CN112057572A - 一种油包水包油型乳液气雾剂及其制备方法 - Google Patents
一种油包水包油型乳液气雾剂及其制备方法 Download PDFInfo
- Publication number
- CN112057572A CN112057572A CN202011077443.2A CN202011077443A CN112057572A CN 112057572 A CN112057572 A CN 112057572A CN 202011077443 A CN202011077443 A CN 202011077443A CN 112057572 A CN112057572 A CN 112057572A
- Authority
- CN
- China
- Prior art keywords
- oil
- parts
- water
- phase
- emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000443 aerosol Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000007764 o/w emulsion Substances 0.000 title abstract description 6
- 238000001856 aerosol method Methods 0.000 title description 2
- 239000000839 emulsion Substances 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000002245 particle Substances 0.000 claims abstract description 19
- 239000007762 w/o emulsion Substances 0.000 claims abstract description 11
- 239000003380 propellant Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 5
- 239000012071 phase Substances 0.000 claims description 63
- 239000003921 oil Substances 0.000 claims description 49
- 235000019198 oils Nutrition 0.000 claims description 46
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 18
- 239000008158 vegetable oil Substances 0.000 claims description 18
- 239000000284 extract Substances 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 12
- -1 polyoxypropylene stearate Polymers 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 8
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 7
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims description 7
- 241000779819 Syncarpia glomulifera Species 0.000 claims description 7
- 239000003995 emulsifying agent Substances 0.000 claims description 7
- 239000001739 pinus spp. Substances 0.000 claims description 7
- 239000001593 sorbitan monooleate Substances 0.000 claims description 7
- 229940035049 sorbitan monooleate Drugs 0.000 claims description 7
- 235000011069 sorbitan monooleate Nutrition 0.000 claims description 7
- 229940036248 turpentine Drugs 0.000 claims description 7
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 6
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 6
- 244000144730 Amygdalus persica Species 0.000 claims description 6
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 6
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 6
- 239000008346 aqueous phase Substances 0.000 claims description 6
- 229940116229 borneol Drugs 0.000 claims description 6
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 6
- 229940056582 human hair preparation Drugs 0.000 claims description 6
- 229940041616 menthol Drugs 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000012046 mixed solvent Substances 0.000 claims description 4
- 241000382455 Angelica sinensis Species 0.000 claims description 3
- 244000020518 Carthamus tinctorius Species 0.000 claims description 3
- 241000258920 Chilopoda Species 0.000 claims description 3
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims description 3
- 241000254173 Coleoptera Species 0.000 claims description 3
- 244000168525 Croton tiglium Species 0.000 claims description 3
- 241000218671 Ephedra Species 0.000 claims description 3
- 241001489978 Eupolyphaga Species 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 3
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 claims description 3
- 241000270273 Ptyas dhumnades Species 0.000 claims description 3
- 241001180876 Saposhnikovia Species 0.000 claims description 3
- 241000131808 Scolopendra Species 0.000 claims description 3
- 244000107975 Strychnos nux-vomica Species 0.000 claims description 3
- 235000017803 cinnamon Nutrition 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 210000003608 fece Anatomy 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 235000019508 mustard seed Nutrition 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 238000007670 refining Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 13
- 229940079593 drug Drugs 0.000 abstract description 8
- 230000007794 irritation Effects 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 238000004945 emulsification Methods 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 239000011505 plaster Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 241000700198 Cavia Species 0.000 description 5
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000004530 micro-emulsion Substances 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 244000153234 Hibiscus abelmoschus Species 0.000 description 1
- 244000245214 Mentha canadensis Species 0.000 description 1
- 235000001878 Mentha haplocalyx Nutrition 0.000 description 1
- ALHUZKCOMYUFRB-OAHLLOKOSA-N Muscone Chemical compound C[C@@H]1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-OAHLLOKOSA-N 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000007227 biological adhesion Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960003639 laurocapram Drugs 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- ALHUZKCOMYUFRB-UHFFFAOYSA-N muskone Natural products CC1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000009286 sanguis draxonis Substances 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Dispersion Chemistry (AREA)
- Insects & Arthropods (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Animal Husbandry (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种油包水包油型乳液气雾剂及其制备方法，所述油包水包油型乳液气雾剂包括油包水包油型乳液和抛射剂，所述油包水包油型乳液中内油相：水相：外油相=2：6～7：9～11（v/v），所述抛射剂用量为乳液质量的10～20%；所述内油相包括辅助用药，所述水相包括主药，所述外油相包括透皮促进剂。所述油包水包油型乳液气雾剂通过两步乳化法制备油包水包油型乳液，所得中间体O/W型乳液的平均粒径为180～220nm，所得O/W/O型乳液的平均粒径为290～420nm，再将O/W/O型乳液与抛射剂封装于加压密闭容器中制得气雾剂。该气雾剂使各组分在乳液结构中合理分布，保持结构稳定，并促进透皮吸收、减少用药刺激。
Description
技术领域
本发明涉及一种中药气雾剂，具体涉及一种油包水包油型乳液气雾剂及其制备方法。
背景技术
镇江膏药是一种主治筋骨疼痛、跌打损伤的中药贴剂，具有祛风止痛、化痞去瘀、舒筋活血、消散顺气的功效。但中药贴剂作为一种传统剂型，具有对皮肤刺激性较大、造成皮肤过敏、贴药处难以清理、污染衣物等缺点，因此需要对其进行剂型改良。外用气雾剂具有用药量少、剂量准确、使用方便、用药刺激性小、可局部定位和速效的优点，可作为局部外用中药贴剂的改良剂型。但是中药贴剂中所含组分较多、作用复杂，如何将各组分结合、发挥各自功效，又保持结构稳定成为需解决的难题。
CN102872288A公开了一种治疗风湿骨痛的中药微乳气雾剂，包括中药人工麝香、血竭、乳香、没药；油相主要是由混合芳香植物油（石蜡油肉、肉桂油、丁香罗勒油、桉叶油、水杨酸甲酯）组成；复合促渗透剂由月桂氮卓酮、冰片、麝香酮、薄荷素油组成；还包括乳化剂、助溶剂和抛射剂。该制剂形成纳米微乳，粒径25～80nm，将处方中名贵中药进行纳米化均质并分散在微乳化体系中，而微乳化体系是采用与皮肤生物黏附性较好的油性体系W/O，药物可以直接渗透进入皮肤，具有更好的局部渗透性，无皮肤刺激性和过敏性，止痛迅速。镇江膏药与之相比具有更复杂的组分，因此需要根据各组分的性质进行剂型改良。
发明内容
本发明的目的在于提供一种油包水包油型乳液气雾剂及其制备方法，使镇江膏药的各组分在该乳液结构中合理分布，保持结构稳定，并促进透皮吸收、减少用药刺激。
本发明的目的通过以下技术方案实现：
一种油包水包油型乳液气雾剂，包括油包水包油型乳液和抛射剂，所述油包水包油型乳液中内油相：水相：外油相=2：6～7：9～11（v/v），乳液平均粒径范围为290～420nm；所述抛射剂用量为乳液质量的10～20%；
所述内油相包括乌梢蛇、羌活、防风、芥子、独活、当归、醉仙桃、血余、马钱子、麻黄、巴豆、白芷、红花、三棱、桃仁和蜣螂虫的提取物，植物油，单甘脂；
所述水相包括生川乌、生草乌、天南星、肉桂、土鳖虫和蜈蚣的提取物，乙醇、丙二醇，水，聚氧丙烯硬脂酸酯，聚氧乙烯单硬脂酸酯；
所述外油相包括冰片，薄荷脑，松节油，植物油，失水山梨醇单油酸酯。
优选的，所述内油相中的单甘脂：植物油=1～3：20（w/w）。
优选的，所述水相中的提取物：聚氧丙烯硬脂酸酯，聚氧乙烯单硬脂酸酯=10：1：1～2（w/w）。
优选的，所述水相中的乙醇：丙二醇：水=10：2～3：2（v/v）。
优选的，所述外油相中的失水山梨醇单油酸酯：植物油=1～2：20（w/w）。
一种油包水包油型乳液气雾剂的制备方法，包括以下步骤：
（1）将生川乌17～25份、生草乌17～25份、天南星17～25份、肉桂8～15份、土鳖虫8～15份和蜈蚣1～1.5份分别破碎成粗粉，分别用乙醇和水提取液，浓缩、干燥得到提取物粉末；将提取物粉末、HLB为12～13.5的复合乳化剂溶于乙醇、丙二醇和水的混合溶剂中，形成水相；
（2）将乌梢蛇8～15份、羌活17～25份、防风17～25份、芥子17～25份、独活17～25份、当归17～25份、醉仙桃17～25份、血余17～25份、马钱子17～25份、麻黄17～25份、巴豆8～15份、白芷17～25份、红花8～15份、三棱17～25份、桃仁17～25份和蜣螂虫8～15份置于提炼锅内，加入植物油，升温至160～180℃，熄火冷却后出药油，加入单甘脂，形成内油相；
（3）将冰片7～15份与薄荷脑3～8份混合研磨，加入松节油7～15份、失水山梨醇单油酸酯和植物油搅拌溶解成油状，形成外油相；
（4）将水相加热至40～80℃，内油相加热至90～110℃，以12000～16000rpm均质水相的同时将内油相加入，均质3～5min，形成O/W型乳液；
（5）将外油相加热至80～100℃，在500～1000prm搅拌外油相的同时加入步骤（4）中的O/W型乳液，继续搅拌冷却至室温，制得O/W/O型乳液；
（6）将步骤（5）中的O/W/O型乳液与抛射剂封装于加压密闭容器中，制得O/W/O型乳液气雾剂。
优选的，所述步骤（4）所得O/W型乳液的平均粒径为180～220nm。
相比于现有技术，本发明的有益技术效果如下：
1）本发明将镇江膏药的各组分分别分散在O/W/O型乳液的内油相、水相、外油相，各自发挥作用。外油相中分布的冰片，薄荷脑，松节油具有透皮促进作用，有利于后续药物渗入皮肤；水相中的生川乌、生草乌、天南星、肉桂、土鳖虫和蜈蚣的提取物为主药，发挥祛风止痛作用；内油相中的乌梢蛇、羌活、防风、芥子、独活、当归、醉仙桃、血余、马钱子、麻黄、巴豆、白芷、红花、三棱、桃仁和蜣螂虫的提取物为辅助用药，发挥舒筋活血、化痞去瘀、消散顺气作用。
2）本发明通过水油比例调节、水相溶剂调节和乳化剂比例调节，使O/W/O型乳液平均粒径范围为290～420nm，有利于促进皮肤吸收，并保持稳定的三相结构。
3）与镇江膏药相比，剂型改良后的气雾剂对用药的皮肤局部刺激性较小，可减少皮肤过敏的发生，且便于携带使用。
附图说明
图1为实施例2的粒径分布图（横坐标粒径，纵坐标强度）；
图2为实施例5的粒径分布图（横坐标粒径，纵坐标强度）。
具体实施方式
实施例1～3 O/W型乳液的制备
（1）将生川乌17～25份、生草乌17～25份、天南星17～25份、肉桂8～15份、土鳖虫8～15份和蜈蚣1～1.5份分别破碎成粗粉，浸入乙醇溶液过夜后回流提取，收集提取液；将药渣加10倍量的水，升温至60℃，超声波提取5h，分离提取液和药渣；将乙醇提取液和水提取液合并，浓缩、干燥得到提取物粉末；用乙醇、丙二醇和水混合溶剂搅拌溶解提取物粉末，并加入聚氧丙烯硬脂酸酯（Atlas G-3608）和聚氧乙烯单硬脂酸酯（Myrj 49）复合乳化剂，形成水相；
（2）将乌梢蛇8～15份、羌活17～25份、防风17～25份、芥子17～25份、独活17～25份、当归17～25份、醉仙桃17～25份、血余17～25份、马钱子17～25份、麻黄17～25份、巴豆8～15份、白芷17～25份、红花8～15份、三棱17～25份、桃仁17～25份和蜣螂虫8～15份置于提炼锅内，加入3倍量的植物油，升温至160℃，熄火冷却后出药油，加入单甘脂，形成内油相；
（3）将水相加热至40℃，内油相加热至80℃，以16000rpm均质水相的同时将内油相加入，均质3min，形成O/W型乳液。
如表1所示，根据水相提取物的溶解性，选用乙醇、丙二醇和水混合溶剂，其中丙二醇的加入调节了水相的粘度，有利于液滴的稳定，延缓乳液分层时间，当乙醇：丙二醇：水（v/v）=10：3：2时，室温下稳定时间为14天。
复合乳化剂由Atlas G-3608和Myrj 49混合达到，两者以1：1、1：1.5、1：2的比例混合时，HLB值分别为12、13、13.5。亲水性复合乳化剂在水油界面形成的复合膜层加固了液滴的稳定性，且随着HLB的升高，更有利于形成小液滴，有利于透皮吸收。
内油相中的单甘脂用于调和植物油，在单甘脂：植物油（w/w）=1～3：20的范围内，单甘脂的加入有利于形成小液滴，但是加入量过大不利于乳液的稳定，后期易出现液滴融合现象。
内油相与水相体积比在2：6～7范围内，既能满足各相中组分比例的需求，又能形成形态清晰、粒径较均一、结构稳定的液滴。当内油相与水相体积比过低时，内油相中药物含量不足而影响药效；当内油相与水相体积比过高时，不易形成O/W液滴且形成液滴粒径大。
因此，实施例2采用控制条件为优选条件，如图1所示，所得O/W型乳液的平均粒径为206 nm，且粒径分布均一，160～179nm处分布9%，180～199nm处分布20%，200～219nm处分布31%，220～239nm处分布25%，240～259nm处分布13%，260～279nm处分布2%。
实施例4～5 O/W/O型乳液的制备
（1）将冰片7～15份与薄荷脑3～8份混合研磨，并加入松节油7～15份，用5倍量的植物油溶解，并按比例加入失水山梨醇单油酸酯（Span 80），形成外油相；
（2）将外油相加热至90℃，在1000prm搅拌外油相的同时加入实施例2所得O/W型乳液，继续搅拌冷却至室温，制得O/W/O型乳液；
（3）将步骤（2）中的O/W/O乳液与抛射剂封装于加压密闭容器中，制得O/W/O型乳液气雾剂。
如表2所示，当Span 80：植物油=1～2：20，内油相：水相：外油相体积比在2：6：9～11范围内时能形成平均粒径为290～420nm的O/W/O液滴，其中所包覆的O/W液滴多为1～3个。当Span 80含量过低或外油相比例过低时，易形成包含多个O/W液滴的O/W/O液滴，在放置过程中已发生内部融合造成不稳定现象；当Span 80含量过高时，水相层不稳定，易破坏三相结构。因此，实施例5采用控制条件为优选条件，如图2所示，所得W/O/W型乳液的平均粒径为295 nm，主要分布于240～380nm，粒径分布较为均一，225～254nm处分布12%，255～284nm处分布23%，285～314nm处分布32%，315～344nm处分布21%，345～374nm处分布10%。
实施例6 局部刺激反应试验
组1：实施例5气雾剂；组2：镇江膏药；空白组1：空白气雾剂；空白组2：空白膏药
将6只豚鼠的背部分别脱毛，分为两组（n=3），A组豚鼠背部左侧喷组1的实施例5气雾剂（按压2次），右侧喷空白组1的空白气雾剂（按压2次）；B组豚鼠背部左侧贴组2的镇江膏药（4cm*4cm），右侧贴空白组2的空白膏药（4cm*4cm），并于第3、5、7天重复给药，第8天去除膏药，温水清洗给药区域，观察各组皮肤状态。
喷涂气雾剂的组1和空白组1的3只豚鼠的背部均未出现红肿现象，而贴涂膏药的组2和空白组2的3只豚鼠的背部均出现不同程度的红肿现象，说明本发明的气雾剂对皮肤局部刺激小。
Claims (7)
1.一种油包水包油型乳液气雾剂，其特征在于，包括油包水包油型乳液和抛射剂，所述油包水包油型乳液中内油相：水相：外油相=2：6～7：9～11（v/v），乳液平均粒径范围为290～420nm；所述抛射剂用量为乳液质量的10～20%；
所述内油相包括乌梢蛇、羌活、防风、芥子、独活、当归、醉仙桃、血余、马钱子、麻黄、巴豆、白芷、红花、三棱、桃仁和蜣螂虫的提取物，植物油，单甘脂；
所述水相包括生川乌、生草乌、天南星、肉桂、土鳖虫和蜈蚣的提取物，乙醇、丙二醇，水，聚氧丙烯硬脂酸酯，聚氧乙烯单硬脂酸酯；
所述外油相包括冰片，薄荷脑，松节油，植物油，失水山梨醇单油酸酯。
2.如权利要求1所述的油包水包油型乳液气雾剂，其特征在于，所述内油相中的单甘脂：植物油=1～3：20（w/w）。
3.如权利要求1所述的油包水包油型乳液气雾剂，其特征在于，所述水相中的提取物：聚氧丙烯硬脂酸酯，聚氧乙烯单硬脂酸酯=10：1：1～2（w/w）。
4.如权利要求1所述的油包水包油型乳液气雾剂，其特征在于，所述水相中的乙醇：丙二醇：水=10：2～3：2（v/v）。
5.如权利要求1所述的油包水包油型乳液气雾剂，其特征在于，所述外油相中的失水山梨醇单油酸酯：植物油=1～2：20（w/w）。
6.权利要求1所述的油包水包油型乳液气雾剂的制备方法，其特征在于，包括以下步骤：
（1）将生川乌17～25份、生草乌17～25份、天南星17～25份、肉桂8～15份、土鳖虫8～15份和蜈蚣1～1.5份分别破碎成粗粉，分别用乙醇和水提取液，浓缩、干燥得到提取物粉末；将提取物粉末、HLB为12～13.5的复合乳化剂溶于乙醇、丙二醇和水的混合溶剂中，形成水相；
（2）将乌梢蛇8～15份、羌活17～25份、防风17～25份、芥子17～25份、独活17～25份、当归17～25份、醉仙桃17～25份、血余17～25份、马钱子17～25份、麻黄17～25份、巴豆8～15份、白芷17～25份、红花8～15份、三棱17～25份、桃仁17～25份和蜣螂虫8～15份置于提炼锅内，加入植物油，升温至160～180℃，熄火冷却后出药油，加入单甘脂，形成内油相；
（3）将冰片7～15份与薄荷脑3～8份混合研磨，加入松节油7～15份、失水山梨醇单油酸酯和植物油搅拌溶解成油状，形成外油相；
（4）将水相加热至40～80℃，内油相加热至90～110℃，以12000～16000rpm均质水相的同时将内油相加入，均质3～5min，形成O/W型乳液；
（5）将外油相加热至80～100℃，在500～1000prm搅拌外油相的同时加入步骤（4）中的O/W型乳液，继续搅拌冷却至室温，制得O/W/O型乳液；
（6）将步骤（5）中的O/W/O型乳液与抛射剂封装于加压密闭容器中，制得O/W/O型乳液气雾剂。
7.如权利要求6所述的油包水包油型乳液气雾剂的制备方法，其特征在于，所述步骤（4）所得O/W型乳液的平均粒径为180～220nm。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011077443.2A CN112057572B (zh) | 2020-10-10 | 2020-10-10 | 一种油包水包油型乳液气雾剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011077443.2A CN112057572B (zh) | 2020-10-10 | 2020-10-10 | 一种油包水包油型乳液气雾剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112057572A true CN112057572A (zh) | 2020-12-11 |
| CN112057572B CN112057572B (zh) | 2022-04-15 |
Family
ID=73654952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011077443.2A Active CN112057572B (zh) | 2020-10-10 | 2020-10-10 | 一种油包水包油型乳液气雾剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112057572B (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872288A (zh) * | 2012-11-05 | 2013-01-16 | 广东同德药业有限公司 | 一种治疗风湿骨痛乳香风湿气雾剂及其制备方法 |
| CN104132891A (zh) * | 2014-07-11 | 2014-11-05 | 江苏七○七天然制药有限公司 | 一种镇江膏药的质量检测方法 |
| CN106900881A (zh) * | 2015-12-22 | 2017-06-30 | 丰益(上海)生物技术研发中心有限公司 | 油包水包油的油脂组合物及其制备方法 |
-
2020
- 2020-10-10 CN CN202011077443.2A patent/CN112057572B/zh active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872288A (zh) * | 2012-11-05 | 2013-01-16 | 广东同德药业有限公司 | 一种治疗风湿骨痛乳香风湿气雾剂及其制备方法 |
| CN104132891A (zh) * | 2014-07-11 | 2014-11-05 | 江苏七○七天然制药有限公司 | 一种镇江膏药的质量检测方法 |
| CN106900881A (zh) * | 2015-12-22 | 2017-06-30 | 丰益(上海)生物技术研发中心有限公司 | 油包水包油的油脂组合物及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 杨明: "《中药药剂学》", 31 July 2016, 中国中医药出版社 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112057572B (zh) | 2022-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3673905B1 (en) | Composition containing cannabidiol and cannabidivarin and application of composition in treatment of dysmenorrhea | |
| CN109996551A (zh) | 从植物源中选择性提取大麻素的方法 | |
| CN1500524A (zh) | 用于抗炎化合物局部释放的载体 | |
| CN1762333A (zh) | 一种微乳制剂及其制备方法 | |
| JP2009057361A (ja) | 皮膚障害を治療し創傷の治癒を促進する植物抽出物の調製方法 | |
| CN103751734B (zh) | 活血止痛巴布膏及其制备方法 | |
| CN112057572B (zh) | 一种油包水包油型乳液气雾剂及其制备方法 | |
| CN109758542B (zh) | 具有健胃作用的复合木香油脂肪乳制剂及制备方法与应用 | |
| CN201658672U (zh) | 一种改进型狗皮膏药 | |
| CN116672427A (zh) | 一种缓解头晕头疼的天然植物提取挥发油及制备方法与应用 | |
| CN101020019A (zh) | 狗皮膏(巴布剂)及其制备方法 | |
| CN102949415B (zh) | 一种蜂胶脂肪乳制剂及其制备方法 | |
| CN101524448B (zh) | 一种镇痛抗炎的中药组合物及其制剂的制备方法和应用 | |
| CN110812377B (zh) | 一种痤疮治疗修复组合物及其应用 | |
| CN1899316A (zh) | 中药微乳制剂及其制备方法 | |
| WO2017206016A1 (zh) | 外敷消炎消肿中药膏剂 | |
| CN109010429B (zh) | 一种用于祛风止痒的中药制剂及其制备方法与应用 | |
| CN101700266A (zh) | 雪莲纳米粒及其制备方法和应用 | |
| CN103330919A (zh) | 一种治疗乳腺增生的中药复方霜剂及其制备方法 | |
| CN101244147A (zh) | 一种治疗性功能障碍的外用组合物及其制法 | |
| CN112791120A (zh) | 一种药物口服乳剂及其制备方法和用途 | |
| CN114699465B (zh) | 一种外用治疗皮肤炎症的沉香提取物及其应用 | |
| CN101721444B (zh) | 雪莲自微乳制剂及其制备方法和应用 | |
| CN1899388A (zh) | 一种双丹软胶囊及其制备方法 | |
| CN101700331B (zh) | 接骨灵喷雾剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |