CN101254168A - Composite high-energy nutrient fluid for dog, grimalkin and fox and method of preparing the same - Google Patents
Composite high-energy nutrient fluid for dog, grimalkin and fox and method of preparing the same Download PDFInfo
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- CN101254168A CN101254168A CNA2008100244392A CN200810024439A CN101254168A CN 101254168 A CN101254168 A CN 101254168A CN A2008100244392 A CNA2008100244392 A CN A2008100244392A CN 200810024439 A CN200810024439 A CN 200810024439A CN 101254168 A CN101254168 A CN 101254168A
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Abstract
The invention discloses a high-energy compound nutrient solution for dogs, cats and foxes and a preparation method thereof. The nutrient solution is prepared by following raw materials (wt%): fat emulsion injection 8.0-14.0, compound amino acid injection 16.0-28.0, sodium chloride 0.3-0.5, glucose 6.0-10.0, and water for injection 50.0-100.0. The nutrient solution can be used for auxiliary treatment of disturbance and malnutrition in small animals caused by diarrhea of dogs, cats and foxes and canine distemper, and prevention of metabolic disturbance and malnutrition syndrome in dogs, cats and foxes. The nutrient solution is prepared by the following steps of blending the raw materials, filtering, quality inspecting, filling and sealing, sterilizing, quanlity inspecting, and packaging. The high-energy compound nutrient solution has the advantages of good safety and reliability, no toxicity, no harmfulness, no residues, simple preparation method, low cost, good auxiliary treatment effect, and high practicability.
Description
Technical field
The present invention relates to a kind of dog, cat, Vulpes usefulness composite high-energy nutrient fluid and preparation method thereof.Relate to a kind of infusion solution and preparation method thereof specifically with makeup energy, body fluid and electrolyte balance effect.The medicine that utilizes the spirit of this invention to produce can be used for toy dysbolismus and the underfed auxiliary treatment that diseases such as toy such as dog, cat, Vulpes diarrhoea, canine distemper cause.
Background technology
Diseases such as dog, cat, Vulpes diarrhoea, canine distemper are the toy commonly encountered diseases, show appetite between period of disease mostly and descend, take food and reduce, and a large amount of losses of energy and body fluid cause syndromes such as dysbolismus and malnutrition.Along with the raising of people's living standard, the number of animals raised of dog, cat, Vulpes is also increasing, and meanwhile, infected animal also increases thereupon.So, develop have makeup energy, body fluid and the medicine of regulating the electrolyte balance effect have good meaning to the curative effect that improves disease.
Summary of the invention
The object of the present invention is to provide a kind of dog, cat, Vulpes to use composite high-energy nutrient fluid and preparation method thereof.
The object of the present invention is achieved like this: it mainly is to be primary raw material with fat emulsion injection, Amino Acid Compound Injection, glucose, sodium chloride etc., forms this invention through operations such as allotment, filtration, quality inspection, embedding, sterilization, quality inspection, packings---dog, cat, Vulpes are used composite high-energy nutrient fluid.
Medicine of the present invention is made (consumption is a weight portion) by following component:
Fat emulsion injection 8.0～14.0 sodium chloride 0.3～0.5
Amino Acid Compound Injection 16.0～28.0 glucoses 6.0～10.0
Water for injection 50.0～100.0.
The weight of the optimization formula of medicine of the present invention is formed:
Fat emulsion injection 11.0～13.0 sodium chloride 0.35～0.42
Amino Acid Compound Injection 21.0～26.0 glucoses 7.5～9.5
Water for injection 70.0～80.0.
The weight of the more preferably prescription of medicine of the present invention is formed:
Fat emulsion injection 10.0 sodium chloride 0.4
Amino Acid Compound Injection 26.00 glucoses 9.5
Water for injection 80.0.
Wherein, the weight proportion of each raw material of fat emulsion injection is
Injection soybean oil 50
Injection lecithin 6
Glycerol for injection 25
Water for injection 500.
Wherein, the weight proportion of each raw material of Amino Acid Compound Injection is
Proline 0.50 tyrosine 0.12 threonine 1.25
Leucine 2.45 valines 1.80 sorbitol 25.00
Tryptophan 0.45 glycine 3.80 methionines 1.12
Cystine 0.05 alanine 1.00 phenylalanine 2.67
Serine 0.50 glutamic acid 0.38 Aspartic Acid 1.25
Isoleucine 1.76 arginine hydrochloride 2.50 histidine monohydrochlorides 1.25
Lysine hydrochloride 2.15 sodium sulfitees 0.25 water for injection 500.
Dog of the present invention, cat, Vulpes with the preparation method of composite high-energy nutrient fluid are:
1. allotment: at first prepare fat emulsion injection and Amino Acid Compound Injection, it is even to measure above-mentioned two kinds of liquid mixing by proportion relation after preparation is finished, add an amount of glucose and sodium chloride, stirring makes it dissolving, then add proper amount of water for injection again, make drug level be regulation content, standby;
2. filter;
3. quality inspection: by the laboratorian character, content etc. is checked, entered next procedure after qualified;
4. embedding: learn from else's experience and wash, dry by the fire vial after qualified and on filling machine, pour into above-mentioned reserve liquid in the bottle and seal;
5. sterilization: adopt pasteurization or ultraviolet sterilization;
6. quality inspection;
7. pack.
After in the infusion solution of producing according to spirit of the present invention injects body, makeup energy and body fluid regain one's strength and appetite dog, cat, Vulpes rapidly, and determined curative effect is the good medicine of treatment dog, cat, Vulpes dysbolismus and malnutrition syndrome.
For showing the therapeutic effect of medicine of the present invention, the present invention has carried out following experiment content to show effect.
1, two kinds of composite nutrient-fluids are tested the white mice resisting fatigue.
The experiment of resisting fatigue endurance is an important observation index analyzing the body physical ability, can reflect the resistance against diseases of body indirectly.This test is by to behind the white mice intravenous administration, the time of observation white mice swimming with a load attached to the body, detects animal antifatigue degree according to the length of swimming time.The results are shown in Table 1:
Two kinds of composite nutrient-fluids of table 1 are to the influence of white mice swimming
By table 1 as seen, experimental group is compared with matched group, and mice swimming is exhausted the time and obviously prolonged, P＜0.01, and difference is extremely remarkable, shows that two kinds of composite nutrient-fluids all can prolong the mice swimming death time, have antifatigue effect to body.Wherein supply dog, cat, Vulpes are more obvious than 10% glucose compound amino-acid nutrition liquid effect with composite high-energy nutrient fluid, reach 790.8min, illustrate that replenishing fat milk and aminoacid etc. can significantly improve the body physical ability, helps the resistance against diseases of enhancing body.
2, two kinds of composite nutrient-fluids are to the mouse lymphocyte conversion test.
Lymhocyte transformation rate is an important indicator estimating cellular immune function, by giving white mice fasting four days, and after the pre-treatment that drinking-water is not limit, the intravenous injection nutritional solution, 1 time/day, inject 2 times, dividing the observation lymhocyte transformation rate of taking a blood sample in 1 day, 3 days, 5 days.The results are shown in Table 2:
Table 2 lymhocyte transformation rate (%)
Result of the test shows that nutritional solution can make lymhocyte transformation rate all significantly raise, and compares P＜0.01 with matched group, difference is extremely remarkable, proves white mice under starvation, extra-nutrition liquid, lymphocyte transformation can be promoted significantly, raise immunity, the resistance against diseases of raising body.
3, clinical treatment example.
Three littermate hangquans that Zhang raises, the about 21kg of body weight, at 4 monthly ages, kind wolf green grass or young crops is not taken food after ill, can drink water, the time vomiting is arranged, it is thin stench and be with the feces of blood to discharge volume.Be diagnosed as Canine parvovirus infection through quick diagnosis reagent kit.Adopt the comprehensive therapy measure, application antiviral and antibacterials virazole 1mL * 2,80,000 * 2 intramuscular injection of gentamycin, twice of every day.Prevent and treat protopathy and secondary infection, wherein two dogs are replenished composite high-energy nutrient fluid, the another dog is replenished 10% glucose injection and carries out auxiliary treatment, to improve blood circulation, corrects acidosis, have additional nutrients and improve Abwehrkraft des Koepers etc., the sick dog of two additional high-energy nutrient fluids was treated after 4 days, got well substantially, the sick dog of replenishing 10% glucose injection gets well after 6 days substantially.Therapeutic outcome shows, the be significantly improved effect of curative effect of composite high-energy nutrient fluid.
The specific embodiment
Embodiment one:
Press the narration weight proportion and take by weighing raw material:
Fat emulsion injection 10.0 sodium chloride 0.4
Amino Acid Compound Injection 26.0 glucoses 9.5
Water for injection 80.0.
Preparation method is as follows:
1, allotment: get injection soybean oil 50g in the dosing pot, be heated to 80 ℃, add injection lecithin 6g, smash to pieces at a high speed, make into even settled solution to dissolving fully.Other gets recipe quantity water for injection and adds glycerol, puts in another dosing pot to mix, and is heated to 60 ℃.Under high-speed stirred, the phospholipid oil solution is slowly added in the glycerine water solution, regulate pH to about 8.0 with sodium hydroxide.Through high pressure homogenize to particle about 0.33 μ m, with 1 μ m filtering with microporous membrane, promptly get fat emulsion injection; Take by weighing each aminoacid by recipe quantity and add in the 500mL water for injection, be heated with stirring to about 90 ℃ and make dissolving, regulate pH to about 6.0 with dilute hydrochloric acid, the active carbon of adding 0.02%, stirred 15 minutes after 5 μ m filter filtering decarbonizations adopt 110 ℃, 30min sterilization, promptly get Amino Acid Compound Injection; Measure above-mentioned two kinds of injection mix homogeneously by the prescription amount, then press the prescription amount and add glucose and sodium chloride, stir after the slightly heated and make it dissolving, then add water for injection again, standby;
2, filter: get above-mentioned reserve liquid, filter with No. 4 sintered glass filters (or the filter membrane in suitable aperture), also available continuous filter unit filters, and is standby;
3, quality inspection: by the laboratorian character, content etc. is checked, entered next procedure after qualified;
4, embedding: learn from else's experience and wash, dry by the fire vial after qualified and on filling machine, pour into above-mentioned reserve liquid in the bottle and seal;
5, sterilization: adopt pasteurization or ultraviolet sterilization to sterilize;
6, quality inspection: by the laboratorian content, character, loading amount etc. are checked, entered next procedure after qualified;
7, packing: promptly get this invention after packing---dog, cat, Vulpes are used composite high-energy nutrient fluid.
Embodiment two:
Press the narration weight proportion and take by weighing raw material:
Fat emulsion injection 8.5 sodium chloride 0.3
Amino Acid Compound Injection 17.0 glucoses 6.0
Water for injection 55.0.
Preparation method is with embodiment one.
Embodiment three:
Press the narration weight proportion and take by weighing raw material:
Fat emulsion injection 14.0 sodium chloride 0.48
Amino Acid Compound Injection 28.0 glucoses 9.8
Water for injection 100.0.
Preparation method is with embodiment one.
Claims (6)
1, a kind of dog, cat, Vulpes are used composite high-energy nutrient fluid, it is characterized in that it is the medicament of being made by following raw material by weight ratio
Fat emulsion injection 8.0～14.0 sodium chloride 0.3～0.5
Amino Acid Compound Injection 16.0～28.0 glucoses 6.0～10.0
Water for injection 50.0～100.0.
2, dog according to claim 1, cat, Vulpes are used composite high-energy nutrient fluid, it is characterized in that the weight proportion of described each raw material is
Fat emulsion injection 11.0～13.0 sodium chloride 0.35～0.42
Amino Acid Compound Injection 21.0～26.0 glucoses 7.5～9.5
Water for injection 70.0～80.0.
3, dog according to claim 1, cat, Vulpes are used composite high-energy nutrient fluid, it is characterized in that the weight proportion of described each raw material is
Fat emulsion injection 10 sodium chloride 0.4
Amino Acid Compound Injection 26.0 glucoses 9.5
Water for injection 80.0.
4, dog according to claim 1, cat, Vulpes are used composite high-energy nutrient fluid, it is characterized in that described
The weight proportion of fat emulsion injection is
Injection soybean oil 50 glycerol for injection 25
Injection lecithin 6 waters for injection 500.
5, dog according to claim 1, cat, Vulpes are used composite high-energy nutrient fluid, it is characterized in that the weight proportion of described Amino Acid Compound Injection is
Proline 0.50 tyrosine 0.12 threonine 1.25
Leucine 2.45 valines 1.80 sorbitol 25.00
Tryptophan 0.45 glycine 3.80 methionines 1.12
Cystine 0.05 alanine 1.00 phenylalanine 2.67
Serine 0.50 glutamic acid 0.38 Aspartic Acid 1.25
Isoleucine 1.76 arginine hydrochloride 2.50 histidine monohydrochlorides 1.25
Lysine hydrochloride 2.15 sodium sulfitees 0.25 water for injection 500.
6, dog according to claim 1, cat, Vulpes are used composite high-energy nutrient fluid, and its feature is that also its preparation method is:
1. allotment: at first prepare fat emulsion injection and Amino Acid Compound Injection, the back is finished in preparation, and to measure above-mentioned two kinds of liquid mixing by proportion relation even, adding glucose and sodium chloride, stirring makes it dissolving, then add water for injection again, make drug level be regulation content, standby;
2. filter;
3. quality inspection: by the laboratorian character, content etc. is checked, entered next procedure after qualified;
4. embedding: learn from else's experience and wash, dry by the fire vial after qualified and on filling machine, pour into above-mentioned reserve liquid in the bottle and seal;
5. sterilization: adopt pasteurization or ultraviolet sterilization;
6. quality inspection;
7. pack.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100244392A CN101254168A (en) | 2008-03-24 | 2008-03-24 | Composite high-energy nutrient fluid for dog, grimalkin and fox and method of preparing the same |
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| CNA2008100244392A CN101254168A (en) | 2008-03-24 | 2008-03-24 | Composite high-energy nutrient fluid for dog, grimalkin and fox and method of preparing the same |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552250A (en) * | 2012-01-04 | 2012-07-11 | 河北科星药业有限公司 | Compound amino acid injection for livestock as well as preparation method and applications thereof |
| CN102641288A (en) * | 2012-05-08 | 2012-08-22 | 海南海医药物安全性评价研究有限责任公司 | Nutrition combination for anti experiment beagle transportation stress |
| CN112190543A (en) * | 2020-08-11 | 2021-01-08 | 河北科星药业有限公司 | Compound amino acid oral solution for dogs and preparation method thereof |
-
2008
- 2008-03-24 CN CNA2008100244392A patent/CN101254168A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552250A (en) * | 2012-01-04 | 2012-07-11 | 河北科星药业有限公司 | Compound amino acid injection for livestock as well as preparation method and applications thereof |
| CN102552250B (en) * | 2012-01-04 | 2014-09-24 | 河北科星药业有限公司 | Compound amino acid injection for livestock as well as preparation method and applications thereof |
| CN102641288A (en) * | 2012-05-08 | 2012-08-22 | 海南海医药物安全性评价研究有限责任公司 | Nutrition combination for anti experiment beagle transportation stress |
| CN102641288B (en) * | 2012-05-08 | 2013-04-10 | 海南海医药物安全性评价研究有限责任公司 | Nutrition combination for anti experiment beagle transportation stress |
| CN112190543A (en) * | 2020-08-11 | 2021-01-08 | 河北科星药业有限公司 | Compound amino acid oral solution for dogs and preparation method thereof |
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Open date: 20080903 |