CN112074269A - 用于男性避孕的非激素组合物和方法 - Google Patents

用于男性避孕的非激素组合物和方法 Download PDF

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Publication number
CN112074269A
CN112074269A CN201980030077.4A CN201980030077A CN112074269A CN 112074269 A CN112074269 A CN 112074269A CN 201980030077 A CN201980030077 A CN 201980030077A CN 112074269 A CN112074269 A CN 112074269A
Authority
CN
China
Prior art keywords
composition
alpha
silodosin
daily
contraceptive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980030077.4A
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English (en)
Chinese (zh)
Inventor
纪尧姆·埃尔格拉维
迈赫迪·埃尔格拉维
P·佩林
S·德鲁彼
V·阿加顿-梅里奥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metso Lab
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Metso Lab
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Filing date
Publication date
Application filed by Metso Lab filed Critical Metso Lab
Publication of CN112074269A publication Critical patent/CN112074269A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CN201980030077.4A 2018-03-23 2019-03-22 用于男性避孕的非激素组合物和方法 Pending CN112074269A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862763129P 2018-03-23 2018-03-23
EP18305328.9 2018-03-23
US62/763129 2018-03-23
EP18305328 2018-03-23
PCT/EP2019/057267 WO2019180217A1 (en) 2018-03-23 2019-03-22 Non-hormonal compositions and methods for male contraception

Publications (1)

Publication Number Publication Date
CN112074269A true CN112074269A (zh) 2020-12-11

Family

ID=65955198

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980030077.4A Pending CN112074269A (zh) 2018-03-23 2019-03-22 用于男性避孕的非激素组合物和方法

Country Status (19)

Country Link
US (3) US10912762B2 (https=)
EP (2) EP3562485B8 (https=)
JP (1) JP7270901B2 (https=)
KR (1) KR102496504B1 (https=)
CN (1) CN112074269A (https=)
AU (1) AU2019237228B2 (https=)
BR (1) BR112020018925A2 (https=)
CA (1) CA3094016C (https=)
DK (2) DK3750538T3 (https=)
ES (2) ES2989170T3 (https=)
FI (1) FI3750538T3 (https=)
IL (1) IL277372B2 (https=)
MA (1) MA53626B1 (https=)
MX (1) MX2020009937A (https=)
PL (2) PL3750538T3 (https=)
PT (1) PT3562485T (https=)
SG (1) SG11202008794TA (https=)
UA (1) UA128502C2 (https=)
WO (1) WO2019180217A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3750538T3 (pl) * 2018-03-23 2024-11-25 Pharmajor International Niehormonalne sposoby męskiej antykoncepcji obejmujące (r) -sylodosynę
AU2023384256A1 (en) * 2022-11-23 2025-03-20 Pharmajor Incorporated Modified-release silodosin compositions and use thereof in methods for male contraception

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1867323A (zh) * 2003-11-10 2006-11-22 埃法尔姆公司 具有聚合物网络的低剂量片剂
CN101316934A (zh) * 2005-09-29 2008-12-03 拜耳医药保健股份公司 用于治疗泌尿系统疾病的pde抑制剂及其组合
CN102283816A (zh) * 2011-08-05 2011-12-21 北京海步国际医药科技发展有限公司 西洛多辛缓释片剂及其制备方法
US20120184591A1 (en) * 2011-01-13 2012-07-19 Watson Pharmaceuticals, Inc. Methods for treating prostatitis
CN106466333A (zh) * 2015-08-18 2017-03-01 国鼎生物科技股份有限公司 良性前列腺增生添加治疗

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1091276A (en) 1911-12-09 1914-03-24 Basf Ag Producing unsaturated terpene hydrocarbons.
US4210644A (en) 1978-02-23 1980-07-01 The Johns Hopkins University Male contraception
DE4308406C1 (de) 1993-03-12 1994-06-16 Jenapharm Gmbh Kombinationspräparat zur Kontrazeption
HUP0300128A3 (en) 2000-02-15 2004-03-29 Schering Ag Male contraceptive composition comprising norethisterone and its use
US20090186896A1 (en) * 2005-09-29 2009-07-23 Bayer Healthcare Ag PDE Inhibitors and Combinations Thereof for the Treatment of Urological Disorders
MX2009003737A (es) * 2006-10-05 2009-06-16 Panacea Biotec Ltd Composicion inyectable en deposito y su procedimiento de preparacion.
GB0700893D0 (en) 2007-01-17 2007-02-21 King S College London Male contraceptive
US20080242717A1 (en) 2007-02-28 2008-10-02 Fumiyasu Sato Methods for treating benign prostatic hyperplasia
WO2014118606A2 (en) * 2013-01-29 2014-08-07 Alembic Pharmaceuticals Limited A novel process for the preparation of silodosin
JPWO2016051782A1 (ja) 2014-09-30 2017-07-13 キッセイ薬品工業株式会社 苦味を有する薬剤の苦味をマスキングした経口投与製剤
PL3750538T3 (pl) * 2018-03-23 2024-11-25 Pharmajor International Niehormonalne sposoby męskiej antykoncepcji obejmujące (r) -sylodosynę

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1867323A (zh) * 2003-11-10 2006-11-22 埃法尔姆公司 具有聚合物网络的低剂量片剂
CN101316934A (zh) * 2005-09-29 2008-12-03 拜耳医药保健股份公司 用于治疗泌尿系统疾病的pde抑制剂及其组合
US20120184591A1 (en) * 2011-01-13 2012-07-19 Watson Pharmaceuticals, Inc. Methods for treating prostatitis
CN102283816A (zh) * 2011-08-05 2011-12-21 北京海步国际医药科技发展有限公司 西洛多辛缓释片剂及其制备方法
CN106466333A (zh) * 2015-08-18 2017-03-01 国鼎生物科技股份有限公司 良性前列腺增生添加治疗

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GAJANAN BHAT等: "BKP 02： prospective double blind randomised study to evaluate the efficacy of siliodosin 8 mg as on demand, reversible, male oral contraceptive", 《INDIAN JOURNAL OF UROLOGY》 *
JIN WANG等: "assessment of tamsulosin as a potential male contraceptive in healthy volunteers", 《UROLOGY》 *
KOBAYASHI K.等: "orgasm is preserved regardless of ejaculatory dysfuntion with selective alpha-1A-blocker administration", 《EUR. UROL. SUPPL.》 *
NIELS KJARGAARD等: "prazosin, an adrenergic blocking agent inadequate as male contraceptive pill", 《CONTRACEPTION》 *
YONG CHEN等: "blockade of α1A-adrenoceptor: A novel possible strategy for male contraception", 《MEDICAL HYPOTHESES》 *

Also Published As

Publication number Publication date
DK3750538T3 (da) 2024-09-23
EP3562485B1 (en) 2020-07-01
JP7270901B2 (ja) 2023-05-11
US11951095B2 (en) 2024-04-09
BR112020018925A2 (pt) 2020-12-29
IL277372B1 (en) 2023-05-01
MA53626B1 (fr) 2024-09-30
EP3750538B1 (en) 2024-08-14
JP2021518438A (ja) 2021-08-02
ES2813084T3 (es) 2021-03-22
IL277372A (en) 2020-11-30
PL3750538T3 (pl) 2024-11-25
US11583518B2 (en) 2023-02-21
PL3562485T3 (pl) 2020-11-16
AU2019237228A1 (en) 2020-10-01
EP3750538A1 (en) 2020-12-16
UA128502C2 (uk) 2024-07-31
US20210113526A1 (en) 2021-04-22
WO2019180217A1 (en) 2019-09-26
KR102496504B1 (ko) 2023-02-06
CA3094016A1 (en) 2019-09-26
US20230145374A1 (en) 2023-05-11
ES2989170T3 (es) 2024-11-25
PT3562485T (pt) 2020-08-27
IL277372B2 (en) 2023-09-01
EP3562485A1 (en) 2019-11-06
RU2020134408A (ru) 2022-04-29
FI3750538T3 (fi) 2024-09-24
MA53626A (fr) 2022-03-09
US10912762B2 (en) 2021-02-09
AU2019237228B2 (en) 2023-06-08
US20190290615A1 (en) 2019-09-26
SG11202008794TA (en) 2020-10-29
NZ767741A (en) 2024-11-29
MX2020009937A (es) 2022-09-30
RU2020134408A3 (https=) 2022-04-29
KR20200135978A (ko) 2020-12-04
DK3562485T3 (da) 2020-08-24
CA3094016C (en) 2023-10-10
EP3562485B8 (en) 2020-08-19

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Application publication date: 20201211

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