CN111643555A - Traditional Chinese medicine for treating insomnia - Google Patents

Traditional Chinese medicine for treating insomnia Download PDF

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Publication number
CN111643555A
CN111643555A CN202010423680.3A CN202010423680A CN111643555A CN 111643555 A CN111643555 A CN 111643555A CN 202010423680 A CN202010423680 A CN 202010423680A CN 111643555 A CN111643555 A CN 111643555A
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raw material
material powder
spina date
water
date seed
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CN202010423680.3A
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Chinese (zh)
Inventor
杨嘉莉
朱凯
蔡玥贇
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Shenzhen Huixin Medical Technology Co ltd
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Shenzhen Huixin Medical Technology Co ltd
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Priority to CN202010423680.3A priority Critical patent/CN111643555A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/24Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine for treating insomnia, and relates to the field of traditional Chinese medicines. The invention relates to a traditional Chinese medicine for treating insomnia, which comprises spina date seed, purple scallop, rauvolfia verticillata and radix Polygoni Ciliinerve, and is prepared from the following raw materials in parts by weight: 15 to 25 grams of spina date seed, 10 to 20 grams of purple scallop tooth, 15 to 20 grams of rauwolfia and 15 to 30 grams of radix salviae miltiorrhizae, wherein the spina date seed is fried by slow fire until the outer skin bulges and bursts, the spina date seed is taken out, cooled, crushed by a crusher, the purple scallop tooth, the rauwolfia and the radix salviae miltiorrhizae are taken, crushed by the crusher, decocted by water twice, the liquid medicine of the two times is combined, filtered, the filtrate is concentrated into clear paste, the obtained thick paste is added with purified water, and then the mixture is centrifugally filtered, refrigerated, kept stand, centrifugally filtered, finally packaged in a bottle with 20ml, sealed, sterilized at high temperature by boiling water, cooled and packaged. The traditional Chinese medicine for treating insomnia disclosed by the invention can fundamentally solve the physical health problem behind insomnia, and particularly vexation and insomnia caused by liver blood deficiency, yang failing to submerge in yin and floating yang to head.

Description

Traditional Chinese medicine for treating insomnia
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine for treating insomnia.
Background
Modern people have a great rise in the number of people with insomnia due to factors such as high working strength, irregular sleeping time, lack of sleep, overlong time for using electronic products and the like; the insomnia is caused by the failure of the liver to store blood, one is the failure of water-fire to succeed and the failure of the heart and kidney to intersect, and the other is the failure of the liver to store blood. The traditional Chinese medicine prescription combines the liver channel and the kidney channel and the traditional Chinese medicinal materials with the efficacy of suppressing yang together, achieves the effects of tonifying liver yin and liver yang and suppressing yang floating in yin, and greatly improves the sleep quality.
Many drugs for treating insomnia on the market can only temporarily relieve symptoms generally, and the problems of body health behind insomnia cannot be fundamentally cured and solved after long-term administration, so that the invention provides the traditional Chinese medicine for treating insomnia.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine for treating insomnia, which is realized by the following technical scheme for solving the technical problems:
a traditional Chinese medicine for treating insomnia comprises spina date seed, purple scallop, rauvolfia verticillata and radix Polygoni Ciliinerve, and comprises the following raw materials by weight: 15-25 g of spina date seed, 10-20 g of concha sieboldii, 15-20 g of rauwolfia verticillata and 15-30 g of radix salviae miltiorrhizae, wherein the spina date seed is fried by slow fire until the outer skin is swelled and burst, taken out, cooled, crushed by a crusher, sieved by a 60-80 mesh sieve to obtain raw material powder for later use, the concha sieboldii, the rauwolfia verticillata and the radix salviae are crushed by the crusher and sieved by a 80-100 mesh sieve to obtain the raw material powder, the raw material powder and the raw material powder prepared from the spina date seed are decocted for two times by adding water, the water with the weight of 10-14 times of the raw material is added for the first time, the decoction is carried; adding 4-6 times of water, decocting for 0.4-0.8 hr, pouring out the medicinal liquid, mixing the two medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.08-1.10 at 50-60 deg.C, adding 4-8 times of purified water into the obtained soft extract, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 10-20 min, cooling, and packaging.
The invention has the following beneficial effects:
1. the traditional Chinese medicine composition disclosed by the invention is used for treating insomnia in a targeted manner, and fundamentally solving the problem of physical health behind insomnia, in particular vexation and insomnia caused by liver blood deficiency, yang failing to submerge in yin and floating yang going up the head.
2. The spina date seed is tonic in sweet and sour, mild in property, good in nourishing heart, tonifying liver and benefiting gallbladder to calm nerves, and is a key medicine for treating uneasiness, insomnia, dreaminess, palpitation and severe palpitation caused by yin and blood deficiency; the purple shellfish is neutral in tooth nature and salty in taste, enters liver meridian, and has the effects of relieving convulsion, soothing the nerves, calming the liver and improving eyesight; the devilpepper is bitter, numb and sweet in taste and cool in nature, and has the effects of calming the nerves, dispersing the toxicity of brain stagnated heat, removing dysphoria, calming the nerves and developing the mind; the Hongyao Zi is sweet in taste and neutral in nature, enters liver meridian, can remove liver fire, and has the effects of clearing away heat and toxic materials, cooling blood and promoting blood circulation.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
in the specific implementation of the invention, the following components in weight percentage can be adopted: 15 g of spina date seed, 10 g of bulbus fritillariae thunbergii, 15 g of rauwolfia verticillata and 15 g of radix polygoni multiflori, wherein the spina date seed is fried by slow fire until the outer skin bulges and bursts, is taken out, is cooled, is crushed by a crusher and is sieved by a 60-mesh sieve to obtain raw material powder for later use, the bulbus fritillariae thunbergii, the rauwolfia verticillata and the radix polygoni rubra are crushed by the crusher and are sieved by a 80-mesh sieve to obtain the raw material powder, the raw material powder and the raw material powder prepared from the spina date seed are decocted by adding water twice, 10 times of the weight of the raw materials; adding 4 times of water, decocting for 0.4 hr, pouring out the medicinal liquid, mixing the two medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.08 at 50 deg.C, adding 4 times of purified water into the thick paste, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 10 min, cooling, and packaging.
Example two:
the invention can also consist of, by weight: 25 g of spina date seed, 20 g of bulbus fritillariae thunbergii, 20 g of rauwolfia verticillata and 30 g of radix polygoni multiflori, wherein the spina date seed is fried by slow fire until the outer skin bulges and bursts, is taken out, is cooled, is crushed by a crusher and is sieved by a 60-mesh sieve to obtain raw material powder for later use, the bulbus fritillariae thunbergii, the rauwolfia verticillata and the radix polygoni rubra are crushed by the crusher and are sieved by a 80-mesh sieve to obtain the raw material powder, the raw material powder and the raw material powder prepared from the spina date seed are decocted by adding water twice, water with the weight of 10 times of; adding 4 times of water, decocting for 0.4 hr, pouring out medicinal liquid, mixing the two medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.10 at 50 deg.C, adding 8 times of purified water, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 20 min, cooling, and packaging.
Example three:
the invention can also consist of, by weight: 20 g of spina date seed, 15 g of bulbus fritillariae thunbergii, 17.5 g of rauwolfia verticillata and 22.5 g of radix salviae miltiorrhizae, wherein the spina date seed is fried by slow fire until the outer skin is swelled and burst, taken out, cooled, crushed by a crusher and sieved by a 70-mesh sieve to obtain raw material powder for later use, the bulbus fritillariae thunbergii, the rauwolfia verticillata and the radix salviae are crushed by the crusher and sieved by a 90-mesh sieve to obtain the raw material powder, the raw material powder and the raw material powder prepared from the spina date seed are decocted by adding water for three times, water in an amount which is 12 times the weight; adding 5 times of water, decocting for 0.4 hr, pouring out medicinal liquid, mixing the three medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.09 at 55 deg.C, adding 6 times of purified water into the obtained soft extract, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 15 min, cooling, and packaging.
Example four:
the invention can also consist of, by weight:
25 g of spina date seed, 10 g of bulbus fritillariae thunbergii, 15 g of rauwolfia verticillata and 30 g of radix polygoni multiflori, wherein the spina date seed is fried by slow fire until the outer skin bulges and bursts, is taken out, is cooled, is crushed by a crusher and is sieved by a 60-mesh sieve to obtain raw material powder for later use, the bulbus fritillariae thunbergii, the rauwolfia verticillata and the radix polygoni rubra are crushed by the crusher and are sieved by a 80-mesh sieve to obtain the raw material powder, the raw material powder and the raw material powder prepared from the spina date seed are decocted by adding water twice, 10 times of the weight of the raw materials are added; adding 4 times of water, decocting for 0.8 hr, pouring out medicinal liquid, mixing the three medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.10 at 55 deg.C, adding 6 times of purified water, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 18 min, cooling, and packaging.
The organic matching and mutual support of the components fundamentally solve the health problem behind insomnia, in particular to vexation and insomnia caused by liver blood deficiency, yang failing to submerge in yin and floating yang to head.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims (5)

1. A traditional Chinese medicine for treating insomnia comprises spina date seeds, purple scallop teeth, rauwolfia and radix salviae miltiorrhizae, and is characterized by comprising the following raw materials by weight: 15-25 g of spina date seed, 10-20 g of concha haliotidis, 15-20 g of rauwolfia verticillata and 15-30 g of radix salviae miltiorrhizae, wherein the spina date seed is fried by slow fire until the outer skin bulges and bursts, the spina date seed is taken out and cooled, and then is put into a grinder to be ground, and is sieved by a 60-80 mesh sieve, so that raw material powder is obtained for later use, the concha haliotidis, the rauwolfia verticillata and the radix salviae are taken and put into the grinder to be ground, and are sieved by a 80-100 mesh sieve, so that the raw material powder is obtained, the raw material powder and the raw material powder prepared from the spina date seed are added with water and decocted for; adding 4-6 times of water, decocting for 0.4-0.8 hr, pouring out the medicinal liquid, mixing the two medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.08-1.10 at 50-60 deg.C, adding 4-8 times of purified water into the obtained soft extract, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 10-20 min, cooling, and packaging.
2. The traditional Chinese medicine for treating insomnia according to claim 1, which is characterized by comprising the following raw materials by weight: 15 g of spina date seed, 10 g of bulbus fritillariae thunbergii, 15 g of rauwolfia verticillata and 15 g of radix polygoni multiflori, wherein the spina date seed is fried by slow fire until the outer skin bulges and bursts, is taken out, is cooled, is crushed by a crusher, is sieved by a 60-mesh sieve to obtain raw material powder for later use, the bulbus fritillariae thunbergii, the rauwolfia verticillata and the radix polygoni rubra are crushed by the crusher and sieved by a 80-mesh sieve to obtain the raw material powder, the raw material powder and the raw material powder prepared from the spina date seed are decocted by adding water twice, water with the weight of 10 times of; adding 4 times of water, decocting for 0.4 hr, pouring out medicinal liquid, mixing the two medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.08 at 50 deg.C, adding 4 times of purified water, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 10 min, cooling, and packaging.
3. The traditional Chinese medicine for treating insomnia according to claim 1, which is characterized by comprising the following raw materials by weight: 25 g of spina date seed, 20 g of bulbus fritillariae thunbergii, 20 g of rauwolfia verticillata and 30 g of radix polygoni multiflori, wherein the spina date seed is fried by slow fire until the outer skin bulges and bursts, is taken out, is cooled, is crushed by a crusher and is sieved by a 60-mesh sieve to obtain raw material powder for later use, the bulbus fritillariae thunbergii, the rauwolfia verticillata and the radix polygoni rubra are crushed by the crusher and are sieved by a 80-mesh sieve to obtain the raw material powder, the raw material powder and the raw material powder prepared from the spina date seed are decocted by adding water twice, water with the weight of 10 times of; adding 4 times of water, decocting for 0.4 hr, pouring out medicinal liquid, mixing the two medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.10 at 50 deg.C, adding 8 times of purified water, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 20 min, cooling, and packaging.
4. The traditional Chinese medicine for treating insomnia according to claim 1, which is characterized by comprising the following raw materials by weight: 20 g of spina date seed, 15 g of bulbus fritillariae thunbergii, 17.5 g of rauwolfia verticillata and 22.5 g of radix salviae miltiorrhizae, wherein the spina date seed is fried by slow fire until the outer skin is swelled and burst, taken out, cooled, crushed by a crusher and sieved by a 70-mesh sieve to obtain raw material powder for later use, the bulbus fritillariae thunbergii, the rauwolfia verticillata and the radix salviae are crushed by the crusher and sieved by a 90-mesh sieve to obtain the raw material powder, the raw material powder and the raw material powder prepared from the spina date seed are decocted by adding water for three times, water with the weight of 12 times of the raw; adding 5 times of water, decocting for 0.4 hr, pouring out medicinal liquid, mixing the three medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.09 at 55 deg.C, adding 6 times of purified water, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 15 min, cooling, and packaging.
5. The traditional Chinese medicine for treating insomnia according to claim 1, which is characterized by comprising the following raw materials by weight: 25 g of spina date seed, 10 g of bulbus fritillariae thunbergii, 15 g of rauwolfia verticillata and 30 g of radix polygoni multiflori, wherein the spina date seed is fried by slow fire until the outer skin bulges and bursts, taken out, cooled, crushed by a crusher, sieved by a 60-mesh sieve to obtain raw material powder for later use, the bulbus fritillariae thunbergii, the rauwolfia verticillata and the radix polygoni rubra are crushed by the crusher and sieved by a 80-mesh sieve to obtain the raw material powder, the raw material powder and the raw material powder prepared from the spina date seed are decocted by adding water twice, water with the weight of 10 times of the raw material is added; adding 4 times of water, decocting for 0.8 hr, pouring out medicinal liquid, mixing the three medicinal liquids, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.10 at 55 deg.C, adding 6 times of purified water, centrifuging, filtering, refrigerating, standing, centrifuging, filtering, packaging in 20ml bottle, sealing, sterilizing with boiling water at high temperature for 18 min, cooling, and packaging.
CN202010423680.3A 2020-05-19 2020-05-19 Traditional Chinese medicine for treating insomnia Pending CN111643555A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101313975A (en) * 2007-06-02 2008-12-03 袁双喜 Anti-neurasthenic medicine liqueur
CN106266638A (en) * 2016-11-11 2017-01-04 东莞市百替生物科技有限公司 A kind of Chinese medicine preparation treating insomnia and preparation method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101313975A (en) * 2007-06-02 2008-12-03 袁双喜 Anti-neurasthenic medicine liqueur
CN106266638A (en) * 2016-11-11 2017-01-04 东莞市百替生物科技有限公司 A kind of Chinese medicine preparation treating insomnia and preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
国家药品监督管理局信息中心等: "《2001/2002临床新药推荐》", 31 July 2003, 吉林科学技术出版社 *
高学敏: "《中药学》", 31 March 2017, 中国中医药出版社 *

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Application publication date: 20200911

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