CN112057437A - 含有透明质酸的药物制剂、药物透皮贴剂及其制备方法 - Google Patents
含有透明质酸的药物制剂、药物透皮贴剂及其制备方法 Download PDFInfo
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- CN112057437A CN112057437A CN202011133063.6A CN202011133063A CN112057437A CN 112057437 A CN112057437 A CN 112057437A CN 202011133063 A CN202011133063 A CN 202011133063A CN 112057437 A CN112057437 A CN 112057437A
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1883450A (zh) * | 2005-06-23 | 2006-12-27 | 广州市拜澳生物科技有限公司 | 一种亲水凝胶贴剂基质 |
CN101700243A (zh) * | 2009-11-20 | 2010-05-05 | 佘振定 | 一种具备治疗功能的新型载药创可贴 |
CN102821791A (zh) * | 2010-03-30 | 2012-12-12 | 磷肌酸有限公司 | 透皮递送贴剂 |
CN104306631A (zh) * | 2014-09-27 | 2015-01-28 | 王纬 | 一种用于治疗颈型颈椎病的膏药及其制备方法 |
CN105709261A (zh) * | 2016-03-14 | 2016-06-29 | 苏州市贝克生物科技有限公司 | 一种治疗痔疮生物敷料的制备方法 |
CN105770974A (zh) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | 一种医用痔疮生物敷料的制备方法 |
CN106422045A (zh) * | 2016-09-05 | 2017-02-22 | 中国科学院理化技术研究所 | 一种柔曲性缓释微针贴片及其制备方法 |
CN106955277A (zh) * | 2017-03-07 | 2017-07-18 | 暨南大学 | 一种含有透明质酸的醇脂质体的透皮给药系统及其制备方法与应用 |
CN109847055A (zh) * | 2018-12-29 | 2019-06-07 | 济南秦鲁药业科技有限公司 | 医用疤痕贴及其制备方法 |
-
2020
- 2020-10-21 CN CN202011133063.6A patent/CN112057437B/zh active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1883450A (zh) * | 2005-06-23 | 2006-12-27 | 广州市拜澳生物科技有限公司 | 一种亲水凝胶贴剂基质 |
CN101700243A (zh) * | 2009-11-20 | 2010-05-05 | 佘振定 | 一种具备治疗功能的新型载药创可贴 |
CN102821791A (zh) * | 2010-03-30 | 2012-12-12 | 磷肌酸有限公司 | 透皮递送贴剂 |
CN104306631A (zh) * | 2014-09-27 | 2015-01-28 | 王纬 | 一种用于治疗颈型颈椎病的膏药及其制备方法 |
CN105709261A (zh) * | 2016-03-14 | 2016-06-29 | 苏州市贝克生物科技有限公司 | 一种治疗痔疮生物敷料的制备方法 |
CN105770974A (zh) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | 一种医用痔疮生物敷料的制备方法 |
CN106422045A (zh) * | 2016-09-05 | 2017-02-22 | 中国科学院理化技术研究所 | 一种柔曲性缓释微针贴片及其制备方法 |
CN106955277A (zh) * | 2017-03-07 | 2017-07-18 | 暨南大学 | 一种含有透明质酸的醇脂质体的透皮给药系统及其制备方法与应用 |
CN109847055A (zh) * | 2018-12-29 | 2019-06-07 | 济南秦鲁药业科技有限公司 | 医用疤痕贴及其制备方法 |
Non-Patent Citations (1)
Title |
---|
蔡成龙 等: "基于透明质酸的药物载体在中药制剂中的应用进展", 《当代化工》 * |
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