WO2017041202A1 - 一种具有防腐功效的组合物及其制备方法和应用 - Google Patents
一种具有防腐功效的组合物及其制备方法和应用 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Definitions
- the invention relates to the technical field of cosmetic additives, in particular to a composition having antiseptic effect without formaldehyde release and without strong reducing agent.
- Cosmetics are rich in nutrients, which are especially suitable for the growth of microorganisms. Therefore, preservatives need to be added to cosmetics.
- the purpose of preservatives in cosmetics is to inhibit the growth and production of microorganisms, to prevent cosmetic deterioration and to maintain freshness and persistence. Sex.
- a composition having preservative efficacy comprising carboxymethyl chitosan and a polyol, and which does not contain formaldehyde and a formaldehyde release.
- the antiseptic composition does not contain any preservative ingredients, and has an bacteriostatic effect against bacteria and fungi and a broad spectrum of antibacterial and antiseptic properties.
- a composition comprising a composition having preservative efficacy comprises components and corresponding parts by weight as follows:
- a further object of the present invention is to provide a process for preparing a composition having preservative efficacy, which is prepared as follows: 0.5-10 parts by weight of carboxymethyl chitosan, 10-80 parts by weight of 1,2- Pentandiol, 10-80 parts by weight of 1,2-octanediol, 10-80 parts by weight of 1,2-hexanediol, 1-30 parts by weight of 1,2-propanediol, 1-30 parts by weight 1,3-butanediol, 1-30 parts by weight of glycerin are mixed and stirred to dissolve uniformly.
- Still another object of the present invention is to provide a composition for preserving a composition having a preservative effect, which is used for preservative preservation of a cosmetic, wherein the composition having a preservative effect is contained in a cosmetic product. It is 0.1-5%.
- the composition having the preservative effect is contained in the cosmetic in an amount of 0.1 to 4%.
- Chitosan is the only cationic biopolysaccharide in nature with good biocompatibility, adhesion, degradability, bacteriostasis and plasticity, which can promote wound healing and tissue regeneration.
- experiments have shown that the bacteriostatic effect of a single carboxymethyl chitosan can not meet the requirements of antibacterial in cosmetics. It has been found that carboxymethyl chitosan as a macromolecular polysaccharide product cannot penetrate efficiently. Bacterial cell wall.
- 1,2-pentanediol CAS No.: 5343-92-0, molecular weight: 104.15, INCI name: pentylenGlyco, has excellent moisturizing properties, can help moisturize and penetrate. In addition, it also has The effect of bacteria and solubilization, the amount of addition is within a certain range, and has an antiseptic effect.
- 1,2-octanediol (octyl glycol), CAS NO.: 1117-86-8, molecular weight: 146.23, INCI name: Caprylyl Glycol, can improve the emollient function of skin care products, also has excellent antimicrobial activity, with The carbon chain length (C8), which promotes the structure of the cell membrane, helps to enhance the efficacy of the preservative system.
- 1,2-hexanediol CAS NO.: 6920-22-5, molecular weight: 118.17, INCI name: 1,2-Hexanediol
- 1,2-propanediol is used as a wetting agent and antifreeze to increase the coordination of the entire preservative system.
- 1.3-Butanediol has the characteristics of diol reactivity, odorless, low toxicity, good water solubility, etc., and is used for humidification and softening of the entire preservative system.
- Glycerol is a colorless, sweet, clear, viscous liquid. It is odorless, warm and sweet, commonly known as glycerin. When used for moisturizing the skin, in addition to moisturizing and moisturizing functions, it also has special effects such as high activity, anti-oxidation and alcohol-promoting.
- the carboxymethylchitosan chitosan is mixed with a polyhydric alcohol, and the osmotic action of the polyol is exerted by the synergistic action of the two, so that the bacteriostatic effect is greatly increased by a geometric index.
- the antiseptic effect of the present invention is safe, non-toxic, side-effect, non-irritating; and has good bacteriostatic action.
- the compounding combination can bring synergistic effect to the antiseptic combination of the composition, and has a remarkable effect on the growth inhibition of bacteria and fungi, and has broad-spectrum antibacterial activity, and can effectively inhibit Gram-negative bacteria, positive bacteria, and yeasts. And mold.
- the preservative composition of the present invention does not contain any preservative component, no formaldehyde release, and no strong reducing agent.
- the compounding system supporting the concept of “without added preservative” is mild in nature, low in irritation and high in safety.
- Example 1 a method for preparing a composition having preservative efficacy is as follows: 0.5 g of carboxymethyl Chitosan, 10 grams of 1,2-pentanediol, 10 grams of 1,2-octanediol, 10 grams of 1,2-hexanediol, 1 gram of 1,2-propanediol, 1 gram The mixture of 1,3-butanediol and 1 g of glycerin was stirred and dissolved to obtain 33.5 g of a composition having antiseptic effect.
- composition with antiseptic effect of the present invention has no toxic effect on the human body by experiments and clinical verification on multiple batches of animals.
- the above-prepared 33.5 g of the preservative-preventing composition was used for the preservation of cosmetics, and the composition having the antiseptic effect was contained in the cosmetic in an amount of 0.1 to 5%. That is, 33.5 g of the antiseptic composition can be used for preservative of cosmetics having a total weight of 670 g to 33500 g.
- the composition having antiseptic effect therein is contained in the cosmetic in an amount of from 0.1 to 4%, i.e., 33.5 g of the preservative-preventing composition is preferably used for preserving cosmetics having a total weight of from 837.5 g to 33,500 g.
- Example 2 a preservative-preparing composition was prepared as follows: 10 g of carboxymethyl chitosan, 80 g of 1,2-pentanediol, and 80 g of 1,2-octanediol 80 g of 1,2-hexanediol, 30 g of 1,2-propanediol, 30 g of 1,3-butanediol, and 30 g of glycerin are mixed and stirred to dissolve uniformly to obtain 340 g. A composition having antiseptic effect.
- Example 3 a preservative-preparing composition was prepared as follows: 5.25 g of carboxymethyl chitosan, 45 g of 1,2-pentanediol, and 45 g of 1,2-octanediol 45 g of 1,2-hexanediol, 15.5 g of 1,2-propanediol, 15.5 g of 1,3-butanediol, and 15.5 g of glycerin were mixed and stirred to dissolve uniformly to obtain 186.75 g of A composition for preservative efficacy.
- composition having antiseptic effect of the present invention is shown in Table 2 below:
- composition of the present invention having preservative efficacy is shown in Table 4 below:
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Abstract
一种具有防腐功效的组合物，包括0.5-10重量份的羧甲基脱乙酰壳多糖、10-80重量份的1，2-戊二醇、10-80重量份的1，2-辛二醇、10-80重量份的1，2-己二醇、1-30重量份的1，2-丙二醇、1-30重量份的1，3-丁二醇、1-30重量份的丙三醇。该组合物的制备方法为将上述物质按重量份混合后搅拌溶解均匀即可。该具有防腐功效的组合物可以用于化妆品中防腐，其在化妆品中的含量为0.1-5％。
Description
本发明涉及化妆品添加剂技术领域，尤其涉及一种不含甲醛释放体、不存在强还原剂的具有防腐功效的组合物。
化妆品中含有丰富的营养物质，特别适合微生物的生长，所以化妆品中需要加入防腐剂，在化妆品中计入防腐剂的目的是为了抑制微生物生长和生成，避免化妆品产生变质现象并且维持新鲜度与持续性。
目前，对于市场上几乎每一种常用的防腐活性成份基本都存在甲醛或者甲醛释放体。而甲醛和甲醛释放体的潜在致癌性、有机卤化合物的潜在致敏性一直被大家所讨论。这两年来，关于尼泊金酯和激素分泌以及某些特定癌症之间的关联引起了公众极大的关注。虽然到目前为止对于这些争论还没有科学的定论，但在化妆品业界都有不同的争议。因此，化妆品行业已经在试图寻找新的化妆品用防腐剂。
发明内容
为了解决现有技术中的问题，本发明的目的是提供一种含有羧甲基脱乙酰壳多糖与多元醇，且不含有甲醛和甲醛释放体的具有防腐功效的组合物。该具有防腐功效的组合物不含有任何禁限用的防腐剂成分，且具有对细菌和真菌较理想的抑菌效果和广谱的抗菌防腐能力。
为实现上述目的，本发明采用以下技术方案：一种具有防腐功效的组合物的组合物包含的组分和对应组分的重量份如下：
本发明的再一目的是提供一种具有防腐功效的组合物的制备方法，其制备方法如下：将0.5-10重量份的羧甲基脱乙酰壳多糖、10-80重量份的1，2-戊二醇、10-80重量份的1，2-辛二醇、10-80重量份的1，2-己二醇、1-30重量份的1，2-丙二醇、1-30重量份的1，3-丁二醇、1-30重量份的丙三醇混合后搅拌溶解均匀即可制得。
本发明的还一目的是提供一种具有防腐功效的组合物的在配制化妆品中的应用，将上述具有防腐功效的组合物用于化妆品的防腐，其中具有防腐功效的组合物在化妆品中的含量为0.1-5％。
优选的技术方案，所述具有防腐功效的组合物在化妆品中的含量为0.1-4％。
脱乙酰壳多糖(CS)是自然界中唯一的阳离子生物多糖，具有良好的生物相容性、黏附性、降解性、抑菌性和可塑性，可促进伤口愈合和组织再生。
羧甲基脱乙酰壳多糖CAS No.：83512-85-0；INCI：CARBOXYMETHYL CHITOSAN，羧甲基脱乙酰壳多糖具有一定的抑菌效果，尤其对霉菌效果显著，其抑菌机理在于其可与细菌细胞壁产生互溶，达到效果。但是实验显示，单一的羧甲基脱乙酰壳聚糖的抑菌效果无法达到在化妆品中抑菌的要求，经研究发现羧甲基脱乙酰壳聚糖作为大分子多糖类产物，无法高效渗透细菌细胞壁。
1，2-戊二醇，CAS No.：5343-92-0，分子量：104.15，INCI名称：pentylenGlyco，具有优异的保湿性能，可帮助保湿和渗透。此外，还具有抑
菌和增溶的效果，添加量在一定范围内，具有防腐效果。
1，2-辛二醇(辛甘醇)，CAS NO.：1117-86-8，分子量：146.23，INCI名称：CaprylylGlycol，可以提高护肤产品的润肤功能，还具有优良的抗微生物活性，具有能促进细胞膜结构讲解的碳链长度(C8)，有助于增强防腐体系功效。
1，2-己二醇，CAS NO.：6920-22-5，分子量：118.17，INCI名称：1，2-Hexanediol，可以提高护肤产品的润肤性能，有效抑制微生物的活性，从而增强防腐体系的功效。
1，2-丙二醇用以作为润湿剂和防冻剂，增加整个防腐体系的协调作用。
1.3-丁二醇具有二元醇的反应性、无臭、低毒、水溶性好等特点，用以整个防腐体系的增湿和软化作用。
丙三醇是无色味甜澄明黏稠液体。其无臭，有暖甜味，俗称甘油。将其用于对皮肤进行滋润时，除具有保湿、保润功能外，还具有高活性、抗氧化、促醇化等特殊功效。
根据上述物质特性，本发明将羧甲基脱乙酰壳聚糖与多元醇混合后，通过两者协同作用，发挥多元醇的渗透作用，使得抑菌效果以几何指数方式大幅增长。
综上所述，本发明的具有防腐功效的组合物安全、无毒副作用、无刺激；抑菌作用好。该复配组合能够给组合物的防腐组合带来协同作用，特别对细菌和真菌的生长抑制具有显著的作用，具广谱的抗菌活性，能有效抑制革兰氏阴性菌，阳性菌，酵母菌以及霉菌。
本发明的防腐剂组合物不含有任何禁限用防腐剂成分，也无甲醛释放体，无强还原剂。支持“无添加防腐剂”概念的复配体系，性质温和，刺激性低，安全性高。
实施例1，一种具有防腐功效的组合物的制备方法如下：将0.5克的羧甲
基脱乙酰壳多糖、10克的1，2-戊二醇、10克的1，2-辛二醇、10克的1，2-己二醇、1克的1，2-丙二醇、1克的1，3-丁二醇、1克的丙三醇混合后搅拌溶解均匀即可制得33.5克的具有防腐功效的组合物。
通过多批次在动物上进行的实验和临床验证，本发明所述的具有防腐功效的组合物对人体无毒害作用。
将上述制得的33.5克具有防腐功效的组合物用于化妆品的防腐，其中具有防腐功效的组合物在化妆品中的含量为0.1-5％。即33.5克该具有防腐功效的组合物可用于总重量为670克至33500克的化妆品进行防腐。该其中具有防腐功效的组合物在化妆品中的含量为0.1-4％，也即33.5克该具有防腐功效的组合物最佳用于总重量为837.5克至33500克的化妆品进行防腐。
实施例2，一种具有防腐功效的组合物的制备方法如下：将10克的羧甲基脱乙酰壳多糖、80克的1，2-戊二醇、80克的1，2-辛二醇、80克的1，2-己二醇、30克的1，2-丙二醇、30克的1，3-丁二醇、30克的丙三醇混合后搅拌溶解均匀即可制得340克的具有防腐功效的组合物。
实施例3，一种具有防腐功效的组合物的制备方法如下：将5.25克的羧甲基脱乙酰壳多糖、45克的1，2-戊二醇、45克的1，2-辛二醇45克的1，2-己二醇、15.5克的1，2-丙二醇、15.5克的1，3-丁二醇、15.5克的丙三醇混合后搅拌溶解均匀即可制得186.75克的具有防腐功效的组合物。
本发明中用到的羧甲基脱乙酰壳聚糖与多元醇(戊二醇事例)复配抑菌效果实验数据如下表1所示。123
| 1 | 2 | 3 | |
| 羧甲基脱乙酰壳聚糖 | 0％ | 0.15％ | 0.15％ |
| 戊二醇 | 2％ | 0％ | 2％ |
| 大肠杆菌菌液 | up to 100％ | up to 100％ | up to％ |
| 第１天(菌落数cfu/g) | 58,000 | 52,000 | 52,800 |
| 1 | 2 | 3 | |
| 第6天(菌落数cfu/g) | 280,000 | 9,050 | 10,000 |
| 第13天(菌落数cfu/g) | 多不可计 | 72,500 | 100 |
| 第17天(菌落数cfu/g) | 多不可计 | 多不可计 | ＜10 |
表1
本发明一种具有防腐功效的组合物如下表2所示：
| 名称 | English name(英文名称) | 含量 | 作用 |
| EDTA-2Na | EDTA-2Na | 0.05％ | 螯合剂 |
| SYMSAVE H | SYMSAVE H | 0.3％ | 抗氧化剂 |
| 甘油 | Glycerine | 5％ | 保湿剂 |
| 汉生胶T | Keltrol T | 0.05％ | 增稠剂 |
| Cosmdia SPL | Cosmdia SPL | 0.2％ | 增稠稳定剂 |
| 水溶性人参皂甙 | Ginsenoside | 0.1％ | 提取物 |
| 无水甜菜碱 | Betaine Anhydrous | 0.5％ | 表面活性剂 |
| 1，3-丁二醇 | 1，3-butylene glycol | 0.3％ | 保湿剂，渗透剂 |
| 1，2戊二醇 | 1，2-Pentanediol | 0.1％ | 保湿剂，渗透剂 |
| 己二醇 | 1，6-Hexanediol | 0.4％ | 保湿剂，渗透剂 |
| 羧甲基脱乙酰壳多糖 | CARBOXYMETHYL CHITOSAN | 0.15％ | 防腐 |
表2
表2中防腐化合物的防腐效能测试数据如下表3所示：
表3
本发明另一种具有防腐功效的组合物如下表4所示：
| 商品名 | English name(英文名称) | 含量 | 作用 |
| 二甲基硅油(200cs) | Silicone PMX-200 | 2.00％ | 肤感调节剂 |
| 辛酸蔡酸三甘油酯 | GTCC(Caprylic/Capric Triglyceride) | 2.00％ | 稳定剂 |
| 棕榈酸乙基己酯 | 2-Ethylhexyl Palmitate | 2.00％ | 肤感调节剂 |
| 碳酸二辛酯 | Dioctyl carbonate | 2.00％ | 软化剂，肤感调节剂 |
| Olivem 1000 | Ceterayl Olivate | 2.00％ | 乳化剂 |
| 白油 | White mineral oil | 2.00％ | 基础油脂 |
| 乳化剂A-165 | Cithrol GMS A/S | 1.00％ | 乳化剂 |
| 十八醇 | Stearyl alcohol | 1.00％ | 基础油脂 |
| 去离子水 | DI water | 77.55％ | 溶剂 |
| 甘油 | Glycerine | 5.00％ | 保湿剂 |
| SEPIPLUS 265 | Sepiplus 265 | 0.80％ | 增稠剂 |
| 戊二醇 | 1，2-PENTANEDIOL | 2.00％ | 渗透剂 |
| 己二醇 | 1，6-Hexanediol | 0.50％ | 渗透剂 |
| 羧甲基脱乙酰壳多糖 | CARBOXYMETHYL CHITOSAN | 0.15％ | 防腐 |
表4
表4中防腐化合物的防腐效能测试数据如下表5所示：
表5
Claims (4)
- 一种具有防腐功效的组合物，其特征在于：所述具有防腐功效的组合物包含的组分和对应组分的重量份如下：
- 一种具有防腐功效的组合物的制备方法，其特征在于：将0.5-10重量份的羧甲基脱乙酰壳多糖、10-80重量份的1，2-戊二醇、10-80重量份的1，2-辛二醇、10-80重量份的1，2-己二醇、1-30重量份的1，2-丙二醇、1-30重量份的1，3-丁二醇、1-30重量份的丙三醇混合后搅拌溶解均匀即可制得。
- 根据权利要求1所述的一种具有防腐功效的组合物的在配制化妆品中的应用，其特征在于：在化妆品中含有上述具有防腐功效的组合物，其中具有防腐功效的组合物在化妆品中的含量为0.1-5％。
- 根据权利要求3所述的一种具有防腐功效的组合物的在配制化妆品中的应用，其特征在于：所述具有防腐功效的组合物在化妆品中的含量为0.1-4％。
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| CN106511119A (zh) * | 2015-09-09 | 2017-03-22 | 上海春露生物化学有限公司 | 一种具有防腐功效的组合物及其制备方法和应用 |
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