7 or 2;
0.1-3 parts of winged seed moringa seed extract, for example, the parts by weight of the winged seed moringa seed extract can be 0.1, 0.2, 0.3, 0.4, 0.5, 0.7, 1, 1.2, 1.3, 1.5, 1.7, 2, 2.3, 2.5, 2.7, 2.9, or 3;
0.5-5 parts of nicotinamide; for example, the weight fraction of nicotinamide can be 0.5, 0.7, 1, 1.2, 1.3, 1.5, 1.7, 2, 2.3, 2.5, 2.7, 2.9, 3, 3.1, 3.3, 3.5, 3.7, 4, 4.1, 4.3, 4.5, 4.7, or 5;
and 0.5-10 parts of a split yeast fermentation product lysate, for example, the weight parts of the split yeast fermentation product lysate can be 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, or 10.
In a preferred embodiment, wherein, according to parts by weight, the composition further comprises:
0.2 to 3 parts of emulsifier, for example, the parts by weight of emulsifier may be 0.2, 0.3, 0.5, 0.7, 1, 1.3, 1.5, 1.7, 2, 2.1, 2.3, 2.5, 2.7 or 3;
1-8 parts of humectant, for example, the humectant can be 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, or 8 parts by weight;
0.05 to 0.3 parts of antioxidant, for example, the parts by weight of said antioxidant may be 0.05, 0.07, 0.1, 0.15, 0.2, 0.25 or 0.3;
and 0.3 to 0.7 parts preservative, for example, the preservative may be present in an amount of 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65 or 0.7 parts by weight.
In a second aspect, the present invention provides a skin care composition, wherein the composition comprises, in parts by weight: 0.2-3 parts of VP/hexadecene copolymer, 0.2-2 parts of polyquaternary ammonium salt-7, 0.1-3 parts of winged seed moringa seed extract, 0.5-5 parts of nicotinamide, 0.5-10 parts of schizosaccharomyces cerevisiae fermentation product lysate, 0.2-3 parts of emulsifier, 1-8 parts of humectant, 0.05-0.3 part of antioxidant and 0.3-0.7 part of preservative;
wherein,
the emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, polysorbate-20, PEG-100 distearate, sorbitan olivil oleate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
the humectant is selected from one or more of glycerol, diglycerol, propylene glycol, 1, 3-butanediol, 1, 2-pentanediol, polyethylene glycol-8, polyethylene glycol-32, glyceryl polyether-7, sodium hyaluronate, glyceryl polyether-26, glyceryl glucoside, sucrose, rhamnose, mannose, raffinose, betaine, erythritol, xylitol, biogum-2, urea, glyceryl polyether-5 lactate, sodium polyglutamate, hydrolyzed sclerotium rolfsii gum, pullulan, tremella polysaccharide and sour bean seed polysaccharide;
the antioxidant is selected from one or more of tocopherol, tert-butyl hydroxy cumin, tert-butyl hydroxy toluene and propyl gallate;
the preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glyceryl caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glyceryl caprylate.
In a third aspect, the present invention provides a skin care composition, wherein the composition comprises, in parts by weight: 1 part of VP/hexadecene copolymer, 0.5 part of polyquaternium-7, 2 parts of moringa pterocarpa seed extract, 3 parts of nicotinamide, 5 parts of schizosaccharomyces cerevisiae fermentation product lysate, 2.5 parts of emulsifier, 6 parts of humectant, 0.1 part of antioxidant and 0.4 part of preservative;
wherein,
the emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate, polysorbate-20, PEG-100 distearate, sorbitan olivil oleate, cetearyl glucoside, PEG-11 methyl ether polydimethylsiloxane and PEG-20 sorbitan cocoate;
the humectant is selected from one or more of glycerol, diglycerol, propylene glycol, 1, 3-butanediol, 1, 2-pentanediol, polyethylene glycol-8, polyethylene glycol-32, glyceryl polyether-7, sodium hyaluronate, glyceryl polyether-26, glyceryl glucoside, sucrose, rhamnose, mannose, raffinose, betaine, erythritol, xylitol, biogum-2, urea, glyceryl polyether-5 lactate, sodium polyglutamate, hydrolyzed sclerotium rolfsii gum, pullulan, tremella polysaccharide and sour bean seed polysaccharide;
the antioxidant is selected from one or more of tocopherol, tert-butyl hydroxy cumin, tert-butyl hydroxy toluene and propyl gallate;
the preservative is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, glycerol caprylate, ethylhexyl glycerol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, caprylyl hydroximic acid and glycerol caprylate.
In a fourth aspect, the present disclosure provides a method for preparing a skin care composition, wherein the method comprises the steps of:
1) Mixing humectant, polyquaternium-7, emulsifier and water, heating to 80-85 deg.C, stirring to dissolve;
2) Dissolving VP/hexadecene copolymer and antioxidant in the material obtained in step one, mixing and heating to 80-85 deg.C, stirring to dissolve, and homogenizing;
3) Emulsifying the material obtained in the second step in a container, adding the lysate of the fermentation product of the second split yeast, the extract of the moringa oleifera seeds, nicotinamide and the preservative when the temperature is reduced to 40-45 ℃, and uniformly stirring.
In a preferred embodiment, the skin care composition is a composition according to the present invention.
In a preferred embodiment of the present invention,
the emulsifier is one or more selected from PEG-20 methyl glucose sesquistearate, PEG-150 distearate and polysorbate-20;
the humectant is selected from one or more of sodium hyaluronate, glyceryl polyether-26 and sucrose;
the antioxidant is selected from one or more of tocopherol, tert-butyl hydroxy cumin and propyl gallate;
the preservative is selected from one or more of methylparaben, propylparaben and phenoxyethanol.
In a fifth aspect, a skin care product is provided, the skin care product comprising the skin care composition of the present invention.
In a sixth aspect, a pharmaceutical composition is provided comprising a safe and effective amount of a skin care composition according to the present invention.
In addition, the invention also provides the application of the skin care composition in preparing a skin care product or a pharmaceutical composition.
In the present invention, a split yeast fermentation product lysate is available ex situ, for example from Chemisches laboratories dr. Kurt Richter Gmbh, batch No. 3191570; moringa oleifera seed extract is commercially available, for example from basf, inc. under batch number 0018879081; the VP/hexadecene copolymer is commercially available, for example, from the Ashland group corporation under the batch number 0002186930.
In the present invention, the emulsifier can improve the surface tension between various constituent phases in the emulsion, so that the emulsion forms a uniform and stable dispersion system or a substance of the emulsion; emulsifiers are surface-active substances which have both hydrophilic and lipophilic groups in the molecule and which accumulate at the oil/water interface and reduce the interfacial tension and the energy required to form an emulsion, thereby increasing the energy of the emulsion.
In the present invention, moisturizers are water-soluble substances that increase skin moisture or reduce the transdermal water loss of the skin.
In the present invention, the antioxidant is a substance that prevents the adverse effect of oxygen; it can prevent or delay the oxidation of skin care products, and is a skin care product additive for improving the stability of the skin care products and prolonging the storage period.
In the present invention, the preservative means a substance added to the skin care composition for the purpose of inhibiting the growth and proliferation of microorganisms in the skin care composition, and is used to prolong the shelf life of the skin care composition.
In the present invention, the skin care product may include a container, instructions for use, use aids, and/or other structures and/or agents as desired for performing the performance test; adjuvants used in the skin care products of the present invention include, but are not limited to, oils, emulsifiers, humectants, thickeners, skin conditioning agents, and/or preservatives; other structures necessary for performing performance tests in the skin care products of the present invention include, but are not limited to, structures for sampling, structures for performing control, and/or structures for observing the assay process or results; the other agents required for performing performance tests in the skin care products of the present invention include, but are not limited to, culture media, detergents, developers, and/or terminators.
In the invention, the pharmaceutical composition comprises the skin care composition and pharmaceutically acceptable auxiliary materials.
In the present invention, a safe and effective amount refers to an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive skin tissue appearance or feel benefit, including the benefits disclosed herein, either individually or in combination, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
Compared with the prior art, the invention has the beneficial effects that:
the skin care composition disclosed by the invention can isolate skin from external environment pollutants in a film forming mode, and the oil-soluble film forming agent VP/hexadecene copolymer is introduced, so that a layer of soft, compact and continuous covering film can be formed on the surface of the skin after the skin care composition is applied, and the covering film has water locking capacity, so that the skin can generate smooth feeling; the polyquaternium-7 which is a water-soluble film forming agent is an effective smoothing and lubricating wetting agent, can generate a smooth residual film which is not sticky and greasy on the skin, can form a water-soluble film and prevents pollution; the environmental pollution is resisted by constructing a skin defense wall; a specific humectant is introduced, so that the skin can be pacified, and the skin can reach the optimal moisturizing state; the specific antioxidant is introduced to resist free radicals, inhibit the generation of lipid peroxide, eliminate excessive oxygen free radicals caused by external factors such as ultraviolet rays and air pollution, and play a role in delaying photoaging, preventing sunburn and inhibiting the generation of sunburn erythema; the moringa oleifera seed extract is matched, so that the free radicals are eliminated, the water can be supplemented, and the effect of moisturizing is achieved; by matching with the nicotinamide disclosed by the invention, the water loss through the skin is reduced, the sebum secretion is reduced, the barrier function of the skin is enhanced, the cohesiveness and the thickness of the stratum corneum are increased, and the maturity of the stratum corneum is increased; the yeast lysate of the yeast for bifida of the invention is matched to repair DNA damaged by light pollution and environmental pollution, keep IL-10/IL12 balance, initiate skin repair, help epidermal cells and dermal cells in skin to resist harmful effects of light pollution, maintain the integrity and vitality of cells, and enable skin to carry out self-repair in a relatively healthy environment.
The skin care composition simultaneously protects and repairs the skin through physical action and chemical action, so that the skin can obtain double modes in a polluted environment, and the influence of pollutants on the skin is isolated by adding the oil-soluble and water-soluble physical film forming agent externally; the antioxidant is added into the medicine to resist the invasion of free radicals; meanwhile, a repair component is added to repair the damaged area.
By screening the types of the components in the skin care composition and adjusting the content of the components in the skin care composition, the skin care composition has stronger environmental pollution resistance and stronger self-repairing capability, and the skin has better repairing effect.
On the other hand, the skin care composition has simple production process and low cost.
Detailed Description
The present invention will be specifically explained below with reference to specific embodiments and examples, and the advantages and various effects of the present invention will be more clearly demonstrated. It will be understood by those skilled in the art that these specific embodiments and examples are illustrative of the invention and are not to be construed as limiting the invention.
Example 1
This example provides a skin care composition, comprising, in parts by weight:
0.2 parts of VP/hexadecene copolymer, 0.2 parts of polyquaternium-7, 0.1 parts of Moringa pterospifolia seed extract, 0.5 parts of nicotinamide, 0.5 parts of schizosaccharomyces cerevisiae fermentation product lysate, 0.2 parts of PEG-20 methyl glucose sesquistearate, 1 part of glyceryl polyether-26, 0.1 parts of sodium hyaluronate, 0.05 parts of tocopherol, 0.3 parts of methylparaben and an appropriate amount of water.
The skin care composition of this example was prepared as follows:
1) Mixing 1 part of glyceryl polyether-26, 0.1 part of sodium hyaluronate, 0.2 part of polyquaternium-7, 0.2 part of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 80 ℃, and stirring to dissolve;
2) Dissolving 0.2 part of VP/hexadecene copolymer and 0.05 part of tocopherol in the material obtained in the first step, mixing and heating to 80 ℃, stirring to dissolve and homogenize the mixture;
3) Emulsifying the material obtained in the second step in a container, adding 0.5 part of schizosaccharomyces cerevisiae fermentation product lysate, 0.1 part of moringa oleifera seed extract, 0.5 part of nicotinamide and 0.3 part of methylparaben when the temperature is reduced to 40 ℃, and uniformly stirring.
Example 2
This example provides a skin care composition comprising, in parts by weight:
3 parts of VP/hexadecene copolymer, 2 parts of polyquaternium-7, 3 parts of moringa oleifera seed extract, 5 parts of nicotinamide, 10 parts of schizosaccharomyces cerevisiae fermentation product lysate, 3 parts of PEG-20 methyl glucose sesquistearate, 8 parts of glyceryl polyether-26, 0.5 part of sodium hyaluronate, 0.3 part of tocopherol, 0.7 part of methylparaben and a proper amount of water.
The skin care composition of this example was prepared as follows:
1) Mixing 8 parts of glyceryl polyether-26, 0.5 part of sodium hyaluronate, 2 parts of polyquaternium-7, 3 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve;
2) Dissolving 3 parts of VP/hexadecene copolymer and 0.3 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 10 parts of the yeast schizolysis product, 3 parts of the moringa oleifera seed extract, 5 parts of nicotinamide and 0.7 part of methyl hydroxybenzoate when the temperature is reduced to 45 ℃, and uniformly stirring.
Example 3
This example provides a skin care composition comprising, in parts by weight:
1 part of VP/hexadecene copolymer, 0.5 part of polyquaternium-7, 2 parts of moringa pterocarpa seed extract, 3 parts of nicotinamide, 5 parts of schizosaccharomyces cerevisiae fermentation product lysate, 2.5 parts of PEG-20 methyl glucose sesquistearate, 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.1 part of tocopherol, 0.4 part of methylparaben and a proper amount of water.
The skin care composition of this example was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of the yeast schizolysis product, 2 parts of the moringa oleifera seed extract, 3 parts of nicotinamide and 0.4 part of methyl hydroxybenzoate when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 1
To further illustrate the beneficial effects of the present invention, comparative example 1 is provided, which is different from example 3 in that: the glyceryl polyether-26 of the present invention was replaced with methyl gluceth-10.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of methyl glucitol polyether-10, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve the mixture;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of the schizosaccharomyces cerevisiae fermentation product lysate, 2 parts of the pterospermum pterocarpum seed extract, 3 parts of nicotinamide and 0.4 part of methylparaben when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 2
To further illustrate the beneficial effects of the present invention, comparative example 2 is provided, which comparative example 2 differs from example 3 in that: PEG-20 methyl glucose sesquistearate of the present invention is replaced with glycerol stearate.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of glyceryl stearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of the schizosaccharomyces cerevisiae fermentation product lysate, 2 parts of the pterospermum pterocarpum seed extract, 3 parts of nicotinamide and 0.4 part of methylparaben when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 3
To further illustrate the beneficial effects of the present invention, comparative example 3 is provided, which comparative example 3 differs from example 3 in that: the tocopherol of the present invention was replaced with catalase.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve the mixture;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of catalase in the material obtained in the step one, mixing and heating to 85 ℃, stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of the yeast schizolysis product, 2 parts of the moringa oleifera seed extract, 3 parts of nicotinamide and 0.4 part of methyl hydroxybenzoate when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 4
To further illustrate the beneficial effects of the present invention, comparative example 4 is provided, which comparative example 4 differs from example 3 in that: the methylparaben of the present invention is replaced with salicylic acid.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve the mixture;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of schizosaccharomyces cerevisiae fermentation product lysate, 2 parts of pterospermum pterocarpum seed extract, 3 parts of nicotinamide and 0.4 part of salicylic acid when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 5
To further illustrate the beneficial effects of the present invention, comparative example 5 is provided, which comparative example 5 differs from example 3 in that: no VP hexadecene copolymer was added.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve;
2) Dissolving 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of the yeast schizolysis product, 2 parts of the moringa oleifera seed extract, 3 parts of nicotinamide and 0.4 part of methyl hydroxybenzoate when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 6
To further illustrate the beneficial effects of the present invention, comparative example 6 is provided, which comparative example 6 differs from example 3 in that: no polyquaternium-7 was added.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of the yeast schizolysis product, 2 parts of the moringa oleifera seed extract, 3 parts of nicotinamide and 0.4 part of methyl hydroxybenzoate when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 7
To further illustrate the beneficial effects of the present invention, comparative example 7 is provided, which comparative example 7 differs from example 3 in that: no Moringa oleifera seed extract was added.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of the yeast schizolysis product, 3 parts of nicotinamide and 0.4 part of methyl hydroxybenzoate when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 8
To further illustrate the beneficial effects of the present invention, comparative example 8 is provided, which comparative example 8 differs from example 3 in that: no niacinamide was added.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve the mixture;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the step two in a container, adding 5 parts of the schizosaccharomyces cerevisiae fermentation product lysate, 2 parts of the pterospermum pterocarpum seed extract and 0.4 part of methylparaben when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 9
To further illustrate the beneficial effects of the present invention, comparative example 9 is provided, which comparative example 9 differs from example 3 in that: no addition of the yeast two split fermentation product lysate.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve the mixture;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) Emulsifying the material obtained in the second step in a container, adding 2 parts of winged seed moringa seed extract, 3 parts of nicotinamide and 0.4 part of methylparaben when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 10
To further illustrate the beneficial effects of the present invention, comparative example 10 is provided, which comparative example 10 differs from example 3 in that: polyquaternium-7 and winged seed Moringa seed extract were not added.
The comparative skin care composition was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of the yeast schizolysis product, 3 parts of nicotinamide and 0.4 part of methyl hydroxybenzoate when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 11
To further illustrate the beneficial effects of the present invention, comparative example 11 is provided, which comparative example 11 differs from example 3 in that: nicotinamide and yeast lysate were not added.
The skin care composition of this example was prepared as follows:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve the mixture;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, stirring to dissolve and homogenize the mixture;
3) Emulsifying the material obtained in the second step in a container, adding 2 parts of the winged seed moringa oleifera seed extract and 0.4 part of methylparaben when the temperature is reduced to 45 ℃, and uniformly stirring.
Comparative example 12
To further illustrate the benefits of the present invention, a skin anti-allergy rejuvenating composition is provided, which is prepared using the method of patent CN 103735458B.
Experiment 1: effect verification
And (3) testing a sample: the present specification describes the samples prepared in examples 1 to 3 and comparative examples 1 to 12.
The experimental method comprises the following steps: 150 volunteers with a large number of pollutants in their environment were selected, wherein the age distribution was 15-60 years, and randomly divided into fifteen groups, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, 10 people per group. Wherein group A applied the skin care composition prepared in example 1 above according to the present invention,
group B applied the skin care composition prepared by the above example 2 of the present invention,
group C applied the skin care composition prepared by the above example 3 of the present invention,
group D applied the skin care composition prepared from comparative example 1,
group E applied the skin care composition prepared from comparative example 2,
group F applied the skin care composition prepared from comparative example 3,
group G applied the skin care composition prepared from comparative example 4,
group H applied the skin care composition prepared from comparative example 5,
group I applied the skin care composition prepared from comparative example 6,
group J applied the skin care composition prepared from comparative example 7,
group K applied the skin care composition prepared from comparative example 8,
group L applied the skin care composition prepared from comparative example 9,
group M applied the skin care composition prepared from comparative example 10,
n groups applied the skin care composition prepared from comparative example 11,
group O applied the skin anti-allergy repair composition prepared by comparative example 12.
The preparation is administered once a day, and 10 days later. The evaluation score was 10 points, and the test evaluation results are shown in table 1 below.
TABLE 1
Figure GDA0002184511720000121
From the above results, it can be seen that:
after the skin care composition provided by the invention is continuously used, pores are reduced, a volunteer reflects that the skin care composition has strong film forming feeling, the skin surface can feel the film forming feeling, the oil secretion of the skin is obviously reduced, the skin inflammation is relieved, and the volunteer can feel good permeability and moisture retention after applying the skin care composition, and has no irritation. The skin care composition disclosed by the invention can relieve the pollution resistance problem of the skin, has the effect of repairing skin injury and has a better skin repairing effect. The skin care composition without the skin care composition has certain anti-inflammatory repair effect, but the anti-environmental pollution effect and the film forming property are obviously poor.
Experiment 2: patch test and allergy test on human skin
And (3) testing a sample: the present specification describes the samples prepared in examples 1 to 3 and comparative examples 1 to 12.
The experimental method comprises the following steps: 90 subjects were selected, with an age distribution of 15-60 years, and randomized into fifteen groups of 6 people each. Wherein, marking a 5cm multiplied by 5cm area of the right forearm of the subject on the flexed side, disinfecting the marked area by using 75% alcohol, and creating the wound by the method: introducing 36-needle micro needles for 30s by using nutrient solution and factors, lightly wiping residual liquid by using a cotton ball soaked by normal saline, and keeping a marked area dry; the spot tester is numbered 0-15, the tested samples are respectively put into the spot tester cells No. 1-15, the dosage is 0.020-0.025g, the subjects are asked to feel, the bathing is prohibited during the tested period, and the normal reaction is negative.
The test sample is delivered to the subject, and acts on the face, neck and back of the ear of the subject, and the skin state of the subject is observed after 10min, and the experimental results are shown in the following table 2.
TABLE 2
Figure GDA0002184511720000122
Figure GDA0002184511720000131
From the above results, it can be seen that:
the spot sticking reaction of the skin care composition is a negative reaction, so that the safety is high; moreover, after the skin care composition of the invention acts on the face, the neck and the back of the ear of a subject, no anaphylactic reaction exists, which shows that the anti-anaphylactic effect of the skin care composition of the invention is better. When the skin care composition of the invention is not used, slight anaphylactic reaction can be seen after the skin care composition is acted on the face and the neck of a subject, which indicates that the anti-allergic effect is poor.
It is to be understood that the invention disclosed is not limited to the particular methodology, protocols, and materials described, as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims.
Those skilled in the art will also recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.

Claims (3)

1. A skin care composition comprises, in combination,
the composition comprises the following components in parts by weight:
1 part of VP/hexadecene copolymer, 0.5 part of polyquaternium-7, 2 parts of moringa pterocarpa seed extract, 3 parts of nicotinamide, 5 parts of schizosaccharomyces cerevisiae fermentation product lysate, 2.5 parts of PEG-20 methyl glucose sesquistearate, 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.1 part of tocopherol, 0.4 part of methylparaben and a proper amount of water;
the skin care composition is prepared by the following steps:
1) Mixing 6 parts of glyceryl polyether-26, 0.3 part of sodium hyaluronate, 0.5 part of polyquaternium-7, 2.5 parts of PEG-20 methyl glucose sesquistearate and a proper amount of water, heating to 85 ℃, and stirring to dissolve the mixture;
2) Dissolving 1 part of VP/hexadecene copolymer and 0.1 part of tocopherol in the material obtained in the step one, mixing and heating to 85 ℃, and stirring to dissolve and homogenize the mixture;
3) And (3) emulsifying the material obtained in the second step in a container, adding 5 parts of the yeast schizolysis product, 2 parts of the moringa oleifera seed extract, 3 parts of nicotinamide and 0.4 part of methyl hydroxybenzoate when the temperature is reduced to 45 ℃, and uniformly stirring.
2. A skin care product, wherein said skin care product comprises the skin care composition of claim 1.
3. Use of the skin care composition of claim 1 in the preparation of a skin care product.
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