CN112190543A - Compound amino acid oral solution for dogs and preparation method thereof - Google Patents
Compound amino acid oral solution for dogs and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Abstract
The invention discloses a compound amino acid oral solution for dogs and a preparation method thereof, the compound amino acid oral solution for dogs is mainly prepared from compound amino acid, and Chinese date and scorched rice sprout components are added, the prepared compound amino acid oral solution contains rich various amino acids, saccharides and proteins, can supplement amino acids required by dog bodies, and has the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves, helping digestion and regulating the middle warmer, strengthening spleen and stimulating appetite. The compound amino acid oral solution for dogs is prepared by the steps of crushing, sieving, mixing, sterilizing, fixing volume, stirring, filtering and the like, the preparation method is simple to operate and low in production cost, and the prepared product is good in stability and suitable for batch production. The invention is suitable for providing the compound amino acid oral solution for dogs, and the compound amino acid oral solution is suitable for the dogs in weak and sick stages.
Description
Technical Field
The invention belongs to the technical field of animal husbandry and veterinary medicine, and particularly relates to a compound amino acid oral solution for dogs and a preparation method thereof.
Background
The weak and sick dogs mostly show symptoms such as appetite reduction, feed intake reduction, physical weakness and the like, and nutrient substances in the dogs are greatly lost due to the symptoms over time, if the symptoms are not timely improved, the dogs grow slowly and even die.
At present, the replenisher for enhancing the body energy of dogs is mainly glucose and sodium chloride injection, and the injection mainly has the balance effects of supplementing water and energy and regulating electrolyte of organisms, and cannot effectively regulate the feed intake of animals and improve the nutritional status of dogs. Particularly, in weak and sick dogs, the appetite of the dogs is enhanced and the eating is promoted by supplementing amino acid, so that the nutrient deficiency symptom of the dogs is improved and the recovery of the dogs is promoted.
Disclosure of Invention
The invention aims to solve the technical problem of providing a compound amino acid oral solution for dogs, which can supplement amino acid, enhance appetite and promote eating so as to improve the nutrient deficiency symptom of the dogs and promote the recovery of the dogs.
The invention aims to solve another technical problem and provides a preparation method of a compound amino acid oral solution for dogs, which is used for preparing the compound amino acid oral solution for dogs, and can supplement amino acid, enhance appetite and promote food intake.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a compound amino acid oral solution for dogs comprises the following raw materials in 1000 parts by weight: 15-25 parts of composite amino acid powder, 60-80 parts of Chinese date, 40-60 parts of scorched rice sprout and the balance of water.
As the limitation of the invention, the raw materials for preparing the composite amino acid powder comprise: 1-3 parts of leucine, 0.5-1 part of isoleucine, 0.4-1 part of valine, 1-2 parts of glycine, 0.3-0.5 part of proline, 0.5-1 part of alanine, 1-2 parts of lysine hydrochloride, 1-2 parts of arginine hydrochloride, 0.1-0.3 part of serine, 0.5-1 part of threonine, 0.5-1 part of histidine hydrochloride, 0.3-0.5 part of methionine, 1-2 parts of phenylalanine and 0.1-0.3 part of tryptophan.
As a further limitation of the invention, the raw materials comprise, by weight, 1000 parts: 20 parts of compound amino acid powder, 60 parts of Chinese date, 40 parts of scorched rice sprout and the balance of water.
As still further limitation of the present invention, the raw materials for preparing the composite amino acid powder include: leucine 1.52 parts, isoleucine 0.68 parts, valine 0.54 parts, glycine 1.30 parts, proline 0.40 parts, alanine 0.75 parts, lysine hydrochloride 1.33 parts, arginine hydrochloride 1.16 parts, serine 0.27 parts, threonine 0.79 parts, histidine hydrochloride 0.98 parts, methionine 0.42 parts, phenylalanine 1.13 parts and tryptophan 0.16 parts.
As a further limitation of the invention, the compound amino acid powder comprises 0.05-0.15 part of ethylparaben.
As a further limitation of the invention, the composite amino acid powder comprises 0.1 part of ethylparaben.
As a further limitation of the invention, the water is purified water.
As a further limitation of the invention, the scorched rice sprout is an externally purchased traditional Chinese medicine decoction piece.
The invention also provides a preparation method of the compound amino acid oral solution for dogs, which comprises the following steps in sequence:
s1, smashing the scorched rice sprouts, removing kernels, removing impurities and cleaning the Chinese dates; mixing to prepare composite amino acid powder;
s2, mixing the charred rice sprout and the Chinese date micro powder, dissolving and sterilizing;
and S3, adding the compound amino acid powder, fixing the volume, stirring and filtering to obtain the compound amino acid oral solution for dogs.
As a further limitation of the preparation method of the invention:
the step S1 includes: respectively carrying out superfine grinding on the scorched rice sprouts and the cleaned jujubes after removing kernels and impurities, and sieving by a sieve of 300-800 meshes to respectively obtain scorched rice sprouts and jujube micro powder; uniformly mixing leucine, isoleucine, valine, glycine, proline, alanine, lysine hydrochloride, arginine hydrochloride, serine, threonine, histidine hydrochloride, methionine, phenylalanine, tryptophan, sucrose and ethylparaben according to a formula ratio to prepare composite amino acid powder;
the step S2 includes: mixing the charred rice sprout and the Chinese date superfine powder, adding water with the weight part of 2-4 times of the total weight parts of the charred rice sprout and the Chinese date superfine powder, stirring at the rotating speed of 100-500 rpm at the temperature of 80-90 ℃ for 5-10 min, and sterilizing at 115 ℃ for 30 min;
the step S3 includes: cooling to 60-70 ℃, adding the composite amino acid powder, and stirring for 10-20 min at a rotation speed of 100-500 rpm in a heat preservation manner; and cooling to room temperature, adding water to a constant volume, stirring at a rotating speed of 100-500 rpm for 5-10 min, and filtering to obtain the compound amino acid oral solution for dogs.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the technical progress that:
the compound amino acid oral solution prepared by taking compound amino acid as a main material and adding Chinese date and scorched rice sprout components contains various rich amino acids, saccharides and proteins, can supplement amino acids required by dogs, and has the effects of tonifying middle-jiao and Qi, nourishing blood and tranquilization, helping digestion and regulating the middle warmer, strengthening spleen and stimulating appetite. Starting from two aspects of supplying nutrient substances externally, promoting the feeding of the dogs and automatically taking in the nutrients, the nutrient deficiency symptom of the dogs is improved, and the recovery of the dogs is promoted.
The compound amino acid oral solution is optimized according to the dosage of the dog, and is suitable for the dog to drink from the physiological perspective of the dog.
The invention adds ethylparaben as preservative, thus avoiding the problem that common preservatives such as benzoic acid and sodium benzoate can only play a role in corrosion prevention in an acidic environment, and having better corrosion prevention effect.
Fourthly, the preparation method of the invention gives consideration to the solubility and stability of each amino acid in the composite amino acid powder, for example, the content of tryptophan dissolved in a solution at 60-70 ℃ is higher, but the content of tryptophan is greatly reduced by continuously raising the temperature.
The method is simple to operate, low in production cost, and the prepared product is good in stability and suitable for batch production.
The invention is suitable for providing the compound amino acid oral solution for dogs, and the compound amino acid oral solution is suitable for the dogs in weak and sick stages.
Detailed Description
Example 1A Compound amino acid oral solution for dogs and a method for preparing the same
A compound amino acid oral solution for dogs comprises the following raw materials: 20kg of compound amino acid powder, 60kg of Chinese date, 40kg of scorched rice sprout and 880kg of water. Wherein the compound amino acid powder comprises 1.52 kg of leucine, 0.68 kg of isoleucine, 0.54 kg of valine, 1.30 kg of glycine, 0.40 kg of proline, 0.75 kg of alanine, 1.33 kg of lysine hydrochloride, 1.16 kg of arginine hydrochloride, 0.27 kg of serine, 0.79 kg of threonine, 0.98 kg of histidine hydrochloride, 0.42 kg of methionine, 1.13 kg of phenylalanine, 0.16 kg of tryptophan, 8.47kg of sucrose and 0.1kg of ethylparaben.
A preparation method of a compound amino acid oral solution for dogs comprises the following steps in sequence:
s1, weighing 60kg of Chinese dates and 40kg of scorched rice sprouts, respectively carrying out ultramicro crushing on the scorched rice sprouts and the Chinese dates subjected to denucleation, impurity removal and cleaning, and sieving by a 800-mesh sieve to respectively obtain scorched rice sprouts and Chinese date superfine powder; weighing 1.52 kg of leucine, 0.68 kg of isoleucine, 0.54 kg of valine, 1.30 kg of glycine, 0.40 kg of proline, 0.75 kg of alanine, 1.33 kg of lysine hydrochloride, 1.16 kg of arginine hydrochloride, 0.27 kg of serine, 0.79 kg of threonine, 0.98 kg of histidine hydrochloride, 0.42 kg of methionine, 1.13 kg of phenylalanine, 0.16 kg of tryptophan, 8.47kg of sucrose and 0.1kg of ethylparaben, and uniformly stirring and mixing to prepare composite amino acid powder;
s2, mixing the charred rice sprout and fructus Jujubae ultramicro powder, adding 400kg purified water, stirring at a rotation speed of 110rpm at 80 deg.C for 10min, and sterilizing at 115 deg.C for 30 min;
s3, cooling to 70 ℃, adding the compound amino acid powder, keeping the temperature and stirring at the rotation speed of 110rpm for 20min, cooling to room temperature, adding 480kg of water to fix the volume, stirring at the rotation speed of 110rpm for 10min, and filtering to obtain the compound amino acid oral solution for dogs.
Example 2-8 preparation method of Compound amino acid oral solution for dogs
Examples 2 to 8 are methods for preparing a compound amino acid oral solution for dogs, respectively, wherein the preparation steps are similar to those of example 1, and only differ from that: the relevant parameters are different, as shown in the following table.
The specific formula of the composite amino acid powder is shown in the following table:
example 9 quality control of Compound amino acid oral solution for dogs
Referring to example 1, a compound amino acid oral solution for dogs was prepared as a comparative example, which was similar to example 1 in formulation and preparation steps except that: the preservative is replaced by equal mass of sodium benzoate from ethylparaben.
The quality of the compound amino acid oral solution for dogs prepared in the examples 1-8 and the comparative example is checked by referring to a method specified by a product quality standard, and the specific conditions are shown in the following table.
As can be seen from the above table, each detection result of the compound amino acid oral solution for dogs prepared in examples 1 to 8 and the comparative example meets the product quality standard, and the amino acid content can meet the nutritional requirement of the dogs for the amino acid.
Example 10 stability testing of Compound amino acid oral solution for dogs
Stability of the compound amino acid oral solution for dogs prepared in examples 1-8 and comparative example is examined, and the specific embodiment is as follows:
taking the compound amino acid oral solution for dogs prepared in the examples 1-8 and the comparative example, placing the oral solution for dogs for 6 months at the temperature of 40 +/-2 ℃ and the relative humidity of 75% +/-5%, and inspecting according to the product quality standard, wherein the specific conditions are shown in the following table.
As can be seen from the above table, the amino acid content and the microbial limit of the compound amino acid oral solution for dogs prepared in examples 1 to 5, 7 and 8 have no significant change through an accelerated test for 6 months; the amino acid content of the compound amino acid oral solution for dogs prepared in example 6 and comparative example is reduced, and the total number of the aerobic bacteria limited by microorganisms and the total number of the mold and the yeast are increased obviously. The results show that the compound amino acid oral solution for dogs prepared in examples 1-5, 7 and 8 has good product stability; the compound amino acid oral solution for dogs prepared in example 6 and the comparative example has a reduced amino acid content due to the amino acid absorption by the microbial propagation, which shows that the compound amino acid oral solution for dogs using ethylparaben as a preservative is more stable than the compound amino acid oral solution for dogs using sodium benzoate as a preservative without the preservative.
Example 11 Effect test of Compound amino acid oral solution for dogs
135 beagle dogs which are clinically diagnosed as protein deficiency are selected and randomly divided into 9 groups which are respectively a control group and test groups 1-8, and the sick dogs are manifested by emaciation, rough and hard fur, lusterless, weight loss, inappetence and listlessness, wherein the sick dogs in the control group take glucose sodium chloride solution orally for 50 mL/time/day and take 7 days continuously; experimental groups 1-8 dogs take the compound amino acid oral solution for dogs prepared in examples 1-8 orally respectively, 50 mL/time/day and 7 days continuously. The body weight and food intake of the sick dogs are counted and recorded, and the specific usage amount and test results are summarized in the following table.
As can be seen from the above table, the food intake increase, weight increase, fur and mental state improvement of the control group dogs are not seen through the treatment observation of 7 days, while the food intake increase, weight increase, fur and mental state improvement of the test groups 1-8 dogs are all increased. Test results show that the compound amino acid oral solution for dogs has the effects of invigorating stomach, promoting digestion and promoting food intake while supplementing amino acids, so that the aims of improving the nutrient deficiency symptom of dogs and promoting the recovery of dogs from the aspects of supplementing nutrient substances externally, promoting the food intake of dogs and independently taking nutrition are fulfilled.
Although the present invention has been described in detail with reference to the above embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described above, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The compound amino acid oral solution for dogs is characterized by comprising the following raw materials in 1000 parts by weight: 15-25 parts of composite amino acid powder, 60-80 parts of Chinese date, 40-60 parts of scorched rice sprout and the balance of water.
2. The compound amino acid oral solution for dogs according to claim 1, wherein the raw materials for preparing the compound amino acid powder comprise the following components in parts by weight: 1-3 parts of leucine, 0.5-1 part of isoleucine, 0.4-1 part of valine, 1-2 parts of glycine, 0.3-0.5 part of proline, 0.5-1 part of alanine, 1-2 parts of lysine hydrochloride, 1-2 parts of arginine hydrochloride, 0.1-0.3 part of serine, 0.5-1 part of threonine, 0.5-1 part of histidine hydrochloride, 0.3-0.5 part of methionine, 1-2 parts of phenylalanine and 0.1-0.3 part of tryptophan.
3. The compound amino acid oral solution for dogs as claimed in claim 2, which is characterized by comprising the following raw materials in 1000 parts by weight: 20 parts of compound amino acid powder, 60 parts of Chinese date, 40 parts of scorched rice sprout and the balance of water.
4. The compound amino acid oral solution for dogs according to claim 3, wherein the raw materials for preparing the compound amino acid powder comprise the following components in parts by weight: leucine 1.52 parts, isoleucine 0.68 parts, valine 0.54 parts, glycine 1.30 parts, proline 0.40 parts, alanine 0.75 parts, lysine hydrochloride 1.33 parts, arginine hydrochloride 1.16 parts, serine 0.27 parts, threonine 0.79 parts, histidine hydrochloride 0.98 parts, methionine 0.42 parts, phenylalanine 1.13 parts and tryptophan 0.16 parts.
5. The compound amino acid oral solution for dogs according to any one of claims 1 to 4, wherein the compound amino acid powder comprises 0.05 to 0.15 parts by weight of ethylparaben.
6. The compound amino acid oral solution for dogs as claimed in claim 5, wherein the compound amino acid powder comprises 0.1 part of ethylparaben by weight.
7. The compound amino acid oral solution for dogs as claimed in any one of claims 1 to 4 and 6, wherein the water is purified water.
8. The compound amino acid oral solution for dogs as claimed in claim 7, wherein the scorched rice sprout is an externally purchased traditional Chinese medicine decoction piece.
9. The preparation method of the compound amino acid oral solution for the dogs as claimed in any one of claims 1 to 8, which comprises the following steps in sequence:
s1, smashing the scorched rice sprouts, removing kernels, removing impurities and cleaning the Chinese dates; mixing to prepare composite amino acid powder;
s2, mixing the charred rice sprout and the Chinese date micro powder, dissolving and sterilizing;
and S3, adding the compound amino acid powder, fixing the volume, stirring and filtering to obtain the compound amino acid oral solution for dogs.
10. The method for preparing the compound amino acid oral solution for the dogs according to claim 9,
the step S1 includes: respectively carrying out superfine grinding on the scorched rice sprouts and the cleaned jujubes after removing kernels and impurities, and sieving by a sieve of 300-800 meshes to respectively obtain scorched rice sprouts and jujube micro powder; uniformly mixing leucine, isoleucine, valine, glycine, proline, alanine, lysine hydrochloride, arginine hydrochloride, serine, threonine, histidine hydrochloride, methionine, phenylalanine, tryptophan and ethylparaben to prepare composite amino acid powder;
the step S2 includes: mixing the charred rice sprout and the Chinese date superfine powder, adding water with the weight part being 2-4 times of the total weight part of the charred rice sprout and the Chinese date superfine powder, stirring at the rotating speed of 100-500 rpm at the temperature of 80-90 ℃ for 5-10 min, and sterilizing at 115 ℃ for 30 min;
the step S3 includes: cooling to 60-70 ℃, adding the composite amino acid powder, and stirring for 10-20 min at a rotation speed of 100-500 rpm in a heat preservation manner; and cooling to room temperature, adding the rest amount of water to a constant volume, stirring at a rotating speed of 100-500 rpm for 5-10 min, and filtering to obtain the compound amino acid oral solution for dogs.
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| CN202010798289.1A CN112190543A (en) | 2020-08-11 | 2020-08-11 | Compound amino acid oral solution for dogs and preparation method thereof |
| PCT/CN2020/116384 WO2022032805A1 (en) | 2020-08-11 | 2020-09-21 | Compound amino acid oral solution for dogs and preparation method therefor |
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| WO2022032805A1 (en) | 2022-02-17 |
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