CN106110167A - One treats lipomatous Chinese medicine composition and preparation method thereof - Google Patents
One treats lipomatous Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention provides one and treat lipomatous Chinese medicine composition, the primary raw material weight portion preparing described Chinese medicine composition consists of: Radix Bupleuri, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Radix Glycyrrhizae, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae, Semen Sinapis Albae, Vascular aurantii, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Retinervus Luffae Fructus, Arisaema Cum Bile, Fructus Amomi；The invention provides a kind of preparation method treating lipomatous Chinese medicine composition.This Traditional Chinese medicine composition formula is scientific and reasonable, each component works in coordination with compatibility, energy fast onset drug effect, has effect of dispersing the stagnated live-QI to relieve the stagnation of QI, eleminating phlegm and freeing channels, drastically removing blood stasis and resolving static blood, prove through lot of experiments, the present invention can activating human body dysfunction, evident in efficacy to lipoma, and curative effect is excellent, giving consideration to both the incidental and fundamental, curative effect certainly, safe ready and having no side effect, there is no any Western medicine or hormone drug composition.
Description
Technical field
The present invention relates to technical field of Chinese medicines, treat lipomatous Chinese medicine composition and preparation side thereof particularly to one
Method.
Background technology
Lipoma is a kind of benign tumor formed by the ripe fatty tissue of hypertrophy.It is more common in the adult in 40-50 year.
Tumor body constitution ground is soft, circular or lobulated, located subcutaneously, can promote；Tumorous size, little is as big, with the hands side of touching in Fructus Jujubae
Energy stereognosis, big swelled surface, but surface skin is normal.Tumor single-shot or multiple, sees any position of body surface, to take on,
The back of the body, abdominal part are common.Many no conscious symptons.Angiolipoma is the lipoma of a specific type, the most common with youngster, good
Send out in lower limb, can conscious pain, touch also have tenderness.
Lipomatous clinical manifestation: lipoma can occur at health with the presence of any position of fatty tissue, the best
Send out in subcutaneous, most common with extremity and abdominal part.Tumor is the most multiple, and minority is single-shot, its clear border, and quality is tough, in leaflet
Shape.With around without adhesion, promote subcutaneous.Owing to there being fiber band to be connected between tumor with skin, when promoting lump, skin
Orange peel can be had to change.Except the swollen beyond the region of objective existence in local, usual no conscious sympton or mild pain, do not cause dysfunction.Allowance for bark lower outside,
Lipoma such as may also occur in after intermuscular septum, muscle deep layer and peritoneum at the position.Subcutaneous fat tumor generally has weak fibrous capsule, and
Deep lipoma is then without peplos, in pseudopodium shape to surrounding tissue infiltration growth.Histological examination is shown: pathological changes peplos is complete, mainly
It is made up of ripe adipose cell.Tumor not only local, in hypodermic layer, and is developed in fascia, between flesh and between muscle layer, and just
Often tissue interface is unclear, in infiltrative growth.Can there be isolatism lipoma and lipomatosis two class.The former is flat or divides
Lobate, matter is soft, clear-cut subcutaneous limit office property swells thing.Matter is soft, can promote, and surface skin is normal, and single-shot infringement occurs late, to send out
Exhibition is slow.The swollen thing of excision is respond well.Betide deep tissue such as peritoneum the latter can cancerate as liposarcoma.Lipomatosis
Family is had to be inclined to.Also known as familial lipoma, swollen thing is little, and the most hundreds of of number, often subcutaneous.
There is a lipomatous multi-medicament for the treatment of though existing, but mostly there is weak curative effect, slow, its curative effect that takes effect unsatisfactory,；
And raw materials used medicine composition drug effect is single in external used medicine prepared by Chinese medicine, crude drug kind is more, some raw material of Chinese medicine medicines with
There is not synergism in other crude drug, have impact on the overall curative effect of Chinese medicine composition.Additionally, existing Chinese medicine composition is many
Number is raw materials used direct pulverizing to be used as medicine, and does not carry out the active component in raw material extracting separation, and non-active ingredients does not has
Removing, impurity is more, and the prescription making Chinese medicine composition is excessive, is unfavorable for that patient takes, and affects the treatment of Chinese medicine composition further
Effect.
Summary of the invention
For above-mentioned problems of the prior art and defect, the invention provides one and treat lipomatous Chinese drug-treated group
Compound and preparation method thereof, said composition is evident in efficacy, safe ready and having no side effect, and its preparation method is efficient, and extraction has
Effect composition is effective, is suitable for commercial production.
The concrete technical scheme of the present invention is as follows:
The lipomatous Chinese medicine composition for the treatment of of the present invention, prepares the primary raw material weight portion composition of described Chinese medicine composition
For: Radix Bupleuri 4-30 part, Pericarpium Citri Reticulatae 2-25 part, Rhizoma Pinelliae 2-25 part, Poria 5-40 part, Radix Glycyrrhizae 1-20 part, Pericarpium Citri Reticulatae Viride 4-30 part, Fructus Gardeniae 2-25
Part, Semen Sinapis Albae 2-25 part, Vascular aurantii 2-25 part, Fructus Hordei Germinatus 5-40 part, raw Fructus Setariae Germinatus 5-40 part, Retinervus Luffae Fructus 4-30 part, Arisaema Cum Bile 1-19
Part, Fructus Amomi 1-20 part.
Preferably, the primary raw material weight portion preparing described Chinese medicine composition consists of: Radix Bupleuri 10-25 part, Pericarpium Citri Reticulatae 8-20
Part, Rhizoma Pinelliae 8-20 part, Poria 10-30 part, Radix Glycyrrhizae 5-15 part, Pericarpium Citri Reticulatae Viride 10-25 part, Fructus Gardeniae 8-20 part, Semen Sinapis Albae 8-20 part, Vascular aurantii
8-20 part, Fructus Hordei Germinatus 10-30 part, raw Fructus Setariae Germinatus 10-30 part, Retinervus Luffae Fructus 10-25 part, Arisaema Cum Bile 5-14 part, Fructus Amomi 5-15 part.
Preferably, the primary raw material weight portion preparing described Chinese medicine composition consists of: Radix Bupleuri 15 parts, Pericarpium Citri Reticulatae 12 parts, half
Summer 12 parts, 20 parts of Poria, 10 parts of Radix Glycyrrhizae, 15 parts of Pericarpium Citri Reticulatae Viride, Fructus Gardeniae 12 parts, Semen Sinapis Albae 12 parts, Vascular aurantii 12 parts, Fructus Hordei Germinatus 20 parts, life
Fructus Setariae Germinatus 20 parts, Retinervus Luffae Fructus 15 parts, Arisaema Cum Bile 9 parts, Fructus Amomi 10 parts.
The weight of composition described above crude drug calculates with crude drug, using weight portion as proportioning, when producing can according to than
Example increases or reduces, as large-scale production can by kilogram in units of, or in units of ton, small-scale production can also with gram or
Milligram is unit, and weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.More than and
The ratio of weight proportion obtains through science screening, can adjust the proportioning of the amount of composition accordingly, be increased or decreased and do not surpass
Crossing 100%, drug effect is constant.
The treatment lipomatous Chinese medicine composition scientific formula of the present invention is reasonable, and its crude drug source is as follows:
Radix Bupleuri: for umbelliferae bupleurum or the dry root of Radix Bupeuri Scorzonerfolii., different by character, practise respectively title " Radix Bupleuri " and
" Radix Bupleuri Scorzonerifolii ", excavates in spring, season in autumn two, removes stem and leaf and silt, is dried.Hardship, is slightly cold, and returns liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, rise
Sun, for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official prolapses, proctoptosis.
Pericarpium Citri Reticulatae: for rutaceae orange and the dry mature skin of variety thereof, medical material is divided into " Pericarpium Citri Reticulatae " and " the oldest
Skin ", harvesting ripe fruit, strip peel, dry or cold drying.Bitter, pungent, temperature, return lung, spleen channel.Regulating qi-flowing for strengthening spleen, dampness
Expectorant, for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
The Rhizoma Pinelliae: for the dry tuber of the aroid Rhizoma Pinelliae, excavate in summer, season in autumn two, cleans, and removes crust and fibrous root,
Dry.Pungent, warm, poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For damp-phlegm cold-phlegm, cough with asthma expectorant
Many, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus；External treatment carbuncle sucutaneous nodule.
Poria:
Radix Glycyrrhizae: for glycyrrhizic legume, Glycyrrhiza inflata Bat.. or Glycyrrhiza glabra L. be dried, spring, season in autumn two excavate, remove fibrous root,
Dry.Sweet, flat, GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, it is used for
Weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity,
Strong.
Pericarpium Citri Reticulatae Viride: for rutaceae orange and the dry young fruit of variety thereof or the peel of immature fruit, 5～receive June
Collection, from the young fruit fallen, dries, and practises and claims " FTUCTUS CITRI IMMATURI " or " Pericarpium Citri Reticulatae Viride "；7～green fruit of gathering August, vertical profile on peel
Become pintongs to base portion, eliminate flesh lobe, dry, practise and claim " Sihuaqingpi ".Bitter, pungent, temperature, return liver, gallbladder, stomach warp.Soothing the liver dispelling the stagnated QI, removing food stagnancy
Change stagnant, for distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.
Fructus Gardeniae: for the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae, its root also can be used as medicine, 9～fruit maturation in November be red
Gather during yellow, remove carpopodium and impurity, steam supreme vapour or put in boiling water boiling the hottest, take out, be dried.Gen Xiaqiu excavates, and cleans and shines
Dry.Hardship, cold, GUIXIN, lung, tri-jiao channel.Pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, vexed for calentura, jaundice dark coloured urine, stranguria with blood
Puckery pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles；External treatment bruise pain, eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis, it is used for
Infectious hepatitis, traumatic injury, acute toothache.
Semen Sinapis Albae: for crucifer Caulis et Folium Sinapis albee, tap plant during fruit maturation at the beginning of autumn late summer.Pungent, temperature, return lung meridian.Temperature
Lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving, breath with cough for cold-phlegm, distending pain in the chest and hypochondrium, the stagnant meridians of expectorant, joint numbness, pain, phlegm-damp stream
Note, carbuncle of yin nature toxic swelling
Vascular aurantii: for the grain in the peel of rutaceae orange, torn by peel, dry.Sweet, bitter, put down, return liver, kidney,
Spleen, stomach warp.Relieve internal heat anticancer, activating QI to eliminate phlegm.
Fructus Hordei Germinatus: the mature fruit for grass Fructus Hordei Vulgaris is dried through germinateing and obtains, and after being soaked in water by wheat grain, keeps
Suitable epidemic disaster, when plumelet length to about 0.5cm, dries or cold drying.Sweet, flat, return spleen, stomach warp.Invigorating the spleen and regulating the stomach, soothing the liver
Circulation of qi promoting, for insufficiency of the spleen lack of appetite, milk smoulders.
Raw Fructus Setariae Germinatus: the mature fruit for grass foxtail millet is dried through germinateing and obtains, and after being soaked in water by foxtail millet paddy, keeps suitable
Suitable epidemic disaster, when fibrous root length to about 6mm, dries or cold drying.Sweet, temperature, return spleen, stomach warp.Help digestion and in, spleen invigorating is opened
Stomach, does not disappears for food stagnation, abdominal distention halitosis, weakness of the spleen and stomach, the most hungry lack of appetite, and Fructus Setariae Germinatus (parched) relatively helps digestion, for the most hungry lack of appetite, Fructus Setariae Germinatus (parched to brown)
Kindization stagnates, and does not disappears for stagnant.
Retinervus Luffae Fructus: for the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae, summer, season in autumn two fruit maturation, peel
Turn yellow, inside is plucked time withered, removes crust and sarcocarp, cleans, dry, removing seed.Sweet, flat, return lung, stomach, Liver Channel.Logical
Network, invigorates blood circulation, and dispels the wind, for arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.
Arisaema Cum Bile: this product is that the fine powder of Rhizoma Arisaematis (processed) processes from strand with cattle, sheep or Fel Sus domestica, or is Arisaema Cum Bile fine powder
Fermented with cattle, sheep or Fel Sus domestica process.Bitter, pungent, cool, return lung, liver, spleen channel.Removing heat-phlegm, dispelling wind and relieving convulsion, for expectorant
Heat cough, coughs up phlegm yellow thick, middle wind-phlegm fan, demented infantile convulsion.
Fructus Amomi: for the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA, between summer, autumn during fruit maturation
Gather, dry or cold drying.Pungent, temperature, return spleen, stomach, kidney channel.Removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive, in turbid damp
Resistance, gastral cavity painful abdominal mass is the most hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
As a further improvement on the present invention, the invention provides one and treat lipomatous preparation, described preparation by
Drug composition is separately made or is formed by with Chinese medicine composition and pharmaceutically acceptable carrier.
Further, described preparation is oral formulations or external preparation, described oral formulations be water extract, tablet, pill,
Water-honeyed pill, concentrated pill, powder, capsule, oral liquid, granule or health tea oral formulations；Described external preparation is stifling
Agent, lotion or unguentum.
Further, described external preparation is capsule, and described capsule includes that ratio of weight and number is 1:1-3 Chinese medicine composition
Thing and adjuvant.
Further, lactose 10-20 part, sodium lauryl sulphate 5-15 part, sucrose monolaurate fat 4-8 part, carboxymethyl
Starch Sodium 3-7 part, microcrystalline silicon 12-18 part, magnesium stearate 5-10 part, eucalyptol 2-6 part.
Further, described capsule filling includes the composition of following parts by weight: Chinese medicine composition 30 parts, lactose 15
Part, sodium lauryl sulphate 10 parts, 6 parts of sucrose monolaurate fat, carboxymethyl starch sodium 5 parts, microcrystalline silicon 14 parts, magnesium stearate
6 parts, eucalyptol 4 parts.
As a further improvement on the present invention, present invention also offers a kind of preparation treating lipomatous Chinese medicine composition
Method, the method comprises the steps:
S1, weigh the Radix Bupleuri of recipe quantity, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Radix Glycyrrhizae, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae 7 taste crude drug, pulverize, mill,
Sieving and make fine powder, the number of described screen cloth is 100-140 mesh, boiling 2 times, and 12 times of water yields decoct 2.5h for the first time, the
8 times of water yields of secondary decoct 1.5h, merge to obtain decocting liquid, are condensed into the clear paste 1 that relative density is 1.25 under the conditions of temperature 45 C, cold
But, the ethanol adding 75% carries out precipitate with ethanol 3h, filters, is condensed into the dry extract 1 that relative density is 1.45 at 50 DEG C；
S2, weigh the Semen Sinapis Albae of recipe quantity, Vascular aurantii, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Retinervus Luffae Fructus, Arisaema Cum Bile, Fructus Amomi 7 taste crude drug,
Pulverizing, mill, sieve and make fine powder, the number of described screen cloth is 50-90 mesh, after stirring, adds 10 times of 75% ethanol
Reflux, extract, 2 times, each 2h, filter, merge back into flow liquid, be concentrated into the clear paste 2 that relative density at 60 DEG C is 1.15, with 5
Clear paste is dissolved by times water yield, upper macroporous resin column, successively with water and the ethanol elution of 40%, reclaims ethanol elution, at 50 DEG C
Under be concentrated into the dry extract 2 that relative density is 1.33；
S3, merging dry extract 1 and dry extract 2, be ground into powder, is subsequently placed in mixing 1h in trough type mixing machine, to obtain final product
Treat lipomatous Chinese medicine composition.
As a further improvement on the present invention, the invention allows for treating lipomatous Chinese medicine composition as treatment fat
The application of fat tumor.
As can be seen here, the lipomatous Chinese medicine composition for the treatment of that the present invention provides, this Traditional Chinese medicine composition formula is scientific and reasonable,
Each component works in coordination with compatibility, energy fast onset drug effect, has effect of dispersing the stagnated live-QI to relieve the stagnation of QI, eleminating phlegm and freeing channels, drastically removing blood stasis and resolving static blood, through lot of experiments
Prove, the present invention can activating human body dysfunction, evident in efficacy to lipoma, and curative effect is excellent, giving consideration to both the incidental and fundamental, curative effect is agree
Fixed, safe ready and having no side effect, there is no any Western medicine or hormone drug composition.
Detailed description of the invention
Below in conjunction with specific embodiment further describe the present invention, advantages of the present invention and feature will be with describe and
Apparent.It should be understood that described embodiment is only exemplary, the scope of the present invention is not constituted any restriction.This area
Skilled artisans appreciated that, lower without departing from the spirit and scope of the present invention can to the details of technical solution of the present invention and
Form is modified or replaces, but these amendments or replacement each fall within protection scope of the present invention.
Embodiment 1:
The present embodiment provides one to treat lipomatous Chinese medicine composition, and this Chinese medicine composition includes following weight grams
Raw material:
Radix Bupleuri 15g, Pericarpium Citri Reticulatae 12g, Rhizoma Pinelliae 12g, Poria 20g, Radix Glycyrrhizae 10g, Pericarpium Citri Reticulatae Viride 15g, Fructus Gardeniae 12g, Semen Sinapis Albae 12g, Fructus Citri tangerinae
Network 12g, Fructus Hordei Germinatus 20g, raw Fructus Setariae Germinatus 20g, Retinervus Luffae Fructus 15g, Arisaema Cum Bile 9g, Fructus Amomi 10g.
The present embodiment additionally provides a kind of preparation method treating lipomatous Chinese medicine composition, comprises the steps:
S1, weigh the Radix Bupleuri of recipe quantity, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Radix Glycyrrhizae, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae 7 taste crude drug, pulverize, mill,
Sieving and make fine powder, the number of described screen cloth is 100-140 mesh, boiling 2 times, and 12 times of water yields decoct 2.5h for the first time, the
8 times of water yields of secondary decoct 1.5h, merge to obtain decocting liquid, are condensed into the clear paste 1 that relative density is 1.25 under the conditions of temperature 45 C, cold
But, the ethanol adding 75% carries out precipitate with ethanol 3h, filters, is condensed into the dry extract 1 that relative density is 1.45 at 50 DEG C；
S2, weigh the Semen Sinapis Albae of recipe quantity, Vascular aurantii, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Retinervus Luffae Fructus, Arisaema Cum Bile, Fructus Amomi 7 taste crude drug,
Pulverizing, mill, sieve and make fine powder, the number of described screen cloth is 50-90 mesh, after stirring, adds 10 times of 75% ethanol
Reflux, extract, 2 times, each 2h, filter, merge back into flow liquid, be concentrated into the clear paste 2 that relative density at 60 DEG C is 1.15, with 5
Clear paste is dissolved by times water yield, upper macroporous resin column, successively with water and the ethanol elution of 40%, reclaims ethanol elution, at 50 DEG C
Under be concentrated into the dry extract 2 that relative density is 1.33；
S3, merging dry extract 1 and dry extract 2, be ground into powder, is subsequently placed in mixing 1h in trough type mixing machine, to obtain final product
Treat lipomatous Chinese medicine composition.
Embodiment 2:
The present embodiment provides one to treat lipomatous Chinese medicine composition, and this Chinese medicine composition includes following weight grams
Raw material:
Radix Bupleuri 4g, Pericarpium Citri Reticulatae 2g, Rhizoma Pinelliae 2g, Poria 5g, Radix Glycyrrhizae 1g, Pericarpium Citri Reticulatae Viride 4g, Fructus Gardeniae 2g, Semen Sinapis Albae 2g, Vascular aurantii 2g, raw wheat
Bud 5g, raw Fructus Setariae Germinatus 5g, Retinervus Luffae Fructus 4g, Arisaema Cum Bile 1g, Fructus Amomi 1g.
Wherein, the preparation method treating lipomatous Chinese medicine composition of the present embodiment is identical with embodiment 1.
Embodiment 3:
The present embodiment provides one to treat lipomatous Chinese medicine composition, and this Chinese medicine composition includes following weight grams
Raw material:
Radix Bupleuri 10g, Pericarpium Citri Reticulatae 8g, Rhizoma Pinelliae 8g, Poria 10g, Radix Glycyrrhizae 5g, Pericarpium Citri Reticulatae Viride 10g, Fructus Gardeniae 8g, Semen Sinapis Albae 8g, Vascular aurantii 8g,
Fructus Hordei Germinatus 10g, raw Fructus Setariae Germinatus 10g, Retinervus Luffae Fructus 10g, Arisaema Cum Bile 5g, Fructus Amomi 5g.
Wherein, the preparation method treating lipomatous Chinese medicine composition of the present embodiment is identical with embodiment 1.
Embodiment 4:
The present embodiment provides one to treat lipomatous Chinese medicine composition, and this Chinese medicine composition includes following weight grams
Raw material:
Radix Bupleuri 25g, Pericarpium Citri Reticulatae 20g, Rhizoma Pinelliae 20g, Poria 30g, Radix Glycyrrhizae 15g, Pericarpium Citri Reticulatae Viride 25g, Fructus Gardeniae 20g, Semen Sinapis Albae 20g, Fructus Citri tangerinae
Network 20g, Fructus Hordei Germinatus 30g, raw Fructus Setariae Germinatus 30g, Retinervus Luffae Fructus 25g, Arisaema Cum Bile 14g, Fructus Amomi 15g.
Wherein, the preparation method treating lipomatous Chinese medicine composition of the present embodiment is identical with embodiment 1.
Embodiment 5:
The present embodiment provides one to treat lipomatous Chinese medicine composition, and this Chinese medicine composition includes following weight grams
Raw material:
Radix Bupleuri 30g, Pericarpium Citri Reticulatae 25g, Rhizoma Pinelliae 25g, Poria 40g, Radix Glycyrrhizae 20g, Pericarpium Citri Reticulatae Viride 30g, Fructus Gardeniae 25g, Semen Sinapis Albae 25g, Fructus Citri tangerinae
Network 25g, Fructus Hordei Germinatus 40g, raw Fructus Setariae Germinatus 40g, Retinervus Luffae Fructus 30g, Arisaema Cum Bile 19g, Fructus Amomi 20g.
Wherein, the preparation method treating lipomatous Chinese medicine composition of the present embodiment is identical with embodiment 1.
Embodiment 6:
The present embodiment provides external preparation prepared by the lipomatous Chinese medicine composition for the treatment of and adjuvant, and described external preparation is
Capsule, described capsule includes ratio of weight and number 1:2 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 30g of embodiment 1, lactose 15g, sodium lauryl sulphate 10g, sucrose monolaurate fat 6g, carboxylic
Methyl starch sodium 5g, microcrystalline silicon 14g, magnesium stearate 6g, eucalyptol 4g.
Embodiment 7:
The present embodiment provides external preparation prepared by the lipomatous Chinese medicine composition for the treatment of and adjuvant, and described external preparation is
Capsule, described capsule includes ratio of weight and number 1:3 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 12g of embodiment 1, lactose 10g, sodium lauryl sulphate 5g, sucrose monolaurate fat 4g, carboxylic first
Base Starch Sodium 3g, microcrystalline silicon 12g, magnesium stearate 5g, eucalyptol 2g.
Embodiment 8:
The present embodiment provides external preparation prepared by the lipomatous Chinese medicine composition for the treatment of and adjuvant, and described external preparation is
Capsule, described capsule includes ratio of weight and number 1:1 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 84g of embodiment 1, lactose 20g, sodium lauryl sulphate 15g, sucrose monolaurate fat 8g, carboxylic
Methyl starch sodium 7g, microcrystalline silicon 18g, magnesium stearate 10g, eucalyptol 6g.
Embodiment 9:
The present embodiment provides honeyed pill prepared by the lipomatous Chinese medicine composition for the treatment of and adjuvant, and the concrete content of described honeyed pill is such as
Under:
The Chinese medicine composition 50g of embodiment 1, refined honey 50g.
The concrete preparation method of described honeyed pill is as follows:
To add refined honey in Chinese medicine composition fine powder, in being preferably, honey, fully mixes, and makes into soft or hard suitable, pill.
Embodiment 10:
The present embodiment provides one to treat lipomatous Chinese medicine composition and tincture made by adjuvant, and described tincture includes following
The raw material of weight grams: Radix Bupleuri 15g, Pericarpium Citri Reticulatae 12g, Rhizoma Pinelliae 12g, Poria 20g, Radix Glycyrrhizae 10g, Pericarpium Citri Reticulatae Viride 15g, Fructus Gardeniae 12g, Semen Sinapis Albae
12g, Vascular aurantii 12g, Fructus Hordei Germinatus 20g, raw Fructus Setariae Germinatus 20g, Retinervus Luffae Fructus 15g, Arisaema Cum Bile 9g, Fructus Amomi 10g, 75% ethanol 800g.
The concrete preparation method of described tincture is as follows: said medicine cleaned up, and dries in the shade and is placed on 75% wine of 800g
In essence alcohol liquid, soaking 10 days, leach medicinal residues, residue wine liquid diafiltration is placed on for twice in Cleaning bottle standby.
It should be noted that described preparation is oral formulations or external preparation, described oral formulations includes but not limited to water
Extract, tablet, pill, water-honeyed pill, concentrated pill, powder, capsule, oral liquid, granule or health tea oral formulations；Described
External preparation includes but not limited to fumigant, lotion or unguentum.
Embodiment 11:
The present embodiment also proposed the lipomatous Chinese medicine composition for the treatment of as treating lipomatous application.
Reference examples 1:
This reference examples provides one to treat lipomatous Chinese medicine composition, and this Chinese medicine composition includes following weight grams
Raw material:
Radix Bupleuri 15g, Pericarpium Citri Reticulatae 12g, Rhizoma Pinelliae 12g, Radix Glycyrrhizae 10g, Pericarpium Citri Reticulatae Viride 15g, Semen Sinapis Albae 12g, Vascular aurantii 12g, raw Fructus Setariae Germinatus 20g,
Retinervus Luffae Fructus 15g, Arisaema Cum Bile 9g, Fructus Amomi 10g.
Reference examples 2:
This reference examples provides one to treat lipomatous Chinese medicine composition, and this Chinese medicine composition includes following weight grams
Raw material:
Radix Bupleuri 35g, Pericarpium Citri Reticulatae 30g, Rhizoma Pinelliae 40g, Poria 50g, Radix Glycyrrhizae 30g, Pericarpium Citri Reticulatae Viride 45g, Fructus Gardeniae 30g, Semen Sinapis Albae 30g, Fructus Citri tangerinae
Network 30g g, Fructus Hordei Germinatus 60g, raw Fructus Setariae Germinatus 45g, Retinervus Luffae Fructus 35g, Arisaema Cum Bile 25g, Fructus Amomi 40g.
Reference examples 3:
This reference examples provides external preparation prepared by the lipomatous Chinese medicine composition for the treatment of and adjuvant, and described external preparation is
Capsule, described capsule includes ratio of weight and number 1:4 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 21g of embodiment 1, lactose 15g, sodium lauryl sulphate 15g, sucrose monolaurate fat 8g, carboxylic
Methyl starch sodium 7g, microcrystalline silicon 18g, magnesium stearate 10g, eucalyptol 6g.
Reference examples 4:
This reference examples provides external preparation prepared by the lipomatous Chinese medicine composition for the treatment of and adjuvant, and described external preparation is
Capsule, described capsule includes ratio of weight and number 1:7 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 12g of embodiment 1, lactose 15g, sodium lauryl sulphate 15g, sucrose monolaurate fat 8g, carboxylic
Methyl starch sodium 7g, microcrystalline silicon 18g, magnesium stearate 10g, eucalyptol 6g.
Test example 1 stability test
1. accelerated test
Example 1, embodiment 6, embodiment 7, reference examples 3 and the mixture of reference examples 4, be divided into 3 batches, respectively numbered sample
Product 1, sample 2, sample 3, sample 4 and sample 5, at temperature 40 DEG C ± 2 DEG C, relative humidity is to put under conditions of 75% ± 5%
Putting 6 months, testing, 1 month period, 2 months, 3 months, 6 the end of month are separately sampled once, by the regulation in Chinese Pharmacopoeia, inspection
Survey the character of mixture, color and luster, abnormal smells from the patient and the content (labelled amount %) of main component, dissolution and have related substance, it was found that
Sample 1, sample 2 and sample 3 indices have no significant change, and sample 4 and sample 5 darken, and precipitation occur, and 6
Slight abnormal flavour all occurred the when of individual month.
2. long term test
Example 1, embodiment 6, embodiment 7, reference examples 3 and the mixture of reference examples 4, be divided into 3 batches, respectively numbered sample
Product 1, sample 2, sample 3, sample 4 and sample 5, at temperature 25 DEG C ± 2 DEG C, relative humidity is to put under conditions of 60% ± 10%
Put 24 months, testing 0 month period, 3 months, 6 months, 9 months, 12 months, 18 months, 24 the end of month separately sampled one
Secondary, by the regulation in Chinese Pharmacopoeia, the detection character of mixture, color and luster, abnormal smells from the patient and the content (labelled amount %) of main component, dissolution
Spend and have related substance, it was found that sample 1, sample 2 and sample 3 indices have no significant change, and sample 4 and sample 5
Darken, precipitation occurs, and slight abnormal flavour all occurred 6 months when, when 12 months, less malodor occurs.
The mixture that conclusion Chinese medicine composition of the present invention is made is due to the reasonable selection of adjuvant, and stability of drug products is good, when storing
Between long, and the addition of carboxymethyl starch sodium and sodium lauryl sulphate more significantly improves the stability of mixture.
Test example 2 toxicity test
(1) acute toxicity test
1. subjects: healthy SD rat
Test group 50 example, male Mus, age 5 week old；
Matched group 50 example, male Mus, age 5 week old.
2. test method:
Test group: the present invention is treated lipomatous Chinese medicine composition normal saline and becomes the solution of 65% concentration,
To rat by a 40mL/kg gavage, double in one day, then drug withdrawal, continues after drug withdrawal to observe 7 days.
Matched group: with normal saline to rat by a 40mL/kg gavage, double in one day, then drug withdrawal, drug withdrawal
Rear continuation is observed 7 days.
3. statistical method: respectively test 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, record the mortality rate of two groups of rats
And rat behavior has Non Apparent Abnormality；After the observation period terminates, put to death rat in the 8th day, carry out cuing open inspection, record two groups of rats
Internal organs abnormal change situation.
4. result of the test:
Result of the test is shown in Table 1.
Table 1 the acute toxicity tests
The comparative result of table 1 is as follows:
From test group and the comparison of matched group, it is the most acute to rat that the present invention treats lipomatous Chinese medicine composition
Toxicity.
5. conclusion: the present invention treats lipomatous Chinese medicine composition, degree of safety is high, without acute toxicity.
(2) long term toxicity test
1. subjects: healthy SD rat
Test group 50 example, male Mus, age 5 week old；
Matched group 50 example, male Mus, age 5 week old.
2. test method:
Test group: the present invention treating lipomatous Chinese medicine composition and is dissolved in water gavage, dosage is with white mouse body
Restatement, every day, 0.05g/kg, continuous 180 days, continued after drug withdrawal to observe 30 days.
Matched group: feeding as test group and without the food of Chinese medicine composition of the present invention, quantity of food also with test group
Equally, and gavage normal saline, continuous 180 days；During 30 day observation period subsequently, rat is treated as test group.
3. statistical method: respectively at test 0 day, 30 days, 60 days, 90 days, 120 days, 150 days, 180 days and observation period knot
Shu Shi, the mortality rate and the rat behavior that record two groups of rats have Non Apparent Abnormality；After the observation period terminates, put to death rat, carry out
Cut open inspection, record the diet of two groups of rats, drinking-water, body weight growth and internal organs abnormal change situation.
4. result of the test: result of the test is shown in Table 2.
Table 2 long term toxicity test result
The comparative result of table 2 is as follows:
From test group and the comparison of matched group, the present invention treats lipomatous Chinese medicine composition to rat without long-term poison
Property；
5. conclusion: the lipomatous Chinese medicine composition for the treatment of of the present invention, degree of safety is high, without long term toxicity.
(3) conclusion
From the acute toxicity tests and long term toxicity test result, the lipomatous Chinese medicine composition for the treatment of of the present invention
Thing, degree of safety is high, avirulence.
Test example 3 bacteriostatic test
Use following compounds, use filter paper enzyme classical in this area to carry out bacteriostatic test.
For examination strain Rhodobacter capsulatus ATCC 11166 purchased from Bei Nuo bio tech ltd, Shanghai.
Culture fluid
Nutrient agar and nutrient broth, purchased from Chen Yu experimental facilities company limited of BeiJing ZhongKe.
Test method
Rhodobacter capsulatus ATCC 11166 is inoculated in agar plate nutritional solution plane, uniformly gathers during inoculation.
Take aseptic circular filter paper sheet, spray solution, the enforcement of 5mL that embodiment 1 Chinese medicine composition of 5mL is dissolved into respectively
The solution that example 2 Chinese medicine composition is dissolved into, to complete wetting, is attached in the agar plate nutritional solution plane of inoculated bacteria.Will
Agar plate is placed in the incubator of 37 DEG C, incubation 4 hours.Measure the diameter of antibacterial ring.Measure and average for 3 times.
Conclusion
The average diameter of the antibacterial ring of the Rhodobacter capsulatus ATCC 11166 of the solution that embodiment 1 Chinese medicine composition is dissolved into
For 11.35mm, the antibacterial ring of the Rhodobacter capsulatus ATCC 11166 of the solution that embodiment 2 Chinese medicine composition is dissolved into average straight
Footpath is 13.96mm.
Treat the test of lipomatous effect assessment
The treatment lipomatous Chinese medicine composition effect of the present invention is as follows:
1, clinical data
Each preferred embodiment of the present invention obtains checking in the scale of 500 people is tested.
2, efficacy evaluation
Recovery from illness: clinical symptoms all disappears, in check in a year, drug withdrawal has no that any pathologic changes later six months:
Effective: clinical symptoms all disappears, drug withdrawal is checked pathological change and is tended to curing after half a year；
Invalid: though clinical symptoms has improvement, but pathological change is without being clearly better.
Each preferred embodiment of the present invention obtains checking in the scale of 500 people is tested, and after medication, has
Dispersing the stagnated live-QI to relieve the stagnation of QI, eleminating phlegm and freeing channels, effect of drastically removing blood stasis and resolving static blood, have good therapeutic effect to lipoma, and cure rate is more than 85%, aobvious
Efficiency is more than 95%.
Model case 1:
Lee, female, 63 years old, long had multiple lipoma, once carried out operation and excises, but gradually increases, with waist later
Abdominal part is most, and extremity take second place, big person such as egg, and the little person such as grain of rice, with surrounding tissue without adhesion.Through taking the Chinese drug-treated group of the present invention
Compound is treated, and after one month, lipoma deliquescing diminishes, and continues to take one month, and less lipoma disappears, bigger fat
Fat tumor is reduced significantly, and after three months, big lipoma disappears, and follows up a case by regular visits to recur the most again.
Model case 2:
Zhang, man, 28 years old, lipomatosis, there is the lipoma about 30 of Semen Glycines size in arm and abdominal part, pressure no
Bitterly, the soft activity of matter, skin color is without exception.Having taken the Chinese medicine composition of the present invention, after one month, lipoma starts deliquescing and becomes
Little, no longer grow new lipoma, after taking three months, lipoma all disappears, and follows up a case by regular visits to recur the most again.
Model case 3:
In certain, female, 40 years old, before 2 years, found that abdominal part, waist, dorsal sc have the lump differed in size, pressure without pain
Sense, is lipomatosis after diagnosing.After taking January, big lipoma deliquescing diminishes, and little lipoma disappears, and takes two
After Yue, lipoma all disappears.
Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching
Stating, but on the basis of the present invention, can make some modifications or improvements it, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (10)
1. treat lipomatous Chinese medicine composition for one kind, it is characterised in that prepare the primary raw material weight of described Chinese medicine composition
Part consists of: Radix Bupleuri 4-30 part, Pericarpium Citri Reticulatae 2-25 part, Rhizoma Pinelliae 2-25 part, Poria 5-40 part, Radix Glycyrrhizae 1-20 part, Pericarpium Citri Reticulatae Viride 4-30 part, Cape jasmine
Sub-2-25 part, Semen Sinapis Albae 2-25 part, Vascular aurantii 2-25 part, Fructus Hordei Germinatus 5-40 part, raw Fructus Setariae Germinatus 5-40 part, Retinervus Luffae Fructus 4-30 part, gallbladder south
Star 1-19 part, Fructus Amomi 1-20 part.
2. the lipomatous Chinese medicine composition for the treatment of as claimed in claim 1, it is characterised in that prepare described Chinese medicine composition
Primary raw material weight portion consists of: Radix Bupleuri 10-25 part, Pericarpium Citri Reticulatae 8-20 part, Rhizoma Pinelliae 8-20 part, Poria 10-30 part, Radix Glycyrrhizae 5-15
Part, Pericarpium Citri Reticulatae Viride 10-25 part, Fructus Gardeniae 8-20 part, Semen Sinapis Albae 8-20 part, Vascular aurantii 8-20 part, Fructus Hordei Germinatus 10-30 part, raw Fructus Setariae Germinatus 10-30
Part, Retinervus Luffae Fructus 10-25 part, Arisaema Cum Bile 5-14 part, Fructus Amomi 5-15 part.
3. the lipomatous Chinese medicine composition for the treatment of as claimed in claim 1, it is characterised in that it is characterized in that, preparation is described
The primary raw material weight portion of Chinese medicine composition consists of: Radix Bupleuri 15 parts, Pericarpium Citri Reticulatae 12 parts, the Rhizoma Pinelliae 12 parts, 20 parts of Poria, Radix Glycyrrhizae 10
Part, 15 parts of Pericarpium Citri Reticulatae Viride, Fructus Gardeniae 12 parts, Semen Sinapis Albae 12 parts, Vascular aurantii 12 parts, Fructus Hordei Germinatus 20 parts, raw Fructus Setariae Germinatus 20 parts, Retinervus Luffae Fructus 15 parts, gallbladder
Rhizoma Arisaematis 9 parts, Fructus Amomi 10 parts.
4. the preparation treating lipomatous Chinese medicine composition as according to any one of claim 1-3, it is characterised in that described
Preparation is separately made by Chinese medicine composition or is formed by with Chinese medicine composition and pharmaceutically acceptable carrier.
5. preparation as claimed in claim 4, it is characterised in that described preparation is oral formulations or external preparation, described oral
Preparation is that water extract, tablet, pill, water-honeyed pill, concentrated pill, powder, capsule, oral liquid, granule or health tea are oral
Preparation；Described external preparation is fumigant, lotion or unguentum.
6. preparation as claimed in claim 5, it is characterised in that described external preparation is capsule, and described capsule includes weight
Amount portion rate is 1:1-3 Chinese medicine composition and adjuvant.
7. preparation as claimed in claim 6, it is characterised in that described adjuvant includes the composition of following parts by weight: lactose 10-
20 parts, sodium lauryl sulphate 5-15 part, sucrose monolaurate fat 4-8 part, carboxymethyl starch sodium 3-7 part, microcrystalline silicon 12-18
Part, magnesium stearate 5-10 part, eucalyptol 2-6 part.
Preparation the most as claimed in claims 6 or 7, it is characterised in that described capsule filling includes the one-tenth of following parts by weight
Point: Chinese medicine composition 30 parts, lactose 15 parts, sodium lauryl sulphate 10 parts, 6 parts of sucrose monolaurate fat, carboxymethyl starch sodium 5
Part, microcrystalline silicon 14 parts, magnesium stearate 6 parts, eucalyptol 4 parts.
9. the preparation method treating lipomatous Chinese medicine composition as according to any one of claim 1-3, its feature
Being, described method comprises the steps:
S1, weigh the Radix Bupleuri of recipe quantity, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Radix Glycyrrhizae, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae 7 taste crude drug, pulverize, mill, sieve
Making fine powder, the number of described screen cloth is 100-140 mesh, boiling 2 times, and 12 times of water yields decoct 2.5h for the first time, for the second time 8
Times water yield decocts 1.5h, merges to obtain decocting liquid, is condensed into the clear paste 1 that relative density is 1.25 under the conditions of temperature 45 C, cooling, adds
The ethanol of 75% carries out precipitate with ethanol 3h, filters, is condensed into the dry extract 1 that relative density is 1.45 at 50 DEG C；
S2, weigh the Semen Sinapis Albae of recipe quantity, Vascular aurantii, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Retinervus Luffae Fructus, Arisaema Cum Bile, Fructus Amomi 7 taste crude drug, powder
Broken, mill, sieve and make fine powder, the number of described screen cloth is 50-90 mesh, after stirring, adds 10 times of 75% ethanol
Reflux, extract, 2 times, each 2h, filters, merges back into flow liquid, be concentrated into the clear paste 2 that relative density at 60 DEG C is 1.15, with 5 times
Clear paste is dissolved by the water yield, upper macroporous resin column, successively with water and the ethanol elution of 40%, reclaims ethanol elution, at 50 DEG C
It is concentrated into the dry extract 2 that relative density is 1.33；
S3, merging dry extract 1 and dry extract 2, be ground into powder, is subsequently placed in mixing 1h in trough type mixing machine, obtains treatment
Lipomatous Chinese medicine composition.
10. the Chinese medicine composition described in an any one of claim 1-3 is as the application in treatment lipoma medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610741007.8A CN106110167A (en) | 2016-08-28 | 2016-08-28 | One treats lipomatous Chinese medicine composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN110960667A (en) * | 2020-01-04 | 2020-04-07 | 贵州松桃玛汝爽苗药养生保健产业有限公司 | External composition for treating lipoma and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178817A (en) * | 2011-04-28 | 2011-09-14 | 刘顺杰 | Chinese medicinal composition for treating multiple lipomas |
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| CN102178817A (en) * | 2011-04-28 | 2011-09-14 | 刘顺杰 | Chinese medicinal composition for treating multiple lipomas |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110960667A (en) * | 2020-01-04 | 2020-04-07 | 贵州松桃玛汝爽苗药养生保健产业有限公司 | External composition for treating lipoma and preparation method and application thereof |
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Application publication date: 20161116 |