CN106266638A - A kind of Chinese medicine preparation treating insomnia and preparation method - Google Patents

A kind of Chinese medicine preparation treating insomnia and preparation method Download PDF

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CN106266638A
CN106266638A CN201610992105.9A CN201610992105A CN106266638A CN 106266638 A CN106266638 A CN 106266638A CN 201610992105 A CN201610992105 A CN 201610992105A CN 106266638 A CN106266638 A CN 106266638A
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黄烜
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Dongguan Biological Technology Co Ltd
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Dongguan Biological Technology Co Ltd
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Abstract

The invention discloses a kind of Chinese medicine preparation treating insomnia and preparation method, a kind of Chinese medicine preparation treating insomnia, is made up of the raw material of following weight portion: 170 230 parts of Rhizoma Gastrodiae, Radix Ginseng 170 230 parts, Ganoderma 170 230 parts, Fructus Corni 120 180 parts, Fructus Lycii 120 180 parts, Radix Polygalae 120 180 parts, Concha Margaritifera 200 400 parts, Ramulus Uncariae Cum Uncis 120 180 parts, Radix Salviae Miltiorrhizae 120 180 parts, Poria cum Radix Pini 70 130 parts, Cortex Albiziae 70 130 parts, Semen Ziziphi Spinosae (parched) 210 270 parts, stir-fry Semen Platycladi 120 180 parts, aspartame 0.001 0.002 parts, sodium benzoate 0.001 0.002 parts.The present invention has effect of Anshen Bunao, and drug effect is notable, can long-term taking, patient is prone to accept.

Description

A kind of Chinese medicine preparation treating insomnia and preparation method
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating insomnia and preparation method.
Background technology
Insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep, also known as falling asleep and maintaining sleep barrier Hinder, cause that difficulty falling asleep, Depth of sleep or frequency be too short for a variety of causes, early awakening and the length of one's sleep not enough or of poor quality etc., be A kind of commonly encountered diseases, insomnia often brings the most painful and psychological burden to patient, can damage because of abuse insomnia drug again Wound body and other every aspects, but also have a lot of method can alleviate and treat insomnia, constitutional can be divided into according to the cause of disease With Secondary cases two class, 1. Primary insomnia generally lacks the clear and definite cause of disease, or still leaves over after getting rid of the cause of disease that may cause insomnia Insomnia, mainly includes Psychophysiological insomnia, idiopathic insomnia and subjective insomnia three types, examining of Primary insomnia The weary specific index of breakthrough, a kind of removing property diagnosis, after the cause of disease that may cause insomnia is excluded or cures, still Can be thought of as Primary insomnia when leaving over insomnia, Psychophysiological insomnia finds that its cause of disease can be traced to the source clinically For some or the long term events impact on brain in patients limbic function stability, the stability of limbic function is unbalance Having ultimately resulted in the disorder of brain sleep function, insomnia occurs；2. insomnia secondary include due to physical disease, mental disorder, The insomnia that drug dependence etc. cause, and the insomnia relevant to sleep disordered breathing, sleep movement obstacle etc., often have a sleepless night and other Disease occurs simultaneously, is sometimes difficult to determine the cause effect relation between these diseases and insomnia, therefore proposes comorbidity insomnia in recent years Concept, in order to describe those simultaneously with the insomnia of other diseases；At present, Chinese medicine insomnia research report increases day by day Many, accepted by numerous insomniacs because its side effect is little, utilized modern science and technology equipment and method, inquired into the insomnia cause of disease sick Machine, screening verification active drug, develop with strong points, curative effect affirmative, the Chinese medicine preparation of dosage form simplicity, be the most urgently to be resolved hurrily Key issue.
Summary of the invention
For solving above-mentioned technical problem, the present invention provides a kind of Chinese medicine preparation treating insomnia, former by following weight portion Material is made: Rhizoma Gastrodiae 170-230 part, Radix Ginseng 170-230 part, Ganoderma 170-230 part, Fructus Corni 120-180 part, Fructus Lycii 120-180 Part, Radix Polygalae 120-180 part, Concha Margaritifera 200-400 part, Ramulus Uncariae Cum Uncis 120-180 part, Radix Salviae Miltiorrhizae 120-180 part, Poria cum Radix Pini's 70-130 part, conjunction Joyous skin 70-130 part, Semen Ziziphi Spinosae (parched) 210-270 part, stir-fry Semen Platycladi 120-180 part, aspartame 0.001-0.002 part, sodium benzoate 0.001-0.002 part；
The present invention also provides for the preparation method of a kind of Chinese medicine preparation treating insomnia, and its preparation process is:
(1) take raw material Rhizoma Gastrodiae, Radix Ginseng, Fructus Corni, Fructus Lycii, Radix Polygalae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Poria cum Radix Pini, Cortex Albiziae are put into pulverizer and pulverize, Cross 50-60 mesh sieve, obtain raw material powder, standby；
(2) take raw material Concha Margaritifera, Ganoderma is put into pulverizer and pulverizes, and crosses 60-80 mesh sieve, obtains raw material powder, standby；
(3) taking raw material Semen Platycladi, fry to heaving with slow fire, complexion changed is deep, takes out, cooling, places into pulverizer and pulverizes, crosses 80-100 Mesh sieve, obtains raw material powder, standby；
(4) take raw material acid Semen Ziziphi Spinosae, fry with slow fire and heave explosion to crust, take out, cool, place into pulverizer and pulverize, cross 60-80 Mesh sieve, obtains raw material powder, standby；
(5) step (1) gained raw material powder and step (2) gained raw material powder are added with (3) gained raw material powder and (4) gained raw material powder Soak by water three times, adds the water of raw material weight 10-12 times amount for the first time, decocts 0.4-1 hour, pour out medicinal liquid；Second time adds raw material The water of weight 6-8 times amount, decocts 0.4-1 hour, pours out medicinal liquid, and third time adds the water of raw material weight 6-8 times amount, decocts 0.4-1 Hour, merging three medicinal liquids, filter, filtrate is concentrated into 55-60 DEG C and surveys relative density is the clear paste of 1.08-1.15, adds 90-95% Appropriate amount of ethanol, 5-10 DEG C when standing 24-48, is filtered, and decompression filtrate recycling ethanol is to without alcohol taste, and filtrate is concentrated into 55-60 DEG C Surveying relative density is the thick paste of 1.25-1.35, standby；
(6) take raw material aspartame, sodium benzoate to be dissolved into respectively in water, standby；
(7) step (5) gained thick paste is added the pure water of its weight 3-5 times amount, adds the aspartame after dissolving, benzene first Acid sodium, 5-10min is to being completely dissolved in stirring, and with centrifugal filtration, revolution 10000-15000r/min, the time is 5-15s, cold preservation, When standing 24-48, then with centrifugal filtration, revolution 16000-20000r/min, the time is 5-15s, is finally packaged in 20ml bottle Sealing, with the sterilizing in 10-15 minute of boiling water high temperature, cooling, packaging, must treat the Chinese medicine preparation of insomnia.
Preferably in scheme, a kind of Chinese medicine preparation treating insomnia, it is made up of the raw material of following weight portion: 200 parts of Rhizoma Gastrodiae, Radix Ginseng 200 parts, Ganoderma 200 parts, Fructus Corni 150 parts, Fructus Lycii 150 parts, Radix Polygalae 150 parts, Concha Margaritifera 300 parts, Ramulus Uncariae Cum Uncis 150 parts, pellet Join 150 parts, Poria cum Radix Pini 100 parts, Cortex Albiziae 100 parts, Semen Ziziphi Spinosae (parched) 240 parts, fry Semen Platycladi 150 parts, aspartame 0.0015 part, benzene first 0.0015 part of sodium of acid；
Its preparation process is:
(1) take raw material Rhizoma Gastrodiae, Radix Ginseng, Fructus Corni, Fructus Lycii, Radix Polygalae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Poria cum Radix Pini, Cortex Albiziae are put into pulverizer and pulverize, Cross 60 mesh sieves, obtain raw material powder, standby；
(2) take raw material Concha Margaritifera, Ganoderma is put into pulverizer and pulverizes, and crosses 80 mesh sieves, obtains raw material powder, standby；
(3) taking raw material Semen Platycladi, fry to heaving with slow fire, complexion changed is deep, takes out, cooling, places into pulverizer and pulverizes, crosses 100 mesh Sieve, obtains raw material powder, standby；
(4) take raw material acid Semen Ziziphi Spinosae, fry with slow fire and heave explosion to crust, take out, cool, place into pulverizer and pulverize, cross 70 mesh Sieve, obtains raw material powder, standby；
(5) step (1) gained raw material powder and step (2) gained raw material powder are added with (3) gained raw material powder and (4) gained raw material powder Soak by water three times, adds the water of raw material weight 10 times amount for the first time, decocts 0.8 hour, pour out medicinal liquid；Second time adds raw material weight 8 The water of times amount, decocts 0.8 hour, pours out medicinal liquid, and third time adds the water of raw material weight 8 times amount, decocts 0.8 hour, merge three times Medicinal liquid, filters, and filtrate is concentrated into 55 DEG C and surveys relative density is the clear paste of 1.08, the appropriate amount of ethanol adding 95%, during 8 DEG C of standings 24, and mistake Filter, decompression filtrate recycling ethanol is to without alcohol taste, and filtrate is concentrated into 60 DEG C and surveys relative density is the thick paste of 1.25, standby；
(6) take raw material aspartame, sodium benzoate to be dissolved into respectively in water, standby；
(7) step (5) gained thick paste is added the pure water of its weight 3 times amount, adds the aspartame after dissolving, benzoic acid Sodium, stirring 5min to being completely dissolved, with centrifugal filtration, revolution 10000r/min, the time is 5s, cold preservation, when standing 24, then with from The heart filters, and revolution 16000r/min, the time is 5s, is finally packaged in 20ml bottle sealing, with the sterilizing in 15 minutes of boiling water high temperature, cold But, packaging, the Chinese medicine preparation of insomnia must be treated.
Used by the present invention, the pharmacology of raw material of Chinese medicine medicine is as follows:
Rhizoma Gastrodiae: meridian distribution of property and flavor: sweet, flat, return Liver Channel；Function cures mainly: suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion；For dizziness of having a headache, numb limbs and tense tendons is little Youngster's infantile convulsion, epilepsy clonus, tetanus.
Radix Ginseng: slightly warm in nature, sweet in the mouth, hardship, GUIXIN, spleen, lung meridian；Function cures mainly: strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, Promote the production of body fluid, calm the nerves；For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung breathes with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, Palpitation with fear insomnia, sexual impotence cold womb；Heart failure, cardiogenic shock.
Ganoderma: meridian distribution of property and flavor: sweet, flat, GUIXIN, lung, liver, kidney channel；Cure mainly asthenia, cough, pant, have a sleepless night, dyspepsia, Malignant tumor etc..
Fructus Corni: meridian distribution of property and flavor: sour, puckery, tepor, return liver, kidney channel；Function cures mainly: liver and kidney tonifying, restrains astringent or styptic treatment for spontaneous sweating, and controlling nocturnal emission with astringent drugs contracts Urine, leukorrhagia stopping only collapses, hidroschesis, in addition with promoting the production of body fluid to quench thirst；For soreness of waist and knee joint, dizziness and tinnitus, forgetful, emission and spermatorrhea, the enuresis is urinated Frequently, bleeding not during menses, menoxenia, profuse sweating collapse, interior-heat is quenched one's thirst.
Fructus Lycii: meridian distribution of property and flavor: sweet, flat, return liver, kidney channel；Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight；For asthenia essence Losing, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Radix Polygalae: meridian distribution of property and flavor: bitter, pungent, warm, GUIXIN, kidney, lung meridian；Function cures mainly: Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, detumescence；For The insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Concha Margaritifera: meridian distribution of property and flavor: salty, cold, return liver, heart channel；Function cures mainly: suppressing the hyperactive liver and subsiding YANG, improving eyesight of calming the frightened；Dizzy for having a headache Dizzy, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.
Ramulus Uncariae Cum Uncis: meridian distribution of property and flavor: sweet, cool, return liver, pericardium channel；Function cures mainly: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion；Dizzy for having a headache Dizzy, dysphoric cold, infantile convulsion tic, pre-eclampsia, hypertension.
Radix Salviae Miltiorrhizae: meridian distribution of property and flavor: bitter, is slightly cold, GUIXIN, Liver Channel；Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness； For menoxenia, amenorrhea dysmenorrhea, the accumulation of note of the ancient Chinese abdominal mass, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia；Hepatosplenomegaly, Angina pectoris.
Poria cum Radix Pini: slightly sweet flavor, slightly warm in nature, return careful, spleen channel；Effect: mind calming, calms the nerves, diuretic；Cure mainly palpitation with fear of having a guilty conscience, forgetful, Insomnia, infantile convulsion, dysuria.
Cortex Albiziae: meridian distribution of property and flavor: sweet, flat, GUIXIN, liver, lung meridian；Function cures mainly: resolving stagnation for tranquilization, promoting blood circulation and detumescence；For the heart God is uneasy, melancholy insomnia, and lung abscess skin ulcer swells, falls and flutter the pain of injury.
Semen Ziziphi Spinosae (parched): meridian distribution of property and flavor: sweet, sour, flat, return liver, gallbladder, heart channel；Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid；With In restlessness of asrhenia type and insomnia, dreaminess of palpitating with fear, body void hyperhidrosis, Tianjin wound is thirsty.
Stir-fry Semen Platycladi: meridian distribution of property and flavor: sweet, flat, GUIXIN, kidney, large intestine channel；Function cures mainly: tranquilizing by nourishing the heart, hidroschesis, intestine moistening；With Have a sleepless night in fidgets due to deficiency, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.
The method have the benefit that the effect with Anshen Bunao, drug effect is notable, can long-term taking, patient is prone to accept.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1
A kind of Chinese medicine preparation treating insomnia, is made up of the raw material of following weight portion: 230 parts of Rhizoma Gastrodiae, Radix Ginseng 230 parts, Ganoderma 230 Part, Fructus Corni 180 parts, Fructus Lycii 180 parts, Radix Polygalae 180 parts, Concha Margaritifera 400 parts, Ramulus Uncariae Cum Uncis 180 parts, Radix Salviae Miltiorrhizae 180 parts, Poria cum Radix Pini 130 parts, Cortex Albiziae 130 parts, Semen Ziziphi Spinosae (parched) 270 parts, stir-fry Semen Platycladi 180 parts, aspartame 0.002 part, sodium benzoate 0.002 part；
Its preparation process is:
(1) take raw material Rhizoma Gastrodiae, Radix Ginseng, Fructus Corni, Fructus Lycii, Radix Polygalae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Poria cum Radix Pini, Cortex Albiziae are put into pulverizer and pulverize, Cross 50-60 mesh sieve, obtain raw material powder, standby；
(2) take raw material Concha Margaritifera, Ganoderma is put into pulverizer and pulverizes, and crosses 60-80 mesh sieve, obtains raw material powder, standby；
(3) taking raw material Semen Platycladi, fry to heaving with slow fire, complexion changed is deep, takes out, cooling, places into pulverizer and pulverizes, crosses 80-100 Mesh sieve, obtains raw material powder, standby；
(4) take raw material acid Semen Ziziphi Spinosae, fry with slow fire and heave explosion to crust, take out, cool, place into pulverizer and pulverize, cross 60-80 Mesh sieve, obtains raw material powder, standby；
(5) step (1) gained raw material powder and step (2) gained raw material powder are added with (3) gained raw material powder and (4) gained raw material powder Soak by water three times, adds the water of raw material weight 10-12 times amount for the first time, decocts 0.4-1 hour, pour out medicinal liquid；Second time adds raw material The water of weight 6-8 times amount, decocts 0.4-1 hour, pours out medicinal liquid, and third time adds the water of raw material weight 6-8 times amount, decocts 0.4-1 Hour, merging three medicinal liquids, filter, filtrate is concentrated into 55-60 DEG C and surveys relative density is the clear paste of 1.08-1.15, adds 90-95% Appropriate amount of ethanol, 5-10 DEG C when standing 24-48, is filtered, and decompression filtrate recycling ethanol is to without alcohol taste, and filtrate is concentrated into 55-60 DEG C Surveying relative density is the thick paste of 1.25-1.35, standby；
(6) take raw material aspartame, sodium benzoate to be dissolved into respectively in water, standby；
(7) step (5) gained thick paste is added the pure water of its weight 3-5 times amount, adds the aspartame after dissolving, benzene first Acid sodium, 5-10min is to being completely dissolved in stirring, and with centrifugal filtration, revolution 10000-15000r/min, the time is 5-15s, cold preservation, When standing 24-48, then with centrifugal filtration, revolution 16000-20000r/min, the time is 5-15s, is finally packaged in 20ml bottle Sealing, with the sterilizing in 10-15 minute of boiling water high temperature, cooling, packaging, must treat the Chinese medicine preparation of insomnia.
Usage: oral, three times a day, each 15ml.
Embodiment 2
A kind of Chinese medicine preparation treating insomnia, is made up of the raw material of following weight portion: 200 parts of Rhizoma Gastrodiae, Radix Ginseng 200 parts, Ganoderma 200 Part, Fructus Corni 150 parts, Fructus Lycii 150 parts, Radix Polygalae 150 parts, Concha Margaritifera 300 parts, Ramulus Uncariae Cum Uncis 150 parts, Radix Salviae Miltiorrhizae 150 parts, Poria cum Radix Pini 100 parts, Cortex Albiziae 100 parts, Semen Ziziphi Spinosae (parched) 240 parts, stir-fry Semen Platycladi 150 parts, aspartame 0.0015 part, sodium benzoate 0.0015 part；
Its preparation process is:
(1) take raw material Rhizoma Gastrodiae, Radix Ginseng, Fructus Corni, Fructus Lycii, Radix Polygalae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Poria cum Radix Pini, Cortex Albiziae are put into pulverizer and pulverize, Cross 50-60 mesh sieve, obtain raw material powder, standby；
(2) take raw material Concha Margaritifera, Ganoderma is put into pulverizer and pulverizes, and crosses 60-80 mesh sieve, obtains raw material powder, standby；
(3) taking raw material Semen Platycladi, fry to heaving with slow fire, complexion changed is deep, takes out, cooling, places into pulverizer and pulverizes, crosses 80-100 Mesh sieve, obtains raw material powder, standby；
(4) take raw material acid Semen Ziziphi Spinosae, fry with slow fire and heave explosion to crust, take out, cool, place into pulverizer and pulverize, cross 60-80 Mesh sieve, obtains raw material powder, standby；
(5) step (1) gained raw material powder and step (2) gained raw material powder are added with (3) gained raw material powder and (4) gained raw material powder Soak by water three times, adds the water of raw material weight 10-12 times amount for the first time, decocts 0.4-1 hour, pour out medicinal liquid；Second time adds raw material The water of weight 6-8 times amount, decocts 0.4-1 hour, pours out medicinal liquid, and third time adds the water of raw material weight 6-8 times amount, decocts 0.4-1 Hour, merging three medicinal liquids, filter, filtrate is concentrated into 55-60 DEG C and surveys relative density is the clear paste of 1.08-1.15, adds 90-95% Appropriate amount of ethanol, 5-10 DEG C when standing 24-48, is filtered, and decompression filtrate recycling ethanol is to without alcohol taste, and filtrate is concentrated into 55-60 DEG C Surveying relative density is the thick paste of 1.25-1.35, standby；
(6) take raw material aspartame, sodium benzoate to be dissolved into respectively in water, standby；
(7) step (5) gained thick paste is added the pure water of its weight 3-5 times amount, adds the aspartame after dissolving, benzene first Acid sodium, 5-10min is to being completely dissolved in stirring, and with centrifugal filtration, revolution 10000-15000r/min, the time is 5-15s, cold preservation, When standing 24-48, then with centrifugal filtration, revolution 16000-20000r/min, the time is 5-15s, is finally packaged in 20ml bottle Sealing, with the sterilizing in 10-15 minute of boiling water high temperature, cooling, packaging, must treat the Chinese medicine preparation of insomnia.
Usage: oral, three times a day, each 15ml.
Embodiment 3
A kind of Chinese medicine preparation treating insomnia, is made up of the raw material of following weight portion: 170 parts of Rhizoma Gastrodiae, Radix Ginseng 170 parts, Ganoderma 170 Part, Fructus Corni 120 parts, Fructus Lycii 120 parts, Radix Polygalae 120 parts, Concha Margaritifera 200 parts, Ramulus Uncariae Cum Uncis 120 parts, Radix Salviae Miltiorrhizae 120 parts, Poria cum Radix Pini 70 parts, Cortex Albiziae 70 parts, Semen Ziziphi Spinosae (parched) 210 parts, stir-fry Semen Platycladi 120 parts, aspartame 0.001 part, sodium benzoate 0.001 part；
Its preparation process is:
(1) take raw material Rhizoma Gastrodiae, Radix Ginseng, Fructus Corni, Fructus Lycii, Radix Polygalae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Poria cum Radix Pini, Cortex Albiziae are put into pulverizer and pulverize, Cross 50-60 mesh sieve, obtain raw material powder, standby；
(2) take raw material Concha Margaritifera, Ganoderma is put into pulverizer and pulverizes, and crosses 60-80 mesh sieve, obtains raw material powder, standby；
(3) taking raw material Semen Platycladi, fry to heaving with slow fire, complexion changed is deep, takes out, cooling, places into pulverizer and pulverizes, crosses 80-100 Mesh sieve, obtains raw material powder, standby；
(4) take raw material acid Semen Ziziphi Spinosae, fry with slow fire and heave explosion to crust, take out, cool, place into pulverizer and pulverize, cross 60-80 Mesh sieve, obtains raw material powder, standby；
(5) step (1) gained raw material powder and step (2) gained raw material powder are added with (3) gained raw material powder and (4) gained raw material powder Soak by water three times, adds the water of raw material weight 10-12 times amount for the first time, decocts 0.4-1 hour, pour out medicinal liquid；Second time adds raw material The water of weight 6-8 times amount, decocts 0.4-1 hour, pours out medicinal liquid, and third time adds the water of raw material weight 6-8 times amount, decocts 0.4-1 Hour, merging three medicinal liquids, filter, filtrate is concentrated into 55-60 DEG C and surveys relative density is the clear paste of 1.08-1.15, adds 90-95% Appropriate amount of ethanol, 5-10 DEG C when standing 24-48, is filtered, and decompression filtrate recycling ethanol is to without alcohol taste, and filtrate is concentrated into 55-60 DEG C Surveying relative density is the thick paste of 1.25-1.35, standby；
(6) take raw material aspartame, sodium benzoate to be dissolved into respectively in water, standby；
(7) step (5) gained thick paste is added the pure water of its weight 3-5 times amount, adds the aspartame after dissolving, benzene first Acid sodium, 5-10min is to being completely dissolved in stirring, and with centrifugal filtration, revolution 10000-15000r/min, the time is 5-15s, cold preservation, When standing 24-48, then with centrifugal filtration, revolution 16000-20000r/min, the time is 5-15s, is finally packaged in 20ml bottle Sealing, with the sterilizing in 10-15 minute of boiling water high temperature, cooling, packaging, must treat the Chinese medicine preparation of insomnia.
Usage: oral, three times a day, each 15ml.
Chinese medicine preparation Ureteral Calculus insomniac 45 example of the present invention, clinical report is as follows:
1, physical data
Clinical observation insomniac 45 example, the maleest 30 examples, female 15 example, age 35-65 year, 50 years old mean age, the shortest course of disease 11 months, the longest 5 years.
2, diagnostic criteria
1. Insomnia difficulty falling asleep, time for falling asleep was more than 30 minutes；2. sleep quality sleep quality declines, and sleep maintains barrier Hindering, number of times >=2 time of awakening whole night, early awakening, sleep quality decline；3. total sleep time total sleep time reduces, and typically less than 6 is little Time；Simultaneously with daytime function obstacle on the basis of above-mentioned symptom；The daytime function infringement that sleep is relevant includes: 1. tired or complete Body is uncomfortable；2. attention, attention maintenance ability or hypomnesis；3. learn, work and (or) social competence decline；4. emotion Fluctuation or irritability；The most drowsy；6. interest, decreased energy；7. work or in driving procedure, erroneous tendancy increases；The tightest , headache, dizzy, or other somatizations relevant with sleep disappearance；9. hypersomnia is paid close attention to；
Insomnia is divided into according to the course of disease: the most acute insomnia, the course of disease >=1 month；The most subacute insomnia, the course of disease>=1 month,<6 months； 3. chronic insomnia, the course of disease >=6 month.
3, Therapeutic Method
Using Chinese medicine preparation of the present invention to treat, oral Chinese medicine preparation of the present invention, three times a day, each 15ml, 7 days is a course for the treatment of.
4, efficacy assessment standard
Cure: transference cure；
Take a turn for the better: clinical symptom relief；
Invalid: clinical symptoms is without improving or increasing the weight of.
5, therapeutic outcome
In clinical treatment insomniac 45 example, curing 32 examples and account for 71.1%, 10 examples that take a turn for the better account for 22.2%, and invalid 3 examples account for 6.7%, always have Efficiency is 93.3%.
6, model case
Case 1: man, 45 years old, main suit: have a sleepless night a year, increase the weight of 1 week to show, patient occurred insomnia before half a year, and day by day added Weight, difficulty falling asleep, early awakening, wake up after can not fall asleep again, decline with irritated, nervous, appetite simultaneously, note meaning power goes down, oral this One course for the treatment of of invention Chinese medicine preparation Chinese medicine preparation, symptom is clearly better, and of the present invention Chinese medicine preparation two courses for the treatment of are administered orally again, and clinic is controlled More.
Case 2: man, 40 years old, main suit: patient occurred insomnia before 1 year, and day by day increased the weight of, the irritable good anger of personality, spleen Gas is dry, and mouth urine smell is smelly, slightly cold perspiration, and antiperspirant is greasy, difficulty falling asleep, early awakening, wake up after can not fall asleep again, simultaneously with irritated, nervous, food Being intended to decline, note meaning power goes down, two courses for the treatment of of oral Chinese medicine preparation of the present invention, and symptom is clearly better, and of the present invention Chinese medicine system is administered orally again Two courses for the treatment of of agent, clinical cure.
Case 3: female, 38 years old, main suit: be insomnia completely at night, the irritable good anger temper of personality was dry, has a sleepless night more than 11 months, and day Gradually increase the weight of, difficulty falling asleep, early awakening, wake up after can not fall asleep again, decline with irritated, nervous, appetite simultaneously, note meaning power goes down, mouth Taking one course for the treatment of of Chinese medicine preparation of the present invention, symptom is clearly better, and of the present invention Chinese medicine preparation two courses for the treatment of, clinical cure are administered orally again.
It should be pointed out that, the detailed description of the invention more representational example that is the present invention, it is clear that the skill of the present invention Art scheme is not limited to above-described embodiment, it is also possible to have many variations；Those of ordinary skill in the art, the most public with present invention institute What what that open or according to file written description was undoubted obtained, all it is considered as this patent scope of the claimed.

Claims (6)

1. the Chinese medicine preparation treating insomnia, it is characterised in that: a kind of Chinese medicine preparation treating insomnia, by following weight portion Raw material is made: Rhizoma Gastrodiae 170-230 part, Radix Ginseng 170-230 part, Ganoderma 170-230 part, Fructus Corni 120-180 part, Fructus Lycii 120- 180 parts, Radix Polygalae 120-180 part, Concha Margaritifera 200-400 part, Ramulus Uncariae Cum Uncis 120-180 part, Radix Salviae Miltiorrhizae 120-180 part, Poria cum Radix Pini's 70-130 part, Cortex Albiziae 70-130 part, Semen Ziziphi Spinosae (parched) 210-270 part, stir-fry Semen Platycladi 120-180 part, aspartame 0.001-0.002 part, benzoic acid Sodium 0.001-0.002 part.
The preparation method of a kind of Chinese medicine preparation treating insomnia the most according to claim 1, it is characterised in that: it prepares step Suddenly it is:
(1) take raw material Rhizoma Gastrodiae, Radix Ginseng, Fructus Corni, Fructus Lycii, Radix Polygalae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Poria cum Radix Pini, Cortex Albiziae are put into pulverizer and pulverize, Cross 50-60 mesh sieve, obtain raw material powder, standby；
(2) take raw material Concha Margaritifera, Ganoderma is put into pulverizer and pulverizes, and crosses 60-80 mesh sieve, obtains raw material powder, standby；
(3) taking raw material Semen Platycladi, fry to heaving with slow fire, complexion changed is deep, takes out, cooling, places into pulverizer and pulverizes, crosses 80-100 Mesh sieve, obtains raw material powder, standby；
(4) take raw material acid Semen Ziziphi Spinosae, fry with slow fire and heave explosion to crust, take out, cool, place into pulverizer and pulverize, cross 60-80 Mesh sieve, obtains raw material powder, standby；
(5) step (1) gained raw material powder and step (2) gained raw material powder are added with (3) gained raw material powder and (4) gained raw material powder Soak by water three times, adds the water of raw material weight 10-12 times amount for the first time, decocts 0.4-1 hour, pour out medicinal liquid；Second time adds raw material The water of weight 6-8 times amount, decocts 0.4-1 hour, pours out medicinal liquid, and third time adds the water of raw material weight 6-8 times amount, decocts 0.4-1 Hour, merging three medicinal liquids, filter, filtrate is concentrated into 55-60 DEG C and surveys relative density is the clear paste of 1.08-1.15, adds 90-95% Appropriate amount of ethanol, 5-10 DEG C when standing 24-48, is filtered, and decompression filtrate recycling ethanol is to without alcohol taste, and filtrate is concentrated into 55-60 DEG C Surveying relative density is the thick paste of 1.25-1.35, standby；
(6) take raw material aspartame, sodium benzoate to be dissolved into respectively in water, standby；
(7) step (5) gained thick paste is added the pure water of its weight 3-5 times amount, adds the aspartame after dissolving, benzene first Acid sodium, 5-10min is to being completely dissolved in stirring, and with centrifugal filtration, revolution 10000-15000r/min, the time is 5-15s, cold preservation, When standing 24-48, then with centrifugal filtration, revolution 16000-20000r/min, the time is 5-15s, is finally packaged in 20ml bottle Sealing, with the sterilizing in 10-15 minute of boiling water high temperature, cooling, packaging, must treat the Chinese medicine preparation of insomnia.
The preparation method of a kind of Chinese medicine preparation treating insomnia the most according to claim 2, it is characterised in that: it prepares step Suddenly it is:
(1) take raw material Rhizoma Gastrodiae, Radix Ginseng, Fructus Corni, Fructus Lycii, Radix Polygalae, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Poria cum Radix Pini, Cortex Albiziae are put into pulverizer and pulverize, Cross 60 mesh sieves, obtain raw material powder, standby；
(2) take raw material Concha Margaritifera, Ganoderma is put into pulverizer and pulverizes, and crosses 80 mesh sieves, obtains raw material powder, standby；
(3) taking raw material Semen Platycladi, fry to heaving with slow fire, complexion changed is deep, takes out, cooling, places into pulverizer and pulverizes, crosses 100 mesh Sieve, obtains raw material powder, standby；
(4) take raw material acid Semen Ziziphi Spinosae, fry with slow fire and heave explosion to crust, take out, cool, place into pulverizer and pulverize, cross 70 mesh Sieve, obtains raw material powder, standby；
(5) step (1) gained raw material powder and step (2) gained raw material powder are added with (3) gained raw material powder and (4) gained raw material powder Soak by water three times, adds the water of raw material weight 10 times amount for the first time, decocts 0.8 hour, pour out medicinal liquid；Second time adds raw material weight 8 The water of times amount, decocts 0.8 hour, pours out medicinal liquid, and third time adds the water of raw material weight 8 times amount, decocts 0.8 hour, merge three times Medicinal liquid, filters, and filtrate is concentrated into 55 DEG C and surveys relative density is the clear paste of 1.08, the appropriate amount of ethanol adding 95%, during 8 DEG C of standings 24, and mistake Filter, decompression filtrate recycling ethanol is to without alcohol taste, and filtrate is concentrated into 60 DEG C and surveys relative density is the thick paste of 1.25, standby；
(6) take raw material aspartame, sodium benzoate to be dissolved into respectively in water, standby；
(7) step (5) gained thick paste is added the pure water of its weight 3 times amount, adds the aspartame after dissolving, benzoic acid Sodium, stirring 5min to being completely dissolved, with centrifugal filtration, revolution 10000r/min, the time is 5s, cold preservation, when standing 24, then with from The heart filters, and revolution 16000r/min, the time is 5s, is finally packaged in 20ml bottle sealing, with the sterilizing in 15 minutes of boiling water high temperature, cold But, packaging, the Chinese medicine preparation of insomnia must be treated.
A kind of Chinese medicine preparation treating insomnia the most according to claim 1, it is characterised in that: by the raw material of following weight portion Make: 200 parts of Rhizoma Gastrodiae, Radix Ginseng 200 parts, Ganoderma 200 parts, Fructus Corni 150 parts, Fructus Lycii 150 parts, Radix Polygalae 150 parts, Concha Margaritifera 300 Part, Ramulus Uncariae Cum Uncis 150 parts, Radix Salviae Miltiorrhizae 150 parts, Poria cum Radix Pini 100 parts, Cortex Albiziae 100 parts, Semen Ziziphi Spinosae (parched) 240 parts, stir-fry Semen Platycladi 150 parts, A Siba Sweet 0.0015 part, sodium benzoate 0.0015 part.
A kind of Chinese medicine preparation treating insomnia the most according to claim 1, it is characterised in that: by the raw material of following weight portion Make: 230 parts of Rhizoma Gastrodiae, Radix Ginseng 230 parts, Ganoderma 230 parts, Fructus Corni 180 parts, Fructus Lycii 180 parts, Radix Polygalae 180 parts, Concha Margaritifera 400 Part, Ramulus Uncariae Cum Uncis 180 parts, Radix Salviae Miltiorrhizae 180 parts, Poria cum Radix Pini 130 parts, Cortex Albiziae 130 parts, Semen Ziziphi Spinosae (parched) 270 parts, stir-fry Semen Platycladi 180 parts, A Siba Sweet 0.002 part, sodium benzoate 0.002 part.
A kind of Chinese medicine preparation treating insomnia the most according to claim 1, it is characterised in that: by the raw material of following weight portion Make: 170 parts of Rhizoma Gastrodiae, Radix Ginseng 170 parts, Ganoderma 170 parts, Fructus Corni 120 parts, Fructus Lycii 120 parts, Radix Polygalae 120 parts, Concha Margaritifera 200 Part, Ramulus Uncariae Cum Uncis 120 parts, Radix Salviae Miltiorrhizae 120 parts, Poria cum Radix Pini 70 parts, Cortex Albiziae 70 parts, Semen Ziziphi Spinosae (parched) 210 parts, stir-fry Semen Platycladi 120 parts, aspartame 0.001 part, sodium benzoate 0.001 part.
CN201610992105.9A 2016-11-11 2016-11-11 A kind of Chinese medicine preparation treating insomnia and preparation method Pending CN106266638A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111643555A (en) * 2020-05-19 2020-09-11 深圳市慧心医学科技有限公司 Traditional Chinese medicine for treating insomnia
CN112755151A (en) * 2021-01-28 2021-05-07 中国人民解放军总医院第一医学中心 Preparation method and pharmaceutical application of traditional Chinese medicine preparation for treating insomnia

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105878707A (en) * 2014-10-11 2016-08-24 王成全 Wuling Anmian Powder

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105878707A (en) * 2014-10-11 2016-08-24 王成全 Wuling Anmian Powder

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111643555A (en) * 2020-05-19 2020-09-11 深圳市慧心医学科技有限公司 Traditional Chinese medicine for treating insomnia
CN112755151A (en) * 2021-01-28 2021-05-07 中国人民解放军总医院第一医学中心 Preparation method and pharmaceutical application of traditional Chinese medicine preparation for treating insomnia

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