CN112057568A - A kind of traditional Chinese medicine composition for treating children's anal fissure and application thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating infantile anal fissure and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1 part of each of watermelon peel, pomegranate peel, wax gourd peel and sugarcane peel and 3 parts of honey. The invention also comprises the application of the traditional Chinese medicine composition in preparing a medicine for treating infantile anal fissure. Its advantages are: the composition has analgesic, antiinflammatory, hemostatic, and wound healing effects. And the adopted medicinal materials are edible medicinal materials, so that the side effects are avoided by external application, the traditional Chinese medicine is safe and reliable, the internal and external consideration is realized, the method is easy to accept, the operation is simple, the price is low, the curative effect is obvious, and the advantages of simplicity, convenience, cheapness and experience of the traditional Chinese medicine are fully embodied.

Description

A kind of traditional Chinese medicine composition for treating children's anal fissure and application thereof

technical field

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating anal fissure in children and its application.

Background technique

Anal fissure is a common anorectal disease in clinic. It occurs in the full-thickness longitudinal dehiscence of the skin of the anal canal and forms an infectious ulcer. Crying, bleeding, or refusing to defecate are typical symptoms of anal fissures in children. From the perspective of disease types, the order of incidence of pediatric anal diseases is anal fissure, rectal polyps, perianal infectious diseases, and rectal prolapse. Generally, the wound surface of pediatric anal fissure is relatively fresh, and complications such as sentinel hemorrhoids or anal papilla hypertrophy are less likely to occur. Therefore, non-surgical methods such as topical medication are generally used in clinical treatment.

Anal fissures belong to the category of "hook intestinal hemorrhoids" in traditional Chinese medicine. Chinese medicine believes that the incidence of anal fissures is mostly caused by blood heat and intestinal dryness, yin deficiency and fluid deficiency, leading to constipation, hard defecation, and anal skin lacerations. Due to the increase of children with functional constipation in children, the treatment rate of anal fissure in children is gradually increasing. In addition, children have weak self-control and poor medical compliance than adults, so the treatment of anal fissures in children is difficult. At present, there are various methods for clinical treatment of anal fissure, including oral probiotics, Baiduobang, Xi Lei powder, and external application of Shengji powder, etc. However, such drugs often have great side effects, such as: (1) Myogenesis Powder (talcum powder, keel, myrrh, catechu, dried blood, etc.), this medicine has the effect of detoxification and muscle regeneration, and is used for wounds and boils for a long time, the muscles are not born, and the mouth is not closed for a long time. Tin powder (ivory chips, indigo naturalis, talcum powder, pearls, artificial bezoar, etc.), this medicine detoxifies and detoxifies, and is used for throat erosion, swelling and pain. The two types of drugs, Shengji Powder and Xi Lei Powder, are both used to promote wound healing. However, due to the large number of ingredients in these two types of drugs, although the effect is significant, safety is an inevitable consideration for every parent. (2) There are many reports in the literature on the external application of honey, mainly boiled into suppositories, which have anti-inflammatory and laxative effects, but the effect of honey suppositories is relatively limited, and the main effect is anti-inflammatory. The treatment of anal fissure in children also requires hemostasis, Pain relief and other effects, need to be compatible with other drug treatment.

Children are the flowers of the motherland and the future of the motherland. The physical and mental health of children is very important to society and a family. Therefore, the prevention and treatment of anal fissures in children is urgent, and children with anal fissures are prone to a series of complications without treatment. disease. Therefore, the present invention aims at the deficiencies in the prior art, by combining diet adjustment and external application of a traditional Chinese medicine composition, while improving stool conditions, it also has the effects of relieving pain, reducing inflammation, stopping bleeding, and promoting wound healing. It has simple operation, low price and obvious curative effect, which fully reflects the advantages of simple, convenient, inexpensive and proven traditional Chinese medicine, and the children's Changpi Powder uses edible medicinal materials, which avoids side effects when used externally, and is safe and reliable. There is no report about a traditional Chinese medicine composition for treating infantile anal fissure and its application of the present invention.

SUMMARY OF THE INVENTION

The purpose of the present invention is to aim at the deficiencies of the prior art, to provide a kind of traditional Chinese medicine composition for the treatment of children's anal fissure and its application.

For realizing the above-mentioned purpose, the technical scheme that the present invention takes is:

On the one hand, the present invention provides a traditional Chinese medicine composition for treating anal fissure in children, the traditional Chinese medicinal composition is made from the following raw materials by weight: -5 parts, sugar cane peel 1-5 parts, honey 1-5 parts.

Preferably, the traditional Chinese medicine composition is prepared from the following raw materials by weight: 1 part of watermelon rind, 1 part of pomegranate rind, 1 part of wax gourd rind, 1 part of sugarcane rind, and 3 parts of honey.

Preferably, it is prepared into a clinically acceptable external pharmaceutical preparation according to the conventional preparation method of traditional Chinese medicine.

Preferably, the external pharmaceutical preparation is an ointment, lotion, liniment, aerosol, gel, or spray.

On the other hand, the present invention provides the application of the above-mentioned traditional Chinese medicine composition in the preparation of a medicine for treating anal fissure in children.

In another aspect, the present invention provides a medicine for treating anal fissure in children, the medicine is made from the above-mentioned traditional Chinese medicine composition.

Further, the present invention provides a spray for treating anal fissure in children, the medicine is made from the above-mentioned traditional Chinese medicine composition.

Preferably, the spray preparation method is:

(1) Get the raw materials: watermelon peel, pomegranate peel, wax gourd peel, sugarcane peel, sun-dried and fried, and honey is dried at low temperature;

(2) Mix the medicinal flavors and grind them into powder.

Solution:

Honey is the king medicine, has lubricating effect, can also reduce inflammation and swelling, and promote wound healing.

Sugarcane rind and watermelon rind are ministerial medicines, which are compatible with honey to increase wound healing ability: sugarcane peel is sweet and cold, clears heat and detoxifies, and is used for children with aphthous ulcers, bald sores, and sores on sitting boards. "Compendium of Materia Medica": the cane peel is burned and mixed with it. "Zhou Yisheng Jiabao Prescription": sugarcane peel burns, and sesame oil blends. Watermelon rind: cool in nature, sweet in taste, non-toxic. Clearing summer heat and relieving fever, quenching thirst, promoting urination, used for polydipsia during summer heat, lack of urination, edema, sores on the tongue, promoting wound healing and promoting human skin metabolism.

Pomegranate peel is an adjuvant: auxiliary effect, astringent and hemostasis, pomegranate peel is sour, astringent, warm in nature, astringent intestinal hemostasis, external treatment for chilblains, etc. "Compendium of Materia Medica": pomegranate peel, wax gourd peel, sugar cane peel three flavors, burning ash for storage, powdered for application. The main characteristics of anal fissure in children are blood in the stool, pain, and pomegranate peel can stop the bleeding.

Wax gourd rind is used as medicine: mixed with various medicines to increase the curative effect, wax gourd rind is sweet, cool in nature, diuretic and detumescence, and external use for falls and injuries. "Compendium of Materia Medica": Use one or two dried wax gourd rinds and one or two real cowhide glue, file them into a pot, fry them for storage, and grind them into powder.

The advantages of the present invention are:

1. During the use of this powder, dry watermelon peel, pomegranate peel, wax gourd peel, and sugarcane peel into equal parts, dry the honey at low temperature, grind the five herbs into powder, and spray them on the anal fissure of children. In addition, it can be used for external use, which has hemostatic effect. It can be ground into powder and sprayed on the wound surface. After anal fissure in children, there is a lot of perianal secretions. In addition, the anus of children is relatively tender, and red buttocks often occur. The powder is used externally and can be collected. Wet to reduce perianal secretions.

2. Aiming at the pathological pathogenesis of pediatric anal fissure, the weight ratio of each raw material drug and the ratio between them is optimized. The various medicinal flavors work synergistically. The clinical results show that the curative effect is good. It is very suitable for clinical application.

3. Various medicinal flavors come from a wide range of sources, the preparation method of the medicinal preparation is simple, the cost is low, and there is no side effect, so it has strong practicability and wide application prospects.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention. In addition, it should be understood that those skilled in the art can make various changes or modifications to the present invention after reading the contents described in the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

Embodiment 1 Chinese medicine composition (one)

The raw materials are obtained according to the following proportions by weight: 1 part of watermelon rind, 1 part of pomegranate rind, 1 part of wax gourd rind, 1 part of sugarcane rind, and 1 part of honey.

Embodiment 2 Chinese medicine composition (two)

The raw materials are obtained according to the following proportions by weight: 5 parts of watermelon skin, 5 parts of pomegranate skin, 5 parts of wax gourd skin, 5 parts of sugar cane skin, and 3 parts of honey.

Embodiment 3 Chinese medicine composition (three)

The raw materials are obtained according to the following proportions by weight: 1 part of watermelon rind, 5 parts of pomegranate rind, 1 part of wax gourd rind, 5 parts of sugar cane rind, and 1 part of honey.

Embodiment 4 Chinese medicine composition (four)

The raw materials are obtained according to the following proportions by weight: 5 parts of watermelon rind, 1 part of pomegranate rind, 5 parts of wax gourd rind, 1 part of sugar cane rind, and 5 parts of honey.

Embodiment 5 Chinese medicine composition (five)

The raw materials are obtained according to the following proportions by weight: 1 part of watermelon rind, 1 part of pomegranate rind, 1 part of wax gourd rind, 1 part of sugarcane rind, and 3 parts of honey.

Example 6 Spray

Preparation:

Take the raw materials according to the proportions by weight described in Examples 1-5 respectively: watermelon peel, pomegranate peel, wax gourd peel, and sugarcane peel, sun-dried and fried with coke, and honey is dried at low temperature; the medicinal flavors are mixed and ground into powder.

Example 7 Ointment

Preparation:

According to the weight portion ratio described in Examples 1-5 respectively, the raw materials are obtained: watermelon peel, pomegranate peel, wax gourd peel, sugar cane peel and honey, and the pharmaceutical excipients are added and prepared according to the conventional preparation method of ointment.

Example 8 lotion

Preparation:

According to the weight portion ratio described in Examples 1-5, the raw materials are respectively obtained: watermelon rind, pomegranate rind, wax gourd rind, sugarcane rind and honey, and the pharmaceutical auxiliary materials are added and prepared according to the conventional preparation method of lotion.

Example 9 Clinical trial

1 Materials and methods

1Clinical data

A total of 232 children who were diagnosed with anal fissures in our hospital from October 2017 to September 2019 were selected, and the children were divided into five groups by random number method, namely the treatment group, the control group, and the control group. , the second group of the comparative example, the third group of the comparative example. The diagnostic criteria for anal fissure refer to the "Traditional Chinese Medicine Diagnosis and Efficacy Standards" promulgated by the State Administration of Traditional Chinese Medicine.

Inclusion criteria: (1) children with anal fissure; (2) age from 2 months to 4 years old, no gender restriction; (3) informed consent of the family members of the children and the cooperation of the children, and able to complete the follow-up; (4) no cerebral blood vessels , liver, kidney and hematopoietic system and other serious primary diseases.

Exclusion criteria: (1) the family members of the children requested to withdraw from the clinical trial; (2) the children had poor compliance and could not cooperate with regular inspections and identifications as required; (3) serious complications and comorbidities occurred, and the trial should not be continued; (4) ) Original anal stenosis, anal surgery or trauma history; (5) Suffering from acute and chronic diarrhea or perianal eczema and other skin diseases; (6) Accompanied by digestive tract infectious diseases, mental illness, diabetes, severe allergies, etc.

This study was approved by the Medical Ethics Committee of Jinshan Hospital Affiliated to Fudan University, and all the families of the children signed informed consent.

1.2 Methods

1.2.1 Questionnaire survey

Before the study, the family members of the children conducted a questionnaire survey (including paper questionnaires and Questionnaire Star software), which mainly included information such as age, course of disease, and eating habits.

1.2.2 Intervention methods

The children in the control group were given dietary adjustment (eat more fruits and vegetables and drink more water).

On the basis of the control group, the treatment group was applied with the spray of this formula (the formula is: 1 part of watermelon rind, 1 part of pomegranate rind, 1 part of wax gourd rind, 1 part of sugarcane rind, 3 parts of honey), and the intervention time was 2 week.

A group of control groups: on the basis of the control group, sprays (the formula: 1 part of watermelon rind, 6 parts of pomegranate rind, 9 parts of wax gourd rind, 8 parts of sugarcane rind, and 7 parts of honey) were applied externally, and the intervention time was 2 week.

Comparative Example Group 2: On the basis of the control group, sprays (the prescription: 1 part of talc, 1 part of hedgehog skin, 1 part of wax gourd skin, 1 part of Poria, and 3 parts of honey) were applied externally, and the intervention time was 2 weeks.

Comparative Example Three groups: on the basis of the control group, sprays were used (prescriptions: qinjing, peach kernels, saponin, 3 grams each, atractylodes, 2 grams each of Fangfeng, 1.5 grams of Treats (wine fried), Angelica tail, Alisma 0.9 grams each, 0.3 grams of betel nut, 3 grams of cooked rhubarb) were applied externally, and the intervention time was 2 weeks.

Blood in the stool, pain and wound healing were scored before and after intervention in each group.

1.2.3 Scoring Criteria

The FLACC scale is used to score pain, which is mainly used as an effective method for pain assessment in children aged 2 months to 7 years. Blood in stool score: 0 points for no blood in stool; 1 point for a small amount of blood in the stool, mainly stained with blood on the toilet paper, red or light in color; Jet-like, red or light color is 3 points. Anal fissure healing was compared with or without anal fissure.

Table 1 FLACC pain scale

1.3 Statistical methods

A database was established with EpiData, and SPSS 17.0 software package was used for statistical analysis. The measurement data that conformed to the normal distribution were expressed as (x±s), the comparison between the two groups was performed using the t test, and the comparison between the two groups was performed using the Mann-Whitney U test; the analysis of the enumeration data was performed using the χ ² test. P<0.05 was considered to be statistically significant.

2 results

2.1 Basic situation

During the treatment, 31 children dropped out. There was no significant difference in the basic conditions (age, condition) of the patients in each group.

2.2 Comparison of blood in stool scores before and after treatment

There was no significant difference in the scores of blood in the stool between the groups before treatment (P>0.05); there were significant differences in the scores of blood in the stool between the groups on the 7th and 14th days of treatment (P<0.05, see Table 2).

Table 2 Comparison of blood in stool scores on the 7th and 14th days after treatment in the five groups [M(P25, P75), points]

2.3 Comparison of pain scores before and after treatment

The pain score of the treatment group on the 14th day of treatment was lower than that of other groups, and the difference was statistically significant (P<0.05, see Table 3).

Table 3 Comparison of pain scores on the 7th and 14th days of treatment in the five groups before treatment (x±s, points)

2.4 Comparison of wound healing before and after treatment

On the 7th day of treatment, 9 cases (21.96%) of the cracks in the treatment group were healed, and 32 cases (78.04%) were not healed; 0 cases were healed and 40 cases (100.0%) were not healed in the control group; 13.16%), 33 cases (86.84%) were not healed; 3 cases (7.70%) were healed, and 36 cases (92.30%) were not healed in the second group; 7 cases (16.28%) were not healed in the third group 36 cases (83.72%). The treatment group was significantly different from the other groups.

On the 14th day of treatment, 38 cases (92.69%) were healed in the treatment group, and 3 cases (7.31%) were not healed; in the control group, 14 cases (35.0%) were healed, and 26 cases (65.0%) were not healed; 27 cases (71.05%) healed and 11 cases (28.95%) were not healed; 24 cases (61.54%) were healed and 15 cases (38.46%) were not healed in the second group; 37 cases (86.05%) were healed in the third group ), did not heal in 6 cases (13.95%). The treatment group was significantly different from the other groups.

3 Discussion

The patent formula provides a traditional Chinese medicine formula for pediatric patients with anal fissure, wherein honey is the monarch medicine, has lubricating effect, can also reduce inflammation and swelling, and promote wound healing. Sugarcane rind and watermelon rind are ministerial medicines, which are compatible with honey to increase wound healing ability: sugarcane peel is sweet and cold, clears heat and detoxifies, and is used for children with aphthous ulcers, bald sores, and sores on sitting boards. Watermelon rind: cool in nature, sweet in taste, non-toxic. Clearing summer heat and relieving fever, quenching thirst, promoting urination, used for polydipsia during summer heat, lack of urination, edema, sores on the tongue, promoting wound healing and promoting human skin metabolism. Pomegranate peel is an adjuvant: auxiliary effect, astringent and hemostasis, pomegranate peel is sour, astringent, warm in nature, astringent intestinal hemostasis, external treatment for chilblains, etc. The main characteristics of anal fissure in children are blood in the stool, pain, and pomegranate peel can stop the bleeding. Wax gourd rind is used as medicine: mixed with various medicines to increase the curative effect, wax gourd rind is sweet, cool in nature, diuretic and detumescence, and external use for falls and injuries. In addition, it can be used for external use, which has hemostatic effect. It can be ground into powder and sprayed on the wound surface. After anal fissure in children, there is a lot of perianal secretions. In addition, the anus of children is relatively tender, and red buttocks often occur. The powder is used externally and can be collected. Wet to reduce perianal secretions. The operation is simple, the price is low, and the curative effect is obvious, which fully reflects the advantages of simple, convenient, inexpensive and proven traditional Chinese medicine.

The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the principles of the present invention, several improvements and supplements can be made, and these improvements and supplements should also be considered as It is the protection scope of the present invention.

Claims (8)

1. The traditional Chinese medicine composition for treating infantile anal fissure is characterized by being prepared from the following raw material medicines in parts by weight: 1-5 parts of watermelon peel, 1-5 parts of pomegranate peel, 1-5 parts of wax gourd peel, 1-5 parts of sugarcane peel and 1-5 parts of honey.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 1 part of watermelon peel, 1 part of pomegranate peel, 1 part of wax gourd peel, 1 part of sugarcane peel and 3 parts of honey.

3. The Chinese medicinal composition according to any one of claims 1 to 2, which is prepared into a clinically acceptable external pharmaceutical preparation according to a conventional Chinese medicinal preparation method.

4. The composition of claim 3, wherein the topical pharmaceutical formulation is selected from the group consisting of a paste, a lotion, a liniment, an aerosol, a gel, and a spray.

5. Use of the Chinese medicinal composition of any one of claims 1-2 in the preparation of a medicament for treating infantile anal fissure.

6. A medicament for treating infantile anal fissure, which is prepared from the traditional Chinese medicine composition of claim 1.

7. A spray for treating infantile anal fissure, which is prepared from the Chinese medicinal composition of claim 1.

8. The spray according to claim 7, which is prepared by a method comprising:

(1) taking raw material medicines: drying watermelon peel, pomegranate peel, wax gourd peel and sugarcane peel in the sun, frying to brown, and drying honey at low temperature;

(2) mixing the medicinal materials, and grinding into powder.