CN104826015A - Traditional Chinese medicine with effects of invigorating kidneys and replenishing essence, dispersing blood stasis and dredging collaterals as well as softening veins and eliminating speckles - Google Patents
Traditional Chinese medicine with effects of invigorating kidneys and replenishing essence, dispersing blood stasis and dredging collaterals as well as softening veins and eliminating speckles Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine with effects of invigorating kidneys and replenishing essence, dispersing blood stasis and dredging collaterals as well as softening veins and eliminating speckles. The traditional Chinese medicine is composed of herba epimedii, ground beeltle, lucid ganoderma, salvia miltiorrhiza, carcuma longa, hawthorns, dandelion and mulberry leaves. The traditional Chinese medicine is specially used for effectively treating renal deficiency and blood stasis and phlegm blocking diseases caused by carotid atherosclerotic plaque. The invention provides a novel ideal drug with a reliable curative effect for treating the diseases and brings a hope for recovery of many old patients suffering from the diseases.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly the Chinese medicine of a kind of kidney tonifying, essence replenishing, disperse blood stasis and dredge collateral, the turbid speckle removing of change, treatment blood stasis due to renal deficiency, the turbid numbness type carotid artery atherosclerosis plaques of expectorant.
Background technology
Along with social industrialization, aged tendency of population, sickness rate and the mortality rate of cerebrovascular come out at the top in senile disease, and in rising trend, the health of serious threat middle-aged and elderly people and life.Carotid arterial atherosclerosis companion Mottling formation is the important pathologic basis of cerebrovascular disease, and atherosclerosis is the key factor causing the disease such as heart and cerebrovascular.Vulnerable plaque occurs that thrombosis that is damaged and its secondary is the pathologic basis that heart acute coronary syndrome occurs, and does not have significant dependency with the narrow concrete degree of vessel lumen that atherosclerosis causes.Carotid Atherosclerosis is each arteriosclerotic part of Whole Body, and its generation, development are closely related with human body cardiocerebrovasculaevents events, and it is reflect whole body structure, function " window " that its 26S Proteasome Structure and Function changes.Therefore intervene as early as possible Carotid Atherosclerosis by for cardiovascular and cerebrovascular disease event 1 grade of prevention, 2 grades to prevent and individuation, specific treatment have very great meaning.
Atheromatous plaque (kidney deficiency blood stasis type), disease sees dizzy headache, numb limbs and tense tendons, soreness of the waist and knees, apathetic expression, drowsirness is forgetful, breast gastral cavity painful abdominal mass is vexed, brain network numbness and thoracic obstruction performance blood stasis due to renal deficiency phlegm-turbidity and blood stasis resistance person.
The traditional Chinese medical science is thought: though the generation of carotid arterial atherosclerosis companion Mottling formation is relevant with the internal organs such as the heart, liver,spleen,kidney, its sick position is at brain, and it is kidney at all.The kidney being the origin of congenital constitution, main Tibetan congenital essence and the essence of five ZANG-organs and six FU-organs China.The raw marrow of kidney, marrow lead in brain.After people to middle age, kidney essense is gradually lost, emptiness of the essence and marrow, and brain is lost and supported, and venation is dry and astringent; Kidney yang deficiency, angry raw YANG deficiency, dysfunction of the spleen in warming, phlegm-damp are not changed, expectorant fat is cohesion, block blood road, hematogenous blockage, gradually amass into the stasis of blood, form blood stasis due to renal deficiency card.And there is dizzy, headache, dizzy, tinnitus, forgetful, hypomnesis, the unable and even numb hand and foot of soreness of the waist and knees, hemiplegia very then dull-witted state is carotid arterial atherosclerosis companion Mottling formation blood stasis due to renal deficiency, the performance of the turbid numbness type of expectorant.
The Chinese patent medicine specially controlling atheromatous plaque is in the market on the low side, the BUCHANG NAOXINTONG generally used, Tong-tian liquid and taponin etc. are for coronary heart disease, cerebral infarction, hypertension, hyperlipidemia and cerebral arteriosclerosis, all belong to their indication, there is the situation that indication is too wide, specific aim is poor, many relatively blood circulation promoting and blood stasis dispelling, and comparatively lack the medicine taken into account while treating atheromatous plaque and treat this basic pathogenesis of suffering from a deficiency of the kidney.
Summary of the invention
Be the Chinese medicine cured mainly in view of there is no for the turbid numbness type of carotid artery atherosclerosis plaques blood stasis due to renal deficiency expectorant at present, the object of the invention is to study a kind of be specifically designed to treat above-mentioned disease kidney tonifying, essence replenishing, disperse blood stasis and dredge collateral, soft pulse speckle removing Chinese medicine.
The Chinese medicine of kidney tonifying, essence replenishing of the present invention, disperse blood stasis and dredge collateral, soft pulse speckle removing is made up of Herba Epimedii, Eupolyphaga Seu Steleophaga, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Fructus Crataegi, Herba Taraxaci, Folium Mori, and the weight portion of each taste Chinese medicine is respectively:
Herba Epimedii 3-8, Eupolyphaga Seu Steleophaga 1.2-3, Ganoderma 2-6, Radix Salviae Miltiorrhizae 3-6, Rhizoma Curcumae Longae 2-5, Fructus Crataegi 3-8, Herba Taraxaci 3-6, Folium Mori 1.6-4.Effect of each taste Chinese medicine is described below:
Herba Epimedii: record Herba Epimedii: “ Fill Ming Door according to essentials of Matea Medica, beneficial smart Gas, Strong muscles and bones, diuresis ".Clinically be mainly used in treatment impotence and seminal emission, muscles and bones and wither diseases such as Soft, rheumatic arthralgia, numb limbs and tense tendons contracture and evident in efficacy, be monarch drug in side.
Proved by modern pharmacology research, Herba Epimedii has increases heart and cerebrovascular blood flow, promotes body medulla hematopoietic system function, regulates human immunologic function and strengthen bone metabolism, have slow down aging, antineoplastic effect.Research shows, the Plasma Middle Molecular Substances of mice can reduce by Herba Epimedii water liquid extract, and sulfhydryl content increases, and thinks that it by having an impact to sulfydryl in mice plasma and medium molecular substance, can play supporing yang effect of Herba Epimedii.Acute and the chronic inflammatory disease that total flavones contained by Herba Epimedii causes for a variety of causes and rat adjuvant inflammation all have and significantly suppress effect.The total flavones of Herba Epimedii can reduce the ratio of malonaldehyde at inflammatory exudate, and the peroxidating of containment ester matter, increases catalase activity, and perhaps this be that Herba Epimedii suppresses inflammatory reaction, the especially another key factor of immunity inflammatory reaction.
Eupolyphaga Seu Steleophaga: these flavour of a drug are salty, cold, return Liver Channel, have the effects such as removing blood stasis with potent drugs hematochezia, reunion of fractured tendons and bones, Shennong's Herbal: " Eupolyphaga Seu Steleophaga, salty in the mouth is trembled with fear.Can main trusted subordinate tremble with fear Hot, treat accumulation of blood eliminating mass abdominal mass, broken hard, hematochezia closes, raw Chuan Ze." be clinically mainly used in tendon breaking fracture, blood stasis do not dispel, in women's amenorrhea, abdomen, the treatment of the disease such as lump in the abdomen mass in the abdomen, is ministerial drug in side.
Modern pharmacological research confirms, Eupolyphaga Seu Steleophaga worm powder extracts can make the index such as blood viscosity, erythrocyte aggregation index, Rigidity of red cells in hematocrit in blood of human body, lectin from hemolymph all obviously reduce, and the constant such as erythrocyte sedimentation rate, blood flow equation index is significantly increased.Produced by effect erythrocyte and reduce blood viscosity effect, there is anticoagulation and antithrombotic efficacy.Eupolyphaga Seu Steleophaga worm powder extracts rabbit inside and outside Blood clotting impact experiment in result: Eupolyphaga Seu Steleophaga worm powder extracts in rabbit body and external part clotting time, prothrombin time, the thrombin time of can making extend, its effect promotes because extract concentrations increases, anticoagulant active does not rely on antithrombin Ⅲ, there is significant anticoagulant efficacy, thrombin in blood is directly played a role.Eupolyphaga Seu Steleophaga worm powder measures the packed cell volume of rat after giving test Mus gavage, red cell deformability, the ratio of erythrocyte membrane malonaldehyde, cholesterol levels and cholesterol/phospholipid.Result of the test shows, and Eupolyphaga Seu Steleophaga can reduce high ester Rat Erythrocytes hematocrit, improves erythrocyte deformability and reduces malonaldehyde, cholesterol levels and the cholesterol/phospholipid ratio of erythrocyte membrane.Research shows that Eupolyphaga Seu Steleophaga has endotheliocyte and protects effect.Eupolyphaga Seu Steleophaga water extract not only can regulating lipid metabolism, also has effect of significant protection endotheliocyte.
Ganoderma: sweet in the mouth is put down, returns the heart in internal organs, lung, liver, kidney channel, can enter the five internal organs and tonification the whole body QI of five ZANG-organs." herbal classic " states Ganoderma: the effect that can obtain strengthening the body resistance, strengthening by means of tonics, life lengthening after " control deafness, easing joint movement, protect gods, beneficial vital essence, Strong muscles and bones " medication, and significantly can strengthen Herba Epimedii kidney tonifying, essence replenishing effect, is ministerial drug in side.
Modern age, pharmacological testing found, ganoderan is Ganoderma principle active component, the most common with the structure of the glucosan of beta comfiguration, most containing branch, had the multiple efficacies such as antitumor, slow down aging, conditioner body immunity function clinically.Test also shows, and Ganoderma has effect of adjusting blood lipid.Take Ganoderma for a long time and can delay and reduce experimental atherosclerosis speckle formation time and degree.Clinical in hyperlipidemia patient, have and obviously fall plasma cholesterol, triglyceride levels effect.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, is attributed to the heart, Liver Channel, can reach effect of promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.The cold and hot labor of smelting, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Stagnated blood can be descended, mend new hemopoietic; Peaceful tire, fall stillborn fetus; Treatment leukorrhagia is collapsed in hemostasis, adjusts married woman's passages through which vital energy circulates irregular, and the blood heresy that disappears is except vexed, and be often used for the treatment of the diseases such as lump in the abdomen, breast ventral spine pain, the tired pain of limbs pyretic arthralgia and various carbuncle skin infection, be ministerial drug in side.
A large amount of pharmacological research confirms, Radix Salviae Miltiorrhizae significantly can reduce the blood viscosity of the patients such as coronary atherosclerotic heart disease, acute myocardial infarction, chronic obstructive pulmonary disease, old myocardial infarction, and other parameter such as indexs such as erythrocyte electrophoretic time, hematocrit, Fibrinogen can be improved in various degree.Radix Salviae Miltiorrhizae can act on multiple thrombin, has resisting blood coagulation effect.Radix Salviae Miltiorrhizae can make Fibrinogen be cracked into fibrin degradation product (FDP) forcefully.Experiment display, normal rabbits, after injection Radix Salviae Miltiorrhizae extract, can be contained platelet function, suppresses body coagulation function, promote plasmin activity in blood.In the extract of Radix Salviae Miltiorrhizae, danshensu has significant antithrombus formation, and antiplatelet gathers and promotes the effects such as body fibrinogen degradation.Effective component in red sage Tanshinone I I A sodium sulfonate has and suppresses platelet adhesion reaction significantly, gathers and thrombotic effect.Acetyl salvianolic acid has the test rat of adenosine diphosphate (ADP), collagen, arachidonic acid and thrombin induction and the platelet aggregation of rabbit significantly contains effect.And while suppression Platelet congregation, acetyl salvianolic acid discharges also to have to collagen-induced 5-hydroxy tryptamine and obviously suppresses effect.
Rhizoma Curcumae Longae: acrid in the mouth, hardship, warm in nature, classify liver spleen two warp of body, can removing blood stasis and circulation of qi promoting, stimulate the menstrual flow and pain relieving, " Bencao Jingshu ": " Rhizoma Curcumae Longae, its bitter in the mouth is pungent bad, pungent perfume (or spice) and dry strong, and its property should not be trembled with fear; hardship can expel the heat-evil, pungent can eliminating stagnation, therefore main trusted subordinate ties the person that belongs to blood system of meter.Hold concurrently and can control gas, so cloud can the therapeutic method to keep the adverse QI flowing downwards again.Its arduous power total, removing blood stasis is except wind heat, and subduing inflammation, its what one is particularly good at also." costa sternales twinges, women's amenorrhea, WEIJIA is gathered, the pain of the wet caused shoulder arm of wind and cold is uncomfortable, fall disease Be very effective such as flutterring pain to be commonly used in treatment, is ministerial drug in side.
Modern pharmacology test confirms, the main matter extracted in Curcuma Chinese medicine is curcumin, and recent test result has confirmed that curcumin has the pharmacological effect widely such as blood fat reducing, anti-inflammatory response, antioxidation, anticoagulant, scavenging free radicals, atherosclerosis.Bibliographical information curcumin has the effect reducing T-CHOL, β-ester albumen, triglyceride level in blood plasma.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, can appetite promoting and the spleen strengthening, promoting digestion and removing stagnation, activating blood circulation and dissipating blood stasis, circulation of qi promoting of eliminating the phlegm." Bencao Jingshu ": " gas is cool for Fructus Crataegi, sour in the mouth, but examining it, to eliminate diet long-pending, and feasible blood stasis of holding concurrently, then know its gas not cold descendants.Fructus Crataegi can enter taste and the eating accumulation that disappears, blood stasis dispelling blood, and on the whole its effect is good at repercussive blood, and dissipating fluid-retention is eaten, row stagnation of QI, strengthening the spleen and stomach." be commonly used in Therapeutic diet stagnant long-pending, enclosed mass gathers, abdomen painful abdominal mass distension, stasis blocking stomachache, phlegm retention, have loose bowels, the disease such as discharging fresh blood stool can reach satisfactory effect, can blood circulation promoting and blood stasis dispelling, vanishing sputum and dispelling knot, eliminating blood stasis and smoothing collaterals, be ministerial drug in side.
Lot of experiments research display, Fructus Crataegi extract has the tune fat effect comparatively determined to the various high ester model that many animals causes.Fructus Crataegi infusion and alcohol extractum is oral can increase lecithin in arteriosclerosis Sanguis Leporis seu oryctolagi, reduces cholesterol and the deposition of ester matter on internal organs.Fructus Crataegi and Fructus Crataegi flavone obviously can reduce blood and liver malonaldehyde level, improve the activity of erythrocyte and liver erythrocuprein.And improve blood GSH-PX activity-reductase activity.Obviously can reduce the rat blood serum T-CHOL of feeding height ester high-cholesterol diet, low-density lipoprotein-cholesterol and Serum Apoprotein-B content, obvious increase blood high density ester gp-cholesterol and Serum apolipoprotein A I concentration, and triglyceride is not had much affect.RT-polymerase chain reaction test shows, high ester high-cholesterol diet obviously can reduce low density lipoprotein receptor Messenger RNA content in rat liver.Fructus Crataegi and Fructus Crataegi flavone obviously can increase low density lipoprotein receptor protein content in rat liver, significantly improve rat liver low density lipoprotein receptor number.Visible Fructus Crataegi and Fructus Crataegi flavone act on and improve rat liver low density lipoprotein receptor transcriptional capability and increase antioxidant levels containment ester matter peroxide and control lipid metabolic disorder.
Herba Taraxaci: sweet in the mouth, micro-hardship, cold, can heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; " book on Chinese herbal medicine is newly organized ": " gas is put down for Herba Taraxaci, bitter in the mouth.Enter sun bright, lunar.Burst hard swollen, disappear tuberculosis.Detoxicating food-poisoning, loose stagnant gas." be adjuvant drug in side.
Herba Taraxaci, modern pharmacological research confirms, the ethanol extraction of Herba Taraxaci has obvious containment effect to human platelet aggregation.Extract has the dependent containment effect of metering to the platelet aggregation that adenosine diphosphate (ADP) is induced, and reaches that to be equivalent to dry root than thrombocyte plasma be 0.04g/ml in concentration, and maximal percentage inhibition reaches 85%.And arachidonic acid and collagen-induced platelet aggregation are not affected.Its alcohol leaching thing is divided into high molecular flow point (>10,000) and low-molecular-weight flow point (<10,000), low-molecular-weight flow point shows the suppression ratio of 91%, and the macromolecule flow point being rich in triterpene and sterol is 80% to the suppression ratio of platelet aggregation.The anticoagulant albumen of one in nearest Herba Taraxaci is purified and identifies out, when this albumen reaches 70,255,873nM, thrombin, partial prothrombinase soak time is increased and extends.
Folium Mori: sweet in the mouth, hardship, cold in nature, return lung, Liver Channel, " Japan hanako materia medica ": " sharp the five internal organs, get round by bribery.The therapeutic method to keep the adverse QI flowing downwards, decoction, except wind pain is perspired, flutters damage blood stasis, and Zheng Hou An ", effect is wind-dispelling heat-dissipating, clearing away dryness lung moistening, stabilize liver sun liter, can liver heat removing and improving eyesight.Medicine is made at Fang Zhongwei.
Adopt high ester hyperlipemia zoopery to show, Folium Mori can contain that in blood, lipid raises and contains effect of atherosclerosis generation.Effect of boasting of one's bit of contribution is conciliate in the heat clearing away that " book on Chinese herbal medicine " only have recorded Folium Mori, but test in modern age shows, and all anti-inflammatory response effects of Folium Mori are dispeled the wind with it, heat clearing away effect is coincide.Folium Mori also have the similar benefiting vital QI and blood in ginsenoside, slow down aging, stablize effect of human body higher nerve systemic-function in addition, Yin Shengli can be eliminated and sharply change the emotion fluctuation caused, increase the activity of erythrocuprein in human body, the generation of noxious products in checking body, reduction removing have generated and have accumulated in the lipofuscin of human body.Folium Mori can improve human body to stress the nerves reaction function of sexual stimulus, improve body tolerance and senile-resistant efficacy.The effects such as Folium Mori can also treat tumor, opposing virus, Folium Mori are containing abundant dietary fiber simultaneously, have loosening bowel to relieve constipation, protection intestinal mucosa effect.Herba Taraxaci and Folium Mori two medicine play the effect of assisting a ruler in governing a country in prescription, can play remarkable inhibitory action to the property of prodrug warm-dryness syndrome, thus make full presciption medicine imitate remarkable and mild in medicine property and.
The present invention cures mainly single-minded: medicine of the present invention is effectively treated for carotid arterial atherosclerosis companion Mottling formation blood stasis due to renal deficiency, the turbid numbness type of expectorant specially.Through studying for a long period of time, clinical application, constantly grope to improve, prove that Chinese Herbs of the present invention is reliable, and medical material is easy to get, can suitability for industrialized production.
The present invention is treatment carotid arterial atherosclerosis companion Mottling formation blood stasis due to renal deficiency, expectorant turbid numbness type disease provides a kind of new ideal medicament, brings glad tidings for numerous rehabilitation suffering from the middle-older patient of above-mentioned disease.
Chinese medicine of the present invention can make the multiple dosage forms such as granule, tablet, capsule as required, take, carry, store all very convenient.
Detailed description of the invention
Embodiment 1:
The Chinese medicine of kidney tonifying, essence replenishing of the present invention, disperse blood stasis and dredge collateral, the turbid speckle removing of change is made up of Herba Epimedii, Eupolyphaga Seu Steleophaga, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Fructus Crataegi, Herba Taraxaci, Folium Mori eight taste Chinese medicine.Get the raw materials ready according to the proportioning of Herba Epimedii 3kg, Eupolyphaga Seu Steleophaga 1.2kg, Ganoderma 4kg, Radix Salviae Miltiorrhizae 3kg, Rhizoma Curcumae Longae 3.3kg, Fructus Crataegi 8kg, Herba Taraxaci 5kg, Folium Mori 3kg.
Radix Salviae Miltiorrhizae in side, Eupolyphaga Seu Steleophaga are crossed scalping, adds 70% alcohol reflux three times, each 1 hour, filter, merging filtrate, reclaim ethanol, medicinal liquid is for subsequent use.Remain 6 taste medicines, decoct with water extraction three times, each 1 hour, filter, filtrate and above-mentioned medicinal liquid merge, and are concentrated into relative density 1.3, dry, pulverize.Add dextrin, correctives, granulate, 80 DEG C of dryings, subpackage, sterilizing and get final product.
Embodiment 2:
The Chinese medicine of kidney tonifying, essence replenishing of the present invention, disperse blood stasis and dredge collateral, the turbid speckle removing of change is made up of Herba Epimedii, Eupolyphaga Seu Steleophaga, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Fructus Crataegi, Herba Taraxaci, Folium Mori eight taste Chinese medicine.Get the raw materials ready according to the proportioning of Herba Epimedii 4kg, Eupolyphaga Seu Steleophaga 3kg, Ganoderma 6kg, Radix Salviae Miltiorrhizae 5kg, Rhizoma Curcumae Longae 4.5kg, Fructus Crataegi 5kg, Herba Taraxaci 4kg, Folium Mori 4kg.
Radix Salviae Miltiorrhizae in side, Eupolyphaga Seu Steleophaga are crossed scalping, adds 70% alcohol reflux three times, each 1 hour, filter, merging filtrate, reclaim ethanol, medicinal liquid is for subsequent use.Remain 6 taste medicines, decoct with water extraction three times, each 1 hour, filter, filtrate and above-mentioned medicinal liquid merge, and are concentrated into relative density 1.3, dry, pulverize.Add dextrin, correctives, granulate, 80 DEG C of dryings, subpackage, sterilizing and get final product.
Embodiment 3:
The present invention is made up of Herba Epimedii, Eupolyphaga Seu Steleophaga, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Fructus Crataegi, Herba Taraxaci, Folium Mori eight taste Chinese medicine.Get the raw materials ready according to the proportioning of Herba Epimedii 5kg, Eupolyphaga Seu Steleophaga 2.5kg, Ganoderma 5kg, Radix Salviae Miltiorrhizae 6kg, Rhizoma Curcumae Longae 5kg, Fructus Crataegi 4kg, Herba Taraxaci 6kg, Folium Mori 1.6kg.
Radix Salviae Miltiorrhizae 6kg in side, Eupolyphaga Seu Steleophaga are crossed scalping, adds 70% alcohol reflux three times, each 1 hour, filter, merging filtrate, reclaim ethanol, medicinal liquid is for subsequent use.Remain 6 taste medicines, decoct with water extraction three times, each 1 hour, filter, filtrate and above-mentioned medicinal liquid merge, and are concentrated into relative density 1.3, dry, pulverize.Add dextrin, correctives, granulate, 80 DEG C of dryings, subpackage, sterilizing and get final product.
Embodiment 4:
The present invention is made up of Herba Epimedii, Eupolyphaga Seu Steleophaga, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Fructus Crataegi, Herba Taraxaci, Folium Mori eight taste Chinese medicine.Get the raw materials ready according to the proportioning of Herba Epimedii 6kg, Eupolyphaga Seu Steleophaga 1.5kg, Ganoderma 2kg, Radix Salviae Miltiorrhizae 4kg, Rhizoma Curcumae Longae 4kg, Fructus Crataegi 3kg, Herba Taraxaci 4.5kg, Folium Mori 2.8kg.
Radix Salviae Miltiorrhizae in side, Eupolyphaga Seu Steleophaga are crossed scalping, adds 70% alcohol reflux three times, each 1 hour, filter, merging filtrate, reclaim ethanol, medicinal liquid is for subsequent use.Remain 6 taste medicines, decoct with water extraction three times, each 1 hour, filter, filtrate and above-mentioned medicinal liquid merge, and are concentrated into relative density 1.3, dry, pulverize.Add dextrin, correctives, granulate, 80 DEG C of dryings, subpackage, sterilizing and get final product.
Embodiment 5:
The present invention is made up of Eupolyphaga Seu Steleophaga, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Fructus Crataegi, Herba Taraxaci, Folium Mori eight taste Chinese medicine.Get the raw materials ready according to the proportioning of Herba Epimedii 7kg, Eupolyphaga Seu Steleophaga 2kg, Ganoderma 3kg, Radix Salviae Miltiorrhizae 4.84kg, Rhizoma Curcumae Longae 2kg, Fructus Crataegi 3kg, Herba Taraxaci 3kg, Folium Mori 2kg.
Radix Salviae Miltiorrhizae in side, Eupolyphaga Seu Steleophaga are crossed scalping, adds 70% alcohol reflux three times, each 1 hour, filter, merging filtrate, reclaim ethanol, medicinal liquid is for subsequent use.Remain 6 taste medicines, decoct with water extraction three times, each 1 hour, filter, filtrate and above-mentioned medicinal liquid merge, and are concentrated into relative density 1.3, dry, pulverize.Add dextrin, correctives, granulate, 80 DEG C of dryings, subpackage, sterilizing and get final product.
Embodiment 6:
The present invention is made up of Eupolyphaga Seu Steleophaga, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Fructus Crataegi, Herba Taraxaci, Folium Mori eight taste Chinese medicine, gets the raw materials ready according to the proportioning of Herba Epimedii 8kg, Eupolyphaga Seu Steleophaga 1.8kg, Ganoderma 4.5kg, Radix Salviae Miltiorrhizae 3.6kg, Rhizoma Curcumae Longae 2.5kg, Fructus Crataegi 6kg, Herba Taraxaci 3.6g, Folium Mori 2kg.
Radix Salviae Miltiorrhizae in side, Eupolyphaga Seu Steleophaga are crossed scalping, adds 70% alcohol reflux three times, each 1 hour, filter, merging filtrate, reclaim ethanol, medicinal liquid is for subsequent use.Remain 6 taste medicines, decoct with water extraction three times, each 1 hour, filter, filtrate and above-mentioned medicinal liquid merge, and are concentrated into relative density 1.3, dry, pulverize.Add dextrin, correctives, granulate, 80 DEG C of dryings, subpackage, sterilizing and get final product.
The production technology that other dosage forms can refer to above-described embodiment makes.
The curative effect of Chinese medicine of the present invention is proved below by way of concrete clinical case.
Case one: Zou so-and-so, female, 71 years old.On May 12nd, 2013, head examined:
Main suit: more than giddy, March of having a headache.Without obvious inducement, with position without obvious relation.Dizzy to be night very, headache is paroxysmal twinge, based on two temporo sides.Companion's soreness of the waist and knees.Previously deny hypertension history, deny diabetes medical history, deny apoplexy medical history.Food receive can, defecate partially dry, urine is adjusted, and night sleeps not good enough, tongue arteries and veins: light red tongue and the stasis of blood are dark, and tongue body is slightly greatly fat, thin white fur of tongue, stringy pulse, and Carotid ultrasonography shows: left common carotid crotch inwall and flat segments inwall atherosclerotic plaque formation (hard speckle, soft speckle).Right carotid crotch inwall atherosclerotic plaque forms (hard speckle, soft speckle);
Western medicine diagnose: carotid arterial atherosclerosis companion Mottling formation;
Tcm diagnosis: item BI-syndrome involved the blood vessels;
Dialectical: the turbid numbness resistance of blood stasis due to renal deficiency expectorant;
Treatment: soft pulse Huaban Tang 4 pairs, is decocted in water for oral dose, 100mL mono-day three times;
Further consultation on May 16 in 2013: tell headache and take a turn for the better to some extent, still tell dizziness, soreness of the waist and knees.Sleep night comparatively and slightly take a turn for the better.Patient's tongue arteries and veins: light red tongue and the stasis of blood are dark, and tongue body is slightly greatly fat, thin white fur of tongue, stringy pulse.Continue with top+Rhizoma Gastrodiae 15g, take 7 pairs, be decocted in water for oral dose, 100ml mono-day three times;
24 days three May in 2013 examines: tell headache substantially without outbreak, also obviously alleviate before dizziness comparatively.Soreness of the waist and knees comparatively before slightly take a turn for the better.Sleep night and improve.Patient's tongue arteries and veins: light red tongue and the stasis of blood are dark, and tongue body is slightly greatly fat, thin white fur of tongue, stringy pulse.Continue clothes with top, after 10 pairs, all cards are all alleviated, and treatment is checked Cervical Vessels color ultrasound after March and shown: left common carotid crotch inwall and flat segments inwall atherosclerotic plaque form (hard speckle, mixed stain).Right carotid crotch inwall atherosclerotic plaque forms (hard speckle, mixed stain).
Case two: king so-and-so, man, 57 years old.On June 8th, 2013, head examined:
Main suit: dizzy, nose heave pain is very after resting the head on.Without obvious inducement, with position without obvious relation.Companion's soreness of the waist and knees.Private prosecution over one year loss of hairs more very, history of past illness provides hypertension history, rule oral blood pressure lowering medicine, controlling of blood pressure situation is good, between 110 ~ 120/70 ~ 80mmHg.Deny diabetes medical history, deny apoplexy medical history.Food receive can, it is unable that stool is separated, and urine is adjusted, and it is poor that night sleeps, tongue arteries and veins: secretly, tongue body is slightly greatly fat, thin white fur of tongue, slow deep-thready pulse, PE:BP115/80mmHg for light red tongue and the stasis of blood, more than have a medical check-up and abnormal sign, Cervical Vessels color ultrasound is shown: bilateral common carotid arteries is atherosis.Left common carotid crotch inwall atherosclerotic plaque is formed (soft speckle, hard speckle), and right carotid crotch inwall atherosclerotic plaque forms (soft speckle);
Western medicine diagnose: carotid arterial atherosclerosis companion Mottling formation;
Tcm diagnosis: item BI-syndrome involved the blood vessels;
Dialectical: blood stasis due to renal deficiency, the turbid numbness resistance of expectorant;
Treatment: soft pulse Huaban Tang 7 pairs, is decocted in water for oral dose, 100mL, one day three times;
Further consultation on June 18 in 2013: tell the basic disappearance of headache, alleviate to some extent before dizziness comparatively.Sleep conscious night comparatively and slightly take a turn for the better.The comparatively front improvement of soreness of the waist and knees and loss of hairs is not obvious.Tongue arteries and veins: light red tongue and the stasis of blood are dark, and tongue body is slightly greatly fat, tongue fur is white, slow deep-thready pulse.Continue with top, take 7 clothes, be decocted in water for oral dose, 100ml, one day three times;
26 days three June in 2013 examines: tell headache substantially without outbreak, also obviously alleviate before dizziness comparatively.Soreness of the waist and knees comparatively before slightly take a turn for the better.Sleep night and improve.Tongue arteries and veins: light red tongue and the stasis of blood are dark, and tongue body is slightly greatly fat, tongue fur is white, slow deep-thready pulse.Continue clothes with top, after 15 pairs, all cards are all alleviated, and treatment checks Cervical Vessels color ultrasound after March: bilateral common carotid arteries is atherosis.Left common carotid crotch inwall atherosclerotic plaque forms (hard speckle) right carotid crotch inwall atherosclerotic plaque and forms (mixed stain).
Case three: Yang, female, 63 years old.On July 8th, 2013, head examined:
Main suit: uncomfortable more than 2 years of dizzy illiteracy, increases the weight of more than 10 days.Readme hypomnesis, nearly thing is easily forgotten, slightly blunt before reaction comparatively.Companion's soreness of the waist and knees, loss of hairs dedentition.Deny previously having hypertension history, deny diabetes medical history, deny apoplexy medical history.Food receive can, constipation with dry stool, urine adjust, easy early awakening of sleeping night, tongue arteries and veins: the body of the tongue stasis of blood is dark partially red, thin white fur of tongue, deep pulse, stringy and rolling pulse, Cervical Vessels color ultrasound is shown: left common carotid is atherosis, and bilateral common carotid arteries crotch inwall is atherosis, and speckle forms (hard speckle), and bilateral vertebral artery blood flow rate increases;
Western medicine diagnose: carotid arterial atherosclerosis companion Mottling formation;
Tcm diagnosis: item BI-syndrome involved the blood vessels;
Dialectical: the turbid numbness resistance of blood stasis due to renal deficiency expectorant;
Treatment: soft pulse Huaban Tang 7 pairs, is decocted in water for oral dose, 100mL, one day three times;
Further consultation on July 16 in 2013: tell dizzy illiteracy comparatively and alleviate to some extent.Sleep conscious night comparatively and slightly take a turn for the better.The comparatively front improvement of soreness of the waist and knees and loss of hairs is not obvious.Hypomnesis slightly takes a turn for the better.Tongue arteries and veins: the body of the tongue stasis of blood is dark partially red, thin white fur of tongue, deep pulse, stringy and rolling pulse.Continue with top, take 7 clothes, be decocted in water for oral dose, 100ml, one day three times;
24 days three July in 2013 examines: also obviously alleviate before telling dizziness comparatively.Soreness of the waist and knees comparatively before slightly take a turn for the better, night sleep improve.Memory comparatively before makes moderate progress.Tongue arteries and veins: light red tongue and the stasis of blood are dark, and tongue body is slightly greatly fat, tongue fur is white, slow deep-thready pulse.Continue clothes with top, after 15 pairs, all cards are all alleviated.Treatment checks Cervical Vessels color ultrasound after March: left common carotid is atherosis, and bilateral common carotid arteries crotch inwall is atherosis, and speckle forms (hard speckle).
Case four: Lee, man, 74 years old.On March 8th, 2014, head examined:
Main suit: in dizzy, vexed more than 10 year of pain, Progressive symmetric erythrokeratodermia increases the weight of 1 year.Dizzy persistence exists, and headache paroxysmal increases the weight of, and based on twinge, mostly occurs and to push up with running.Companion's blurring of vision, soreness of the waist and knees, tooth pine are dealt with.Previously deny hypertension history, deny diabetes medical history, deny apoplexy medical history.Food receive can, two just adjust, night sleep poor.Tongue arteries and veins: pale tongue and the stasis of blood are dark, have ecchymosis petechia, tongue body slight of stature, white and thin fur, stringy and thready pulse sinks.Neck color ultrasound: right carotid is atherosis, left common carotid crotch inwall is atherosis, and speckle forms (hard speckle), right carotid crotch inwall is atherosis, and speckle forms (soft speckle), subclavian artery inwall atherosis speckle in right side forms (hard speckle), and right side vertebral artery speed increases;
western medicine diagnose: carotid arterial atherosclerosis companion Mottling formation;
Tcm diagnosis: item BI-syndrome involved the blood vessels;
Dialectical: the turbid numbness resistance of blood stasis due to renal deficiency expectorant;
Treatment: soft pulse Huaban Tang 3 pairs, is decocted in water for oral dose, 100mL, one day three times;
Further consultation on March 12 in 2014: tell headache and take a turn for the better to some extent, still tell dizziness, soreness of the waist and knees.Sleep night comparatively and slightly take a turn for the better.Patient's tongue arteries and veins: pale tongue and the stasis of blood are dark, have ecchymosis petechia, tongue body slight of stature, white and thin fur, stringy and thready pulse sinks.To continue with top Rhizoma Chuanxiong dosage as 25g, add Fructus Viticis 30g, take 7 clothes, be decocted in water for oral dose, 100ml, Tid;
20 days three March in 2014 examines: tell headache substantially without outbreak, also obviously alleviate before dizziness comparatively.Blurring of vision, soreness of the waist and knees comparatively before slightly take a turn for the better.Sleep night and improve.Patient's tongue arteries and veins: pale tongue and the stasis of blood are dark, ecchymosis petechia comparatively before reduce to some extent, tongue body slight of stature, white and thin fur, stringy and thready pulse sinks.Continue clothes with top, after 15 pairs, all cards are all alleviated, treatment checks Cervical Vessels color ultrasound after March: right carotid is atherosis, and left common carotid crotch inwall is atherosis, and speckle forms (hard speckle), and right carotid crotch inwall is atherosis, and speckle forms (mixed stain).
Case five: Cai so-and-so, man, 73 years old.On October 5th, 2014, head examined:
Main suit: have a headache more than half a year, increase the weight of 1 week.Headache is outbreak in paroxysmal, based on twinge, is multiplely born in rear pillow part.Companion is dizzy, and knee joint is soft, knee pain, and winter, more so neck was strong.History of past illness provides hypertension history, existing oral nifedipine slow-release sheet 20mg mono-day twice, and controlling of blood pressure situation can; Previously diagnosis carbohydrate tolerance reduces, and existing to keep on a diet and to strengthen motor control blood glucose, glycemic control situation can.Deny apoplexy medical history.Food receive can, constipation with dry stool, urine can, night sleep not good enough, dreaminess, need oral estazolam 1mg sleep before take with auxiliary sleep.Tongue arteries and veins: pale tongue is slightly dark, and tongue is white, weak pulse.Cervical Vessels color ultrasound: bilateral common carotid arteries is atherosis.Left common carotid flat segments inwall, crotch inwall and internal carotid artery and the atherosis speckle of external carotid artery inwall are formed, and (soft speckle, hard speckle) accompanies local vascular narrow.Right carotid flat segments inwall, crotch inwall and internal carotid artery and the atherosis speckle of external carotid artery inwall are formed (soft speckle, hard speckle);
Western medicine diagnose: carotid arterial atherosclerosis companion Mottling formation;
Tcm diagnosis: item BI-syndrome involved the blood vessels;
Dialectical: the turbid numbness resistance of blood stasis due to renal deficiency expectorant;
Treatment: soft pulse Huaban Tang 5 pairs, is decocted in water for oral dose, 100mL, one day three times;
Further consultation on October 11 in 2014: tell Headache attacks frequency and reduce to some extent, degree alleviates to some extent, still tells giddy, knee joint is sour, cold, bitterly, neck is strong.Sleep night comparatively and slightly take a turn for the better, still oral estazolam is with assisting sleep.Patient's tongue arteries and veins: pale tongue is dark, tongue is white, weak pulse.Continue and add Ramulus Cinnamomi 12g, Cortex Eucommiae 15g with top, take 7 clothes, be decocted in water for oral dose, 100ml, one day three times;
20 days three October in 2014 examines: tell headache and be comparatively before clearly better, and outbreak twice in about 10 days, degree is lighter.Alleviate to some extent before giddy comparatively.Readme knees soreness cold type of pain comparatively before slightly take a turn for the better.Sleep night and improve, estazolam can not be relied on independently to fall asleep.State micro-thirst with desire to drink.Patient's tongue arteries and veins: pale tongue, yellow and thin fur, weak pulse.Continue and remove Ramulus Cinnamomi with top, take 10 clothes, be decocted in water for oral dose, 100ml, one day three times;
The four diagnostic methods on November 3 in 2014: headache disappears substantially.Knees soreness cold type of pain comparatively before take a turn for the better to some extent.Sleep night and improve.Food is received can.Pale tongue, white and thin fur, weak pulse.Continue with top, pay 5 pairs, all cards are all alleviated.Treatment is checked Cervical Vessels color ultrasound after March and is shown: bilateral common carotid arteries is atherosis.Left common carotid flat segments inwall, internal carotid artery and the atherosis speckle of external carotid artery inwall form the atherosis speckle of (mixed stain, hard speckle) right carotid crotch inwall and internal carotid artery and external carotid artery inwall and are formed (mixed stain, hard speckle).
Case six: field so-and-so, man, 74 years old.On November 8th, 2014, head examined:
Main suit: left side Head And Face paroxysmal constriction, twinge, companion's sweating, tinnitus, even had palpitation.Food receive can, two just adjust, sleep night can, previously have hypertension history 10 years, be up to 180/90mmHg, at ordinary times rule enalapril meleate (enalapril, metoprolol), controlling of blood pressure situation can; Deny diabetes medical history, deny apoplexy medical history.Tongue arteries and veins: pale tongue and the stasis of blood are dark, and have ecchymosis petechia, tongue is few, stringy and thready pulse.PE:BP130/80mmHg, haves a medical check-up and positive sign.Cervical Vessels color ultrasound: bilateral common carotid arteries is atherosis, bilateral common carotid arteries crotch inwall atherosclerotic plaque forms (soft speckle), and right side vertebral artery Signal aspects is not good enough, in conjunction with clinical;
Western medicine diagnose: carotid arterial atherosclerosis companion Mottling formation;
Tcm diagnosis: item BI-syndrome involved the blood vessels;
Dialectical: the turbid numbness resistance of blood stasis due to renal deficiency expectorant;
Treatment: soft pulse Huaban Tang 3 pairs, is decocted in water for oral dose, 100mL, one day three times;
Further consultation on November 12 in 2014: still tell left side Head And Face paroxysmal constriction, twinge.Cardiopalmus slightly takes a turn for the better, and still states tinnitus very.Patient's tongue arteries and veins: pale tongue and the stasis of blood are dark, have ecchymosis petechia, white and thin fur, stringy and thready pulse.Continue and take 7 clothes with top, be decocted in water for oral dose, 100ml, one day three times;
20 days three November in 2014 examines: slightly take a turn for the better before telling left side Head And Face paroxysmal constriction, twinge comparatively, and still very, cardiopalmus disappears tinnitus, and sweating takes a turn for the better.Patient's tongue arteries and veins: pale tongue and the stasis of blood are dark, ecchymosis petechia comparatively before reduce to some extent, white and thin fur, stringy and thready pulse.Continue clothes with top, after 15 pairs, all cards are all alleviated.Treatment was checked after March: bilateral common carotid arteries is atherosis, and bilateral common carotid arteries crotch inwall atherosclerotic plaque forms (mixed stain).
Case seven: what so-and-so, female, 68 years old.On November 2nd, 2014, head examined:
Main suit: left dusk, rises very, bradykinesia morning, and companion's tinnitus, finger tip is numb.Food receive can, two just adjust, night sleep poor.Previously have hypertension history 4 years, be up to 165/95mmHg, at ordinary times rule enalapril meleate (concrete depressor is not quite clear), controlling of blood pressure situation can; Once be diagnosed as " cerebral infarction " at his institute's row nuclear magnetic resonance, NMR before 4 years.Previously there is " cervical spondylosis " medical history, deny diabetes medical history.Tongue arteries and veins: the body of the tongue stasis of blood is dark, partially red, has ecchymosis, yellow, greasy and thin fur, stringy and thready pulse.PE:BP135/65mmHg, haves a medical check-up and positive sign.Cervical Vessels color ultrasound is shown: 1. bilateral common carotid arteries is atherosis.2. the atherosis speckle of left common carotid crotch inwall formed (hard speckle) 3. the atherosis speckle of right carotid crotch inwall formed (soft speckle) accompany local vascular narrow;
Western medicine diagnose: carotid arterial atherosclerosis companion Mottling formation;
Tcm diagnosis: item BI-syndrome involved the blood vessels;
Dialectical: the turbid numbness resistance of blood stasis due to renal deficiency expectorant;
Treatment: soft pulse Huaban Tang 3 pairs, is decocted in water for oral dose, 100mL, one day three times;
Further consultation on November 12 in 2014: still tell left side Head And Face paroxysmal constriction, twinge.Cardiopalmus slightly takes a turn for the better, and still states tinnitus very.Patient's tongue arteries and veins: pale tongue and the stasis of blood are dark, have ecchymosis petechia, white and thin fur, stringy and thready pulse.Continue and take 7 clothes with top, be decocted in water for oral dose, 100ml, one day three times;
20 days three November in 2014 examines: slightly take a turn for the better before telling left side Head And Face paroxysmal constriction, twinge comparatively, and still very, cardiopalmus disappears tinnitus, and sweating takes a turn for the better.Patient's tongue arteries and veins: pale tongue and the stasis of blood are dark, ecchymosis petechia comparatively before reduce to some extent, white and thin fur, stringy and thready pulse.Continue clothes with top, after 15 pairs, all cards are all alleviated.Treatment is checked Cervical Vessels color ultrasound after March and is shown: 1. bilateral common carotid arteries is atherosis.2. the atherosis speckle of left common carotid crotch inwall is formed.3. the atherosis speckle of right carotid crotch inwall forms (mixed stain).
Claims (1)
1. the Chinese medicine of kidney tonifying, essence replenishing, disperse blood stasis and dredge collateral, soft pulse speckle removing, it is characterized in that being made up of Herba Epimedii, Eupolyphaga Seu Steleophaga, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Fructus Crataegi, Herba Taraxaci, Folium Mori, the weight portion of each taste Chinese medicine is respectively: Herba Epimedii 3-8, Eupolyphaga Seu Steleophaga 1.2-3, Ganoderma 2-6, Radix Salviae Miltiorrhizae 3-6, Rhizoma Curcumae Longae 2-5, Fructus Crataegi 3-8, Herba Taraxaci 3-6, Folium Mori 1.6-4.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106266456A (en) * | 2016-09-18 | 2017-01-04 | 广西大学 | A kind of external-applied ointment containing insecticide |
| CN106615455A (en) * | 2016-12-23 | 2017-05-10 | 河池市金边土鳖虫养殖专业合作社 | Oriental cockroach health-preservation tea and preparation method thereof |
| CN106615454A (en) * | 2016-12-23 | 2017-05-10 | 河池市金边土鳖虫养殖专业合作社 | Opisthoplatia orientalis health-care tea and preparation method thereof |
| CN106728903A (en) * | 2016-12-22 | 2017-05-31 | 河池市金边土鳖虫养殖专业合作社 | It is a kind of to treat OPISTHOPLATIA wine of traumatic injury and preparation method thereof |
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| CN1442190A (en) * | 2003-04-01 | 2003-09-17 | 四川省中医药研究院中医研究所 | Chinese medicine possessing kidney supplementing brain fortifying, statis transforming and vessel freeing actions |
| JP2005343872A (en) * | 2004-06-07 | 2005-12-15 | Kao Corp | Aromatase activator |
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| CN1442190A (en) * | 2003-04-01 | 2003-09-17 | 四川省中医药研究院中医研究所 | Chinese medicine possessing kidney supplementing brain fortifying, statis transforming and vessel freeing actions |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266456A (en) * | 2016-09-18 | 2017-01-04 | 广西大学 | A kind of external-applied ointment containing insecticide |
| CN106728903A (en) * | 2016-12-22 | 2017-05-31 | 河池市金边土鳖虫养殖专业合作社 | It is a kind of to treat OPISTHOPLATIA wine of traumatic injury and preparation method thereof |
| CN106615455A (en) * | 2016-12-23 | 2017-05-10 | 河池市金边土鳖虫养殖专业合作社 | Oriental cockroach health-preservation tea and preparation method thereof |
| CN106615454A (en) * | 2016-12-23 | 2017-05-10 | 河池市金边土鳖虫养殖专业合作社 | Opisthoplatia orientalis health-care tea and preparation method thereof |
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