CN112057568B - Traditional Chinese medicine composition for treating infantile anal fissure and application thereof - Google Patents
Traditional Chinese medicine composition for treating infantile anal fissure and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Abstract
The invention relates to a traditional Chinese medicine composition for treating infantile anal fissure and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1 part of each of watermelon peel, pomegranate peel, wax gourd peel and sugarcane peel and 3 parts of honey. The invention also comprises the application of the traditional Chinese medicine composition in preparing a medicine for treating infantile anal fissure. Its advantages are: the composition has analgesic, antiinflammatory, hemostatic, and wound healing effects. And the adopted medicinal materials are edible medicinal materials, so that the side effects are avoided by external application, the traditional Chinese medicine is safe and reliable, the internal and external consideration is realized, the method is easy to accept, the operation is simple, the price is low, the curative effect is obvious, and the advantages of simplicity, convenience, cheapness and experience of the traditional Chinese medicine are fully embodied.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating infantile anal fissure and application thereof.
Background
Anal fissure is a common clinical anorectal disease, and occurs when the whole layer of the anal canal skin longitudinally cracks and forms infectious ulcer, the morbidity of people is 2.19%, and the diagnosis rate of a special department is about 14%. Crying, bleeding or refusing when defecation occurs are typical symptoms of anal fissure in children. From the disease species, the anal diseases of children are anal fissure, rectal polyp, perianal infectious diseases, rectal prolapse and the like in sequence. Generally, the wound surface of the infantile anal fissure is fresh, and complications such as sentinel hemorrhoid or hypertrophy of anal papilla are rarely caused, so that the clinical treatment at present generally adopts non-operative methods such as local medication and the like, and the methods for treating the infantile anal fissure such as oral administration, external application and the like are endless.
Anal fissure belongs to the category of 'rhynchophorus' in the traditional Chinese medicine, and the traditional Chinese medicine considers that the anal fissure is mostly caused by constipation and struggle of defecation due to blood heat and dryness of the intestine and yin deficiency and body fluid deficiency, so that anal skin laceration is caused to cause the anal fissure. Because the number of children with functional constipation increases, the diagnosis rate of anal fissure of children gradually increases, and in addition, the children have weak self-control ability and poorer medical treatment property than adults, the treatment of anal fissure of children is troublesome. At present, the clinical treatment methods for anal fissure are various, including oral probiotic, Baiduobang, tin powder, and myogenic powder, etc., however, the medicines often have great side effects, such as: (1) shengji powder (talcum powder, dragon's bone, myrrh, catechu, dragon's blood) has the functions of detoxicating and promoting tissue regeneration, and is used for treating long-term ulceration of wound and furuncle, muscle disunion and healing wound. The tin powder (ivory, natural indigo, talcum powder, pearl, artificial bezoar, etc.) has the effects of removing toxic substance and eliminating slough, and can be used for treating sore throat, erosion, etc. The two types of medicines, namely granulation promoting powder and tin powder, are used for promoting wound healing, but because the two types of medicines have more components, although the effect is obvious, the two types of medicines are the problem which is inevitably considered by each parent for safety. (2) At present, most of the honey external application reports are reported in documents, the honey external application is mainly decocted into suppository which has the effects of diminishing inflammation and relaxing bowel, but the honey suppository has a relatively limited effect, has the main effect of diminishing inflammation, and has the effects of stopping bleeding, relieving pain and the like in treatment of infantile anal fissure and is required to be matched with other medicines for treatment.
The children are flowers of the motherland, are the future of the motherland, and the physiological and psychological health of the children is vital to the society and a family, so that the prevention and treatment of the anal fissure of the children are not slow, and a series of complications are easy to occur when the anal fissure of the children is not treated. Therefore, aiming at the defects in the prior art, the invention combines the diet regulation with the external application of the traditional Chinese medicine composition, has the effects of relieving pain, diminishing inflammation, stopping bleeding and promoting wound healing while improving the defecation condition, is compatible internally and externally, has the advantages of easy acceptance, simple operation, low price and obvious curative effect, fully embodies the advantages of simplicity, convenience, cheapness and effectiveness of the traditional Chinese medicine, adopts edible medicinal materials for external application, avoids side effects and is safe and reliable. The traditional Chinese medicine composition for treating infantile anal fissure and the application thereof are not reported at present.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating infantile anal fissure and application thereof, aiming at the defects of the prior art.
In order to achieve the purpose, the invention adopts the technical scheme that:
on one hand, the invention provides a traditional Chinese medicine composition for treating infantile anal fissure, which is prepared from the following raw material medicines in parts by weight: 1-5 parts of watermelon peel, 1-5 parts of pomegranate peel, 1-5 parts of wax gourd peel, 1-5 parts of sugarcane peel and 1-5 parts of honey.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1 part of watermelon peel, 1 part of pomegranate peel, 1 part of wax gourd peel, 1 part of sugarcane peel and 3 parts of honey.
Preferably, the externally applied pharmaceutical preparation which is clinically acceptable is prepared according to the conventional preparation method of the traditional Chinese medicine.
Preferably, the external pharmaceutical preparation is a paste, a lotion, a liniment, an aerosol, a gel and a spray.
On the other hand, the invention provides the application of the traditional Chinese medicine composition in preparing the medicine for treating the infantile anal fissure.
In another aspect, the invention provides a medicine for treating infantile anal fissure, which is prepared from the traditional Chinese medicine composition.
Further, the invention provides a spray for treating infantile anal fissure, and the medicine is prepared from the traditional Chinese medicine composition.
Preferably, the preparation method of the spray comprises the following steps:
(1) taking raw material medicines: drying watermelon peel, pomegranate peel, wax gourd peel and sugarcane peel in the sun, frying to brown, and drying honey at low temperature;
(2) mixing the medicinal materials, and grinding into powder.
Square solution:
the honey is a monarch drug, has lubricating effect, and also has effects of diminishing inflammation, relieving swelling, and promoting wound healing.
The sugarcane peel and the watermelon peel are ministerial drugs and are compatible with honey, so that the wound healing capacity is improved: the sugarcane peel is sweet and cold, has the effects of clearing away heat and toxic materials, and can be used for treating infantile aphtha, alopecia, and sore of sitting plate. Compendium of materia Medica: the sugarcane peel is burned and ground and mixed. Zhou Yi Sheng Jia Bao Fang: the sugarcane peel is burnt and stored, and is mixed with sesame oil and coated. Watermelon peel: cool in nature, sweet in taste and non-toxic. Clearing summer heat, relieving fever, quenching thirst and promoting urination, is used for treating summer heat, polydipsia, oliguria, edema and aphtha of the mouth and the tongue, and has the effects of promoting wound healing and promoting skin metabolism of a human body.
Pomegranate rind is an adjuvant: auxiliary action, astringing to stop bleeding, pomegranate rind is sour and astringent in taste, warm in nature, astringing intestine to stop bleeding, and externally treating chilblain for long time and not cured. The book Ben Cao Hui Yan (treatise on materia Medica): pomegranate rind, Chinese waxgourd rind and sugarcane rind, burning ash, storing, grinding and applying. The anal fissure of children is mainly characterized by hematochezia, pain and pomegranate rind stopping bleeding.
The Chinese waxgourd peel is used as a messenger drug: the Chinese herbal medicines are mixed, the curative effect is improved, the Chinese waxgourd peel is sweet in taste and cool in nature, the diuresis is promoted, the swelling is reduced, and the injury is threatened by traumatic injury through external application. Compendium of materia Medica: dried Chinese waxgourd peel and real oxhide gelatin are used, and then are filed into a pot to be fried and ground into powder.
The invention has the advantages that:
1. in the application process of the powder, watermelon peel, pomegranate peel, wax gourd peel and sugarcane peel are dried and parched to be respectively divided into equal parts, honey is dried at low temperature, and 5 medicines are respectively divided into equal parts and ground into powder, and the powder is sprayed to anal fissure of children. The external preparation is stir-baked to brown for external use, has the effect of stopping bleeding, is ground into powder and externally sprayed on the wound surface, can absorb dampness and reduce the perianal secretion due to more perianal secretion after the anal fissure of the child and the tender anus of the child and the occurrence of red buttocks.
2. Aiming at the pathological pathogenesis of the anal fissure of the child, the raw material medicines and the weight part ratio thereof are preferably selected, the raw material medicines act synergistically, the clinical result shows that the curative effect is good, the symptoms of hematochezia and pain can be well relieved, the fracture healing is convenient, and the medicine can be well applied to clinic.
3. The source of each medicine is wide, the preparation method of the medicinal preparation is simple and convenient, the cost is low, no side effect is caused, and the medicinal preparation has strong practicability and wide application prospect.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.
EXAMPLE 1 Chinese medicinal composition 1
The raw material medicaments are taken according to the following weight portion: 1 part of watermelon peel, 1 part of pomegranate peel, 1 part of wax gourd peel, 1 part of sugarcane peel and 1 part of honey.
EXAMPLE 2 Chinese medicinal composition (II)
The raw material medicaments are taken according to the following weight portion: 5 parts of watermelon peel, 5 parts of pomegranate peel, 5 parts of wax gourd peel, 5 parts of sugarcane peel and 3 parts of honey.
EXAMPLE 3 Chinese medicinal composition (III)
The raw material medicaments are taken according to the following weight portion: 1 part of watermelon peel, 5 parts of pomegranate peel, 1 part of wax gourd peel, 5 parts of sugarcane peel and 1 part of honey.
EXAMPLE 4 Chinese medicinal composition (IV)
The raw material medicaments are taken according to the following weight portion: 5 parts of watermelon peel, 1 part of pomegranate peel, 5 parts of wax gourd peel, 1 part of sugarcane peel and 5 parts of honey.
EXAMPLE 5 Chinese medicinal composition (V)
The raw material medicaments are taken according to the following weight portion: 1 part of watermelon peel, 1 part of pomegranate peel, 1 part of wax gourd peel, 1 part of sugarcane peel and 3 parts of honey.
Example 6 spray
The preparation method comprises the following steps:
the raw material medicaments are taken according to the weight parts of the embodiments 1-5 respectively: drying watermelon peel, pomegranate peel, wax gourd peel and sugarcane peel in the sun, frying to brown, and drying honey at low temperature; mixing the medicinal materials, and grinding into powder.
Example 7 paste
The preparation method comprises the following steps:
the raw material medicaments are taken according to the weight parts of the embodiments 1-5 respectively: watermelon peel, pomegranate peel, wax gourd peel, sugarcane peel and honey, and medicinal auxiliary materials are added to prepare the ointment according to a conventional preparation method.
Example 8 lotion
The preparation method comprises the following steps:
the raw material medicaments are taken according to the weight parts of the embodiments 1-5 respectively: watermelon peel, pomegranate peel, wax gourd peel, sugarcane peel and honey, and medicinal auxiliary materials are added to prepare the lotion according to a conventional preparation method.
Example 9 clinical trial
1 data and method
1 clinical data
232 cases of sick children who see a hospital and have anal fissure in 2017, 10-2019 and 9 are selected, and the sick children are divided into five groups by a random digital method, wherein the five groups are respectively a treatment group, a control group, a comparative group and a comparative group. The anal fissure diagnosis standard refers to the 'standard of curative effect for diagnosing diseases of traditional Chinese medicine' issued by the State administration of traditional Chinese medicine.
Inclusion criteria were: (1) infant with anal fissure; (2) the age is 2 months to 4 years old, and the nature is not limited; (3) the family members of the children patients can agree with the information and cooperate with the children patients to complete follow-up visits; (4) there are no serious primary diseases of cerebral vessels, liver, kidney and hemopoietic system.
Exclusion criteria: (1) the family members of the children patients require to quit the clinical test; (2) the compliance of the children patients is poor, and regular examination and identification cannot be matched according to requirements; (3) serious complications and complications appear in clinic, and the test is not suitable to be carried out continuously; (4) the prior history of anal stenosis, operation or trauma of the anal region; (5) has dermatosis such as acute and chronic diarrhea or perianal eczema; (6) accompanied by digestive tract infectious diseases, psychosis, diabetes, severe allergy, etc.
The study was approved by the ethical committee of the medical science of Jinshan Hospital, university of Compound Dane, and all children patients signed informed consent.
1.2 methods
1.2.1 questionnaire survey
Before the research is carried out, the family members of the children patients firstly carry out questionnaires (comprising paper questionnaires and questionnaire star software) which mainly comprise information such as age, course of disease, eating habits and the like.
1.2.2 intervention methods
The children patients in the control group adopt diet adjustment (eating more fruits and vegetables and drinking more water).
The treatment group is coated with the spray (the formula comprises 1 part of exocarpium Citrulli, 1 part of pericarpium Granati, 1 part of exocarpium Benincase, 1 part of cortex Sacchari sinensis, and 3 parts of Mel) on the basis of control group, and intervention time is 2 weeks.
Comparative example one set: on the basis of a control group, a spray (the formula comprises 1 part of watermelon peel, 6 parts of pomegranate peel, 9 parts of Chinese waxgourd peel, 8 parts of sugarcane peel and 7 parts of honey) is externally coated, and the intervention time is 2 weeks.
Comparative examples two groups: on the basis of a control group, a spray (the formula is 1 part of talcum, 1 part of hedgehog skin, 1 part of Chinese waxgourd skin, 1 part of tuckahoe and 3 parts of honey) is externally coated, and the intervention time is 2 weeks.
Comparative three groups: on the basis of the control group, spray (the prescription is that large-leaf gentian root, peach kernel, Chinese honeylocust fruit, 3 g of each, atractylodes rhizome, ledebouriella root, 2 g of each, corktree bark, 0.5 g of Chinese angelica root, 0.9 g of oriental water plantain, 0.3 g of areca seed and 3 g of cooked rhubarb) is externally applied, and the intervention time is 2 weeks.
Hematochezia, pain and laceration healing were scored before and after each group intervention.
1.2.3 Scoring criteria
The pain scoring adopts a FLACC scale, and is mainly used for an effective method for evaluating the pain of children aged 2 months to 7 years, and the method comprises the following 5 steps: facial expressions (face), limb movements (legs), activities (activity), see table 1. Stool blood score: the stool-free blood is 0 point; a small amount of excrement blood, which is mainly contaminated by excrement paper, and the color red or light is 1 point; medium volume of hematochezia, bleeding with drip, red or light color 2 points; profuse bleeding in defecation, with a spray pattern, red or pale in color of 3 points. Anal fissure healing was compared with anal fissure.
TABLE 1 FLACC pain scoring method
1.3 statistical methods
The database was built with EpiData and statistical analysis was performed using the SPSS 17.0 software package. The measurement data conforming to normal distribution is expressed by (x +/-s), the two groups are compared by adopting a t test, and the two groups are compared by adopting a Mann-Whitney U test; analysis of the count data was performed using chi2And (6) checking. With P<A difference of 0.05 is statistically significant.
2 results
2.1 basic case
In the course of treatment, 31 children patients fell off. There was no significant difference in the basic condition (age, condition) among the patients in each group.
2.2 comparison of fecal blood scores before and after treatment
The difference is not statistically significant (P >0.05) when the scores of the hematochezia before the treatment of each group are compared; the differences were statistically significant when compared with the fecal blood scores at day 7 and 14 of treatment in each group (P <0.05, see Table 2).
TABLE 2 comparison of fecal blood scores before and after treatment on days 7 and 14 [ M (P25, P75, points ]
2.3 comparison of pain scores before and after treatment
The treatment group had a lower pain score on day 14 of treatment than the other groups, with statistical significance for the difference (P <0.05, see table 3).
TABLE 3 comparison of pain scores (x + -s, points) before treatment, on days 7 and 14 of treatment in five groups
2.4 comparison of breach healing before and after treatment
On day 7 of treatment, the treatment group had 9 healed splits (21.96%), 32 non-healed splits (78.04%); control group had 0 healed lacerations and 40 non-healed lacerations (100.0%); comparative example a set of cracks healed 5 cases (13.16%), non-healed 33 cases (86.84%); comparative example two sets of splits healed 3 (7.70%) and not 36 (92.30%); comparative example three groups of splits healed 7 (16.28%) and non-healed 36 (83.72%). The treatment groups were statistically different from the rest of the groups.
On day 14 of treatment, 38 cases (92.69%) of the treatment group had healed lacerations, 3 cases (7.31%) had not healed; the control group had 14 healed lacerations (35.0%), 26 non-healed lacerations (65.0%); comparative example a set of cracks healed 27 cases (71.05%), not healed 11 cases (28.95%); comparative example two groups of splits healed 24 cases (61.54%), non-healed 15 cases (38.46%); comparative example three groups of splits healed 37 cases (86.05%) and 6 unhealed cases (13.95%). The treatment groups were statistically different from the rest of the groups.
Discussion of 3
The prescription provides a traditional Chinese medicine prescription for children anal fissure patients, wherein honey is a monarch drug, has a lubricating effect, and can also diminish inflammation, reduce swelling and promote wound healing. The sugarcane peel and the watermelon peel are ministerial drugs and are compatible with honey, so that the wound healing capacity is improved: the sugarcane peel is sweet and cold, has the effects of clearing away heat and toxic materials, and can be used for treating infantile aphtha, alopecia, and sore of sitting plate. Watermelon peel: cool in nature, sweet in taste and non-toxic. Clearing summer heat, relieving fever, quenching thirst and promoting urination, is used for treating summer heat, polydipsia, oliguria, edema and aphtha of the mouth and the tongue, and has the effects of promoting wound healing and promoting skin metabolism of a human body. Pomegranate rind is an adjuvant: auxiliary action, astringing to stop bleeding, pomegranate rind is sour and astringent in taste, warm in nature, astringing intestine to stop bleeding, and externally treating chilblain for long time and not cured. The anal fissure of children is mainly characterized by hematochezia, pain and pomegranate rind stopping bleeding. The Chinese waxgourd peel is used as a messenger drug: the Chinese herbal medicines are mixed, the curative effect is improved, the Chinese waxgourd peel is sweet in taste and cool in nature, the diuresis is promoted, the swelling is reduced, and the injury is threatened by traumatic injury through external application. The external preparation is stir-baked to brown for external use, has the effect of stopping bleeding, is ground into powder and externally sprayed on the wound surface, can absorb dampness and reduce the perianal secretion due to more perianal secretion after the anal fissure of the child and the tender anus of the child and the occurrence of red buttocks. Simple operation, low price and obvious curative effect, and fully embodies the advantages of simplicity, convenience, cheapness and effectiveness of the traditional Chinese medicine.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.
Claims (7)
1. The external traditional Chinese medicine composition for treating infantile anal fissure is characterized by being prepared from the following raw materials in parts by weight: 1 part of watermelon peel, 1 part of pomegranate peel, 1 part of wax gourd peel, 1 part of sugarcane peel and 3 parts of honey.
2. The traditional Chinese medicine composition of claim 1, which is prepared into a clinically acceptable external pharmaceutical preparation according to a conventional traditional Chinese medicine preparation method.
3. The composition of claim 2, wherein the topical pharmaceutical formulation is selected from the group consisting of a paste, a lotion, a liniment, an aerosol, a gel, and a spray.
4. The use of the Chinese medicinal composition of claim 1 in the preparation of a topical medicament for the treatment of infantile anal fissure.
5. An external medicine for treating infantile anal fissure, which is characterized in that the medicine is prepared from the traditional Chinese medicine composition of claim 1.
6. A spray for treating infantile anal fissure, which is prepared from the Chinese medicinal composition of claim 1.
7. The spray according to claim 6, which is prepared by a method comprising:
(1) taking raw material medicines: drying watermelon peel, pomegranate peel, wax gourd peel and sugarcane peel in the sun, frying to brown, and drying honey at low temperature;
(2) mixing the medicinal materials, and grinding into powder.
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