CN111588795B

CN111588795B - Chinese medicinal composition for treating burn, scald, wound and skin injury, and its preparation method

Info

Publication number: CN111588795B
Application number: CN202010443025.4A
Authority: CN
Inventors: 徐勋
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-22
Filing date: 2020-05-22
Publication date: 2022-02-01
Anticipated expiration: 2040-05-22
Also published as: CN111588795A

Abstract

The invention discloses a traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages, which comprises the following raw materials in parts by weight: 20-60 parts of diverse wormwood herb, 15-50 parts of lithospermum, 5-30 parts of rheum officinale, 0.9-20 parts of mint, 0.25-18 parts of paris polyphylla and 0.1-9 parts of pseudo-ginseng. The beverage also comprises alcohol, wherein the proportion relation of the alcohol to the total weight of the raw materials is 50:30, and the concentration of the alcohol is 55% voL. The traditional Chinese medicine composition combines various medicines, has the functions of promoting granulation and removing necrotic tissue, clearing heat and toxic materials and relieving pain, has targeting property, can directly reach the focus of infection, takes effect quickly, is cool and comfortable after being sprayed with the medicine, has no stabbing, hot and burning pain, avoids the pain of the body of a patient, and has no scar after healing.

Description

Chinese medicinal composition for treating burn, scald, wound and skin injury, and its preparation method

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages and a preparation method thereof.

Background

Skin injuries such as burns, scalds, wounds and skin lesions occur in daily life, and not only the patient suffers pain, but also symptoms such as pain, itching and sepsis are accompanied.

At present, in the process of treating the skin injury, the wound is required to be covered, and the dressing needs to be changed frequently, so that inconvenience and pain are brought to a patient, and scars are easy to generate after healing.

Therefore, the development of a medicament for treating skin injury with convenient use and good healing effect is a problem which needs to be solved urgently by the technical personnel in the field.

Disclosure of Invention

In view of the above, the present invention provides a Chinese medicinal composition for treating burns, scalds, wounds and skin damages.

In order to achieve the purpose, the invention adopts the following technical scheme:

a traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages comprises the following raw materials in parts by weight: 20-60 parts of diverse wormwood herb, 15-50 parts of lithospermum, 5-30 parts of rheum officinale, 0.9-20 parts of mint, 0.25-18 parts of paris polyphylla and 0.1-9 parts of pseudo-ginseng.

The traditional Chinese medicine composition takes diverse wormwood herb as a monarch drug; the lithospermum is taken as a ministerial drug; mint is used as an adjuvant drug; seven-leaf-branch flower is used as a guiding drug. The medicines are used together, and the functions of promoting granulation and removing necrotic tissue, clearing away heat and toxic materials, resisting bacteria and diminishing inflammation and relieving pain are achieved. The compatibility of medicines of the invention has targeting property, can directly reach the focus, has quick effect, takes effect quickly, is cool and comfortable after spraying the medicine, has no stabbing, hot and burning pain, avoids the physical pain of patients, and has no scar after healing.

Siphonostegia chinensis Benth is bitter in nature and warm in taste. It contains volatile oil, coumarin, 7-methoxy coumarin, palmitic acid, hyoscyami, trans-o-hydroxy cinnamic acid, tricin, inositol monomethyl ether, etc., has effects of removing blood stasis, dredging channels, healing sore, and relieving swelling, and is effective in stopping bleeding of wound, traumatic injury, incised wound hemorrhage, and carbuncle toxic swelling. The invention takes the stir-fried herba artemisiae anomala as the monarch drug, and can strengthen the hemostatic effect on the affected parts such as scalds, wounds, damaged skin and the like. Radix Arnebiae is sweet, salty and cold in nature and can cool blood, remove blood stasis, promote blood circulation, remove toxic substance, promote eruption, and inhibit permeability of capillary vessel. The invention takes the lithospermum as a ministerial drug, the lithospermum has wide inhibiting effect on staphylococcus aureus, bacillus prodigiosus, pyogenic bacteria and escherichia coli, can strengthen the antibacterial and anti-inflammatory effects after wound hemostasis, forms a layer of protective film at the wound, prevents the secondary infection of bacteria at the wound and can promote the growth of epithelial cells at the wound. The nature and taste of rhubarb: bitter and cold, purging heat-toxin, breaking accumulation and removing blood stasis, it can be used for abscess, swelling and toxin, furuncle, and injury due to fire and dampness. Rhubarb contains rhein, emodin, physcion and aloe-emodin, wherein the aloe-emodin has the strongest effect, can block the synthesis of bacterial nucleic acid and protein, can inhibit the abnormal metabolism of eicosanoids, increases a cell protection mechanism, resists coagulation and thrombus and improves microcirculation. The peppermint is pungent in flavor and cool in property, good at moving the skin and exterior, and can eliminate edema and disperse muscle heat, and is effective for carbuncle, gangrene, scabies and epilepsy. The catecholic acid contained in herba Menthae is effective antiinflammatory agent, and can inhibit 3 a-hydroxysteroid dehydrogenase, the included spearmint oil hydrocarbon has antiinflammatory effect, and the included menthol has antiinflammatory and analgesic effects. The invention takes the mint as adjuvant drug, and is beneficial to diminishing inflammation, desensitizing and resisting bacteria of the damaged wound. Paris polyphylla, rhizoma paridis, with bitter taste, has the effects of clearing away heat and toxic material, cooling liver and arresting convulsion, is suitable for treating various heat-toxin sores and ulcers, and has antibacterial effect on various bacteria such as intestinal bacilli, pyococcus, etc. The invention takes the paris polyphylla as a guiding drug, strengthens the analgesic effect and relieves the pain of the injury and the patient. Notoginseng radix is sweet in nature, slightly bitter and warm in taste, and can dissipate blood stasis to stop bleeding, relieve swelling and alleviate pain.

Preferably, the traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages comprises the following raw materials in parts by weight: 40 parts of diverse wormwood herb, 35 parts of lithospermum, 20 parts of rhubarb, 10 parts of mint, 9 parts of paris polyphylla and 4 parts of pseudo-ginseng.

Preferably, the traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages further comprises alcohol, wherein the weight ratio of the alcohol to the total raw materials is 50:30, and the alcohol concentration is voL% 55%. The alcohol can dissolve the effective components of other materials during the soaking process, and has anti-inflammatory and antibacterial effects.

Another object of the present invention is to provide a method for preparing a Chinese medicinal composition for treating burns, scalds, wounds and skin lesions, comprising the following steps:

(1) crushing the artemisia anomala to 80-200 meshes, and frying the artemisia anomala to be scorched black at 45-90 ℃ to obtain the traditional Chinese medicine powder A.

Pulverizing rhubarb into 100-180 meshes, spraying lime water, standing for 8h, and parching at 30-70 ℃ to dry to obtain Chinese medicinal powder B. Wherein the degree of parching is changed from lime color to peach color.

(2) And (3) completely crushing the traditional Chinese medicine powder A and the traditional Chinese medicine powder B, the lithospermum, the mint, the paris polyphylla and the pseudo-ginseng to 100-300 meshes to obtain traditional Chinese medicine powder C.

(3) Soaking the Chinese medicinal powder C in ethanol, and sealing for thirty days to obtain topical Chinese medicinal composition for treating skin injury.

Preferably, the diverse wormwood herb is crushed and fried to be scorched black at 60 ℃ to obtain the traditional Chinese medicine powder A.

Preferably, radix et rhizoma Rhei is pulverized, sprayed with lime water, and left to stand for 8h and then fried to dryness at 40 deg.C to obtain Chinese medicinal powder B.

Preferably, the concentration of the lime water is 2-5% wt, and the weight ratio of the lime water to the rheum officinale is 3: 8.

The main active components of rhubarb are free anthraquinone derivatives and bound anthraquinone derivatives, while the free anthraquinone derivatives (rhein, emodin, physcion, aloe-emodin, physcion, rhein and the like) which play a role in bacteriostasis are mainly used, and the bound anthraquinone derivatives in the rhubarb can be converted into the free anthraquinone derivatives by processing the rhubarb with lime water, so that the effect of the rhubarb is further enhanced.

The traditional Chinese medicine composition can be prepared into clinically acceptable spray or paste by adjusting the adding amount of alcohol or adding conventional auxiliary materials (starch and the like) according to a conventional method; preferably a spray.

After the Chinese medicinal composition is sprayed on the skin of an affected part, the Chinese medicinal composition can be sprayed into a film without dressing, and can be used for exposed treatment, hemostasis and wound protection; the infection is prevented, and the exogenous pollution of bacteria is thoroughly isolated and avoided; the traditional Chinese medicine composition has the advantages of rapid pain relief, strong antibacterial ability, shortened treatment time, no pain of dressing change when a patient changes the medicine, quick effect and short treatment course; the scar is not left after healing, and the physiological function of the joint can be kept; greatly saving medical expenses.

The invention also aims to provide application of the traditional Chinese medicine composition for treating burns, scalds, wounds and skin injuries in preparation of a medicine for treating skin injuries.

Preferably, the application of the traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages in preparing the skin burn and scald medicine.

Preferably, the application of the traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages in preparing the skin wound medicine.

Preferably, the application of the traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages in preparing the skin damage medicine.

According to the technical scheme, the invention discloses a traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages and a preparation method and application thereof. Compared with the prior art, the traditional Chinese medicine composition has the beneficial effects that (1) the traditional Chinese medicine composition has the functions of promoting granulation, removing necrotic tissue, clearing heat, detoxifying and relieving pain by combining various medicines, the compatibility of medicines has targeting property, can directly reach the focus of infection, takes effect quickly, is cool and comfortable after being sprayed with the medicine, has no prickle, hot and burning pain, avoids the pain of the body of a patient, and has no scar after healing. (2) After being sprayed on the skin of an affected part, the traditional Chinese medicine composition can be sprayed into a film, dressing wrapping, exposure treatment, hemostasis and wound protection are not needed, and the pain of dressing exchange when a patient changes the medicine is avoided. (3) For burn and scald patients, no scar remains after healing, and joint physiological function can be maintained.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.

Fig. 1 is a diagram of a patient with burns and scalds treated by the traditional Chinese medicine composition in the embodiment 3, wherein the left half part of fig. 1 is the third day of scalds, and the right half part of fig. 1 is the sixth day of scalds.

Fig. 2 is a diagram of a patient with burns and scalds treated by the traditional Chinese medicine composition in the embodiment 3, which is the same patient as the patient in fig. 1, wherein the left half part of the diagram 2 shows the twelfth day of the burns and the right half part of the diagram 2 shows the healed state.

Fig. 3 is a diagram of a patient with burns and scalds treated by the traditional Chinese medicine composition in example 3, wherein the left half of fig. 3 is a first day of scalds, and the right half of fig. 3 is a diagram of pictures after the scalds are healed.

Fig. 4 is a diagram of a patient with a wound treated by the traditional Chinese medicine composition of example 3, wherein the left half of fig. 4 is the first day of the wound, and the right half of fig. 4 is the second day of the wound.

FIG. 5 is a drawing of a patient with a wound treated by the Chinese medicinal composition of example 3, wherein the left half of FIG. 5 is a drawing of the wound, and the right half of FIG. 5 is a drawing of the wound after healing.

FIG. 6 is a diagram of a patient with skin damage treated by the Chinese medicinal composition of example 3, wherein the left half of FIG. 6 is a diagram of skin damage, and the right half of FIG. 6 is a diagram of the patient with skin damage after healing.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The raw materials used in the embodiment of the invention are purchased from commercial sources, and the sources are not limited.

The methods not mentioned are all routine experimental methods.

Example 1

Weighing 20 parts of diverse wormwood herb, 15 parts of lithospermum, 5 parts of rhubarb, 1 part of mint, 0.25 part of paris polyphylla, 0.1 part of pseudo-ginseng and 68.92 parts of 55% voL alcohol according to the formula.

Pulverizing herba Artemisiae Anomalae to 80 mesh, and parching at 45 deg.C to brown to obtain Chinese medicinal powder A.

Pulverizing radix et rhizoma Rhei to 100 mesh, spraying radix et rhizoma Rhei powder with 2% of lime water, standing for eight hours, and parching at 30 deg.C until lime color is peach red to obtain Chinese medicinal powder B.

Pulverizing the Chinese medicinal powder A, B, radix Arnebiae, herba Menthae, rhizoma Helminthostachydis Zeylanicae, and Notoginseng radix to 100 mesh to obtain Chinese medicinal powder C;

soaking the Chinese medicinal powder C in ethanol, and storing in a sealed porcelain bottle for thirty days to obtain the topical Chinese medicinal composition for treating skin injury.

Example 2

According to the formula, 60 parts of diverse wormwood herb, 50 parts of lithospermum, 30 parts of rhubarb, 20 parts of mint, 18 parts of paris polyphylla, 9 parts of pseudo-ginseng and 311.67 parts of 55% voL alcohol are weighed.

Pulverizing herba Artemisiae Anomalae to 200 mesh, and parching at 90 deg.C to brown to obtain Chinese medicinal powder A.

Pulverizing radix et rhizoma Rhei to 180 mesh, spraying 5 wt% lime water on radix et rhizoma Rhei powder, standing for eight hours, and parching at 70 deg.C until lime color is peach red to obtain Chinese medicinal powder B.

Pulverizing the Chinese medicinal powder A, B, radix Arnebiae, herba Menthae, rhizoma Helminthostachydis Zeylanicae, and Notoginseng radix to 300 mesh to obtain Chinese medicinal powder C;

Example 3

Weighing 40 parts of diverse wormwood herb, 35 parts of lithospermum, 20 parts of rhubarb, 10 parts of mint, 9 parts of paris polyphylla, 4 parts of pseudo-ginseng and 196.7 parts of 55% voL alcohol according to the formula.

Pulverizing herba Artemisiae Anomalae to 150 mesh, and parching at 60 deg.C to brown to obtain Chinese medicinal powder A.

Pulverizing radix et rhizoma Rhei to 150 mesh, spraying radix et rhizoma Rhei powder with 3% of lime water, standing for eight hours, and parching at 40 deg.C until lime color is peach red to obtain Chinese medicinal powder B;

pulverizing the Chinese medicinal powder A, the Chinese medicinal powder B, radix Arnebiae, herba Menthae, rhizoma Helminthostachydis Zeylanicae, and Notoginseng radix to 250 mesh to obtain Chinese medicinal powder C;

Test 1 safety test (multiple complete skin irritation test)

(1) Test subjects: the Chinese medicinal composition prepared in example 3.

(2) Test animals: rabbits, general grade, were purchased from taiping biotechnology limited, hannan.

(3) The detection basis is as follows: disinfection Specification 2002 edition 2.3.3.3.3.

(4) And (3) detecting the concentration: stock solution

(5) The detection method comprises the following steps:

3 white rabbits (female 2, male 1) with the weight of 2.0kg-2.5kg, wherein the hair on both sides of the back of the rabbits is cut off 24 hours before the test, the hair removal areas on the left side and the right side are both about 3cmx3cm, the left side is a medicine application area, and the right side is a control area. Respectively measuring 0.5mL of a test object, directly and uniformly coating the test object on the skin of an animal medicine application area, then covering the test object with a non-irritating plastic film, and fixing the test object with the non-irritating adhesive tape for 4 hours. Control areas were coated with an equal amount of saline. After 4h of application, the application area was rinsed with warm water to remove residues. The application is carried out once a day for 14 days. The local skin reactions were observed at 24h after each application, the average integral per animal per day (irritation index) (average integral per animal per day ═ total integral of erythema and edema per number of animals tested 14 d/animal tested x 14) was calculated, and the skin irritation intensity was determined as in table 2-12 of "disinfection specifications" 2002 edition.

(6) And (4) testing results:

the results of the multiple intact skin irritation tests of rabbits are shown in table 1.

TABLE 1

Through detection, according to the classification standard of skin irritation strength in 2002 edition of disinfection technical Specification, the original liquid of the traditional Chinese medicine composition in the example 3 has no irritation to the experimental result of multiple complete skin irritation of rabbits.

Test 2 safety test (skin allergy test)

(1) Test subjects: the Chinese medicinal composition prepared in example 3.

(2) Test animals: guinea pigs, general grade, weight 200-.

(4) And (3) detecting the concentration: stock solution

(5) The detection method comprises the following steps:

skin allergy tests were carried out according to the hygienic Standard for Disposable sanitary articles GB15979-2002 and the Disinfection technical Specification 2002. The test is totally provided with three groups: test group, positive control group, negative control group.

To test groups of guinea pigs, test substance induction and challenge treatments are given. The positive control group is given positive sensitizer (2, 4-dinitrochlorobenzene with dimethyl sulfoxide as solvent) to induce and excite treatment. The negative control group was given only the test substance challenge treatment.

The guinea pigs were depilated approximately 3cmx3cm from the left side of the back 24h prior to the trial.

And (3) induction contact: the test substance 0.5mL is applied to the left unhaired skin, covered with two layers of gauze and a layer of cellophane, and sealed and fixed with a non-irritating adhesive tape for 6h, and repeated again on day 7 and 14 in the same manner. The positive control group was treated with 1.0% 2.4-dinitrochlorobenzene (0.5 mL).

And (3) exciting contact: at 14d after the last induction contact, 0.5mL of the test substance was applied to the right depilation region for 6 hours in the same manner as the induction contact. The negative control group was treated with 0.5mL of the test substance. The positive control group was treated with 0.5mL of 0.5% 2.4-dinitrochlorobenzene. Skin reactions were observed at 24h and 48h after cover removal and skin reaction scores and sensitization intensity were graded as in tables 2-18 and tables 2-19 in section II 2.3.6 of Disinfection Specification (2002 edition).

(6) Test results

The results of the guinea pig skin allergy test are shown in table 2.

TABLE 2

According to detection, the skin allergy test result of the traditional Chinese medicine composition stock solution for the guinea pigs in the example 3 is judged to have no skin allergy according to the sensitization intensity grading standard.

Test 3 Effect test

(1) Test drugs:

the Chinese medicinal composition prepared in example 3 was used as a test group, and seven kinds of detoxifying and blood-activating ointments [ Hongyun pharmacy (yuxi) limited ] were used as a control group.

(2) The administration subjects were:

burn and scald-those with the area below 50% of the burn and scald area below deep II degree.

Trauma-bleeding, see volunteers with muscle tissue (area less than 5 cm square).

Skin breakdown-minor injury, volunteers with general area skin damage below 10 square centimeters.

(3) The administration method comprises the following steps:

the test group is sprayed on the affected part, and the liquid medicine completely covers the affected part once every 2-4 hours.

The control group is applied to affected part, and the ointment is applied to affected part for 3 times daily.

(4) Basis for judging therapeutic effect

The method has the following advantages: the wound surface is improved and can not heal naturally.

The effect is shown: the wound surface heals and a slight scar is left.

And (3) curing: the wound surface is healed without scars.

(5) The results of the effect tests are shown in table 3. (see the attached figures 1-6 for use effect.)

TABLE 3

Trial 4 clinical study individual case

(1) Zhushuangbao, male, 4 years old but 3 months, Yunnan Pu' er, initial diagnosis time: in 2019, 4 and 22 days, father complaints in 2019, 4 and 21 days, seven pm, mother prepares dinner in rural home, places the cooked big pot of beef soup on the ground, and when the infant is played in a kitchen, the infant accidentally falls into the pot of beef soup on the ground to scald the back (neck to hip). A mother immediately holds up and takes off clothes and trousers to see the back (neck to hip) of a scald, peels off the skin at the scald and generates a large blister without special treatment, and sends the skin to an emergency department of Puer first-person hospital to seek a diagnosis by family members, and after western medicine examination, takes the skin of the scald wound to drop, local edema and base flush, mainly takes 2-degree scald, and requires inpatient infusion and planting of four artificial skins. The village in the place where the children live in the khaki area falls behind the economy, so that the children cannot bear huge medical expenses, and the uncle father has been seeking a diagnosis in 6-15 months in 2018, so that the children are brought to the department for the diagnosis due to the scald.

In 2019, 22 am in 4.8 am, the mother holds the infant to a clinic for treatment, the back of the infant is scalded, red, swollen, painful and painful, and the crying is not constant, 13 hours, the porridge and rice are not taken, and only a small amount of water can be drunk. The infant is not treated in the hospital.

Physical examination: red, swollen, painful, irritable, thirst, little drinking water, 38.2 degrees body temperature, burning pain, no speaking, patients with dysphoria and poor spirit.

Treatment of the condition: the outpatient service treats the infant with 'back scald and infection', confirms that scald wounds are all soaked with water, skin falls off, the basement is flush, and the infant is mainly treated with the medicament in the embodiment 3 of the invention to treat the back scald of the infant.

8 o' clock 45 minutes in the 22 morning of 4 months in 2019, the first treatment of the infant patient is started, the liquid medicine is uniformly sprayed on the scalded part of the body of the infant patient, and about three minutes, the infant patient does not feel pain to the mother and needs to drink milk. 150 ml of milk is taken by the sick children, in order to prevent the sick children from vomitting during treatment, the second spraying of the liquid medicine is started at 10 am on 22 morning of 4 month and 4 month in 2019, and the whole back of the sick children is sprayed with the liquid medicine three times at intervals of five minutes. After about one hour, the infant asks to lie on the mother to sleep. 3 pm and 15 pm in 4 and 22 months in 2019, the infant awakens automatically, actively requires to eat an ice bar (the cold is the heat evil entering the interior), and is taken with the rice porridge cooked by the isatis root. Spraying the liquid medicine for the third time at 40 minutes 4 pm on 4 months and 22 days in 2019, and spraying the liquid medicine for the whole back of the child three times at intervals of five minutes.

In 2019, 4, 23, 9 am, the infant is recumbent by holding the toy pistol in the arms of parents, the toy pistol is held by hands, the mind is clear, the complexion is sallow, people can be identified, and the blood pressure, the body temperature, the pulse beat, the respiratory urine volume are all normal.

And (3) treatment scheme preparation: calculated according to 15 hours, the liquid medicine is sprayed once every three hours, and five minutes are taken as treatment intervals every time, and the liquid medicine is integrally sprayed on the back of the child patient three times. When the patient is waited for the generation of the blisters, the blisters cannot be broken and can only be automatically broken (because a large amount of body fluid seeps out, hypovolemic shock is easy to occur, infection and organ failure are easy to occur due to unstable shock, and the later treatment is greatly influenced).

24 months 4 and 2019, the patient has no fever, no infection in the scald, clear mind, normal diet and stool, scabbing in the scald position on the back and no ulceration of the blister. (treatment protocol as above)

In 2019, 4 and 27 days, the patient child can recover well and eat normally after the double-diagnosis, and the patient child can walk by himself without limb obstruction. (treatment protocol as above)

In 2019, 5 and 3 days, during the re-diagnosis, the infant patient is walking into the clinic by the mother, the back blister is automatically broken, the scalded part is healed and scabbed, the skin is recovered well, the diet is normal, the infant patient can walk by itself without limb obstruction, the infant patient can move freely, the infant patient can stretch and bend the waist, and the infant patient does not have the symptoms of chilly, fever, dry mouth, scanty urine and the like. (treatment protocol as above)

In 2019, 5 and 7 days, the father of the child generates a picture, the scalded part on the back does not have hyperplastic scars, only a small amount of scabbed parts do not fall off, the child does not have the sequelae of limb dyskinesia, and the child feels excitement every ten thousand!

(2) Somebody in flood, male, age 32, yunnan kunming, professional chef. The initial diagnosis time is 7 months and 24 days in 2017, the patient mainly complains about the pain of the patient after burning due to the gas leakage and fire in the kitchen, and more parts of the right hand and the whole limb are burned in the rescue process, and part of the skin is torn off for more than two hours. The patient can be suffered from red, swelling, pain and pain at various parts of the whole body for 2 hours due to fire scald. The patient is not treated outside the hospital, and is admitted to the clinic as "fire burn" in order to make further system diagnosis and treatment. Admission symptoms are as follows: the skin sore surface is flush, blister, edema, erosion, exudation, thin blister wall, severe pain, erosion and incrustation due to blister, coma and delirium, mental retardation, acute pain and illness, dysphoria, thirst, little drinking water, high body temperature, burning pain, no speaking, mild diet, night sleep, scanty and brownish urine, and constipation.

Physical examination: t:36 ℃ P:78 times/min R:19 times/min BP: 120/85 mmHg. The skin and sclera of the whole body are not yellow-stained, macula and pigmentation are not seen, superficial lymph nodes of the whole body are not touched and swollen, five sense organs of the skull are not deformed, double eyelids are not swollen, and pupils on two sides are sensitive to light reflection.

History of the past: it is good for health. Disclaimer the history of chronic diseases such as hypertension, coronary heart disease and diabetes, disclaimer the history of infectious diseases such as hepatitis, tuberculosis, typhoid and malaria, disclaimer the history of major trauma, operation and blood transfusion, and disclaimer the history of food and drug allergy.

Treatment of the condition: the patient uses the medicine of the invention in the example 3 to spray the right arm focus once every two hours. After 24 hours, the focus blister starts to be collected, and after 72 hours, partial wounds are scabbed. The patients have clear mind, body-checking cooperation, answering questions, clear speech and obviously relieved pain in the treatment process. On the fourth day to the twenty-fifth day, the patient carries the medicine of the invention by himself, and the spraying treatment is carried out on the part of the right burn and scald once every four hours. Twenty-five days later, the limb skin of the patient recovers elasticity, luster and normal, the motor function is not obstructed, and the patient is very satisfied with the treatment!

(3) A certain king, male 40 years old, Yunnan Kunming, professional worker. The initial diagnosis time is 2019, 5 months and 20 days, and the patient mainly complains about the injury, pain, swelling, numbness of right ankle joint and limited movement of the right foot caused by falling down by riding the electric bicycle in rainy days. The patient suffered from the trauma caused by falling down by riding an electric vehicle in the rainy day in 5 and 10 days in 2019, and the patient was diagnosed with right foot infectious trauma, pain, swelling, numbness of right ankle joint, limited activity, traumatic inflammation and mild ankle joint insufficiency, and after being treated by the silver-phenol antibacterial solution and the quick wound spray in the first hospital in the market, the pain and symptoms were relieved, but the wound was pus-flowing and not healed.

Physical examination: t: 36.6 ℃ P: 80 times/min R: 20 times/min BP: 130/90 mmHg. Good general condition, normal development, moderate nutrition, clear mind, painful appearance and cooperative physical examination. No nausea, vomiting, chest pain, chest distress, abdominal pain, abdominal distension, no big urine and incontinence.

History of the past: the patient denied food drug allergy history, denied hepatitis tuberculosis history, denied major surgery, denied blood transfusion history, denied hypertension history, denied diabetes.

Treatment of the condition: the patient was sprayed on the lesion every four hours with the drug of example 3 of the invention in the clinic. After spraying the medicine, the pain of the patient is relieved, the wound starts to heal after 12 hours, and after 24 hours, part of the wound still has dirt (the amount of pus is reduced and tissue exudate exists among the wounds), so that new granulation tissues grow out of the wound surface and scabs appear on the edge of the wound. After the third day, the wound is scabbed and has no obvious pus, the wound area is reduced, the depth is obviously reduced, and then the patient carries the medicine by himself and carries out spraying treatment on the injured part of the right foot three times a day. Sixthly, the patient goes to the clinic for rechecking, the foot injury part is scabbed and falls off, the wound is completely healed, the skin recovers elasticity, the luster is normal, the motor function is not obstructed, no symptom is repeated, and the patient is very satisfied with the treatment!

(4) Shen somewhere, male, age 40, Yunnan Kunming, professional engineer. The preliminary diagnosis time is 2018, 8 and 6 days, and the patient mainly complains that when the lard is refined at home at noon in 2018, 8 and 4 days, the oil temperature is too high to cause fire, the patient burns the right face by flame during fire extinguishing, and is washed by cold water after being scalded by oil, and toothpaste is smeared on the affected part of the face. The pain and symptoms are not relieved, liquid flows out of a scalded mouth, the burning pain is strong, and the pain relieving effect is reflected. The patient can go to his place for treatment, and the patient can feel the pain and the appearance of the patient and check the physical cooperation.

Physical examination: body temperature 37 ℃, pulse: 80 times per minute, 120/80 blood pressure, black skin of the scald part on the right face, bright red base at the denuded part, punctate hemorrhage, and tissue exudation.

Treatment of the condition: after the face of the patient is washed and disinfected, the medicine of the invention in the embodiment 3 is sprayed on the focus once every 15 minutes (the medicine dose is not too much and can be used a little for a plurality of times because the face skin is delicate). After spraying the medicine for about five minutes, the reaction pain of the patient is relieved, and after 1 hour, the scald part of the face has no burning pain. Then spraying once per hour. The medicine is used for four times from 30 points 9 to 30 points 10 to 30 points 6 days 8 and 6 months 2018, and 80 milliliters of the medicine is used from 30 points 11 to 30 points 22 to 30 points.

When the patient rechecks at 9 o' clock 8, 7 and 7 in 2018, the healing phenomenon of the scald wound begins, the wound surface has no exudation tissue fluid, and the red and swollen part has detumescence! The patients are arranged to carry the medicine, the spraying treatment is carried out on the right side face injury part five times a day, the scald part is not scratched in the treatment period, spicy stimulating food is seldom eaten, wine is infrequently drunk, the diet is light, and fresh vegetables and fruits are frequently eaten.

16 months 8 in 2018, the patients come to the clinic by themselves for rechecking, the face is not damaged, scabs do not exist, the skin recovers elasticity, the luster is normal, and the treatment effect and the treatment scheme are very satisfied.

The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A traditional Chinese medicine composition for external use for treating burns, scalds, wounds and skin damages is characterized by comprising the following raw materials in parts by weight: 20-60 parts of diverse wormwood herb, 15-50 parts of lithospermum, 5-30 parts of rheum officinale, 0.9-20 parts of mint, 0.25-18 parts of paris polyphylla, 0.1-9 parts of pseudo-ginseng and alcohol;

wherein the ratio of alcohol to the total weight of the above Chinese medicinal materials is 50:30, and the concentration of alcohol is 55% voL.

2. The preparation method of the externally used traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages, which is characterized by comprising the following steps:

(1) crushing the artemisia anomala to 80-200 meshes, and frying the artemisia anomala to be scorched black at 45-90 ℃ to obtain traditional Chinese medicine powder A;

crushing rhubarb to 100-180 meshes, spraying lime water, standing for 8 hours, and frying at 30-70 ℃ to dry to obtain Chinese medicinal powder B;

(2) completely crushing the traditional Chinese medicine powder A, the traditional Chinese medicine powder B, lithospermum, mint, paris polyphylla and pseudo-ginseng to 100-300 meshes to obtain traditional Chinese medicine powder C;

3. The preparation method of the external traditional Chinese medicine composition for treating burns, scalds, wounds and skin damages according to claim 2, wherein the concentration of the lime water is 2-5% by weight, and the weight ratio of the lime water to the rhubarb is 3: 8.