Summary of the invention
The poisonous side effect of medicine that the present invention is primarily aimed at present treatment epilepsy is many, is prone to develop immunity to drugs, and is prone to repeatedly; Unsatisfactory curative effect, it is not enough to cure the symptoms, not the disease etc., and a kind of determined curative effect is provided; Comprehensively regulating does not recur after the treatment and cheap, the medicine of the treatment epilepsy that has no side effect.
The present invention also provides the method for preparing of this medicine.
The present invention for realizing the technical scheme that above-mentioned purpose is taked is:
A kind of medicine of treating epilepsy is to be crude drug with following parts of medicines by weight:
Lapis Chloriti 50~60, Cornu Saigae Tataricae powder 20~30, Rhizoma Gastrodiae 20~30, Ramulus Uncariae Cum Uncis 20~30, Radix Salviae Miltiorrhizae 20~30, the Radix Paeoniae Alba 20~30, the Rhizoma Atractylodis Macrocephalae 20~30, Poria (processed with Cinnabaris) 20~30, Rhizoma Acori Graminei 20~30, Radix Polygalae 20~30, Bombyx Batryticatus 15~20, Scorpio 10~15, Arisaema Cum Bile 10~15, Alumen 10~15, Fructus Gleditsia 50~60, succinum 10~15;
Wherein said Poria (processed with Cinnabaris) is that the outer surface that Cinnabaris is sticked in the Poria piece is processed with 2~3 parts of Cinnabaris and 20~30 parts of Poria piece stirring and evenly mixings.
The method for preparing of medicine that the present invention treats epilepsy is following:
Earlier Radix Polygalae and Bombyx Batryticatus are fried to Huang; Rhizoma Atractylodis Macrocephalae humus flava usta is fried to yellowish-brown; It is to soak 3~5 hours in 10~20% the saline that Scorpio adds mass fraction, pulls out, the Scorpio of soaking is added in the boiling water again, and intense fire boiled 8~12 minutes, pulled the oven dry detoxification out; Again Alumen and Fructus Gleditsia are fried in shallow oil dried back pulverize together; The Radix Polygalae that to fry at last and Bombyx Batryticatus, Rhizoma Atractylodis Macrocephalae (parched); The powder that toxicide Scorpio, Alumen and Fructus Gleditsia are ground into and other crude drug mix homogeneously; Be ground into 80~100 purpose powder after the drying, process according to every bag 13~15 gram packings behind the sterilizing.
Lapis Chloriti has the expectorant of the bob therapeutic method to keep the adverse QI flowing downwards, checking hyperfunction of the liver for relieving convulsion effect in the prescription of the present invention; That cornu saigae tatariace powder has is analgesic, calmness and anticonvulsant action; Rhizoma Gastrodiae has wind-damp dispelling, convulsion, the effect of pain relieving, promoting flow of QI and blood; Ramulus Uncariae Cum Uncis has the heat clearing away suppressing the hyperactive liver, the effect of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.; Radix Salviae Miltiorrhizae has blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, the effect of removing heat from blood repercussive; The Radix Paeoniae Alba has nourishing blood to suppress the hyperactive liver, slow middle pain relieving, and yin fluid astringing is received the effect of antiperspirant; The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect; Poria (processed with Cinnabaris) has promoting diuresis to eliminate damp pathogen, the effect of invigorating spleen and relieving mental stress; Rhizoma Acori Graminei has has one's ideas straightened out, and allays excitement the effect of removing dampness to restore normal function of the stomach; Radix Polygalae has the Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm to have one's ideas straightened out the effect of dissipation carbuncle; Bombyx Batryticatus has expelling wind to relieve convulsion, the effect of dissipating phlegm and resolving masses; Scorpio has dispels the wind, relieving convulsion, collateral dredging, antidotal effect; Arisaema Cum Bile has removing heat-phlegm, the effect of dispelling wind and relieving convulsion; Alumen has the detoxifcation parasite killing, dampness removing to stop itchin, hemostasis, antidiarrheal, expectorant effect; Fructus Gleditsia has has one's ideas straightened out, and eliminates the phlegm the effect of relieving constipation; Succinum has tranquillizing the mind by relieving convulsion, dissipating blood stasis hemostasis, the effect of relieving stranguria by diuresis;
The compatibility relationship of prescription of the present invention is: with Lapis Chloriti, and Cornu Saigae Tataricae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis are monarch drug, suppressing the hyperactive liver and subsiding YANG, inducing resuscitation, relieving convulsion relieving convulsion; With Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria (processed with Cinnabaris), Rhizoma Acori Graminei, Radix Polygalae is a ministerial drug, and blood circulation promoting and blood stasis dispelling is rubbed the liver pathogenic fire purging, and replenishing QI to invigorate the spleen eliminates the phlegm and calms the nerves; With Bombyx Batryticatus, Scorpio, Arisaema Cum Bile is an adjuvant drug, active eliminating the phlegm, relieving convulsion; With Alumen, Fructus Gleditsia, succinum are messenger drug, consciousness-restoring and orifice-opening, tranquillizing the mind by relieving convulsion.
For further showing the therapeutic effect of medicine of the present invention, done following clinical verification:
The patient chooses
80 epileptics of hospital outpatient picked at random, be divided into two groups by the table of random number method, matched group 40 examples, 40 examples are organized in treatment.
Diagnostic criteria
Epilepsy diagnostic criteria: 1. outbreak repeatedly, but spontaneous remission; 2. Acute onset can be recovered through treatment is many, if with the passing of time take place frequently, and diseases such as then can be concurrent forgetful, dementia; 3. before sick the sending out premonitory symptom is often arranged, morbidity can have inducement; 4. the electroencephalogram performance is unusual.
Epilepsy classification diagnostic criteria: 1. YANG epilepsy: the soldier is right to fall forward, syncope, and the strong convulsion contracture of extremity, sound in mouthful, spit out white foams, dysphoria, the upward adverse flow of QI raucous breath, rale is filtered, the halitosis dry stool; Red tongue or dark red, yellow and greasy fur, stringy and rolling pulse; 2. epilepsy of YIN type: the soldier is right to fall forward, syncope, and slobbering, tic of the limbs is unable, and wriggling of the limbs, extremity are not warm, enuresis and encopresis; Pale tongue, few tongue, thready and weak pulse.
The syndrome diagnostic criteria: 1. scorching on the wind-fire, close in the expectorant heat: the soldier falls forward right dusk, and tic of the limbs is strong, or roars, upward adverse flow of QI raucous breath, manic uneasiness, constipation dark coloured urine; Red tongue with yellowish and greasy fur, slippery and rapid pulse; 2. pneumatic stagnation of phlegm, violate on the turbid pathogen: the soldier falls forward right dusk, looks on the order eyeball, spits out white foams tetany, gurgling with sputum; Body of the tongue is light red, and tongue is greasy in vain, rolling pulse; 3. stop in the blood stasis, clear key is obstructed: send out the then finally right servant of dusk clonic convulsion and twitch the face cyanotic lips; Purplish tongue or petechia is arranged, stringy pulse or puckery; 4. deficiency of both the heart and spleen, wind syndrome caused by deficiency is more moving: epilepsy does not heal for a long time, and the soldier falls forward right dusk, coma, pale complexion is spat out white foams, and tic of the limbs is unable, and the locked mouth order closes, enuresis and encopresis; Pale tongue, tongue is white, deep and weak pulse; 5. kidney unit is not enough, and incite in the endogenous wind border; The soldier falls forward right dusk, the extremity cold of the limbs, and limb is jerked unable, wriggling of the limbs; Deep red tongue, few tongue or no fur, stringy and thready pulse.
Epilepsy is standard by stages: 1. stage of attack: coma, and tic of the limbs, stiffness of the nape and back etc. belong to the outbreak stage; 2. catabasis: paresthesia epilepsy is alleviated, and it is clear that mind is changeed.
Therapeutic Method
The treatment group: medicine of the present invention, every day three times, each one bag, every bag of 15g, the child is cut down according to the circumstance, and takes with celery soup after the meal.
Matched group: take because of treatment epileptics Western medicine gets for a long time; Body is produced certain toxic and side effects; Present multidrug resistance; The Chinese traditional treatment scheme is adopted in this development test, should be according to similar comparable generally acknowledged effectively contrast principle, so adopt the Yixian pill treatment epileptics all kinds " composition: living Rhizoma Typhonii, Rhizoma Arisaematis (system), Rhizoma Pinelliae (processed), Fructus Gleditsiae Abnormalis, Bombyx Batryticatus (stir-fry), Zaocys (system), Scolopendra, Scorpio, Alumen, Realgar, Cinnabaris " of the auspicious magnificent pharmaceutical manufacturing in Hubei; The accurate word of traditional Chinese medicines: Z20013078. specification: 3g * 12 bag * box, usage and consumption: an oral 3g; 2-3 time on the one; Children's is cut down according to the circumstance.With 1 month be 1 course of treatment, treat half a year at least, followed up a case by regular visits to once in every month, does evaluation later six months respectively with medication before the treatment, before the treatment, further consultation and fill in CRF when following up a case by regular visits to.
All experimenters all must not merge medicine that uses any other treatment epilepsy and the medicine that possibly influence clinical efficacy and untoward reaction evaluation at duration of test.
Observation index
Itemized record medical history, attack times, medication history; All carry out head CT and/or MRI inspection before going into group; The all capable EEG(electrocardiogram) examination of all cases, part patient's row long-range video recording eeg monitoring; Conventional row NC; Regularly do routine blood test, hepatic and renal function inspection; Every month with examining record curative effect and possible untoward reaction.
The therapeutic evaluation standard:
Two groups all with the seizure frequency in January before the patient treatment as baseline, respectively with the treatment back six months seizure frequency compare.Criterion of therapeutical effect according to first academic meeting formulation of national epileptics: 1. produce effects reduces >=75% for treatment back seizure frequency than baseline; 2. effectively be to reduce 50%~74% than baseline; 3. invalid be change with baseline 50% or outbreak increase.
Statistical method
Curative effect application card side between two groups is carried out significance test.Data use SPSS 11.5 software kits to carry out statistical analysis, the relatively employing four fold table data X2 of rate check between sample, α=0.05.
Therapeutic outcome
Age of onset, the course of disease, attack times, sex, history of past illness etc. are through statistical procedures between two groups, P>0.05, there was no significant difference.
After treatment group and matched group were treated six months respectively, the total effective rate of induced seizures frequency was following: treatment group 87.5%, and matched group 75.0%, concrete outcome is seen table 1.
Table 1: the curative effect of showing effect behind two groups of epilepsy therapies relatively
Group |
n |
Recovery from illness and produce effects |
Progressive |
Invalid |
Worsen |
Total effective rate (%) |
The treatment group |
40 |
15 |
20 |
5 |
0 |
87.5 |
Matched group |
40 |
11 |
19 |
10 |
0 |
75.0 |
Clinical observation shows: medicine of the present invention has good and clinical curative effect to the treatment epilepsy, and is with the obvious advantage, and drug price of the present invention is cheap, has no side effect.
The specific embodiment
Embodiment 1
A kind of medicine of treating epilepsy is that the medicine with following weight is a crude drug:
Lapis Chloriti 5kg, Cornu Saigae Tataricae powder 2kg, Rhizoma Gastrodiae 2kg, Ramulus Uncariae Cum Uncis 2kg, Radix Salviae Miltiorrhizae 2kg, Radix Paeoniae Alba 2kg, Rhizoma Atractylodis Macrocephalae 2kg, Poria (processed with Cinnabaris) 2kg, Rhizoma Acori Graminei 2kg, Radix Polygalae 2kg, Bombyx Batryticatus 1.5kg, Scorpio 1kg, Arisaema Cum Bile 1kg, Alumen 1kg, Fructus Gleditsia 5kg, succinum 1kg;
Wherein Poria (processed with Cinnabaris) is that the outer surface that Cinnabaris is sticked in the Poria piece is processed with 0.2 kg Cinnabaris and 2kg Poria piece stirring and evenly mixing.
Concrete method for preparing is:
Earlier Radix Polygalae and Bombyx Batryticatus are fried to Huang; Rhizoma Atractylodis Macrocephalae humus flava usta is fried to yellowish-brown; It is to soak 3 hours in 10% the saline that Scorpio adds mass fraction, pulls out, the Scorpio of soaking is added in the boiling water again, and intense fire boiled 8 minutes, pulled the oven dry detoxification out; Again Alumen and Fructus Gleditsia are fried in shallow oil dried back pulverize together; The Radix Polygalae that to fry at last and Bombyx Batryticatus, Rhizoma Atractylodis Macrocephalae (parched); The powder that toxicide Scorpio, Alumen and Fructus Gleditsia are ground into and other crude drug mix homogeneously are ground into 80 purpose powder after the drying, process according to every bag 13 gram packings behind the sterilizing.
Instructions of taking:
The grand mal patient once two wraps, and three times on the one, the child is cut down according to the circumstance, and takes with celery soup, and 30 days is a course of treatment, generally uses for three to six courses of treatment.The petit mal patient, one time one bag, three times on the one, the child is cut down according to the circumstance, and takes with celery soup, and 30 days is a course of treatment, generally uses for three to six courses of treatment.Limitation and psychomotor activity patient, one time one bag, one day twice, the child was cut down according to the circumstance, and took with celery soup, general two to three courses of treatment.
Embodiment 2
A kind of medicine of treating epilepsy is that the medicine with following weight is a crude drug:
Lapis Chloriti 5.5kg, Cornu Saigae Tataricae powder 2.5kg, Rhizoma Gastrodiae 2.5kg, Ramulus Uncariae Cum Uncis 2.5kg, Radix Salviae Miltiorrhizae 2.5kg, Radix Paeoniae Alba 2.5kg, Rhizoma Atractylodis Macrocephalae 2.5kg, Poria (processed with Cinnabaris) 2.5kg, Rhizoma Acori Graminei 2.5kg, Radix Polygalae 2.5kg, Bombyx Batryticatus 1.75kg, Scorpio 1.25kg, Arisaema Cum Bile 1.25kg, Alumen 1.25kg, Fructus Gleditsia 5.5kg, succinum 1.25kg;
Wherein Poria (processed with Cinnabaris) is that the outer surface that Cinnabaris is sticked in the Poria piece is processed with 0.2 kg Cinnabaris and 2.5 kg Poria piece stirring and evenly mixings.
Concrete method for preparing is:
Earlier Radix Polygalae and Bombyx Batryticatus are fried to Huang; Rhizoma Atractylodis Macrocephalae humus flava usta is fried to yellowish-brown; It is to soak 4 hours in 15% the saline that Scorpio adds mass fraction, pulls out, the Scorpio of soaking is added in the boiling water again, and intense fire boiled 10 minutes, pulled the oven dry detoxification out; Again Alumen and Fructus Gleditsia are fried in shallow oil dried back pulverize together; The Radix Polygalae that to fry at last and Bombyx Batryticatus, Rhizoma Atractylodis Macrocephalae (parched); The powder that toxicide Scorpio, Alumen and Fructus Gleditsia are ground into and other crude drug mix homogeneously are ground into 90 purpose powder after the drying, process according to every bag 14 gram packings behind the sterilizing.
Instructions of taking:
The grand mal patient once two wraps, and three times on the one, the child is cut down according to the circumstance, and takes with celery soup, and 30 days is a course of treatment, generally uses for three to six courses of treatment.The petit mal patient, one time one bag, three times on the one, the child is cut down according to the circumstance, and takes with celery soup, and 30 days is a course of treatment, generally uses for three to six courses of treatment.Limitation and psychomotor activity patient, one time one bag, one day twice, the child was cut down according to the circumstance, and took with celery soup, general two to three courses of treatment.
Embodiment 3
A kind of medicine of treating epilepsy is that the medicine with following weight is a crude drug:
Lapis Chloriti 6kg, Cornu Saigae Tataricae powder 3kg, Rhizoma Gastrodiae 3kg, Ramulus Uncariae Cum Uncis 3kg, Radix Salviae Miltiorrhizae 3kg, Radix Paeoniae Alba 3kg, Rhizoma Atractylodis Macrocephalae 3kg, Poria (processed with Cinnabaris) 3kg, Rhizoma Acori Graminei 3kg, Radix Polygalae 3kg, Bombyx Batryticatus 2kg, Scorpio 1.5kg, Arisaema Cum Bile 1.5kg, Alumen 1.5kg, Fructus Gleditsia 6kg, succinum 1.5kg;
Wherein Poria (processed with Cinnabaris) is that the outer surface that Cinnabaris is sticked in the Poria piece is processed with 0.3 kg Cinnabaris and 2.7kg Poria piece stirring and evenly mixing.
Concrete method for preparing is:
Earlier Radix Polygalae and Bombyx Batryticatus are fried to Huang; Rhizoma Atractylodis Macrocephalae humus flava usta is fried to yellowish-brown; It is to soak 5 hours in 20% the saline that Scorpio adds mass fraction, pulls out, the Scorpio of soaking is added in the boiling water again, and intense fire boiled 12 minutes, pulled the oven dry detoxification out; Again Alumen and Fructus Gleditsia are fried in shallow oil dried back pulverize together; The Radix Polygalae that to fry at last and Bombyx Batryticatus, Rhizoma Atractylodis Macrocephalae (parched); The powder that toxicide Scorpio, Alumen and Fructus Gleditsia are ground into and other crude drug mix homogeneously are ground into 100 purpose powder after the drying, process according to every bag 15 gram packings behind the sterilizing.
Instructions of taking:
The grand mal patient once two wraps, and three times on the one, the child is cut down according to the circumstance, and takes with celery soup, and 30 days is a course of treatment, generally uses for three to six courses of treatment.The petit mal patient, one time one bag, three times on the one, the child is cut down according to the circumstance, and takes with celery soup, and 30 days is a course of treatment, generally uses for three to six courses of treatment.Limitation and psychomotor activity patient, one time one bag, one day twice, the child was cut down according to the circumstance, and took with celery soup, general two to three courses of treatment.