CN112121064A - Chinese medicinal preparation for treating epilepsy and preparation method thereof - Google Patents
Chinese medicinal preparation for treating epilepsy and preparation method thereof Download PDFInfo
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- CN112121064A CN112121064A CN202011168531.3A CN202011168531A CN112121064A CN 112121064 A CN112121064 A CN 112121064A CN 202011168531 A CN202011168531 A CN 202011168531A CN 112121064 A CN112121064 A CN 112121064A
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Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating epilepsy and a preparation method thereof, wherein the traditional Chinese medicine preparation for treating epilepsy comprises the following traditional Chinese medicine components in parts by weight, namely amber, antelope horn, bezoar and menthol; the amber of the invention has the effects of relieving convulsion, soothing the nerves, dissipating blood stasis, stopping bleeding, promoting diuresis, treating stranguria, treating infantile convulsion, epilepsy, palpitation and insomnia; the cornu Saigae Tataricae has effects of suppressing hyperactive liver, calming endogenous wind, removing liver fire, improving eyesight, dispelling blood stasis, and removing toxic substance; the artificial bezoar has the effects of clearing away heart-fire, eliminating phlegm, inducing resuscitation, cooling liver, calming endogenous wind, clearing away heat and toxic materials, eliminating phlegm and arresting convulsion; the Mentholum has effects of exciting nerve and refreshing brain; the traditional Chinese medicine preparation has the effects of calming liver wind, relieving spasm and arresting epilepsy by combining all the medicines, treats the symptoms of epilepsy in case of emergency, can eliminate phlegm and dampness, cool lung and clear liver, takes the root into consideration, and has obvious effect of treating epilepsy with excessive phlegm-fire and excessive liver-fire. The composition is prepared by mixing Succinum, cornu Saigae Tataricae, artificial bezoar, and Mentholum, grinding, and adding water; the food is convenient and quick to eat.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating epilepsy and a preparation method thereof.
Background
Epilepsy, commonly known as epilepsy, is a chronic disease of transient cerebral dysfunction caused by paroxysmal abnormal discharge of cerebral neurons; according to the latest epidemiological data in China, epilepsy has become the second most common disease of the neurology department, which is second to headache.
At present, the treatment of epilepsy at home and abroad mainly takes drug therapy as main treatment; most epileptics, who are treated with regular antiepileptic drugs, have seizures that can be controlled in about 70% of patients, but have seizures that cannot be controlled well in 20-30% of subjects, becoming refractory epilepsy; when the western medicine is applied to resist epilepsy, how to further improve the treatment effective rate is still a serious clinical problem; epilepsy is called epilepsy syndrome in traditional Chinese medicine, and a plurality of single medicines and empirical prescriptions with effect are screened out through a large number of clinical practices; the traditional Chinese medicine is combined with western medicine for treatment, so that the treatment effect is improved, and the tolerance is good; the causes of epilepsy are complex, most of the epilepsy is phlegm-damp constitution, and liver fire is excessive; or thick flavor of the paste and the girder after overeating, phlegm dampness coming internally; phlegm-dampness obstructing the interior, transforming into heat, phlegm heat being in the middle, phlegm being in earth, and phlegm heat causing the liver wood to be restrained, and liver being excited to be acute, so tetany is seen; the liver governs tendons and is acute with the symptoms of strong and straight neck and back; phlegm-heat clouding the eyes and causing coma; restlessness due to phlegm-heat disturbing the heart; the key points of the pathogenesis of the syndrome are that phlegm-heat is blocked internally to cause liver wind; for it is good at dispelling wind and relieving spasm, clearing heat and resolving phlegm.
Most of the existing epilepsy preparations have complex formula and complex preparation process; therefore, how to overcome the above technical problems and disadvantages is a problem to be solved.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides the traditional Chinese medicine preparation for treating the epilepsy and the preparation method thereof, wherein the traditional Chinese medicine preparation has the advantages of simple formula, simple preparation and good treatment effect.
In order to achieve the purpose, the technical scheme of the invention is as follows: a traditional Chinese medicine preparation for treating epilepsy comprises, by weight, 5-15g of amber, 0.5-1.5g of antelope horn, 0.2-0.8g of bezoar and 0.1-0.5g of menthol.
Furthermore, the traditional Chinese medicine preparation for treating epilepsy comprises the following traditional Chinese medicine components, by weight, 8-12g of amber, 0.8-1.2g of antelope horn, 0.4-0.6g of bezoar and 0.1-0.3g of menthol.
Furthermore, the traditional Chinese medicine preparation for treating epilepsy comprises the following traditional Chinese medicine components, by weight, 10g of amber, 1g of antelope horn, 0.5g of bezoar and 0.2g of menthol.
Further, the bezoar is an artificial bezoar.
Further, the preparation method of the traditional Chinese medicine preparation for treating epilepsy comprises the following steps:
(1) selecting and removing impurities: selecting and removing surface impurities of the raw materials;
(2) soaking and cleaning: putting the selected raw materials into a stainless steel container, and cleaning for 15-20 minutes by using an ultrasonic medicine washing machine to ensure that the surfaces of the raw materials are cleaned;
(3) and (3) drying: drying the cleaned raw materials in a low-temperature drying oven for 4-6 hours at 60-80 deg.C, standing at normal temperature, and taking out;
(4) weighing: weighing the dried raw materials according to the proportion of any one of claims 1 to 3;
(5) grinding: and (4) uniformly mixing the raw materials weighed in the step (4), crushing into medicinal powder, and sieving the medicinal powder with a 100-mesh sieve.
Compared with the prior art, the traditional Chinese medicine preparation for treating epilepsy has the beneficial effects that: amber, sweet and neutral, enters heart, liver and small intestine meridians; mainly calm the five internal organs, calm soul, eliminate blood stasis and dredge five stranguria, has the effects of relieving convulsion and soothing the nerves, dissipating blood stasis and stopping bleeding, inducing diuresis and freeing strangury, treating infantile convulsion and epilepsy, palpitation and insomnia, and is a monarch drug; the antelope horn is salty in taste and cold in nature, and enters liver and heart meridians; has effects in calming liver, stopping endogenous wind, removing liver heat, improving eyesight, dispelling blood stasis, and removing toxic substances; the antelope horn strengthens the treatment effect of the monarch drug and is a ministerial drug; the artificial bezoar has the efficacies of clearing away heart-fire, eliminating phlegm, inducing resuscitation, cooling liver, calming endogenous wind, clearing away heat and toxic materials, resolving phlegm and arresting convulsion, and is an adjuvant drug; the mint ice is pungent and cool, belongs to a medicine for stimulating and dredging orifices, has the functions of exciting nerves and refreshing, and is used as a messenger medicine; the traditional Chinese medicine preparation has the effects of calming liver wind, relieving spasm and arresting epilepsy by combining all the medicines, treats the symptoms of epilepsy in case of emergency, can eliminate phlegm and dampness, cool lung and clear liver, takes the root into consideration, and has obvious effect of treating epilepsy with excessive phlegm-fire and excessive liver-fire. The composition is prepared by mixing Succinum, cornu Saigae Tataricae, artificial bezoar, and Mentholum, grinding, and adding water; the eating is convenient and quick; meanwhile, the medicine has better use safety, adverse reactions and evaluation made by contraindication than the medicine sold in the market.
Detailed Description
The Chinese medicinal preparation for treating epilepsy of the present invention is described in more detail by the following specific embodiments, but the scope of the present invention should not be limited thereby.
Example 1
The embodiment provides a traditional Chinese medicine preparation for treating epilepsy and a preparation method thereof.
The traditional Chinese medicine preparation for treating epilepsy comprises the following traditional Chinese medicine components, by weight, 5g of amber, 0.5g of antelope horn, 0.2g of bezoar and 0.1g of menthol.
The preparation method of the traditional Chinese medicine preparation for treating epilepsy comprises the following steps:
weighing the raw materials, selecting and removing surface impurities; putting the selected raw materials into a stainless steel container, and cleaning for 15 minutes by using an ultrasonic medicine washing machine to ensure that the surfaces of the raw materials are cleaned; drying the cleaned raw materials in a low-temperature drying oven for 4 hours at 80 ℃, standing at normal temperature, and taking out; mixing the dried raw materials uniformly, pulverizing into medicinal powder, and sieving with 100 mesh sieve.
Example 2
The embodiment provides a traditional Chinese medicine preparation for treating epilepsy and a preparation method thereof.
The traditional Chinese medicine preparation for treating epilepsy comprises the following traditional Chinese medicine components, by weight, 15g of amber, 1.5g of antelope horn, 0.8g of bezoar and 0.5g of menthol.
The preparation method of the traditional Chinese medicine preparation for treating epilepsy comprises the following steps:
weighing the raw materials, selecting and removing surface impurities; putting the selected raw materials into a stainless steel container, and cleaning for 20 minutes by using an ultrasonic medicine washing machine to ensure that the surfaces of the raw materials are cleaned; drying the cleaned raw materials in a low-temperature drying oven for 6 hours at 60 deg.C, standing at normal temperature, and taking out; mixing the dried raw materials uniformly, pulverizing into medicinal powder, and sieving with 100 mesh sieve.
Example 3
The embodiment provides a traditional Chinese medicine preparation for treating epilepsy and a preparation method thereof.
The traditional Chinese medicine preparation for treating epilepsy comprises the following traditional Chinese medicine components, by weight, 10g of amber, 1g of antelope horn, 0.5g of bezoar and 0.2g of menthol.
The preparation method of the traditional Chinese medicine preparation for treating epilepsy comprises the following steps:
weighing the raw materials, selecting and removing surface impurities; putting the selected raw materials into a stainless steel container, and cleaning for 18 minutes by using an ultrasonic medicine washing machine to ensure that the surfaces of the raw materials are cleaned; drying the cleaned raw materials in a low-temperature drying oven for 5 hours at 70 deg.C, standing at normal temperature, and taking out; mixing the dried raw materials uniformly, pulverizing into medicinal powder, and sieving with 100 mesh sieve.
First, clinical data
The test method comprises the following steps: randomized, positive drug control clinical study.
Safety evaluation index: general physical examination, blood, urine and stool routine, liver and kidney functions, electrocardiogram, adverse reaction and the like.
The number of cases: 95 cases of the treatment group and 95 cases of the control group, and 190 cases in total; of 190 patients, 100 men and 90 women have an age distribution of 2-65 years, the average age is 42.6 years, 60 men and 60 women with the age above 40 years have a disease course of 3 months to 8 years, and the traditional Chinese medicine distinguishes syndrome. The medicine is evenly distributed in a treatment group and a control group according to age groups and sexes.
Second, test the medicine
Table 1: test drug and reference drug instruction sheet
Table 2: therapeutic effect observation index instruction table
Table 3: score standard basis table
Third, the therapeutic effect
Table 4: results of treatment
The treatment effect data show that the traditional Chinese medicine composition has a good treatment effect on people over 40 years old, and the middle-aged and old people have a large proportion of phlegm-dampness constitution in China.
On the whole, compared with the medicines in the prior art, the traditional Chinese medicine preparation has obviously better effect than the medicines in the prior art.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. The traditional Chinese medicine preparation for treating epilepsy is characterized by comprising the following traditional Chinese medicine components, by weight, 5-15g of amber, 0.5-1.5g of antelope horn, 0.2-0.8g of bezoar and 0.1-0.5g of menthol.
2. The Chinese medicinal preparation for treating epilepsy of claim 1, wherein: the traditional Chinese medicine preparation for treating epilepsy comprises, by weight, 8-12g of amber, 0.8-1.2g of antelope horn, 0.4-0.6g of bezoar and 0.1-0.3g of menthol.
3. The Chinese medicinal preparation for treating epilepsy of claim 1, wherein: the traditional Chinese medicine preparation for treating epilepsy comprises the following traditional Chinese medicine components, by weight, 10g of amber, 1g of antelope horn, 0.5g of bezoar and 0.2g of menthol.
4. The Chinese medicinal preparation for treating epilepsy according to any one of claims 1 to 3, wherein: the calculus bovis is artificial calculus bovis.
5. A process for preparing a Chinese medicinal preparation for the treatment of epilepsy as claimed in any one of claims 1 to 3, wherein: the method comprises the following steps:
(1) selecting and removing impurities: selecting and removing surface impurities of the raw materials;
(2) soaking and cleaning: putting the selected raw materials into a stainless steel container, and cleaning for 15-20 minutes by using an ultrasonic medicine washing machine to ensure that the surfaces of the raw materials are cleaned;
(3) and (3) drying: drying the cleaned raw materials in a low-temperature drying oven for 4-6 hours at 60-80 deg.C, standing at normal temperature, and taking out;
(4) weighing: weighing the dried raw materials according to the proportion of any one of claims 1 to 3;
(5) grinding: and (4) uniformly mixing the raw materials weighed in the step (4), crushing into medicinal powder, and sieving the medicinal powder with a 100-mesh sieve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011168531.3A CN112121064A (en) | 2020-10-28 | 2020-10-28 | Chinese medicinal preparation for treating epilepsy and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011168531.3A CN112121064A (en) | 2020-10-28 | 2020-10-28 | Chinese medicinal preparation for treating epilepsy and preparation method thereof |
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| CN112121064A true CN112121064A (en) | 2020-12-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202011168531.3A Pending CN112121064A (en) | 2020-10-28 | 2020-10-28 | Chinese medicinal preparation for treating epilepsy and preparation method thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356136A (en) * | 2001-12-03 | 2002-07-03 | 鲁坪 | Chinese medicine for treating epilepsy |
| CN1491687A (en) * | 2003-08-22 | 2004-04-28 | 孙元林 | Medicine for treating epilepsy |
| CN1615949A (en) * | 2004-09-16 | 2005-05-18 | 唐玉厚 | Medicine for treating epilepsia |
| CN1954876A (en) * | 2006-10-11 | 2007-05-02 | 刘光跃 | Traditional Chinese medicine for treating epilepsy disease |
| CN103381223A (en) * | 2012-05-01 | 2013-11-06 | 刘宝环 | Medicament for treating epilepsy |
| CN105770373A (en) * | 2016-03-18 | 2016-07-20 | 雷允上药业有限公司 | Traditional Chinese medicine composition for treating pediatric febrile convulsion and preparation method and application of traditional Chinese medicine composition for treating pediatric febrile convulsion |
| CN106138805A (en) * | 2016-07-15 | 2016-11-23 | 刘福坤 | A kind of method utilizing five kinds of skill of handling needles to coordinate treatment by Chinese herbs epileptics |
-
2020
- 2020-10-28 CN CN202011168531.3A patent/CN112121064A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356136A (en) * | 2001-12-03 | 2002-07-03 | 鲁坪 | Chinese medicine for treating epilepsy |
| CN1491687A (en) * | 2003-08-22 | 2004-04-28 | 孙元林 | Medicine for treating epilepsy |
| CN1615949A (en) * | 2004-09-16 | 2005-05-18 | 唐玉厚 | Medicine for treating epilepsia |
| CN1954876A (en) * | 2006-10-11 | 2007-05-02 | 刘光跃 | Traditional Chinese medicine for treating epilepsy disease |
| CN103381223A (en) * | 2012-05-01 | 2013-11-06 | 刘宝环 | Medicament for treating epilepsy |
| CN105770373A (en) * | 2016-03-18 | 2016-07-20 | 雷允上药业有限公司 | Traditional Chinese medicine composition for treating pediatric febrile convulsion and preparation method and application of traditional Chinese medicine composition for treating pediatric febrile convulsion |
| CN106138805A (en) * | 2016-07-15 | 2016-11-23 | 刘福坤 | A kind of method utilizing five kinds of skill of handling needles to coordinate treatment by Chinese herbs epileptics |
Non-Patent Citations (3)
| Title |
|---|
| 张龙霏等: "羚羊角药理研究概况", 《中国医药导报》 * |
| 陈敏等: "南星琥珀散治疗癫痫9例报告", 《河南诊断与治疗杂志》 * |
| 韦运兴等: "琥珀散治疗癫痫13例", 《河南中医》 * |
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Application publication date: 20201225 |
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