WO2022032805A1 - Compound amino acid oral solution for dogs and preparation method therefor - Google Patents

Compound amino acid oral solution for dogs and preparation method therefor Download PDF

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WO2022032805A1
WO2022032805A1 PCT/CN2020/116384 CN2020116384W WO2022032805A1 WO 2022032805 A1 WO2022032805 A1 WO 2022032805A1 CN 2020116384 W CN2020116384 W CN 2020116384W WO 2022032805 A1 WO2022032805 A1 WO 2022032805A1
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parts
amino acid
compound amino
dogs
oral solution
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PCT/CN2020/116384
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French (fr)
Chinese (zh)
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裴有志
陈淑芳
李凤英
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河北科星药业有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Definitions

  • the invention belongs to the technical field of animal husbandry and veterinary medicine, in particular to a compound amino acid oral solution for dogs and a preparation method thereof.
  • Dogs in the frail and onset period usually show symptoms such as decreased appetite, reduced feed intake, and physical weakness. With the extension of time, the nutrients in their bodies will be lost due to the above symptoms. Slow growth or even death.
  • the supplementary fluids used to enhance the physical fitness of dogs are mainly glucose and sodium chloride injections.
  • Such injections mainly play a role in replenishing water and energy and regulating the balance of electrolytes in the body, but cannot effectively regulate animal feed intake and improve the nutritional status of dogs. .
  • the technical problem to be solved by the present invention is to provide a compound amino acid oral solution for dogs that can supplement amino acids, enhance appetite, and promote eating, so as to improve the nutritional deficiency symptoms of dogs and promote the recovery of dogs.
  • Another technical problem to be solved by the present invention is to provide a preparation method of compound amino acid oral solution for dogs, which is used to prepare compound amino acid oral solution for dogs that can supplement amino acids, enhance appetite, and promote eating.
  • a compound amino acid oral solution for dogs based on 1000 parts by weight, the raw materials include: 15-25 parts of compound amino acid powder, 60-80 parts of jujube, 40-60 parts of Jiaogu sprouts, and the balance is water.
  • the raw materials for making the compound amino acid powder include: 1-3 parts of leucine, 0.5-1 part of isoleucine, 0.4-1 part of valine, 1-2 parts of glycine, and proline 0.3-0.5 part of acid, 0.5-1 part of alanine, 1-2 parts of lysine hydrochloride, 1-2 parts of arginine hydrochloride, 0.1-0.3 part of serine, 0.5-1 part of threonine, histidine hydrochloride 0.5-1 part, 0.3-0.5 part of methionine, 1-2 parts of phenylalanine, and 0.1-0.3 part of tryptophan.
  • the raw materials include: 20 parts of compound amino acid powder, 60 parts of jujube, 40 parts of Jiaogu sprouts, and the balance is water.
  • the raw materials for making the compound amino acid powder include: 1.52 parts of leucine, 0.68 parts of isoleucine, 0.54 parts of valine, 1.30 parts of glycine, 0.40 parts of proline, and 0.40 parts of alanine. 0.75 parts of acid, 1.33 parts of lysine hydrochloride, 1.16 parts of arginine hydrochloride, 0.27 parts of serine, 0.79 parts of threonine, 0.98 parts of histidine hydrochloride, 0.42 parts of methionine, 1.13 parts of phenylalanine, chromophore 0.16 parts of amino acid.
  • the compound amino acid powder includes 0.05-0.15 parts of ethyl paraben.
  • the compound amino acid powder includes 0.1 part of ethyl paraben.
  • the water is purified water.
  • the Jiaogu sprouts are outsourced Chinese herbal decoction pieces.
  • the present invention also provides a preparation method of the above-mentioned compound amino acid oral solution for dogs, which comprises the following steps:
  • the step S1 includes: superfinely pulverizing the Jiaogu sprouts and the jujubes cleaned by removing the cores and impurities, and passing through a 300-800 mesh sieve to obtain the Jiaogu sprouts and jujube micropowders respectively; Acid, Glycine, Proline, Alanine, Lysine Hydrochloride, Arginine Hydrochloride, Serine, Threonine, Histidine Hydrochloride, Methionine, Phenylalanine, Tryptophan, Sucrose, Nitrogen Poljin ethyl ester, mix uniformly according to the formula ratio to obtain compound amino acid powder;
  • the step S2 includes: mixing Jiaogu sprouts and jujube ultrafine powder, adding water whose weight portion is 2 to 4 times the total weight of Jiaogu sprouts and jujube ultrafine powder, and stirring at a temperature of 80 to 90°C at a rotating speed of 100 to 500 rpm. 5 ⁇ 10min, sterilize at 115°C for 30min;
  • the step S3 includes: cooling to 60-70° C., adding compound amino acid powder, stirring at a rotational speed of 100-500 rpm for 10-20 minutes; cooling to room temperature, adding water to the volume, stirring at a rotational speed of 100-500 rpm for 5-10 minutes, and filtering to obtain Compound amino acid oral solution for dogs.
  • the present invention is based on compound amino acids, adding jujube and Jiaogu sprouts, and the prepared compound amino acid oral solution is rich in a variety of amino acids, carbohydrates and proteins, which can supplement the amino acids required by the dog's body, and has the function of invigorating the middle and nourishing qi. , Nourishing and calming the nerves, digestion, and the effect of invigorating the spleen and appetizing. From the two aspects of supplementing nutrients from the outside, promoting the dog's eating, and ingesting nutrients independently, it can improve the symptoms of nutritional deficiencies in dogs and promote the recovery of dogs.
  • the present invention optimizes the compound amino acid component according to the dosage of the dog, and develops the compound amino acid oral solution suitable for the dog to drink from the perspective of the dog's physiology.
  • the present invention adds ethyl paraben as a preservative, which avoids the problem that common preservatives such as benzoic acid and sodium benzoate must be in an acidic environment to have a preservative effect, and the preservative effect is better.
  • the preparation method of the present invention takes into account the solubility and stability of each amino acid in the compound amino acid powder.
  • the dissolved content of tryptophan in the solution at 60-70 ° C is relatively high, but if the temperature continues to increase, its content will be greatly reduced.
  • the selected cooling temperature can better ensure the dissolution and mixing of the compound amino acid powder, and at the same time, the content of each amino acid can be kept to the maximum extent.
  • the method of the invention is simple in operation, low in production cost, and has good stability of the prepared product, which is suitable for mass production.
  • the invention is suitable for providing a compound amino acid oral solution for dogs, and the compound amino acid oral solution is suitable for dogs in frail and diseased stages to drink.
  • Embodiment 1 A kind of compound amino acid oral solution for dogs and preparation method thereof
  • a compound amino acid oral solution for dogs the raw materials of which include: compound amino acid powder 20kg, jujube 60kg, Jiaogu bud 40kg, and water 880kg.
  • the compound amino acid powder includes leucine 1.52kg, isoleucine 0.68kg, valine 0.54kg, glycine 1.30kg, proline 0.40kg, alanine 0.75kg, lysine hydrochloride 1.33kg, arginine hydrochloride Acid 1.16kg, Serine 0.27kg, Threonine 0.79kg, Histidine Hydrochloride 0.98kg, Methionine 0.42kg, Phenylalanine 1.13kg, Tryptophan 0.16kg, Sucrose 8.47kg, Ethylparaben 0.1kg.
  • a preparation method of compound amino acid oral solution for dogs comprising the steps of sequentially performing the following steps:
  • Embodiment 2 ⁇ 8 The preparation method of compound amino acid oral solution for dogs
  • Embodiments 2 to 8 are respectively a preparation method of compound amino acid oral solution for dogs, wherein the preparation steps are similar to those of embodiment 1, and the difference is only that the relevant parameters are different, as shown in the following table.
  • Embodiment 9 Quality detection of compound amino acid oral solution for dogs
  • a compound amino acid oral solution for dogs is prepared with reference to Example 1 as a comparative example.
  • the formulation and preparation steps of the comparative example are similar to those of Example 1, except that the preservatives used are replaced by ethylparaben, etc. quality sodium benzoate.
  • test results of the compound amino acid oral solution for dogs prepared in Examples 1 to 8 and Comparative Example all meet the requirements of the product quality standard, and the amino acid content can meet the nutritional needs of dogs for amino acids.
  • a total of 135 beagle dogs clinically diagnosed with protein deficiency were selected and randomly divided into 9 groups, namely the control group and the experimental group 1-8.
  • the diseased dogs showed weight loss, rough and dull coat, weight loss, and loss of appetite. and lethargy, wherein the control group of sick dogs orally oral glucose sodium chloride solution, 50mL/time/day, used for 7 days; experimental group 1 ⁇ 8 sick dogs orally orally respectively the dog compound amino acid oral solution prepared by embodiment 1 ⁇ 8, 50mL/time /day, for 7 consecutive days.
  • the body weight and food intake of the sick dogs were counted and recorded, and the specific dosage and test results were summarized in the following table.

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Abstract

Disclosed are a compound amino acid oral solution for dogs and a preparation method therefor. The compound amino acid oral solution for dogs is mainly composed of compound amino acids, is added with jujube and fried rice sprout components, can supplement amino acids required by dogs, and has the functions of tonifying middle-Jiao and Qi, nourishing the blood and tranquilization, promoting digestion and regulating the middle warmer, and tonifying spleen and whetting the appetite. The compound amino acid oral solution for dogs is prepared by the steps of pulverizing, sieving, mixing, sterilizing, regulating a constant volume, stirring, filtering, etc. has simple operations, low costs, and good product stability, and is suitable for mass production. The compound amino acid oral solution for dogs is suitable for consumption in frail and diseased dogs.

Description

一种犬用复方氨基酸口服溶液及其制备方法A kind of compound amino acid oral solution for dogs and preparation method thereof 技术领域technical field
本发明属于畜牧兽医技术领域，具体地说是一种犬用复方氨基酸口服溶液及其制备方法。The invention belongs to the technical field of animal husbandry and veterinary medicine, in particular to a compound amino acid oral solution for dogs and a preparation method thereof.
背景技术Background technique
体弱、发病期的犬多表现为食欲下降、采食量减少、身体虚弱等症状，随着时间的延长，其体内的营养物质会由于上述症状出现大量流失，如不及时改善，将导致犬生长缓慢甚至死亡。Dogs in the frail and onset period usually show symptoms such as decreased appetite, reduced feed intake, and physical weakness. With the extension of time, the nutrients in their bodies will be lost due to the above symptoms. Slow growth or even death.
目前用于增强犬体能的补充液主要为葡萄糖、氯化钠注射液，此类注射液主要起补充水分和能量、调节机体电解质的平衡作用，无法有效调节动物采食量、改善犬体营养状况。尤其是体弱、发病期间的犬，更需要通过补充氨基酸，增强食欲，促进进食，以改善犬的营养缺乏症状，促进犬痊愈。At present, the supplementary fluids used to enhance the physical fitness of dogs are mainly glucose and sodium chloride injections. Such injections mainly play a role in replenishing water and energy and regulating the balance of electrolytes in the body, but cannot effectively regulate animal feed intake and improve the nutritional status of dogs. . Especially for dogs who are weak and during the disease period, it is necessary to supplement amino acids, increase appetite, and promote eating, so as to improve the symptoms of nutritional deficiencies in dogs and promote the recovery of dogs.
发明内容SUMMARY OF THE INVENTION
本发明要解决的技术问题，是提供一种能够补充氨基酸，增强食欲，促进进食的犬用复方氨基酸口服溶液，以改善犬的营养缺乏症状，促进犬痊愈。The technical problem to be solved by the present invention is to provide a compound amino acid oral solution for dogs that can supplement amino acids, enhance appetite, and promote eating, so as to improve the nutritional deficiency symptoms of dogs and promote the recovery of dogs.
本发明要解决的另一个技术问题，是提供一种犬用复方氨基酸口服溶液的制备方法，用于制备能够补充氨基酸，增强食欲，促进进食的犬用复方氨基酸口服溶液。Another technical problem to be solved by the present invention is to provide a preparation method of compound amino acid oral solution for dogs, which is used to prepare compound amino acid oral solution for dogs that can supplement amino acids, enhance appetite, and promote eating.
为实现上述目的，本发明所采用的技术方案如下：For achieving the above object, the technical scheme adopted in the present invention is as follows:
一种犬用复方氨基酸口服溶液，以1000份重量份计，其原料包括：复合氨基酸粉15～25份、大枣60～80份、焦谷芽40～60份，余量为水。A compound amino acid oral solution for dogs, based on 1000 parts by weight, the raw materials include: 15-25 parts of compound amino acid powder, 60-80 parts of jujube, 40-60 parts of Jiaogu sprouts, and the balance is water.
作为本发明的限定，制成所述复合氨基酸粉的原料包括：亮氨酸1～3份、异亮氨酸0.5～1份、缬氨酸0.4～1份、甘氨酸1～2份、脯氨酸0.3～0.5份、丙氨酸0.5～1份、盐酸赖氨酸1～2份、盐酸精氨酸1～2份、丝氨酸0.1～0.3份、苏氨酸0.5～1份、盐酸组氨酸0.5～1份、甲硫氨酸0.3～0.5份、苯丙氨酸1～2份、色氨酸0.1～0.3份。As a limitation of the present invention, the raw materials for making the compound amino acid powder include: 1-3 parts of leucine, 0.5-1 part of isoleucine, 0.4-1 part of valine, 1-2 parts of glycine, and proline 0.3-0.5 part of acid, 0.5-1 part of alanine, 1-2 parts of lysine hydrochloride, 1-2 parts of arginine hydrochloride, 0.1-0.3 part of serine, 0.5-1 part of threonine, histidine hydrochloride 0.5-1 part, 0.3-0.5 part of methionine, 1-2 parts of phenylalanine, and 0.1-0.3 part of tryptophan.
作为本发明的进一步限定，以1000份重量份计，其原料包括：复合氨基酸粉20份、大枣60份、焦谷芽40份，余量为水。As a further limitation of the present invention, based on 1000 parts by weight, the raw materials include: 20 parts of compound amino acid powder, 60 parts of jujube, 40 parts of Jiaogu sprouts, and the balance is water.
作为本发明的再进一步限定，制成所述复合氨基酸粉的原料包括：亮氨 酸1.52份、异亮氨酸0.68份、缬氨酸0.54份、甘氨酸1.30份、脯氨酸0.40份、丙氨酸0.75份、盐酸赖氨酸1.33份、盐酸精氨酸1.16份、丝氨酸0.27份、苏氨酸0.79份、盐酸组氨酸0.98份、甲硫氨酸0.42份、苯丙氨酸1.13份、色氨酸0.16份。As a further limitation of the present invention, the raw materials for making the compound amino acid powder include: 1.52 parts of leucine, 0.68 parts of isoleucine, 0.54 parts of valine, 1.30 parts of glycine, 0.40 parts of proline, and 0.40 parts of alanine. 0.75 parts of acid, 1.33 parts of lysine hydrochloride, 1.16 parts of arginine hydrochloride, 0.27 parts of serine, 0.79 parts of threonine, 0.98 parts of histidine hydrochloride, 0.42 parts of methionine, 1.13 parts of phenylalanine, chromophore 0.16 parts of amino acid.
作为本发明的更进一步限定，所述复合氨基酸粉包括尼泊金乙酯0.05～0.15份。As a further limitation of the present invention, the compound amino acid powder includes 0.05-0.15 parts of ethyl paraben.
作为本发明的更进一步限定，所述复合氨基酸粉包括尼泊金乙酯0.1份。As a further limitation of the present invention, the compound amino acid powder includes 0.1 part of ethyl paraben.
作为本发明的更进一步限定，所述水为纯化水。As a further limitation of the present invention, the water is purified water.
作为本发明的更进一步限定，所述焦谷芽为外购中药饮片。As a further limitation of the present invention, the Jiaogu sprouts are outsourced Chinese herbal decoction pieces.
本发明还提供了上述犬用复方氨基酸口服溶液的制备方法，包括依次进行以下步骤：The present invention also provides a preparation method of the above-mentioned compound amino acid oral solution for dogs, which comprises the following steps:
S1、粉碎焦谷芽及去核除杂洗净的大枣；混合制备复合氨基酸粉；S1, pulverize coke sprouts and jujubes that have been pitted and cleaned; mixed to prepare compound amino acid powder;
S2、混合焦谷芽、大枣微粉，溶解，灭菌；S2. Mix coke sprouts and jujube powder, dissolve and sterilize;
S3、加入复合氨基酸粉，定容，搅拌，过滤得到犬用复方氨基酸口服溶液。S3, adding compound amino acid powder, constant volume, stirring, and filtering to obtain compound amino acid oral solution for dogs.
作为本发明制备方法的进一步限定：As a further limitation of the preparation method of the present invention:
所述步骤S1包括：分别将焦谷芽、去核除杂洗净的大枣超微粉碎，过300～800目筛，分别得到焦谷芽、大枣微粉；将亮氨酸、异亮氨酸、缬氨酸、甘氨酸、脯氨酸、丙氨酸、盐酸赖氨酸、盐酸精氨酸、丝氨酸、苏氨酸、盐酸组氨酸、甲硫氨酸、苯丙氨酸、色氨酸、蔗糖、尼泊金乙酯，按配方比例混合均匀，制得复合氨基酸粉；The step S1 includes: superfinely pulverizing the Jiaogu sprouts and the jujubes cleaned by removing the cores and impurities, and passing through a 300-800 mesh sieve to obtain the Jiaogu sprouts and jujube micropowders respectively; Acid, Glycine, Proline, Alanine, Lysine Hydrochloride, Arginine Hydrochloride, Serine, Threonine, Histidine Hydrochloride, Methionine, Phenylalanine, Tryptophan, Sucrose, Nitrogen Poljin ethyl ester, mix uniformly according to the formula ratio to obtain compound amino acid powder;
所述步骤S2包括：将焦谷芽、大枣超微粉混合，加入重量份数为焦谷芽、大枣超微粉总重量份数2～4倍的水，以转速100～500rpm在80～90℃温度下搅拌5～10min，于115℃灭菌30min；The step S2 includes: mixing Jiaogu sprouts and jujube ultrafine powder, adding water whose weight portion is 2 to 4 times the total weight of Jiaogu sprouts and jujube ultrafine powder, and stirring at a temperature of 80 to 90°C at a rotating speed of 100 to 500 rpm. 5～10min, sterilize at 115℃ for 30min;
所述步骤S3包括：冷却至60～70℃，加入复合氨基酸粉，以转速100～500rpm保温搅拌10～20min；冷却至室温，加水定容，再以转速100～500rpm搅拌5～10min，过滤得到犬用复方氨基酸口服溶液。The step S3 includes: cooling to 60-70° C., adding compound amino acid powder, stirring at a rotational speed of 100-500 rpm for 10-20 minutes; cooling to room temperature, adding water to the volume, stirring at a rotational speed of 100-500 rpm for 5-10 minutes, and filtering to obtain Compound amino acid oral solution for dogs.
由于采用了上述的技术方案，本发明与现有技术相比，所取得的技术进步在于：Owing to adopting the above-mentioned technical scheme, compared with the prior art, the technical progress achieved in the present invention is:
一、本发明以复合氨基酸为主，添加大枣、焦谷芽成分，制备所得的复方氨基酸 口服溶液含有丰富的多种氨基酸、糖类及蛋白质，可补充犬体所需氨基酸，并具有补中益气、养血安神、消食和中、健脾开胃的功效。从外部补充营养物质和促进犬进食、自主摄入营养两个方面出发，改善犬的营养缺乏症状，促进犬痊愈。1. The present invention is based on compound amino acids, adding jujube and Jiaogu sprouts, and the prepared compound amino acid oral solution is rich in a variety of amino acids, carbohydrates and proteins, which can supplement the amino acids required by the dog's body, and has the function of invigorating the middle and nourishing qi. , Nourishing and calming the nerves, digestion, and the effect of invigorating the spleen and appetizing. From the two aspects of supplementing nutrients from the outside, promoting the dog's eating, and ingesting nutrients independently, it can improve the symptoms of nutritional deficiencies in dogs and promote the recovery of dogs.
二、本发明根据犬的用量将复合氨基酸组分进行了优化，从犬的生理角度出发研制出适于犬饮用的复方氨基酸口服溶液。2. The present invention optimizes the compound amino acid component according to the dosage of the dog, and develops the compound amino acid oral solution suitable for the dog to drink from the perspective of the dog's physiology.
三、本发明添加尼泊金乙酯作为防腐剂，避免了常用防腐剂如苯甲酸、苯甲酸钠必须在酸性环境下才能起到防腐作用的问题，防腐效果更佳。3. The present invention adds ethyl paraben as a preservative, which avoids the problem that common preservatives such as benzoic acid and sodium benzoate must be in an acidic environment to have a preservative effect, and the preservative effect is better.
四、本发明的制备方法兼顾复合氨基酸粉中各氨基酸的溶解性和稳定性，如色氨酸在60～70℃的溶液内溶解含量较高，但继续升高温度，其含量将大幅下降，本发明经多次实验、检测，选取出的冷却温度可更好地保证复合氨基酸粉的溶解混合，同时最大限度的保留各氨基酸含量。Fourth, the preparation method of the present invention takes into account the solubility and stability of each amino acid in the compound amino acid powder. For example, the dissolved content of tryptophan in the solution at 60-70 ° C is relatively high, but if the temperature continues to increase, its content will be greatly reduced. After many experiments and detections, the selected cooling temperature can better ensure the dissolution and mixing of the compound amino acid powder, and at the same time, the content of each amino acid can be kept to the maximum extent.
五、本发明方法操作简单、生产成本低廉，且制备所得的产品稳定性良好，适于批量生产。Fifth, the method of the invention is simple in operation, low in production cost, and has good stability of the prepared product, which is suitable for mass production.
本发明适用于提供一种犬用复方氨基酸口服溶液，该复方氨基酸口服溶液适用于体弱、发病期的犬饮用。The invention is suitable for providing a compound amino acid oral solution for dogs, and the compound amino acid oral solution is suitable for dogs in frail and diseased stages to drink.
具体实施方式detailed description
实施例1一种犬用复方氨基酸口服溶液及其制备方法Embodiment 1 A kind of compound amino acid oral solution for dogs and preparation method thereof
一种犬用复方氨基酸口服溶液，其原料包括：复合氨基酸粉20kg、大枣60kg、焦谷芽40kg，水880kg。其中复合氨基酸粉包括亮氨酸1.52kg、异亮氨酸0.68kg、缬氨酸0.54kg、甘氨酸1.30kg、脯氨酸0.40kg、丙氨酸0.75kg、盐酸赖氨酸1.33kg、盐酸精氨酸1.16kg、丝氨酸0.27kg、苏氨酸0.79kg、盐酸组氨酸0.98kg、甲硫氨酸0.42kg、苯丙氨酸1.13kg、色氨酸0.16kg、蔗糖8.47kg、尼泊金乙酯0.1kg。A compound amino acid oral solution for dogs, the raw materials of which include: compound amino acid powder 20kg, jujube 60kg, Jiaogu bud 40kg, and water 880kg. The compound amino acid powder includes leucine 1.52kg, isoleucine 0.68kg, valine 0.54kg, glycine 1.30kg, proline 0.40kg, alanine 0.75kg, lysine hydrochloride 1.33kg, arginine hydrochloride Acid 1.16kg, Serine 0.27kg, Threonine 0.79kg, Histidine Hydrochloride 0.98kg, Methionine 0.42kg, Phenylalanine 1.13kg, Tryptophan 0.16kg, Sucrose 8.47kg, Ethylparaben 0.1kg.
一种犬用复方氨基酸口服溶液的制备方法，包括依次进行如下步骤：A preparation method of compound amino acid oral solution for dogs, comprising the steps of sequentially performing the following steps:
S1、称取大枣60kg、焦谷芽40kg，分别将焦谷芽、去核除杂洗净的大枣超微粉碎，过800目筛，分别得到焦谷芽、大枣超微粉；称取亮氨酸1.52kg、异亮氨酸0.68kg、缬氨酸0.54kg、甘氨酸1.30kg、脯氨酸0.40kg、丙氨酸0.75kg、盐酸赖氨酸1.33kg、盐酸精氨酸1.16kg、丝氨酸0.27kg、苏氨酸0.79kg、盐酸组氨酸0.98kg、甲硫氨酸0.42kg、苯丙氨酸1.13kg、色氨酸0.16kg、蔗糖8.47kg、 尼泊金乙酯0.1kg，搅拌混合均匀，制得复合氨基酸粉；S1, take by weighing 60kg of jujube, 40kg of Jiaogu buds, respectively by ultrafine pulverization of Jiaogu buds, the jujubes cleaned by removing the core and removing impurities, cross 800 mesh sieves, obtain respectively Jiaogu buds, jujube ultrafine powder; take by weighing 1.52kg of leucine, Isoleucine 0.68kg, Valine 0.54kg, Glycine 1.30kg, Proline 0.40kg, Alanine 0.75kg, Lysine Hydrochloride 1.33kg, Arginine Hydrochloride 1.16kg, Serine 0.27kg, Threonine 0.79kg, histidine hydrochloride 0.98kg, methionine 0.42kg, phenylalanine 1.13kg, tryptophan 0.16kg, sucrose 8.47kg, ethyl paraben 0.1kg, stir and mix to obtain compound amino acid pink;
S2、将焦谷芽、大枣超微粉混合，加入400kg纯化水，以转速110rpm在80℃温度下搅拌10min，115℃灭菌30min；S2. Mix Jiaogu sprouts and jujube ultrafine powder, add 400kg of purified water, stir at 80°C for 10min at a rotating speed of 110rpm, and sterilize at 115°C for 30min;
S3、冷却至70℃，加入复合氨基酸粉，以转速110rpm保温搅拌20min，冷却至室温，加入480kg水定容，再以转速110rpm搅拌10min，过滤，得到犬用复方氨基酸口服溶液。S3. Cool to 70° C., add compound amino acid powder, keep stirring at 110 rpm for 20 min, cool to room temperature, add 480 kg of water to make the volume, and then stir at 110 rpm for 10 min, and filter to obtain compound amino acid oral solution for dogs.
实施例2～8犬用复方氨基酸口服溶液的制备方法Embodiment 2～8 The preparation method of compound amino acid oral solution for dogs
实施例2～8分别为一种犬用复方氨基酸口服溶液的制备方法，其中制备步骤与实施例1相似，不同之处仅在于：相关参数不同，具体见下表。Embodiments 2 to 8 are respectively a preparation method of compound amino acid oral solution for dogs, wherein the preparation steps are similar to those of embodiment 1, and the difference is only that the relevant parameters are different, as shown in the following table.
Figure PCTCN2020116384-appb-000001
Figure PCTCN2020116384-appb-000001
其中复合氨基酸粉的具体配方见下表：The specific formula of the compound amino acid powder is shown in the following table:
Figure PCTCN2020116384-appb-000002
Figure PCTCN2020116384-appb-000002
实施例9犬用复方氨基酸口服溶液的质量检测Embodiment 9 Quality detection of compound amino acid oral solution for dogs
参照实施例1制备一种犬用复方氨基酸口服溶液作为对比实施例，对比实施例的配方、制备步骤与实施例1相似，不同之处仅在于：所用防腐剂由尼泊金乙酯更换为等质量的苯甲酸钠。A compound amino acid oral solution for dogs is prepared with reference to Example 1 as a comparative example. The formulation and preparation steps of the comparative example are similar to those of Example 1, except that the preservatives used are replaced by ethylparaben, etc. quality sodium benzoate.
参照产品质量标准规定的方法对实施例1～8、对比实施例制备的犬用复方氨基酸口服溶液的质量进行检验，具体情况见下表。The quality of the compound amino acid oral solution for dogs prepared in Examples 1 to 8 and Comparative Example was tested with reference to the method specified in the product quality standard. The specific conditions are shown in the following table.
Figure PCTCN2020116384-appb-000003
Figure PCTCN2020116384-appb-000003
由上表可知，实施例1～8、对比实施例制备的犬用复方氨基酸口服溶液各项检测结果均符合产品质量标准规定，氨基酸含量能够满足犬对氨基酸的营养需求。As can be seen from the above table, the test results of the compound amino acid oral solution for dogs prepared in Examples 1 to 8 and Comparative Example all meet the requirements of the product quality standard, and the amino acid content can meet the nutritional needs of dogs for amino acids.
实施例10犬用复方氨基酸口服溶液的稳定性测试Example 10 Stability test of compound amino acid oral solution for dogs
对实施例1～8、对比实施例制备的犬用复方氨基酸口服溶液进行稳定性考察，具体实施方案如下：The stability of the compound amino acid oral solution for dogs prepared in Examples 1 to 8 and Comparative Example was investigated, and the specific embodiments are as follows:
取实施例1～8、对比实施例制备的犬用复方氨基酸口服溶液，在温度40℃±2℃、相对湿度75％±5％的条件下放置6个月，按产品质量标准进行检验，具体情况见下表。Take the compound amino acid oral solution for dogs prepared in Examples 1 to 8 and Comparative Example, and place it for 6 months under the conditions of a temperature of 40 ° C ± 2 ° C and a relative humidity of 75% ± 5%, and inspected according to product quality standards. See the table below.
Figure PCTCN2020116384-appb-000004
Figure PCTCN2020116384-appb-000004
由上表可知，经6个月的加速试验，实施例1～5、7、8制备的犬用复方氨基酸口服溶液氨基酸含量和微生物限度无显著变化；实施例6、对比实施例制备的犬用复方氨基酸口服溶液氨基酸含量均有所下降，微生物限度需氧菌总数及霉菌和酵母菌总数均显著上升。结果表明，实施例1～5、7、8制备的犬用复方氨基酸口服溶液产品稳定性良好；而实施例6、对比实施例制备的犬用复方氨基酸口服溶液因微生物繁殖吸收氨基酸造成氨基酸含量下降，说明以尼泊金乙酯作为防腐剂的犬用复方氨基酸口服溶液较未添加防腐剂、以苯甲酸钠作为防腐剂的犬用复方氨基酸口服溶液更稳定。As can be seen from the above table, through the accelerated test of 6 months, the amino acid content and microbial limit of the compound amino acid oral solution for dogs prepared in Examples 1 to 5, 7, and 8 have no significant changes; The amino acid content of compound amino acid oral solution decreased, and the total number of microbial limit aerobic bacteria and the total number of mold and yeast increased significantly. The results show that the compound amino acid oral solutions for dogs prepared in Examples 1 to 5, 7, and 8 have good stability; while the compound amino acid oral solutions for dogs prepared in Example 6 and Comparative Example are due to microbial reproduction and absorption of amino acids, resulting in a decrease in amino acid content. , indicating that the compound amino acid oral solution for dogs with ethyl paraben as a preservative is more stable than the compound amino acid oral solution for dogs without preservatives and with sodium benzoate as a preservative.
实施例11犬用复方氨基酸口服溶液的效果测试Example 11 Effect test of compound amino acid oral solution for dogs
选取经临床诊断为蛋白质缺乏症的比格犬135只，随机均分为9组，分别为对照组和试验组1～8，病犬表现为消瘦、被毛粗硬无光泽、体重减轻、食欲不振及精神萎靡，其中对照组病犬口服葡萄糖氯化钠溶液，50mL/次/日，连用7日；实验组1～8病犬分别口服实施例1～8制备的犬用复方氨基酸口服溶液，50mL/次 /日，连用7日。统计并记录病犬的体重及进食量，具体用法用量及试验结果汇总如下表。A total of 135 beagle dogs clinically diagnosed with protein deficiency were selected and randomly divided into 9 groups, namely the control group and the experimental group 1-8. The diseased dogs showed weight loss, rough and dull coat, weight loss, and loss of appetite. and lethargy, wherein the control group of sick dogs orally oral glucose sodium chloride solution, 50mL/time/day, used for 7 days; experimental group 1～8 sick dogs orally orally respectively the dog compound amino acid oral solution prepared by embodiment 1～8, 50mL/time /day, for 7 consecutive days. The body weight and food intake of the sick dogs were counted and recorded, and the specific dosage and test results were summarized in the following table.
Figure PCTCN2020116384-appb-000005
Figure PCTCN2020116384-appb-000005
由上表可知，经过7日的治疗观察，对照组病犬未见进食量增加、体重增长、被毛及精神状态改善，而试验组1～8的病犬进食量均有增加，体重均有增长，被毛及精神状态也均有改善。试验结果表明，本发明的一种犬用复方氨基酸口服溶液在补充氨基酸的同时，具有健胃消食、促进进食的功效，从而达到从外部补充营养物质和促进犬进食、自主摄入营养两个方面出发，改善犬的营养缺乏症状，促进犬痊愈的目的。It can be seen from the above table that after 7 days of treatment and observation, the dogs in the control group did not see an increase in food intake, weight gain, coat and mental state improvement, while the dogs in the experimental groups 1 to 8 all increased their food intake and body weight. Coat and mental state also improved. The test results show that the compound amino acid oral solution for dogs of the present invention has the effects of strengthening the stomach, digesting food, and promoting eating while supplementing amino acids, so as to achieve two aspects of externally supplementing nutrients and promoting dogs to eat and ingest nutrients independently. The purpose is to improve the symptoms of nutritional deficiencies in dogs and promote the recovery of dogs.
需要说明的是，以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照上述实施例对本发明进行了详细的说明，对于本领域技术人员来说，其依然可以对上述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。It should be noted that the above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art can still The technical solutions described in the above embodiments are modified, or some technical features thereof are equivalently replaced. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims (10)

  1. 一种犬用复方氨基酸口服溶液，其特征在于，以1000份重量份计，其原料包括：复合氨基酸粉15～25份、大枣60～80份、焦谷芽40～60份，余量为水。A compound amino acid oral solution for dogs, characterized in that, based on 1000 parts by weight, the raw materials include: 15-25 parts of compound amino acid powder, 60-80 parts of jujube, 40-60 parts of Jiaogu sprouts, and the balance is water.
  2. 根据权利要求1所述的一种犬用复方氨基酸口服溶液，其特征在于，以重量份计，制成所述复合氨基酸粉的原料包括：亮氨酸1～3份、异亮氨酸0.5～1份、缬氨酸0.4～1份、甘氨酸1～2份、脯氨酸0.3～0.5份、丙氨酸0.5～1份、盐酸赖氨酸1～2份、盐酸精氨酸1～2份、丝氨酸0.1～0.3份、苏氨酸0.5～1份、盐酸组氨酸0.5～1份、甲硫氨酸0.3～0.5份、苯丙氨酸1～2份、色氨酸0.1～0.3份。The compound amino acid oral solution for dogs according to claim 1, wherein, in parts by weight, the raw materials for making the compound amino acid powder include: 1-3 parts of leucine, 0.5-3 parts of isoleucine 1 part, 0.4-1 part of valine, 1-2 parts of glycine, 0.3-0.5 part of proline, 0.5-1 part of alanine, 1-2 parts of lysine hydrochloride, 1-2 parts of arginine hydrochloride , 0.1-0.3 parts of serine, 0.5-1 part of threonine, 0.5-1 part of histidine hydrochloride, 0.3-0.5 part of methionine, 1-2 parts of phenylalanine, and 0.1-0.3 part of tryptophan.
  3. 根据权利要求2所述的一种犬用复方氨基酸口服溶液，其特征在于，以1000份重量份计，其原料包括：复合氨基酸粉20份、大枣60份、焦谷芽40份，余量为水。A kind of compound amino acid oral solution for dogs according to claim 2, is characterized in that, in 1000 parts by weight, its raw material comprises: 20 parts of compound amino acid powder, 60 parts of jujube, 40 parts of Jiaogu sprouts, the balance is water .
  4. 根据权利要求3所述的一种犬用复方氨基酸口服溶液，其特征在于，以重量份计，制成所述复合氨基酸粉的原料包括：亮氨酸1.52份、异亮氨酸0.68份、缬氨酸0.54份、甘氨酸1.30份、脯氨酸0.40份、丙氨酸0.75份、盐酸赖氨酸1.33份、盐酸精氨酸1.16份、丝氨酸0.27份、苏氨酸0.79份、盐酸组氨酸0.98份、甲硫氨酸0.42份、苯丙氨酸1.13份、色氨酸0.16份。The compound amino acid oral solution for dogs according to claim 3, wherein, in parts by weight, the raw materials for making the compound amino acid powder include: 1.52 parts of leucine, 0.68 parts of isoleucine, 0.54 parts of amino acid, 1.30 parts of glycine, 0.40 parts of proline, 0.75 parts of alanine, 1.33 parts of lysine hydrochloride, 1.16 parts of arginine hydrochloride, 0.27 parts of serine, 0.79 parts of threonine, 0.98 parts of histidine hydrochloride parts, 0.42 parts of methionine, 1.13 parts of phenylalanine, and 0.16 parts of tryptophan.
  5. 根据权利要求1～4任意一项所述的一种犬用复方氨基酸口服溶液，其特征在于，以重量份计，所述复合氨基酸粉包括尼泊金乙酯0.05～0.15份。The compound amino acid oral solution for dogs according to any one of claims 1 to 4, characterized in that, in parts by weight, the compound amino acid powder comprises 0.05-0.15 parts of ethyl paraben.
  6. 根据权利要求5所述的一种犬用复方氨基酸口服溶液，其特征在于，以重量份计，所述复合氨基酸粉包括尼泊金乙酯0.1份。The compound amino acid oral solution for dogs according to claim 5, wherein, in parts by weight, the compound amino acid powder comprises 0.1 part of ethyl paraben.
  7. 根据权利要求1～4、6任意一项所述的一种犬用复方氨基酸口服溶液，其特征在于，所述水为纯化水。The compound amino acid oral solution for dogs according to any one of claims 1 to 4 and 6, wherein the water is purified water.
  8. 根据权利要求7所述的一种犬用复方氨基酸口服溶液，其特征在于，所述焦谷芽为外购中药饮片。The compound amino acid oral solution for dogs according to claim 7, wherein the Jiaogu sprouts are outsourced Chinese medicine decoction pieces.
  9. 权利要求1～8任一项所述一种犬用复方氨基酸口服溶液的制备方法，包括依次进行以下步骤：The preparation method of a compound amino acid oral solution for dogs according to any one of claims 1 to 8, comprising the steps of successively performing the following steps:
    S1、粉碎焦谷芽及去核除杂洗净的大枣；混合制备复合氨基酸粉；S1, pulverize coke sprouts and jujubes that have been pitted and cleaned; mixed to prepare compound amino acid powder;
    S2、混合焦谷芽、大枣微粉，溶解，灭菌；S2. Mix coke sprouts and jujube powder, dissolve and sterilize;
    S3、加入复合氨基酸粉，定容，搅拌，过滤得到犬用复方氨基酸口服溶液。S3, adding compound amino acid powder, constant volume, stirring, and filtering to obtain compound amino acid oral solution for dogs.
  10. 根据权利要求9所述的一种犬用复方氨基酸口服溶液的制备方法，其特征在于，A kind of preparation method of compound amino acid oral solution for dogs according to claim 9, is characterized in that,
    所述步骤S1包括：分别将焦谷芽、去核除杂洗净的大枣超微粉碎，过300～800目筛，分别得到焦谷芽、大枣微粉；将亮氨酸、异亮氨酸、缬氨酸、甘氨酸、脯氨酸、丙氨酸、盐酸赖氨酸、盐酸精氨酸、丝氨酸、苏氨酸、盐酸组氨酸、甲硫氨酸、苯丙氨酸、色氨酸、尼泊金乙酯混合均匀，制得复合氨基酸粉；The step S1 includes: superfinely pulverizing the Jiaogu sprouts and the jujubes cleaned by removing the cores and impurities, and passing through a 300-800 mesh sieve to obtain the Jiaogu sprouts and jujube micropowders respectively; Acid, Glycine, Proline, Alanine, Lysine Hydrochloride, Arginine Hydrochloride, Serine, Threonine, Histidine Hydrochloride, Methionine, Phenylalanine, Tryptophan, Paraben Ethyl ester is mixed evenly to obtain compound amino acid powder;
    所述步骤S2包括：将焦谷芽、大枣超微粉混合，加入重量份数为焦谷芽、大枣超微粉总重量份数2～4倍的水，以转速100～500rpm在80～90℃温度下搅拌5～10min，于115℃灭菌30min；The step S2 includes: mixing Jiaogu sprouts and jujube ultrafine powder, adding water whose weight portion is 2 to 4 times the total weight of Jiaogu sprouts and jujube ultrafine powder, and stirring at a temperature of 80 to 90°C at a rotating speed of 100 to 500 rpm. 5～10min, sterilize at 115℃ for 30min;
    所述步骤S3包括：冷却至60～70℃，加入复合氨基酸粉，以转速100～500rpm保温搅拌10～20min；冷却至室温，加余量水定容，再以转速100～500rpm搅拌5～10min，过滤得到犬用复方氨基酸口服溶液。The step S3 includes: cooling to 60-70° C., adding compound amino acid powder, stirring at a speed of 100-500 rpm for 10-20 min; cooling to room temperature, adding the remaining amount of water to make the volume, and stirring at a speed of 100-500 rpm for 5-10 min , and filtered to obtain compound amino acid oral solution for dogs.
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