CN114984077A - 一种无醇免洗消毒凝胶及其制备方法 - Google Patents
一种无醇免洗消毒凝胶及其制备方法 Download PDFInfo
- Publication number
- CN114984077A CN114984077A CN202210598856.8A CN202210598856A CN114984077A CN 114984077 A CN114984077 A CN 114984077A CN 202210598856 A CN202210598856 A CN 202210598856A CN 114984077 A CN114984077 A CN 114984077A
- Authority
- CN
- China
- Prior art keywords
- alcohol
- parts
- free
- gel
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title description 5
- 238000001879 gelation Methods 0.000 title description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000419 plant extract Substances 0.000 claims abstract description 13
- 108010039918 Polylysine Proteins 0.000 claims abstract description 12
- 229920000656 polylysine Polymers 0.000 claims abstract description 12
- 239000003899 bactericide agent Substances 0.000 claims abstract description 10
- 239000003906 humectant Substances 0.000 claims abstract description 9
- 239000002904 solvent Substances 0.000 claims abstract description 8
- 239000002562 thickening agent Substances 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- 238000003756 stirring Methods 0.000 claims description 21
- 239000008367 deionised water Substances 0.000 claims description 12
- 229910021641 deionized water Inorganic materials 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 230000000249 desinfective effect Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 6
- 229920000053 polysorbate 80 Polymers 0.000 claims description 6
- 241000219357 Cactaceae Species 0.000 claims description 5
- 229940069521 aloe extract Drugs 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 229940049638 carbomer homopolymer type c Drugs 0.000 claims description 2
- 229940043234 carbomer-940 Drugs 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 244000007835 Cyamopsis tetragonoloba Species 0.000 claims 1
- -1 hydroxypropyl Chemical group 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 22
- 230000000694 effects Effects 0.000 abstract description 6
- 244000052616 bacterial pathogen Species 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 11
- 206010040880 Skin irritation Diseases 0.000 description 5
- 230000036556 skin irritation Effects 0.000 description 5
- 231100000475 skin irritation Toxicity 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 241000222122 Candida albicans Species 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 229940095731 candida albicans Drugs 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229920013818 hydroxypropyl guar gum Polymers 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Alternative & Traditional Medicine (AREA)
- Oncology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种无醇免洗消毒凝胶，按质量份计，包括杀菌剂0.01‑0.2份、保湿剂0.05‑0.25份、增稠剂2‑25份、水20‑80份、植物提取物1‑20份、增溶剂1‑10份和pH调节剂制成。本发明针对醇类物质气味重、易燃且对皮肤有刺激作用的问题，以超支化聚赖氨酸替代乙醇作为抗菌剂，在保证抗菌效果的同时，可以解决上述含醇类免洗消毒凝胶的不足。选用特定的植物提取液不仅提高了消毒凝胶的亲肤润肤效果，并且与超支化聚赖氨酸可以产生协同抗菌的效果，进一步提升消毒凝胶的杀菌性能。本发明提供的一种无醇免洗消毒凝胶能快速杀灭皮肤表面上常见的致病菌，具有广谱、强大的杀菌效果，具有良好的持久力，可以对皮肤起到长效保护作用。
Description
技术领域
本发明涉及一种无醇免洗消毒凝胶及其制备方法，属于卫生保健领域。
背景技术
科学抗菌可以做到尽力预防和抑制病菌入侵人体，在后疫情时代，抗菌、消毒将成为必然趋势。
环境中存在着各种各样的细菌、真菌等致病菌。手部是我们日常生活中使用最多的部位，因此常会带有各种各样的病原微生物；这些微生物不仅可能使自己染病，还可能传播给他人。80％的病原微生物可以通过正确的洗手方式消除，而其余的20％则需要通过消毒药物除去。免洗手消毒凝胶作为一种高效、便捷的手消毒方法，相比消毒液等其他方式更加安全、便捷。
现有市面上的免洗洗手液以及免洗消毒凝胶的消毒抗菌作用主要来源于成分中60-80％的醇类物质，或是额外添加的抑菌剂如三氯生或葡萄糖酸氯己定。然而酒精属于易燃物品，不可带上火车、高铁和飞机，并且酒精在常温下易挥发，可通过皮肤、鼻腔或口腔吸入人体，不适用于酒精过敏人群。此外，对于儿童或是皮肤较为敏感的人群来说，含酒精的洗手液过于刺激，可能会引起肌肤干裂、过敏等症状，对于皮肤有伤口的人而言刺激作用更显著。此外，由于酒精的易挥发性导致酒精对真菌等真核致病菌的抑菌效果不强。
发明内容
本发明的目的在于针对现有技术的不足，提供一种杀菌性能优异、安全无醇免洗消毒凝胶及其制备方法。该凝胶可以解决含乙醇消毒制品无法带上火车、高铁、飞机等交通工具、气味刺激、对人体皮肤存在刺激性的问题。
本发明的目的是通过以下技术方案实现的：
一种无醇免洗消毒凝胶，包括杀菌剂、保湿剂、增稠剂、增溶剂、植物提取物、水和pH调节剂制成。所述杀菌剂包括分子量3000-6000Da的超支化聚赖氨酸，所述植物提取物包括芦荟提取液、仙人掌提取液中的至少一种。
各物料按重量份计为：超支化聚赖氨酸0.01-0.2份，保湿剂0.05-0.25份，增稠剂2-25份，水20-80份，植物提取物1-20份，增溶剂1-10份。
具体地，所述保湿剂为甘油。
具体地，所述增稠剂为羟丙甲基纤维素、羟乙基纤维素、羟丙基瓜尔胶、聚乙烯醇、羧甲基纤维素、羧甲基壳聚糖、卡波姆940中的至少一种。
具体地，所述增溶剂包括吐温20、吐温60、吐温80中的至少一种。
具体地，所述pH调节剂包括三乙醇胺、1mol/L的氢氧化钠水溶液、磷酸缓冲液、柠檬酸、柠檬酸钠中的至少一种。
进一步地，无醇免洗消毒凝胶按照以下步骤制备：
(1)将2-25份增稠剂、1-10份增溶剂加入到20-80份去离子水中，充分搅拌至混合均匀。
(2)将0.01-0.2份杀菌剂加入步骤(1)所得产物中，继续搅拌反应，充分搅拌至混合均匀。
(3)向步骤(2)所得产物中加入0.05-0.25份保湿剂、1-20份植物提取物，充分搅拌至混合均匀。
(4)向步骤(3)所得产物中加入适量pH调节剂调节溶液pH至7，持续搅拌至体系透明均匀，离心脱泡后获得均一凝胶，得到无醇免洗消毒凝胶。
本发明的有益效果是：
第一，本发明采用一种超支化聚赖氨酸替代乙醇作为杀菌剂，可以解决乙醇消毒凝胶无法带上火车、高铁、飞机的问题。
第二，本发明采用一种超支化聚赖氨酸替代乙醇作为杀菌剂，具有广谱、高效的杀菌效果，对大肠杆菌和金黄色葡萄球菌、绿脓杆菌及白色念珠菌都具有良好的杀灭作用，稳定性好，无刺激，可以解决乙醇消毒凝胶的刺激性气味以及对人体皮肤的刺激性。
第三，本发明添加的植物提取物可以和超支化聚赖氨酸一起协同灭菌，同时还可以促进肌肤保湿、滋润肌肤，不仅有消炎止痒的功效，还具有保湿护肤功效。
具体实施方式
以下结合实施例进一步说明本发明的技术方案，但这些实施例并不用于限制本发明。
实施例1：
将1份甘油与2份吐温80加入80份去离子水中充分搅拌溶解，再向其中加入0.02份分子量3000-6000的超支化聚赖氨酸，充分搅拌溶解；向其中加入5份芦荟提取液、5份仙人掌提取液、0.25份甘油，充分搅拌溶解，最后加入pH调节剂将pH调节至7，加入去离子水补齐质量分数到100份，离心脱泡。最后得到一种无醇免洗消毒凝胶。
实施例2：
将1份甘油与2份吐温80加入80份去离子水中充分搅拌溶解，再向其中加入0.01份分子量3000-6000的超支化聚赖氨酸，充分搅拌溶解；向其中加入5份芦荟提取液、5份仙人掌提取液、0.25份甘油，充分搅拌溶解，最后加入pH调节剂将pH调节至7，加入去离子水补齐质量分数到100份，离心脱泡。最后得到一种无乙醇免洗手消毒凝胶。
对比例1
将1份甘油与2份吐温80加入90份去离子水中充分搅拌溶解，再向其中加入0.01份分子量3000-6000的超支化聚赖氨酸，充分搅拌溶解；加入0.25份保湿剂，充分搅拌溶解，最后加入pH调节剂将pH调节至7，加入去离子水补齐质量分数到100份，离心脱泡。最后得到一种无醇免洗消毒凝胶。
对比例2
将1份甘油与2份吐温80加入80份去离子水中充分搅拌溶解，充分搅拌溶解，再向其中加入5份芦荟提取液、5份仙人掌提取液、0.25份甘油，充分搅拌溶解，最后加入pH调节剂将pH调节至7，加入去离子水补齐质量分数到100份，离心脱泡。最后得到一种无醇免洗消毒凝胶。
对比例3
CN 111714424A中制备的一种免洗手消毒凝胶，其主要杀菌成分为乙醇。
实施例1同实施例2，不同之处在于杀菌剂的质量分数分别为0.02％和0.01％。
实施例2同对比例1，不同之处在于对比例1中用等量去离子水替代了植物提取液。
实施例2同对比例2，不同之处在于对比例2中用等量去离子水替代了杀菌剂。
效果验证例
抗菌试验：
1、检测所有实施例和对比例中制备得到的无醇免洗手消毒凝胶对大肠杆菌、金黄色葡萄球菌、白色念珠菌的灭菌效果。具体检测方法参考15979-2002《一次性使用卫生用品卫生标准》附录C4进行试验，用样品原液，与细菌共培养16h，试验温度37℃。
2、试验菌株：大肠杆菌(ATCC25922)，金黄色葡萄球菌(ATCC6538)，白色念珠菌(ATCC10231)，以上菌种代数为4代，并用含0.03mol/L的磷酸盐缓冲液(PBS)配制细菌悬液。
3、试验样品：以上各实施例样品1-4、对比例。
皮肤刺激性实验：
1、实验动物准备：实验前日，将家兔背部脊柱两侧毛剪掉，去毛范围左、右各约3cm*3cm。
2、实验与对照：正式实验时，将实施例样品0.2g涂抹于左侧去毛皮肤上，每天涂抹一次，连续涂抹14d。右侧皮肤作为对照。
3、实验观察：每天观察皮肤反映，按《化妆品安全性评价程序和方法》GB7919-87中表1评分，并根据评分结果按照GB7919-87中表2评价样品的皮肤刺激强度。
无醇免洗消毒凝胶对金黄色葡萄球菌、大肠杆菌、白色念珠菌的杀菌数据见表1，皮肤刺激性结果见表2：
表1杀菌实验结果
通过实施例2、对比例1、对比例2可见超支化聚赖氨酸与植物提取液存在协同抑菌作用。
表2皮肤刺激评分表
通过上表数据可见根据本发明的配方制备的无醇免洗消毒凝胶无皮肤刺激性。
Claims (7)
1.一种无醇免洗消毒凝胶，其特征在于，按质量份计，包括杀菌剂0.01-0.2份、保湿剂0.05-0.25份、增稠剂2-25份、水20-80份、植物提取物1-20份、增溶剂1-10份和pH调节剂制成；所述杀菌剂包括分子量3000-6000Da的超支化聚赖氨酸。
2.根据权利要求1所述的一种无醇免洗消毒凝胶，其特征在于，所述保湿剂为甘油。
3.根据权利要求1所述的一种无醇免洗消毒凝胶，其特征在于，所述的增稠剂包括羟丙甲基纤维素、羟乙基纤维素、羟丙基瓜尔胶、聚乙烯醇、羧甲基纤维素、羧甲基壳聚糖、卡波姆940中的至少一种。
4.根据权利要求1所述的一种无醇免洗消毒凝胶，其特征在于，所述的植物提取物包括芦荟提取液、仙人掌提取液中的至少一种。
5.根据权利要求1所述的一种无醇免洗消毒凝胶，其特征在于，所述的增溶剂包括吐温20、吐温60、吐温80中的至少一种。
6.根据权利要求1所述的一种无醇免洗消毒凝胶，其特征在于，所述的pH调节剂包括三乙醇胺、1mol/L的氢氧化钠水溶液、磷酸缓冲液、柠檬酸、柠檬酸钠中的至少一种。
7.权利要求1-6任一项所述的一种无醇免洗消毒凝胶的制备方法，其特征在于，所述方法包括以下步骤：
(1)将2-25份增稠剂、1-10份增溶剂加入到20-80份去离子水中，充分搅拌至混合均匀；
(2)将0.01-0.2份杀菌剂加入步骤(1)所得产物中，继续搅拌反应，充分搅拌至混合均匀；
(3)向步骤(2)所得产物中加入0.05-0.25份保湿剂、1-20份植物提取物，充分搅拌至混合均匀；
(4)向步骤(3)所得产物中加入适量pH调节剂调节溶液pH至7，持续搅拌至体系透明均匀，离心脱泡后获得均一凝胶，得到无醇免洗消毒凝胶。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210598856.8A CN114984077A (zh) | 2022-05-30 | 2022-05-30 | 一种无醇免洗消毒凝胶及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210598856.8A CN114984077A (zh) | 2022-05-30 | 2022-05-30 | 一种无醇免洗消毒凝胶及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114984077A true CN114984077A (zh) | 2022-09-02 |
Family
ID=83029933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210598856.8A Pending CN114984077A (zh) | 2022-05-30 | 2022-05-30 | 一种无醇免洗消毒凝胶及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114984077A (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112245334A (zh) * | 2020-09-18 | 2021-01-22 | 江苏龙蟠科技股份有限公司 | 一种无醇免洗手消毒凝胶及其制备方法 |
| CN113349201A (zh) * | 2021-07-05 | 2021-09-07 | 无锡宏霸医疗科技有限公司 | 一种无乙醇凝胶型免洗消毒剂及其制备方法 |
| CN113577377A (zh) * | 2021-08-17 | 2021-11-02 | 浙江大学 | 一种活性氧消除抗菌消炎水凝胶皮肤敷料及其制备方法 |
-
2022
- 2022-05-30 CN CN202210598856.8A patent/CN114984077A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112245334A (zh) * | 2020-09-18 | 2021-01-22 | 江苏龙蟠科技股份有限公司 | 一种无醇免洗手消毒凝胶及其制备方法 |
| CN113349201A (zh) * | 2021-07-05 | 2021-09-07 | 无锡宏霸医疗科技有限公司 | 一种无乙醇凝胶型免洗消毒剂及其制备方法 |
| CN113577377A (zh) * | 2021-08-17 | 2021-11-02 | 浙江大学 | 一种活性氧消除抗菌消炎水凝胶皮肤敷料及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 冼寒梅 等: "《广西临床常用中草药》", 31 March 2007, 广西科学技术出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103356738B (zh) | 一种皮肤消毒凝胶及其应用 | |
| KR20150097560A (ko) | 식물성 항균 조성물 | |
| EP2937101A1 (en) | Semi-fluidic composition for lubricating, moisture retaining, disinfecting, sterilizing and method using the same | |
| JP2007536233A (ja) | ポリカチオン抗菌薬による治療 | |
| MXPA06000543A (es) | Composiciones antimicrobianas que contienen combinaciones sinergicas de compuestos de amonio cuaternario y aceites esenciales y/o constituyentes de estos. | |
| CN107412585B (zh) | 一种绿色环保型免洗手消毒凝胶及其制备方法 | |
| CN102246794A (zh) | 一种杀灭微生物的组合物 | |
| CN106798716A (zh) | 免洗型纳米银抗菌洗手液 | |
| WO2021217324A1 (zh) | 消毒剂组合物、其制备方法和用途 | |
| CN108653121A (zh) | 一种含中草药成分的抑菌洗手消毒液 | |
| CN113440441B (zh) | 一种含精油的口腔抑菌组合物及其制备方法 | |
| CN113209003A (zh) | 一种生物型免洗手抑菌凝胶及制备方法、应用 | |
| WO2008061375A1 (en) | Antiseptic | |
| CN109498535B (zh) | 抑菌组合物、抑菌免洗凝胶及其制备方法和应用 | |
| CN112006921A (zh) | 一种具有护肤功能的免洗酒精凝胶及其制备方法 | |
| CN111329820A (zh) | 一种具有保湿、除臭功能的手部消毒液及其制备方法 | |
| CN114984077A (zh) | 一种无醇免洗消毒凝胶及其制备方法 | |
| CN102771519A (zh) | 一种手机天然芳香除菌剂 | |
| CN111973535B (zh) | 一种艾叶免洗消毒凝胶及其制备方法 | |
| CN112587421A (zh) | 一种含植物提取物的免洗手消毒凝胶及其制备方法和应用 | |
| CN113521042A (zh) | 一种儿童专用无醇免洗病毒灭活消毒剂及其制备方法 | |
| CN113967185A (zh) | 一种免洗消毒液及其制备方法 | |
| CN112494388A (zh) | 无醇型驱蚊止痒喷雾及其制备方法 | |
| CN112057401A (zh) | 一种免洗手复合醇消毒液及其制备方法 | |
| CN111956516A (zh) | 免水洗抗菌香氛组合物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220902 |