CN112006921A - 一种具有护肤功能的免洗酒精凝胶及其制备方法 - Google Patents
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Abstract
本发明公开了一种具有护肤功能的免洗酒精凝胶及其制备方法，其重量组分如下：乙醇70‑75%，去离子水29‑40%，卡波姆0.1%‑1%，氨甲基丙醇0.05%‑0.2%，保湿剂1‑5%，皮肤健康促进剂0.1%‑0.5%，功能性植物提取液0.01‑0.05%，红没药醇，洋甘菊提取液0.01‑0.05%，所述皮肤健康促进剂是烟酰胺、神经酰胺、维生素e、维生素k、维生素D、氨基酸（包括甘氨酸和脯氨酸），五胜肽，泛醇，白藜芦醇，橙皮苷，尿囊素，水杨酸，透明质酸中一种或几种。本发明能够迅速杀灭皮肤表面的常见致病菌，广谱抗菌性且作用持久，效果可靠，无潜在健康风险，本发明中添加的皮肤促进剂对皮肤有修复功能，反复多次使用不仅不会对皮肤造成负担而且有显著的修复功效。
Description
技术领域
本发明涉及免洗酒精凝胶制备技术领域，具体为一种具有护肤功能的免洗酒精凝胶及其制备方法。
背景技术
2019年底，新型冠状病毒全球蔓延，对人类的公共健康安全造成了极大威胁，目前可以确定的新型冠状病毒传播途径主要为直接传播、气溶胶传播和接触传播，其中接触传播是指飞沫沉积在物品表面，接触污染手后，再接触口腔、鼻腔、眼睛等粘膜，导致感染，因此对于接触传播最有效的预防新型冠状病毒感染方式，注意手部卫生，目前市场上对于手用消毒凝胶的需求量迅速激增，是因为消毒凝胶使用方便，能够迅速杀死皮肤上的细菌，使之对他人不构成传播疾病的危险，并可保护个人免受感染。
目前市面上手用消毒凝胶的杀菌成分主要是以碘类、醇类、三氯羟基二苯醚（DP300）、胍类、季铵盐类及其复方制剂为主，其中乙醇类消毒剂占主要份额，乙醇能有效对抗多种微生物，如革兰氏阳性菌和革兰氏阴性菌及真菌，它也能比其他抗菌产品更快地杀死微生物，另外，由于大剂量的酒精的存在，所以可不使用额外防腐剂，但是目前大多数乙醇类消毒凝胶在杀死细菌的同时也使得皮肤迅速干燥，对皮肤健康产生负面影响，特别是医护人员的长期、大量使用，会造成手部皮肤干燥、皲裂等。
但是仅仅简单的在手用消毒凝胶产品中加入保湿剂虽然可以一定程度改善皮肤健康，但是保湿剂的加入通常有一个缺点，那就是会导致产品过度堆积和粘稠，对于使用者的体验感来说是不愉快的，对于医务工作者而言，还会增加戴手套的难度，降低工作效率。
发明内容
本发明的目的在于提供一种具有护肤功能的免洗酒精凝胶及其制备方法，以解决上述背景技术提出的问题。
为实现上述目的，本发明提供如下技术方案：一种具有护肤功能的免洗酒精凝胶及其制备方法，其重量组分如下：乙醇70-75%，去离子水29-40%，卡波姆0.1%-1%，氨甲基丙醇0.05%-0.2%，保湿剂1-5%，皮肤健康促进剂0.1%-0.5%，功能性植物提取液0.01-0.05%，红没药醇，洋甘菊提取液0.01-0.05%。
优选的，所述保湿剂是丙二醇、聚乙二醇、丙三醇、甘油-环氧乙烷加成物，橄榄油，凡士林等一种或几种。
优选的，所述皮肤健康促进剂是烟酰胺、神经酰胺、维生素e、维生素k、维生素D、氨基酸（包括甘氨酸和脯氨酸），五胜肽，泛醇，白藜芦醇，橙皮苷，尿囊素，水杨酸，透明质酸中一种或几种。
优选的，所述功能性植物提取液是红没药醇、马芷苋提取液、洋甘菊提取液、金盏花提取液，葡萄籽提取液，鼠尾草提取液，芦荟提取液，欧洲七叶树提取液，薰衣草提取液，迷迭香提取液，积雪草提取液，芍药花提取液等中一种或几种。
优选的，所述乙醇的浓度不低于75%。
优选的，本发明的另一个发明目的是提供一种具有护肤功能的免洗酒精凝胶的制备方法，包括以下步骤：（1）按配比将保湿剂、皮肤促进剂、功能性植物提取液和去离子进行充分混合；（2）将卡波姆加入上述的混合液中，搅拌后静置24h使其充分溶胀；（3）加入乙醇，搅拌均匀；（4）加入氨甲基丙醇调节溶液的pH值至6.5-7，即得免洗酒精凝胶。
与现有技术相比，本发明的有益效果如下：
1、本发明能够迅速杀灭皮肤表面的常见致病菌，广谱抗菌性且作用持久，效果可靠，无潜在健康风险，本发明中添加的皮肤促进剂对皮肤有修复功能，反复多次使用不仅不会对皮肤造成负担而且有显著的修复功效。
具体实施方式
下面将结合本发明实施例中，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
为实现上述目的，本发明提供如下技术方案：一种具有护肤功能的免洗酒精凝胶及其制备方法，其重量组分如下：乙醇70-75%，去离子水29-40%，卡波姆0.1%-1%，氨甲基丙醇0.05%-0.2%，保湿剂1-5%，皮肤健康促进剂0.1%-0.5%，功能性植物提取液0.01-0.05%，红没药醇，洋甘菊提取液0.01-0.05%。
乙醇选用浓度为75%的乙醇。
实施例一：
称取1g丙三醇，0.1g烟酰胺，0.05g红没药醇和40ml去离子水进行混合；再将0.1g卡波姆撒入前述混合液中，搅拌后静置24h使其充分溶胀；加入70g乙醇，搅拌均匀后，加入0.05ml氨甲基丙醇调节溶液的pH值至7，即得免洗酒精凝胶。
实施例二：
称取0.8g橄榄油，0.15g甘氨酸，2g马齿苋提取液和40ml去离子水进行混合；再将0.1g卡波姆撒入前述混合液中，搅拌后静置24h使其充分溶胀；加入70g乙醇，搅拌均匀后，加入0.05ml氨甲基丙醇调节溶液的pH值至7，即得免洗酒精凝胶。
实施例三：
称取1.5g甘油，0.08g烟酰胺，0.02g红没药醇，2g马齿苋提取液和40ml去离子水进行混合；再将0.1g卡波姆撒入前述混合液中，搅拌后静置24h使其充分溶胀；加入70g乙醇，搅拌均匀后，加入0.05ml氨甲基丙醇调节溶液的pH值至7，即得免洗酒精凝胶。
对比例：称取0.1g卡波姆入40ml去离子水进行混合，搅拌后静置24h使其充分溶胀；加入70g乙醇，搅拌均匀后，加入0.05ml氨甲基丙醇调节溶液的pH值至7，即得免洗酒精凝胶对比例。
为了验证本发明的消毒凝胶的杀菌效果与护肤作用，特做以下试验：
试验一：上述实施例1-3，对比例中的消毒凝胶按照《消毒技术规范》2.1.1有关方法来测定其杀灭微生物指标，具体如表1所示；
表1.杀灭微生物指标
上表1采用悬浮液定量杀灭试验的方法对消毒凝胶进行了杀菌效果监测，结果显示实施例1-3和对比例对大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌的杀灭对数值均大于5，白色念珠菌的杀灭对数大于4，即证明消毒凝胶可有效杀灭皮肤表面的常见致病菌。
试验二：上述实施例1-3与对比例中的消毒凝胶的保湿性评价
使用皮肤水分测试仪（Corneometer®CM82）测定，一般在20℃和50%相对湿度环境下测量，测试时需将水分测试探头垂直地压在被测皮肤表面，探头顶部被压回一段距离，探头内部有一弹簧使探头顶部保持0.16N的压力压在皮肤表面，一秒钟内主机上就显示出结果，并给出提示声音，对比了不同实施例和对比例产品使用前后手部皮肤表面湿度，结果如下表2所示：
表2.使用2小时后保湿性对比
表2结果显示，本发明消毒凝胶对皮肤有较好的保湿作用，可有效避免长期大量使用造成的皮肤干燥、皲裂。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (6)
1.一种具有护肤功能的免洗酒精凝胶及其制备方法，其特征在于：其重量组分如下：乙醇70-75%，去离子水29-40%，卡波姆0.1%-1%，氨甲基丙醇0.05%-0.2%，保湿剂1-5%，皮肤健康促进剂0.1%-0.5%，功能性植物提取液0.01-0.05%，红没药醇，洋甘菊提取液0.01-0.05%。
2.根据权利要求1所述的一种具有护肤功能的免洗酒精凝胶及其制备方法，其特征在于：所述保湿剂是丙二醇、聚乙二醇、丙三醇、甘油-环氧乙烷加成物，橄榄油，凡士林等一种或几种。
3.根据权利要求1所述的一种具有护肤功能的免洗酒精凝胶及其制备方法，其特征在于：所述皮肤健康促进剂是烟酰胺、神经酰胺、维生素e、维生素k、维生素D、氨基酸（包括甘氨酸和脯氨酸），五胜肽，泛醇，白藜芦醇，橙皮苷，尿囊素，水杨酸，透明质酸中一种或几种。
4.根据权利要求1所述的一种具有护肤功能的免洗酒精凝胶及其制备方法，其特征在于：所述功能性植物提取液是红没药醇、马芷苋提取液、洋甘菊提取液、金盏花提取液，葡萄籽提取液，鼠尾草提取液，芦荟提取液，欧洲七叶树提取液，薰衣草提取液，迷迭香提取液，积雪草提取液，芍药花提取液等中一种或几种。
5.根据权利要求1所述的一种具有护肤功能的免洗酒精凝胶及其制备方法，其特征在于：所述乙醇的浓度不低于75%。
6.本发明的另一个发明目的是提供一种具有护肤功能的免洗酒精凝胶的制备方法，包括以下步骤：（1）按配比将保湿剂、皮肤促进剂、功能性植物提取液和去离子进行充分混合；（2）将卡波姆加入上述的混合液中，搅拌后静置24h使其充分溶胀；（3）加入乙醇，搅拌均匀；（4）加入氨甲基丙醇调节溶液的pH值至6.5-7，即得免洗酒精凝胶。
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| CN113995696A (zh) * | 2021-12-20 | 2022-02-01 | 上海家化联合股份有限公司 | 水性分散组合物及其制备方法 |
| CN114259413A (zh) * | 2021-12-20 | 2022-04-01 | 上海家化联合股份有限公司 | 凝胶组合物 |
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| CN111214416A (zh) * | 2020-03-05 | 2020-06-02 | 合肥亿帆生物制药有限公司 | 一种免手洗护肤消毒凝胶及其制备方法 |
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| CN104523545A (zh) * | 2014-12-22 | 2015-04-22 | 合肥天一生物技术研究所 | 一种抗菌护肤手消毒液及其制备方法 |
| CN111214416A (zh) * | 2020-03-05 | 2020-06-02 | 合肥亿帆生物制药有限公司 | 一种免手洗护肤消毒凝胶及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113995696A (zh) * | 2021-12-20 | 2022-02-01 | 上海家化联合股份有限公司 | 水性分散组合物及其制备方法 |
| CN114259413A (zh) * | 2021-12-20 | 2022-04-01 | 上海家化联合股份有限公司 | 凝胶组合物 |
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