WO2021227214A1 - 一种杀菌消毒组合物 - Google Patents
一种杀菌消毒组合物 Download PDFInfo
- Publication number
- WO2021227214A1 WO2021227214A1 PCT/CN2020/098787 CN2020098787W WO2021227214A1 WO 2021227214 A1 WO2021227214 A1 WO 2021227214A1 CN 2020098787 W CN2020098787 W CN 2020098787W WO 2021227214 A1 WO2021227214 A1 WO 2021227214A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polyhexamethylene biguanide
- sterilization
- water
- disinfection
- formula
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 34
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 64
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims abstract description 45
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 20
- 150000001413 amino acids Chemical class 0.000 claims abstract description 18
- 239000000419 plant extract Substances 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 239000007864 aqueous solution Substances 0.000 claims description 18
- 238000005259 measurement Methods 0.000 claims description 17
- 235000001014 amino acid Nutrition 0.000 claims description 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 10
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 8
- 229940069521 aloe extract Drugs 0.000 claims description 8
- 235000003704 aspartic acid Nutrition 0.000 claims description 8
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 8
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- 230000000249 desinfective effect Effects 0.000 claims description 6
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 5
- RJZNPROJTJSYLC-LLINQDLYSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O RJZNPROJTJSYLC-LLINQDLYSA-N 0.000 claims description 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 5
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 5
- 235000004279 alanine Nutrition 0.000 claims description 5
- 235000013922 glutamic acid Nutrition 0.000 claims description 5
- 239000004220 glutamic acid Substances 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 235000004400 serine Nutrition 0.000 claims description 5
- 241000233866 Fungi Species 0.000 claims description 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000004471 Glycine Substances 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 17
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 abstract description 7
- 241000700605 Viruses Species 0.000 abstract description 6
- 230000006870 function Effects 0.000 abstract description 5
- 239000002253 acid Substances 0.000 abstract description 3
- 230000003501 anti-edematous effect Effects 0.000 abstract description 3
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 238000005536 corrosion prevention Methods 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000000474 nursing effect Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
- 239000007788 liquid Substances 0.000 description 15
- 230000003020 moisturizing effect Effects 0.000 description 13
- 230000000694 effects Effects 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 3
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 241001506047 Tremella Species 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- 101800001147 Octapeptide 1 Proteins 0.000 description 2
- 241000908178 Tremella fuciformis Species 0.000 description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RXGSAYBOEDPICZ-UHFFFAOYSA-N 2-[6-[[amino-(diaminomethylideneamino)methylidene]amino]hexyl]-1-(diaminomethylidene)guanidine Chemical compound NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)N RXGSAYBOEDPICZ-UHFFFAOYSA-N 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000893966 Trichophyton verrucosum Species 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 235000014104 aloe vera supplement Nutrition 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000008288 physiological mechanism Effects 0.000 description 1
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- -1 polysaccharide compound Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Definitions
- the invention relates to the technical field of sterilization and disinfection preparations, in particular to a sterilization and disinfection composition.
- Polyhexamethylene biguanide and its hydrochloride due to its weak cationic characteristics, high activity, easy to adsorb on the surface of bacteria and viruses, and close contact with these microorganisms, destroy the division and replication of bacteria and viruses; on the other hand, the polymer chain The coverage prevents microorganisms from obtaining oxygen, destroys the living environment of microorganisms, and promotes their death.
- the remarkable feature of polyhexamethylene biguanide and its hydrochloride is a broad-spectrum antibacterial and obvious antibacterial effect. It can kill Gram-positive bacteria, Gram-negative bacteria, fungi (various ringworms and molds) and yeasts.
- Ability Very low toxicity, no irritation to skin and eyes, no sensitization, long-term use, no toxicity to the human body and the environment.
- polyhexamethylene biguanide and its hydrochloride salt are allowed to be used in disinfection products for personal hygiene, disinfection in private and public places, disinfection in food and catering, antiseptic in cosmetics, and other industrial fields.
- the Chinese patent application document with application number 201110151285.5 discloses the application of a chemical composition composed of ethanol, polyhexamethylene biguanide or its salt, and isopropanol in the preparation of antimicrobial products, wherein the weight ratio of ethanol and isopropanol The sum is not more than 60%;
- the Chinese patent application document with application number 200910114010.7 discloses a kind of polyhexamethylene biguanide and ethanol as the main bactericidal active ingredients, nonylphenol polyoxyethylene ether surfactant and glycerin as auxiliary ingredients
- the Chinese patent application document with the application number 200910114009.4 discloses a liquid disinfectant formula, which is composed of polyaminopropyl biguanide, nonylphenol polyoxyethylene ether, and fragrance.
- the Chinese patent application file with application number 03139745.x discloses a disinfection product composed of 95% ethanol, polyhexamethylene biguanide, fragrance, and water balance.
- the ingredients in addition to the biguanide ingredients, also contain alcohols or surfactants.
- Alcohols or surfactants have strong degreasing properties. Frequent use of these disinfectants for a long time may cause damage to hands and skin.
- ethanol is flammable. If the content of such alcohol is too high, there will be certain safety hazards, which will cause inconvenience to use, transportation, and storage.
- One or more combinations of polyhexamethylene biguanide or its salt, peptides, water-soluble plant extracts, and amino acids are formulated into skin care, moisturizing, sterilizing and disinfecting compositions, which have not been reported.
- the purpose of the present invention is to ensure that the antibacterial properties of polyhexamethylene biguanide or its hydrochloride are strengthened by formula combination, and at the same time, the introduction of peptides, water-soluble plant extracts, amino acids or any combination of one or more While enhancing the antibacterial and bactericidal effect, the introduction of peptides enhances the skin care effect of the composition, and has the functions of anti-inflammatory, repair, and anti-edema.
- the introduction of water-soluble plant extracts achieves sterilization and disinfection at the same time, so that the skin is very good. Good protection, moisturizing, and nourishment; the introduction of amino acids can maintain the formula system to maintain weak acid performance and better adapt to the skin. It is also easy to adsorb on the surface of bacteria and viruses by polyhexamethylene biguanide or its hydrochloride. The sterilization and disinfection environment.
- the sterilization and disinfection composition of the present invention is composed of the following components:
- a polyhexamethylene biguanide or its salt A polyhexamethylene biguanide or its salt
- the polyhexamethylene biguanide or its salt of the present invention is selected from one or two arbitrary combinations of polyhexamethylene biguanide and polyhexamethylene biguanide hydrochloride, and the amount is 1 to the total mass of the composition. 15%;
- the synergist of the present invention is selected from one or several arbitrary combinations of peptides, water-soluble plant extracts, and amino acids, preferably a combination of peptides, water-soluble plant extracts, and amino acids, and most preferably A combination of peptides, water-soluble plant extracts, and amino acids.
- the dosage is 1-20% of the total mass of the composition;
- the peptide of the present invention is a small molecule protein, also known as a polypeptide or peptide. It is composed of amino acids with a certain sequence connected by amide bonds. The two amino acids are called di-peptides, and the three amino acids are called di-peptides. Three peptides, and so on. As people continue to study the microstructure and physiological mechanism of their own skin, they recognize that peptides play an important role in the growth, development and metabolism of organisms. The skin care effect is reflected in the promotion of collagen production, anti-free radical oxidation, anti-inflammatory repair, Anti-edema and other functions.
- the peptide molecule has numerous amino groups, and when combined with polyhexamethylene biguanide or its hydrochloride, it will strengthen the adsorption on the surface of bacteria and viruses, thereby strengthening the sterilization and disinfection functions. At the same time, the skin care effect of the peptide will also be well reflected in the sterilization and disinfection of the hands and skin.
- the peptide of the present invention is selected from one or several combinations of hexapeptide, acetyl hexapeptide, pentapeptide-3, and acetyl octapeptide-1;
- the water-soluble plant extract of the present invention is selected from one or a combination of aloe extract and white fungus extract;
- Aloe extract contains a variety of moisturizing ingredients and nutrients that are beneficial to the human body. It has the effects of nourishing moisturizing, sun protection, and anti-inflammatory. At the same time, it has significant effects on softening the skin, astringent, preventing rough skin, and keeping the skin delicate and white. .
- the combination of aloe vera extract and polyhexamethylene biguanide or its hydrochloride salt will achieve good protection, moisturization and nourishment of the skin while achieving sterilization and disinfection.
- Tremella fuciformis extract The main active ingredient of Tremella fuciformis extract is polysaccharide compound, which has the functions of smoothing the skin texture, super moisturizing, and conditioning the skin tone. It has strong permeability, is easy to absorb, safe and gentle, and has a smooth skin feel.
- the combination of Tremella extract and polyhexamethylene biguanide or its hydrochloride salt will achieve good protection, moisturizing and nourishing the skin while achieving sterilization and disinfection.
- the amino acid of the present invention has a good regulation of moisture, acid-base, and balance of oil, has improved the anti-allergic ability of sensitive skin, promotes skin metabolism and blood circulation, prevents the occurrence of wrinkles, helps the skin to effectively moisturize and hydrate, and It can maintain enough collagen fibers and elastic fibers to make the skin smooth, delicate and elastic.
- the addition of amino acids can also maintain the formula system to maintain weak acid properties and better adapt to the skin. It is also easier for polyhexamethylene biguanide or its hydrochloride to adsorb on the surface of bacteria and viruses to maintain a good sterilization and disinfection environment.
- the amino acid of the present invention is selected from one or more combinations of aspartic acid, glutamic acid, alanine, serine, and glycine.
- the water in the present invention is deionized water, and the amount is 70-95% of the total mass of the composition.
- the preparation method of the sterilization and disinfection composition of the present invention is as follows:
- the polyhexamethylene biguanide or its salt is mixed with water according to the formula to prepare the polyhexamethylene biguanide or its salt aqueous solution;
- the material used in the invention has good biocompatibility, is easy to degrade, is environmentally friendly, does not contain alcohol components such as ethanol, is not flammable, and is safe for transportation and storage.
- the skin care moisturizing antibacterial disinfectant composition of the present invention can be formed into various preparation forms such as a sterilizing disinfectant, a skin moisturizing antibacterial disinfecting hand soap, a skin care moisturizing antibacterial disinfecting spray, a water-free skin care moisturizing sterilizing disinfecting hand washing lotion and the like.
- the antibacterial effect is tested according to the QB/T 2738-2012 standard issued and implemented by the Ministry of Industry and Information Technology of the People's Republic of China in 2012.
- the polyhexamethylene biguanide is mixed with water to prepare a polyhexamethylene biguanide aqueous solution; continue to add the aloe extract according to the measurement; stir for 4 minutes and stand for 35 minutes; continue to stir into a uniform transparent liquid.
- Sterilization effect test method According to the QB/T 2738-2012 standard issued and implemented by the Ministry of Industry and Information Technology of the People’s Republic of China in 2012, the antibacterial effect is tested.
- the specific method is QB/T2738-20127.2 antibacterial effect of antibacterial daily chemical products Test method (hanging titration method), the action concentration is the original solution, the action time is 2 minutes, the higher the bactericidal rate, the better the bactericidal effect;
- Example one Example two 72.5
- Example four 73.5 Example five 72.8
- Example Six 74.1 Example Seven 72.6
- Example 9 Example ten 71.3
- Example 11 71.7
- Example 12 70.9 Embodiment 13 71.3
Abstract
一种杀菌消毒组合物，基于聚六亚甲基双胍或其盐酸盐的抗菌性基础上，引入胜肽、水溶性植物提取物、氨基酸中的一种或几种任意组合，强化抗菌效果的同时，胜肽的引入提高组合物对皮肤的护理作用，起到消炎修复、抗水肿等功能；水溶性植物提取物的引入实现杀菌消毒的同时，使皮肤得到很好的保护、保湿、滋养；氨基酸的引入可维持配方体系保持弱酸性能，更好的和皮肤相适应，也为聚六亚甲基双胍或其盐酸盐更容易吸附于细菌病毒表面维持很好的杀菌消毒环境，该杀菌消毒组合物可以广泛用于个人护理、卫生消杀、工业防腐等领域。
Description
本发明涉及杀菌消毒制剂技术领域，尤其涉及一种杀菌消毒组合物。
随着地球环境的演化，人类活动的增加，卫生消毒杀菌越来越受到人们的重视。高效，生物相容性好，对人类温和的消杀制品一直是人们的追求，是保护健康环境，预防疾病发生的重要材料。
聚六亚甲基双胍及其盐酸盐，由于其弱阳离子特征，活性高，容易吸附于细菌、病毒表面，与这些微生物紧密接触，破坏了细菌、病毒的分裂复制；另一方面，聚合链的覆盖使微生物获取氧的途径受阻，破坏微生物生存环境，促使其死亡。聚六亚甲基双胍及其盐酸盐显著特点是广谱抗菌，抗菌效果明显，对革兰氏阳性菌、革兰氏阴性菌、真菌(多种癣菌和霉菌)和酵母菌均具有杀伤能力；毒性很低，对皮肤及眼睛无刺激反应，无致敏性，长期使用对人体及环境无毒性。
国内外，聚六亚甲基双胍及其盐酸盐被允许用于个人卫生用杀菌产品、私人场所和公共场所的消毒、食品和餐饮领域的消毒、化妆品的防腐，以及其他一些工业领域。
申请号201110151285.5的中国专利申请文件公开了含有乙醇、聚六亚甲基双胍或其盐、异丙醇组成的化学组合物在制备抗微生物产品中的应用，其中乙醇和异丙醇的重量比之和不超过60％；申请号为200910114010.7的中国专利申请文件，公开了一种由聚六亚甲基双胍和乙醇为主要杀菌有效成分、壬基酚聚氧乙烯醚表面活性剂和甘油为辅助成分的皮肤消毒产品；申请号为200910114009.4的中国专利 申请文件公开了一种液体消毒剂配方，由聚胺丙基双胍、壬基酚聚氧乙烯醚、香精组成。申请号为03139745.x的中国专利申请文件，公开了一种由95％乙醇、聚六亚甲基双胍、香味剂、水余量组成的消毒产品，95％乙醇的用量在35-69％；
以往的这些发明，除双胍类成分外，成分中还含有醇类物质或表面活性剂，醇类或表面活性剂有很强的脱脂性，长期频繁使用这些杀菌消毒剂用，可能使手、皮肤的干燥缺水、发红，甚至皲裂；此外，乙醇是易燃物，这样的醇类含量若过高，有一定安全隐患，对使用、运输、储存都会带来不便。
由聚六亚甲基双胍或其盐与胜肽、以及水溶性植物提取物、氨基酸的一种或几种组合，配制成护肤保湿杀菌消毒组合物，未见报道。
发明内容
本发明的目的是在保证通过配方组合强化聚六亚甲基双胍或其盐酸盐的抗菌性能的同时，引入胜肽、水溶性植物提取物、氨基酸中的一种或几种任意组合的增效剂，增强抗菌杀菌效果的同时，胜肽的引入提高组合物对皮肤的护理作用，起到消炎修复、抗水肿等功能；水溶性植物提取物的引入实现杀菌消毒的同时，使皮肤得到很好的保护、保湿、滋养；氨基酸的引入可维持配方体系保持弱酸性能，更好的和皮肤相适应，也为聚六亚甲基双胍或其盐酸盐更容易吸附于细菌病毒表面维持很好的杀菌消毒环境。
本发明所述的一种杀菌消毒组合物由以下组分组成：
A聚六亚甲基双胍或其盐
本发明所述聚六亚甲基双胍或其盐选自聚六亚甲基双胍、聚六亚甲基双胍盐酸盐中的一种或两种任意组合，用量占组合物总质量的1-15％；
B增效剂
本发明所述增效剂选自胜肽、水溶性植物提取物、氨基酸中的一种或几种任意组合，优选胜肽、水溶性植物提取物、氨基酸中两种物质的组合，最优选胜肽、水溶性植物提取物、氨基酸三种物质组合。用量占组合物总质量的1-20％；
本发明所述胜肽(peptide)即小分子的蛋白质，又称多肽或肽，它是由具有一定序列的氨基酸通过酰胺键相连，2个氨基酸组成的叫二胜肽，3个氨基酸组成的叫三胜肽，依次类推。随着人们对自身皮肤微观结构和生理机制不断研究认识到，肽在生物的生长、发育和代谢中起着重要作用，对皮肤护理作用体现在促进胶原蛋白生成、抗自由基氧化、消炎修复、抗水肿等功能。
胜肽分子有众多的氨基，与聚六亚甲基双胍或其盐酸盐组合，将强化在细菌和病毒表面的吸附，进而强化杀菌消毒功能。同时，胜肽的皮肤护理作用也将在对手、皮肤杀菌消毒的同时很好的得以体现。
本发明所述胜肽选自六胜肽、乙酰六胜肽、五胜肽-3、乙酰基八肽-1的一种或几种组合；
本发明所述水溶性植物提取物选自芦荟提取物、银耳提取物的一种或两种组合；
芦荟提取物含有多种对人体有益的保湿成分和营养成分，具有营 养保湿、防晒、抗炎等功效，同时，它对软化皮肤、收敛、防止皮肤粗糙、保持皮肤细嫩白洁等都有显著功效。芦荟提取物与聚六亚甲基双胍或其盐酸盐类组合，将在实现杀菌消毒的同时，使皮肤得到很好的保护、保湿、滋养。
银耳提取物的主要活性成分是多糖类化合物，具有平滑肌肤纹理、超强补水保湿、调理肌肤气色等功效，且渗透性强，易于吸收、安全而温和、肤感顺滑。银耳提取物与聚六亚甲基双胍或其盐酸盐类组合，将在实现杀菌消毒的同时，使皮肤得到很好的保护、保湿、滋养。
本发明所述氨基酸有很好的调节水分、酸碱、平衡油脂，有改善敏感性皮肤的抗敏能力，促进肌肤的新陈代谢和促进血液循环，防止皱纹的发生，帮助肌肤有效保湿补水作用，并能维持足够的胶原纤维和弹性纤维，使皮肤柔滑，细腻富有弹性。氨基酸的加入还可维持配方体系保持弱酸性能，更好的和皮肤相适应，也为聚六亚甲基双胍或其盐酸盐更容易吸附于细菌病毒表面维持很好的杀菌消毒环境。
本发明所述的氨基酸选自天冬氨酸、谷氨酸、丙氨酸、丝氨酸、甘氨酸中的一种或多种组合。
C水
本发明所述水为去离子水，用量占组合物总质量的70-95％。
本发明所述的一种杀菌消毒组合物的制备方法如下：
第一步，按配方计量将聚六亚甲基双胍或其盐与水混合，配制成聚六亚甲基双胍或其盐水溶液；
第二步，按配方计量继续加入其它剩余组分；
第三步，缓慢搅拌1-5分钟；
第四步，静置20-40分钟；
第五步，继续将物料搅匀得成品。
本发明所用材料生物相容性好，易降解，绿色环保，不含乙醇等醇类组分，不易燃，运输储存安全。
本发明的护肤保湿抗菌消毒组合物可形成除菌消毒剂、护肤保湿抗菌消毒洗手液、护肤保湿抗菌消毒喷雾剂、免过水护肤保湿除菌消毒洗手露等多种制剂形式。
以下实施例中按照中华人民共和国工业和信息化部2012年发布和实施的QB/T 2738-2012标准测试抗菌效果。
实施例一：
配方：
聚六亚甲基双胍盐酸盐 4.0％
乙酰六胜肽 1.0％
水 95％
按此配方计量将聚六亚甲基双胍盐酸盐和水混合，配置成聚六亚甲基双胍盐酸盐水溶液；按计量继续加入乙酰六胜肽；搅拌一分钟，静置三十分钟后；继续搅拌成均匀透明液体。
实施例二
配方：
按此配方计量将聚六亚甲基双胍盐酸盐和水混合，配置成聚六亚甲基双胍盐酸盐水溶液；按计量继续加入五胜肽-3、银耳提取物；搅拌5分钟，静置40分钟后；继续搅拌成均匀透明液体。
实施例三
配方：
按此配方计量将聚六亚甲基双胍与水混合，配置成聚六亚甲基双胍水溶液；按计量继续加入天冬氨酸、丝氨酸；搅拌3分钟，静置20分钟后；继续搅拌成均匀透明液体。
实施例四
配方：
按此配方计量将聚六亚甲基双胍盐酸盐与水混合，配制聚六亚甲基双胍盐酸盐水溶液；按计量继续加入五胜肽-3、丙氨酸、甘氨酸、芦荟提取物；搅拌2分钟，静置35分钟后；继续搅拌成均匀透明液体。
实施例五
配方：
按此配方计量将聚六亚甲基双胍、聚六亚甲基双胍盐酸盐与水混合，配制聚六亚甲基双胍及其盐酸盐水溶液；按计量加入天冬氨酸、丙氨酸、谷氨酸、芦荟提取物、银耳提取物；搅拌5分钟，静置40分钟后，继续搅拌成均匀透明液体。
实施例六
配方：
按此配方计量将聚六亚甲基双胍与水混合，配制成聚六亚甲基双胍水溶液；按计量继续加入谷氨酸、丙氨酸、银耳提取物、六胜肽；搅拌4分钟，静置25分钟后；继续搅拌成均匀透明液体。
实施例七：
配方：
按此配方计量将聚六亚甲基双胍盐酸盐、聚六亚甲基双胍和水混合，配置成聚六亚甲基双胍及其盐酸盐水溶液；按计量继续加入六胜肽、芦荟提取物、甘氨酸；搅拌2分钟，静置35分钟后；继续搅拌成均匀透明液体。
实施例八
配方：
按此配方计量将聚六亚甲基双胍盐酸盐和水混合，配置成聚六亚甲基双胍盐酸盐水溶液；按计量继续加入五胜肽-3、六胜肽；搅拌5分钟，静置40分钟后；继续搅拌成均匀透明液体。
实施例九
配方：
按此配方计量将聚六亚甲基双胍盐酸盐和水混合，配置成聚六亚甲基双胍盐酸盐水溶液；按计量继续加入五胜肽-3、乙酰基八肽-1、乙酰六胜肽；搅拌3分钟，静置35分钟后；继续搅拌成均匀透明液体。
实施例十
配方：
按此配方计量将聚六亚甲基双胍和水混合，配置成聚六亚甲基双胍水溶液；按计量继续加入天冬氨酸、丝氨酸；搅拌2分钟，静置20分钟后；继续搅拌成均匀透明液体。
实施例十一
配方：
聚六亚甲基双胍 1.0％
天冬氨酸 20.0％
水 79.0％
按此配方计量将聚六亚甲基双胍与水混合，配置成聚六亚甲基双胍水溶液；按计量继续加入天冬氨酸；搅拌3分钟，静置30分钟后；继续搅拌成均匀透明液体。
实施例十二
配方：
按此配方计量将聚六亚甲基双胍与水混合，配置成聚六亚甲基双胍水溶液；按计量继续加入天冬氨酸、丝氨酸、谷氨酸；搅拌5分钟，静 置40分钟后；继续搅拌成均匀透明液体。
实施例十三
配方：
聚六亚甲基双胍 1.0％
芦荟提取物 20.0％
水 79.0％
按此配方计量将聚六亚甲基双胍与水混合，配置成聚六亚甲基双胍水溶液；按计量继续加入芦荟提取物；搅拌4分钟，静置35分钟后；继续搅拌成均匀透明液体。
实施例十四
配方：
按此配方计量将聚六亚甲基双胍与水混合，配置成聚六亚甲基双胍水溶液；按计量继续加入芦荟提取物、银耳提取物；搅拌2分钟，静置40分钟后；继续搅拌成均匀透明液体。
对比例一
配方：
按此配方计量将聚六亚甲基双胍盐酸盐和水混合，配置成聚六亚甲基双胍盐酸盐水溶液；按计量继续加入乙醇、异丙醇；搅拌一分钟，静置三十分钟后；继续搅拌均匀得到对比例一。
对比例二
配方：
按此配方计量将聚六亚甲基双胍盐酸盐和水混合，配置成聚六亚甲基双胍盐酸盐水溶液；按计量继续加入壬基酚聚氧乙烯醚表面活性剂、甘油；搅拌一分钟，静置三十分钟后；继续搅拌均匀得到对比例二。
测试方法及测试结果
(1)杀菌效果测试方法：按照中华人民共和国工业和信息化部2012年发布和实施的QB/T 2738-2012标准测试抗菌效果，具体方法为QB/T2738-20127.2抗菌型日化产品的杀菌效果检验方法(悬滴定量法)，作用浓度为原液，作用时间为2分钟，杀菌率越高，则杀菌效果越好；
(2)保湿效果测试方法：
配制试样配方：三压硬脂酸10％、十六醇3％、实施例或者对比例中消毒组合物0.5％、氢氧化钾10％、香精1％、防腐剂0.5％、去离子水75％； 将配置好的上述样品置入以硅胶为干燥剂的同一干燥器环境中，放置48h后，称出样品水分减少量，保水量＝残余水分质量/样品质量，保水量越高，则样品的保湿效果越好。
表1 杀菌效果测试结果
表2 保湿效果测试结果
| 样品名称 | 保水量(％) |
| 实施例一 | 70.9 |
| 实施例二 | 72.5 |
| 实施例三 | 70.4 |
| 实施例四 | 73.5 |
| 实施例五 | 72.8 |
| 实施例六 | 74.1 |
| 实施例七 | 72.6 |
| 实施例八 | 70.6 |
| 实施例九 | 71.6 |
| 实施例十 | 71.3 |
| 实施例十一 | 71.7 |
| 实施例十二 | 70.9 |
| 实施例十三 | 71.3 |
| 实施例十四 | 71.2 |
| 对比例一 | 67.4 |
| 对比例二 | 65.8 |
Claims (6)
- 一种杀菌消毒组合物，其特征在于所述杀菌消毒组合物由以下组分组成：A.聚六亚甲基双胍或其盐所述的聚六亚甲基双胍或其盐选自聚六亚甲基双胍、聚六亚甲基双胍盐酸盐中的一种或两种任意组合，用量占组合物总质量的1-15％；B.增效剂所述增效剂选自胜肽、水溶性植物提取物、氨基酸中的一种或几种任意组合；C.所述水为去离子水，用量占组合物总质量的70-95％；所述的杀菌消毒组合物的制备方法如下：第一步，按配方计量将聚六亚甲基双胍或其盐与水混合，配制成聚六亚甲基双胍或其盐水溶液；第二步，按配方计量继续加入其它剩余组分；第三步，缓慢搅拌1-5分钟；第四步，静置20-40分钟；第五步，继续将物料搅匀得成品。
- 根据权利要求1所述的一种杀菌消毒组合物，其特征在于所述的多肽选自六胜肽、乙酰六胜肽、五胜肽-3、乙酰基八肽-1的一种或几种组合。
- 根据权利要求1所述的一种杀菌消毒组合物，其特征在于所述水溶性植物提取物选自芦荟提取物、银耳提取物的一种或两种组合。
- 根据权利要求1所述的一种杀菌消毒组合物，其特征在于所述的氨基酸选自天冬氨酸、谷氨酸、丙氨酸、丝氨酸、甘氨酸中的一种或多种组合。
- 根据权利要求1所述的一种杀菌消毒组合物，其特征在于所述的增效剂优选胜肽、水溶性植物提取物、氨基酸中两种物质的组合。
- 根据权利要求1所述的一种杀菌消毒组合物，其特征在于所述的增效剂更优选胜肽、水溶性植物提取物、氨基酸中三种物质的组合。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010392046.8A CN111494280A (zh) | 2020-05-11 | 2020-05-11 | 一种杀菌消毒组合物 |
| CN202010392046.8 | 2020-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2021227214A1 true WO2021227214A1 (zh) | 2021-11-18 |
Family
ID=71865178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2020/098787 WO2021227214A1 (zh) | 2020-05-11 | 2020-06-29 | 一种杀菌消毒组合物 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN111494280A (zh) |
| WO (1) | WO2021227214A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972350A (zh) * | 2020-12-21 | 2021-06-18 | 西埔(福建)医药用品有限公司 | 一种不含酒精的外科手消毒剂 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104271126A (zh) * | 2012-05-11 | 2015-01-07 | 协和发酵生化株式会社 | 肤质改善剂 |
| CN106818837A (zh) * | 2016-12-12 | 2017-06-13 | 昆山博青生物科技有限公司 | 生物抗菌多肽制剂、制备方法及其应用 |
| CN109432396A (zh) * | 2019-01-22 | 2019-03-08 | 宇肽生物(东莞)有限公司 | 一种抗菌祛痘活性多肽 |
| CN110731910A (zh) * | 2019-11-27 | 2020-01-31 | 湖南贝恩叮当猫婴童用品有限公司 | 一种婴童护肤霜 |
| CN111000748A (zh) * | 2020-01-08 | 2020-04-14 | 上海瑾亭化妆品有限公司 | 一种多肽修护面霜及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109497093A (zh) * | 2018-11-26 | 2019-03-22 | 浙江舒是生物科技有限公司 | 一种消毒液 |
| CN111109301A (zh) * | 2019-12-31 | 2020-05-08 | 张立波 | 一种复合消毒剂及其制备方法和用途 |
-
2020
- 2020-05-11 CN CN202010392046.8A patent/CN111494280A/zh active Pending
- 2020-06-29 WO PCT/CN2020/098787 patent/WO2021227214A1/zh active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104271126A (zh) * | 2012-05-11 | 2015-01-07 | 协和发酵生化株式会社 | 肤质改善剂 |
| CN106818837A (zh) * | 2016-12-12 | 2017-06-13 | 昆山博青生物科技有限公司 | 生物抗菌多肽制剂、制备方法及其应用 |
| CN109432396A (zh) * | 2019-01-22 | 2019-03-08 | 宇肽生物(东莞)有限公司 | 一种抗菌祛痘活性多肽 |
| CN110731910A (zh) * | 2019-11-27 | 2020-01-31 | 湖南贝恩叮当猫婴童用品有限公司 | 一种婴童护肤霜 |
| CN111000748A (zh) * | 2020-01-08 | 2020-04-14 | 上海瑾亭化妆品有限公司 | 一种多肽修护面霜及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111494280A (zh) | 2020-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TR201808833T4 (tr) | 1,2 dekandiol ve ayrıca antimikrobiyal aktif bileşikler içeren sinerjik aktif preparatlar. | |
| CN111110577B (zh) | 一种温和型除螨止痒沐浴露及其制备方法 | |
| US20080057136A1 (en) | Disinfecting Composition and Methods of Making and Using Same | |
| US9393261B2 (en) | Antimicrobial anti-chafing chelated silver oxide compound | |
| JPH09157176A (ja) | オトギリソウ、ボダイジュ抽出物含有抗アレルギー剤、 皮膚外用剤及び浴用剤 | |
| WO2021217324A1 (zh) | 消毒剂组合物、其制备方法和用途 | |
| EP3761945A1 (en) | Preservation of personal care compositions | |
| JP2011074082A (ja) | 防腐殺菌剤及び人体施用組成物 | |
| CN111297730A (zh) | 长效无害免洗不易燃高分子乙醇消毒剂 | |
| CN114432170A (zh) | 一种温和的宠物用沐浴露及其制备工艺 | |
| WO2021227214A1 (zh) | 一种杀菌消毒组合物 | |
| CN114028546A (zh) | 复合多肽杀菌制剂及其制备方法和用途 | |
| JP3253982B2 (ja) | にきび用化粧料 | |
| CN113633600B (zh) | 一种无醇免水洗消毒洗手液及其制备方法 | |
| US20230301884A1 (en) | Antiseptic compositions | |
| CN101548683B (zh) | 一种液体消毒剂及其制备方法 | |
| JP2009191019A (ja) | 皮膚若しくは毛髪用化粧料 | |
| CN112716820A (zh) | 一种抗菌护肤免洗剂及其制备方法 | |
| KR20200062103A (ko) | 폴리감마글루탐산 또는 그 염을 함유하는 여성 질 건강 개선용 조성물 | |
| WO2020057285A1 (zh) | 一种苍术油和/或桂枝油、生产方法及其应用 | |
| JP4953409B2 (ja) | 抗菌剤 | |
| CN113521042A (zh) | 一种儿童专用无醇免洗病毒灭活消毒剂及其制备方法 | |
| KR102630903B1 (ko) | 신규 용도 | |
| RU2067444C1 (ru) | Косметический бальзам для ухода за кожей и волосами | |
| CN110652533A (zh) | 一种抑菌组合物及其应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 20935605 Country of ref document: EP Kind code of ref document: A1 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 20935605 Country of ref document: EP Kind code of ref document: A1 |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 20935605 Country of ref document: EP Kind code of ref document: A1 |
|
| 32PN | Ep: public notification in the ep bulletin as address of the adressee cannot be established |
Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 23/06/2023) |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 20935605 Country of ref document: EP Kind code of ref document: A1 |