WO2020057285A1 - 一种苍术油和/或桂枝油、生产方法及其应用 - Google Patents

一种苍术油和/或桂枝油、生产方法及其应用 Download PDF

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WO2020057285A1
WO2020057285A1 PCT/CN2019/099838 CN2019099838W WO2020057285A1 WO 2020057285 A1 WO2020057285 A1 WO 2020057285A1 CN 2019099838 W CN2019099838 W CN 2019099838W WO 2020057285 A1 WO2020057285 A1 WO 2020057285A1
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oil
atractylodes
extractor
extract
powder
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PCT/CN2019/099838
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English (en)
French (fr)
Inventor
许旭东
朱霄伟
马国需
朱乃亮
Original Assignee
中国医学科学院药用植物研究所
三角山(北京)生物科技有限公司
信阳市三角山生物科技有限公司
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Priority claimed from CN201811079020.7A external-priority patent/CN110896969B/zh
Priority claimed from CN201811078894.0A external-priority patent/CN110327251B/zh
Priority claimed from CN201811078923.3A external-priority patent/CN110326627B/zh
Priority claimed from CN201811093829.5A external-priority patent/CN110917076A/zh
Priority claimed from CN201811094481.1A external-priority patent/CN110917078B/zh
Priority claimed from CN201811095048.XA external-priority patent/CN110327259B/zh
Priority claimed from CN201811094187.0A external-priority patent/CN110917077B/zh
Application filed by 中国医学科学院药用植物研究所, 三角山(北京)生物科技有限公司, 信阳市三角山生物科技有限公司 filed Critical 中国医学科学院药用植物研究所
Publication of WO2020057285A1 publication Critical patent/WO2020057285A1/zh

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    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00Essential oils; Perfumes
    • C11B9/02Recovery or refining of essential oils from raw materials

Definitions

  • the invention belongs to the technical field of sterilization, disinfection and antisepsis, and particularly relates to the extraction and application of natural plant essential oils.
  • Atractylodes volatile oil mainly contains volatile substances such as ⁇ -eupanol, atractylol, atractylone, atractylol, elemyl alcohol and the like. Not only can it have a certain killing effect on Mycobacterium tuberculosis, Pseudomonas aeruginosa in the air, but also it has a strong killing effect on E. coli and Staphylococcus aureus.
  • Cinnamon stick (volatile) oil mainly contains volatile substances such as benzaldehyde, phenylpropanal, trans-cinnamaldehyde, and cinnamaldehyde, and has significant antibacterial, sedative, analgesic effects.
  • the object of the present invention is to provide atractylodes oil and / or twig oil, a production method and application thereof.
  • a method for producing atractylodes oil and / or osmanthus oil wherein the atractylodes oil and / or osmanthus oil is continuously prepared by the following process:
  • the extraction liquid in the first storage tank is separated to obtain atractylodes oil and / or twig oil.
  • the atractylodes rhizome powder and the cinnamon stick powder are mixed in proportion before performing the vegetable oil extraction process.
  • the active plant components undergo a high-temperature reaction and binding process during extraction, a stronger synergistic bactericidal effect can be formed.
  • an extraction system of atractylodes oil and / or twig oil including:
  • An extractor with a feeding port and a discharging port, in which a screw conveyor is provided;
  • the first liquid storage tank is selectively communicated with the extractor through the first gas-liquid part circuit and the first siphon part circuit, respectively;
  • the second liquid storage tank is selectively communicated with the extractor through the second gas-liquid part circuit and the second siphon part circuit, respectively;
  • the cooler is arranged near the extractor on the first gas-liquid part circuit and the second gas-liquid part circuit.
  • the first gas-liquid part circuit includes a first vertical pipeline communicating with the top of the first liquid storage tank, a common vertical pipeline communicating with the top of the extractor, and communicating both and A horizontal pipeline provided with a valve;
  • the second gas-liquid part circuit includes a second vertical pipeline communicating with the top of the second liquid storage tank, a common vertical pipeline communicating with the top of the extractor, and a communication between the two and A horizontal pipeline provided with a valve; and a valve is respectively provided in the first siphon part circuit and the second siphon part circuit.
  • the first siphon part circuit and the second siphon part circuit each have an upwardly bent portion and their highest points are lower than the top of the extractor.
  • Atractylodes oil and / or tangerine oil produced by the above-mentioned production method.
  • Atractylol the main active ingredient in atractylodes volatile oil
  • cinnamaldehyde the main active ingredient in volatile oils of cinnamon sticks
  • the mechanism may be that atractylol and cinnamaldehyde synergistically inhibit bacterial cell wall synthesis, that is, inhibition of mucosal synthase (including transpeptidase, carboxyl fetus) Enzymes, endopeptidases), thereby hindering the synthesis of peptidoglycans of the cell wall, causing cell wall defects and rupture of the cells.
  • an air freshening spray the composition of which is: atractylodes oil: 1.0% -1.5%, twig oil: 0.8% -1.2%, cocoamide DEA: 0.5% -1.0%, Sodium lauryl ether sulfate: 3% -4%, TEA sodium lauryl sulfate: 2.0% -3.0%, glycerol: 5% -8%, borneol: 0.2% -0.3%, nano-scale titanium dioxide 1.0-2.0%, Pure water balance.
  • a disinfecting effervescent tablet comprising (by weight ratio): atractylodes volatile oil 1.0% -1.5%, laurel volatile oil 0.8% -1.2%, ⁇ -cyclodextrin 5.0% -10.0 %, Sodium bicarbonate 2.0% -4.0%, citric acid 9.0% -10.0%, sodium dodecylsulfonate 5.0% -8.0%, calcium sulfate 2.0% -4.0%, hydroxypropyl cellulose 16.0% -40.0% , HPMC-polyol complex 10% -20%, the balance of sodium stearate.
  • a mouthwash the composition of which is: Atractylodes volatile oil: 1.0% -1.5%, Guizhi volatile oil: 1.0% -1.5%, cocoamide DEA: 0.5% -1.0%, lauryl Sodium ether sulfate: 3% -4%, TEA sodium lauryl sulfate: 2.0% -3.0%, purified water: balance.
  • a children's wet tissue which is composed of dust-free paper and wet tissue liquid, wherein the composition of the wet tissue liquid is: mint extract 1% -1.5%, honeysuckle extract 2.0-3.0%, Yellow chrysanthemum extract 1.5-2.0%, atractylodes oil 1.0% -1.5%, twig oil 0.8% -1.2%, sodium citrate 0.1% -0.2%, alkyl polyglucosamine 15% -18%, glycerin 2%- 3%, the balance of pure water.
  • a bath lotion comprising: mint extract 1% -1.5%, Gesanghua extract 2.0-3.0%, atractylodes oil: 1.0% -1.5%, twig oil: 1.0% -1.2%, cocoamide DEA: 0.5% -1.0%, TEA sodium lauryl sulfate: 2.0% -3.0%, CP-920 pearlescent pulp 1.0% -2.0%, glycerol 0.5% -0.8%, flavor 0.1% -0.3%, purified water: balance.
  • a bathing fluid for children comprising: 1.0% -1.5% of atractylodes oil, 0.8% -1.2% of tangerine oil, 0.1% -0.2% of sodium citrate, and 15% of alkyl polyglucose. -18%, glycerin 2% -3%, mint 1% -1.5%, acacia powder 1.0% -2.0%, wormwood extract 1.5-2.0%, honeysuckle extract 2.0-3.0%, pure water balance.
  • a shampoo the composition of which is: atractylodes oil 1.0% -1.5%, twig oil 1.0% -1.2%, cocoamide DEA 0.5% -1.0%, TEA dodecane Sodium sulphate 2.0% -3.0%, Shouwu extract 1.0% -2.0%, saponin powder 1.0-2.0%, sodium citrate 0.5-0.8%, table salt 0.5% -0.8%, flavor 0.1% -0.3%, Pure water balance.
  • FIG. 1 is a schematic diagram of a vegetable oil extraction system (apparatus) according to the present invention.
  • FIG. 2 is a dissolution release curve of sterilizing components in water of a commonly used effervescent tablet prepared in Application Example 2.
  • FIG. 2 is a dissolution release curve of sterilizing components in water of a commonly used effervescent tablet prepared in Application Example 2.
  • FIG. 3 is a schematic diagram of the extraction process of the wormwood extract and / or honeysuckle extract in Application Example 5 and the Gesanghua extract in Application Example 6.
  • the invention designs a fast (uninterrupted) vegetable oil extraction system to meet the vegetable oil raw materials required for industrial production of mouthwash.
  • the meanings of vegetable oil, essential oil and volatile oil are the same, and they are all extracts of corresponding plants mentioned below.
  • the vegetable oil extraction system of the present invention includes a first liquid storage tank 10 and a second liquid storage tank 20, a cooler 30, and an extractor 40.
  • the bottom of the first liquid storage tank 10 is provided with a drain pipe 11 on which a valve 12 is installed.
  • the top is connected to the top of the extractor 40 through a first gas-liquid partial circuit, and the upper side is connected to the The bottom of the extractor 40 is communicated.
  • the first gas-liquid part circuit includes a first vertical pipe 13 communicating with the top of the first liquid storage tank 10, a common vertical pipe 33 communicating with the top of the extractor 40, and a valve 14 connecting both of them. Horizontal pipeline.
  • the first siphon part circuit 50 is provided with a valve 51. As shown in FIG. 1, the first siphon section circuit 50 has an upwardly bent portion and its highest point is lower than the top of the extractor 40.
  • the bottom of the second liquid storage tank 20 is provided with a drain pipe 21 having a valve 22 mounted thereon, the top communicates with the top of the extractor 40 through a second gas-liquid part circuit, and the upper side is connected with a second siphon part
  • the circuit 60 is in communication with the bottom of the extractor 40.
  • the second gas-liquid part circuit includes a second vertical pipe 23 communicating with the top of the second liquid storage tank 20, a common vertical pipe 33 communicating with the top of the extractor 40, and a valve 24 connecting both of them. Horizontal pipeline.
  • the second siphon part circuit 60 is provided with a valve 61. As shown in FIG. 1, the first siphon section circuit 60 also has an upwardly bent portion and its highest point is lower than the top of the extractor 40.
  • first gas-liquid partial circuit and the second gas-liquid partial circuit shown have a common vertical pipe 33, and the common vertical pipe 33 passes through the cooler 30.
  • first gas-liquid part circuit and the second gas-liquid part circuit may not have a common vertical pipe 33, but each may have a vertical pipe passing through the cooler 30. In this case, The valve 14 and the valve 24 are omitted.
  • a screw conveyor 44 is installed in the extractor 40 to transfer (dried) plant particles or powder added from the top feeding port 41 of the extractor 40 along the length of the extractor (horizontal direction shown) until the extractor discharges Near mouth 42.
  • the powder particles in the screw conveyor 44 will be in direct contact with the liquid in the extractor 40.
  • plant particles or powder such as rhizome root or cinnamon stick particles are added through the feeding port 41 of the extractor 40, and the screw conveyor 44 is activated to spread the plant particles in the horizontal direction of the extractor 40 to the vicinity of the discharge port 42 of the extractor 40 .
  • Valves 24 and 61 are closed; valves 14 and 51 are opened.
  • the cooler 30 is started.
  • the first liquid storage tank 10 is heated until the pure water therein continues to boil to continuously form water vapor.
  • the water vapor formed in the first liquid storage tank 10 passes upward through the first vertical pipeline 13 and the horizontal pipeline and then downwards through the common vertical pipeline 33, and becomes condensed water and passes into the extractor when passing through the cooler 30 40.
  • Valves 14 and 51 are closed; valves 24 and 61 are opened.
  • the second liquid storage tank 20 is heated to perform the same extraction process.
  • the valve 12 is opened to drain the extraction liquid in the first liquid storage tank 10 through the drainage pipe 11 and then separated into distilled water and vegetable (extraction) oil.
  • the first liquid storage tank 10 and the second liquid storage tank 20 work alternately, and cooperate with the rapid conveyance / discharge of the screw conveyor 44, thereby realizing (uninterrupted) rapid industrial-scale extraction of vegetable oil.
  • Application example 1 air freshening spray
  • Air is one of the conditions on which we live. Fresh air will bring people a pleasant mood. Air is also one of the main media for the spread of germs. With the continuous development of cities, the population size continues to increase, and the population density is high. Poor air quality worsens the environment, harmful substances in the air increase, odors and air infections affect people's mood, health, and work efficiency. In order to kill harmful microorganisms in the air and remove odors, modern homes, hospitals, hotels, restaurants and other public places often use air freshening sprays into the air. Air freshening spray, also known as "environmental perfume", as the name suggests, refers to a medicine that can make the air fresher.
  • Common air freshening sprays are composed of ethanol, essence, deionized water and other ingredients. They are used to mask odors and reduce people's uncomfortable odors by emitting fragrances. They are a chemical product applied in the field of environmental sanitation since the 20th century. Most of the air freshening sprays currently on the market contain artificial chemical sterilants, which are often exposed to the air containing chemical products, which may cause certain harm to the human body. Therefore, in order to purify indoor air, it is particularly important to develop safe and effective natural air fresh disinfection products.
  • An air freshening spray the composition of which is: atractylodes volatile oil: 1.0% -1.5%, twig volatile oil: 0.8% -1.2%, cocoamide DEA: 0.5% -1.0%, sodium lauryl ether sulfate: 3%- 4%, TEA sodium lauryl sulfate: 2.0% -3.0%, glycerol: 5% -8%, borneol: 0.2% -0.3%, nano-scale titanium dioxide 1.0-2.0%, the balance of purified water.
  • the nano-scale titanium dioxide is anatase-type titanium dioxide having a particle diameter of 100 nm or less.
  • This titanium dioxide has a significant catalytic function, which will produce a photocatalytic reaction similar to photosynthesis, and the components of atractylodes lancea and osmanthus volatile oil in the spray will produce free hydroxyl and active oxygen with strong oxidation ability.
  • Strong photo-redox function can oxidatively decompose various organic compounds and some inorganic substances, and effectively remove formaldehyde remaining in the room.
  • the specific production method of the above air freshening spray includes:
  • cocoamide DEA lauryl ether sodium sulfate
  • TEA sodium lauryl sulfate
  • DEA diethylamine group
  • TEA triethylamine group
  • Example 1 weight composition of spray, same hereinafter
  • Atractylodes volatile oil 1.0%, twig volatile oil: 0.8%, cocoamide DEA: 0.5%, sodium lauryl ether sulfate: 3%, TEA sodium lauryl sulfate: 2.0%, glycerol: 5%, borneol: 0.2% , Nano anatase type titanium dioxide 1.0%, the balance of purified water.
  • Atractylodes volatile oil 1.0%, twig volatile oil: 1.0%, cocoamide DEA: 0.5%, sodium lauryl ether sulfate: 3%, TEA sodium lauryl sulfate: 2.0%, glycerol: 5%, borneol: 0.2% , Nano anatase type titanium dioxide 1.0%, the balance of purified water.
  • Atractylodes volatile oil 1.5%
  • Guizhi volatile oil 0.8%
  • cocoamide DEA 0.5%
  • sodium lauryl ether sulfate 3%
  • TEA sodium lauryl sulfate
  • glycerol 5%
  • borneol 0.2%
  • Nano anatase type titanium dioxide 1.0%, the balance of purified water.
  • Atractylodes volatile oil 1.5%
  • Guizhi volatile oil 1.0%
  • cocoamide DEA 0.5%
  • sodium lauryl ether sulfate 3%
  • TEA sodium lauryl sulfate
  • glycerol 5%
  • borneol 0.2%
  • Nano anatase type titanium dioxide 1.0%, the balance of purified water.
  • Atractylodes volatile oil 1.5%
  • Guizhi volatile oil 1.2%
  • cocoamide DEA 0.5%
  • sodium lauryl ether sulfate 3%
  • TEA sodium lauryl sulfate
  • glycerol 5%
  • borneol 0.2%
  • Nano anatase type titanium dioxide 1.0%, the balance of purified water.
  • test sites were selected, such as toilets, basements, laboratories, kitchens, air-conditioned rooms, garbage rooms, and decoration rooms as test places.
  • the air freshening sprays obtained in Examples 1 to 5 were used in the above places, and a spray containing no Atractylodes and Cinnamomum extract components was used as a control for a comparative example.
  • the results are shown in Table 1.
  • the evaluation criteria are: ⁇ —No odor; ⁇ —Weak odor; ⁇ —Significant odor
  • Example 2 Example 3
  • Example 4 Example 5 Comparative example bathroom ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ basement ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ laboratory ⁇ ⁇ ⁇ ⁇ ⁇ kitchen ⁇ ⁇ ⁇ ⁇ ⁇ Air-conditioned rooms ⁇ ⁇ ⁇ ⁇ ⁇ Garbage room ⁇ ⁇ ⁇ ⁇ ⁇ Decoration room ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇
  • test bacteria and the air spray mixed solution are respectively added to 4.5ml of the sterilized neutralizer, and mixed.
  • the logarithmic value of killing (KL) the logarithmic value of the average live bacteria concentration of the control group (No)-the logarithmic value of the live bacteria concentration of the test group (Nx).
  • KL the logarithmic value of killing
  • No the logarithmic value of the average live bacteria concentration of the control group
  • Nx the logarithmic value of the live bacteria concentration of the test group
  • the present invention sets up a natural green air freshening spray, which has the characteristics of high temperature resistance, oxidation resistance and long-term moisture retention, which can remove some odor substances in the air and maintain indoor fragrance for a long time;
  • the two essential oils of Atractylodes sylvestris and Guizhi have synergistic effects. Together with the catalytic oxidation of titanium dioxide, it can significantly remove indoor formaldehyde and has a common effect on common bacteria Gram-positive bacteria, Gram-negative bacteria, fungi, yeast Bacteria etc. have fast and lasting sterilization instead of bacteriostasis, and have good air purification effect.
  • An effervescent tablet is a tablet containing an effervescent disintegrant.
  • Effervescent disintegrants are usually a mixture of organic acids and sodium carbonate, sodium bicarbonate (baking soda).
  • the effervescent tablet itself is dry and free of water, and the two substances in the effervescent disintegrant cannot react without being ionized.
  • an acid-base reaction between the two substances generates a large amount of carbon dioxide, which causes the tablet to rapidly disintegrate and melt, and sometimes the bubbles generated by the disintegration will also cause the tablet to roll up and down in the water, accelerating its disintegration and melt.
  • the invention provides a disinfecting effervescent tablet, which comprises (by weight): 1.0% -1.5% of atractylodes volatile oil, 0.8% -1.2% of volatile oil from twig of cinnamon, 5.0% -10.0% of ⁇ -cyclodextrin, and sodium bicarbonate 2.0% -4.0%, citric acid 9.0% -10.0%, sodium dodecylsulfonate 5.0% -8.0%, calcium sulfate 2.0% -4.0%, hydroxypropyl cellulose 16.0% -40.0%, HPMC-polyol The compound is 10% -20%, the balance of sodium stearate. Among them, HPMC stands for hydroxypropyl methyl cellulose.
  • the polyol in the HPMC-polyol complex includes, but is not limited to, the following polyols: one or more of lactose, sucrose, glucose, fructose, sorbitol, mannitol, and xylitol The combination.
  • the weight ratio of HPMC and polyol is preferably between 1 / 0.1 and 1/10.
  • the disinfecting effervescent tablet may include: 1.0% -1.2% of Atractylodes volatile oil, 0.8% -1.0% of Cinnamomum volatile oil, ⁇ -cyclodextrin 5.0% -10.0%, and sodium bicarbonate 2.0%- 3.0%, citric acid 9.0% -10.0%, sodium dodecylsulfonate 5.0% -7.0%, calcium sulfate 2.0% -3.0%, hydroxypropyl cellulose 20.0% -40.0%, HPMC-polyol complex 10 % -20%, the balance of sodium stearate.
  • the production method of the disinfection effervescent tablet includes:
  • Essential oil microcapsules were prepared by drying the precipitate
  • sodium stearate is added and tabletted to prepare a sterile effervescent tablet.
  • the shape of the disinfecting effervescent tablet of the present invention is preferably made into a flat shape, which is a thin sheet with a length of 5 cm, a width of 2 cm, and a thickness of 0.1 cm. Quickly disintegrates in minutes.
  • the disinfection effervescent tablet adopts a slow and controlled release preparation process, which can control the slow release of sterilizing ingredients and can continuously maintain a certain sterilizing ingredient concentration for 72 hours.
  • the produced sustained-release tablets are longer-lasting than ordinary tablets, and will not be completely released as soon as ordinary tablets arrive in water. They have a relatively constant release dose per unit time to maintain a constant concentration of bactericidal ingredients in water and sterilizing efficacy. More durable.
  • the disinfection effervescent tablet can be sterilized, non-toxic and harmless, environmentally friendly, easy to measure, easy to dissolve, carry, and convenient to use.
  • the present invention has the advantages of forming a pure natural green disinfecting effervescent tablet, which is non-toxic and harmless, and environmentally friendly.
  • the combination of two essential oils has a synergistic effect on common harmful bacteria: golden yellow Staphylococcus, Candida albicans, Escherichia coli, Streptococcus, etc. have a fast and lasting killing effect.
  • the disinfection effervescent tablet prepared according to the present invention has a good use effect, has no irritation and side effects on the human body, has a significant sterilization and disinfection effect, and is safe and reliable.
  • the present invention can avoid: wet granulation and sieving difficulties; wet granulation tablets have unstable weight; wet granulation release behavior is unstable; fluidity problems of powder tableting; powder tableting The problem of astringency; the problem of unstable film weight.
  • the effervescent tablet is made according to the preparation process. When used, it is placed in a domestic humidifier, which disintegrates quickly within 1 minute. The domestic humidifier uses ultrasonic waves to atomize the water, and the atomized water is blown out of the casing by a fan to sterilize the ingredients. It can be diffused with water mist to achieve the purpose of disinfection and sterilization of indoor space.
  • Example 2 (Commonly used germicidal effervescent tablets)
  • the effervescent tablet is made according to the preparation process. When used, it is put into water and quickly disintegrated to obtain a disinfection and sterilization solution. It is used for sterilization and disinfection of environmental items. It can continuously maintain a certain concentration of sterilization ingredients for 72 hours and continue sterilization.
  • Example 3 (Commonly used germicidal effervescent tablets)
  • the effervescent tablet is made according to the preparation process. When used, it is put into water and quickly disintegrated to obtain a disinfection and sterilization solution. It is used for sterilization and disinfection of environmental items. It can continuously maintain a certain concentration of sterilization ingredients for 72 hours and continue sterilization.
  • Example 4 (Commonly used germicidal effervescent tablets)
  • the effervescent tablet is made according to the preparation process. When used, it is put into water and quickly disintegrated to obtain a disinfection and sterilization solution. It is used for sterilization and disinfection of environmental items. It can continuously maintain a certain concentration of sterilization ingredients for 72 hours and continue sterilization.
  • test bacteria interact with the disinfected effervescent tablet aqueous solution for each predetermined time, and 0.5 ml of the test bacteria and the disinfected effervescent tablet aqueous solution are respectively added to 4.5 ml of the sterilized neutralizer and mixed.
  • Each tube of test bacteria and the disinfected effervescent tablet aqueous solution was added with a neutralizing agent for 10 minutes, and then 1.0 ml of the sample solution was respectively taken, and the number of viable bacteria was measured according to the live bacteria culture counting method.
  • Each tube of sample solution was inoculated into 2 plates. . If there are a large number of colonies growing on the plate, a serial 10-fold dilution can be performed and then counted for live bacteria culture.
  • the logarithmic value of killing (KL) the logarithmic value of the average live bacteria concentration of the control group (No)-the logarithmic value of the live bacteria concentration of the test group (Nx).
  • KL the logarithmic value of killing
  • No the logarithmic value of the average live bacteria concentration of the control group
  • Nx the logarithmic value of the live bacteria concentration of the test group
  • FIG. 2 is a dissolution release curve of germicidal components in water of a disinfecting effervescent tablet prepared according to Examples 2-4 of the present invention.
  • the sustained-release tablets made according to the present invention have a longer release time than ordinary tablets, and will not be completely released as soon as ordinary tablets reach the water, and have a relatively constant release dose per unit time. Keeping the concentration of sterilizing ingredients in water constant, the sterilizing effect is more durable.
  • the invention synergistically sterilizes two kinds of pure natural plant essential oils that have bactericidal effects, such as atractylodes lancea and osmanthus fragrans, and further adopts a controlled release material for encapsulation, so that the effervescent tablet can dissolve common bacteria Gram-positive bacteria, Gram-negative bacteria, fungi, yeasts, etc. have a fast and long-lasting bactericidal effect, and have a good sterilization effect.
  • the invention solves the shortcomings of traditional disinfectants such as short sterilization time, irritating the skin and polluting the environment, and has the advantages of long-lasting sterilization and disinfection, no skin irritation, environmental protection, easy to measure, easy to dissolve, portable and convenient to use.
  • Oral health is a mirror of the quality of life.
  • oral problems have received more and more attention, and oral odors can easily leave an impolite impression in conversation.
  • the focus of oral hygiene is to control plaque, eliminate dirt and food residues, enhance physiological stimulation, so that the oral cavity has a clean and healthy environment, so as to exert its physiological functions and maintain oral health.
  • the oral cavity is especially irritating when eating. In the case of inconvenient brushing of food and after meals, it is easy to cause a large number of harmful bacteria in the oral cavity to multiply and produce bad breath.
  • oral mouthwashes In recent years, more oral mouthwashes have been used. At present, there are many types of oral mouthwashes on the market. Most of them have chemical synthetic bactericidal ingredients, and have certain toxic and side effects and environmental pollution. Oral mouthwashes containing pure natural plant extracts usually only have antibacterial and bacteriostatic effects, and cannot effectively kill oral harmful bacteria (the sterilization effect reaches the national standard of 5 logarithmic sanitizers).
  • the invention provides a natural plant mouthwash that can be quickly sterilized.
  • Its composition is (weight ratio): atractylodes oil: 1.0% -1.5%, twig oil: 1.0% -1.5%, cocoamide DEA: 0.5% -1.0%, sodium lauryl ether sulfate: 3% -4%, TEA sodium lauryl sulfate: 2.0% -3.0%, purified water: balance.
  • DEA diethylamino
  • TEA stands for triethylamine.
  • the above-mentioned method for producing a mouthwash includes:
  • the above stirring adopts mechanical stirring at normal temperature, the time is 15-20 minutes, and the stirring speed is about 200 rpm.
  • the mouthwash of the invention is simple to prepare, environmentally friendly and pollution-free, raw materials are easily available, and equipment investment is small, which is convenient to operate.
  • the mouthwash of the invention can quickly sterilize, inhibit the growth of oral microorganisms, keep the mouth clean and free of breath, and has no irritation and side effects on the human body.
  • Atractylodes volatile oil 1.0%, cocoamide DEA: 0.5%, sodium lauryl ether sulfate: 3%, TEA sodium lauryl sulfate: 2.0%, purified water: balance.
  • Atractylodes volatile oil 1.0%, twig volatile oil: 1.5%, cocoamide DEA: 0.5%, sodium lauryl ether sulfate: 3%, TEA sodium lauryl sulfate: 2.0%, purified water: balance.
  • Atractylodes volatile oil 1.2%, twig volatile oil: 1.2%, cocoamide DEA: 0.5%, sodium lauryl ether sulfate: 3%, TEA sodium lauryl sulfate: 2.0%, purified water: balance.
  • Atractylodes volatile oil 1.5%
  • twig volatile oil 1.0%
  • cocoamide DEA 0.5%
  • sodium lauryl ether sulfate 3%
  • TEA sodium lauryl sulfate: 2.0%
  • purified water balance.
  • Atractylodes volatile oil 1.5%
  • twig volatile oil 1.2%
  • cocoamide DEA 0.5%
  • sodium lauryl ether sulfate 3%
  • TEA sodium lauryl sulfate
  • purified water balance.
  • test bacteria and mouthwash interact with each other for a predetermined time, and 0.5ml of the test bacteria and mouthwash mixed solution is added to 4.5ml of the sterilized neutralizer and mixed.
  • the logarithmic value of killing (KL) the logarithmic value of the average live bacteria concentration of the control group (No)-the logarithmic value of the live bacteria concentration of the test group (Nx).
  • KL the logarithmic value of killing
  • No the logarithmic value of the average live bacteria concentration of the control group
  • Nx the logarithmic value of the live bacteria concentration of the test group
  • Atractylodes oil and cinnamon oil alone has a strong killing effect on Staphylococcus epidermidis with a killing logarithmic value (KL)> 5.0, but the killing logarithmic value of streptococcus and lactobacillus does not reach the effect.
  • KL killing logarithmic value
  • the main active ingredients have a synergistic effect.
  • the dosage can be significantly inhibited against Staphylococcus epidermidis, Streptococcus, and Lactobacillus. They are 6.06, 5.93, 5.90, and 6.05, respectively.
  • the pure natural plant oral germicidal mouthwash of the present invention does not contain chemically synthesized bactericidal ingredients.
  • the germicidal ingredients are compound plant essential oils, which are more specific to common oral bacteria such as Staphylococcus epidermidis, type A and anaerobic streptococcus, lactic acid bacteria Strong, the effect is significant, the effect can reach and exceed 5 national standards of sanitary disinfectants.
  • Wet paper towel is a cleaning article made of pure water, moisturizing agent, preservative and antibacterial agent for cleaning and rubbing the human body.
  • Children's skin is relatively tender, it is easy to breed bacteria, and it has low resistance to stimuli from the external environment.
  • the existing moisturizers, preservatives, and antibacterial agents used in the existing wet paper towels are chemical components. These have certain harm to children's skin, have greater irritation to the skin, and can easily cause allergic reactions.
  • the invention provides a children's wet wipes, which are composed of dust-free paper and wet wipes, wherein the composition of the wet wipes is (weight percentage): mint extract 1% -1.5%, honeysuckle extract 2.0-3.0%, yellow Chrysanthemum extract 1.5-2.0%, atractylodes oil 1.0% -1.5%, twig oil 0.8% -1.2%, sodium citrate 0.1% -0.2%, alkyl polyglucosamine 15% -18%, glycerin 2% -3 %, The balance of pure water.
  • the method for producing the above-mentioned children's wet tissue includes:
  • the preparation of wet wipes and the use of wet wipes to soak dust-free paper, wherein the preparation of wet wipes include:
  • the dust-free paper of the present invention may be a commercially available dust-free paper.
  • the yellow chrysanthemum flower extract and / or honeysuckle extract are preferably obtained by the following methods to ensure the stability of the extract and the antibacterial and anti-inflammatory effect:
  • the mint extract is preferably obtained by physically squeezing fresh mint leaves and taking fresh juice, centrifuging with a high-speed filter (4000 rpm), discarding the precipitated mint liquid, and then minting The liquid was frozen in a refrigerator at -80 ° C until the liquid was completely solid, and the solid was put into a freeze dryer for 48 hours to obtain mint extract (powder).
  • the children's wet paper towel produced according to the present invention has no irritation and side effects, has a significant sterilization and disinfection effect, is safe and reliable, and is environmentally friendly.
  • the children's wet tissues of the present invention can easily remove human skin stains, and can also effectively sterilize, moisturize, care for the skin, have no residue, and dry quickly during normal use time.
  • the children's wet wipes produced according to the present invention are excellent in performance and the active ingredients are stable for a long time.
  • Mint extract 1% honeysuckle extract 2.0%, yellow chrysanthemum extract 1.5%, atractylodes volatile oil 1.0%, twig volatile oil 0.8%, sodium citrate 0.1%, alkyl polyglucosamine 15%, glycerin 2%, purified water margin.
  • Mint extract 1.2% honeysuckle extract 2.5%, yellow chrysanthemum extract 1.5%, atractylodes volatile oil 1.0%, twig volatile oil 0.8%, sodium citrate 0.1%, alkyl polyglucosamine 15%, glycerin 2%, purified water margin.
  • Mint extract 1.5%, honeysuckle extract 2.0%, yellow chrysanthemum extract 2.0%, atractylodes volatile oil 1.0%, twig volatile oil 0.8%, sodium citrate 0.1%, alkyl polyglucosamine 15%, glycerin 2%, purified water margin.
  • Mint extract 1.5%, honeysuckle extract 3.0%, yellow chrysanthemum extract 2.0%, atractylodes volatile oil 1.0%, twig volatile oil 0.8%, sodium citrate 0.1%, alkyl polyglucosamine 15%, glycerin 2%, purified water margin.
  • the animal tissue test was used to perform the wet tissue irritation test.
  • 50 healthy mice were selected and divided into five groups of 10 rats.
  • the left and right sides of the white spine of the mouse were shaved with an electric razor using the same method of self-contrast on the left and right sides.
  • Shave with a shaving area of 2cm * 2cm. Take the wipes (original solution) prepared in Examples 1-5 and apply them to the hairless skin on the left side of the back of the mouse as the experimental group. Treat it as a blank control group. Observe every other group whether there is redness, swelling and allergies around the skin of the experimental group. Wash the wipes with warm water for 24 hours to observe the results.
  • Test 2 quantitative suspension sterilization test
  • test bacteria and the stock solution are continued for each predetermined time, and 0.5 ml of the test bacteria and the stock solution are respectively added to 4.5 ml of the sterilized neutralizer and mixed.
  • KL logarithmic value of killing
  • No the logarithmic value of the average viable bacterial concentration of the control group
  • Nx the logarithmic value of the viable bacterial concentration of the test group
  • the children's wet wipes prepared by the present invention have high protection, high safety, low irritation, and can be safely decontaminated.
  • the common wet tissues have gram-positive bacteria, gram-negative bacteria, fungi, yeasts, etc. Fast, long-lasting bactericidal instead of bacteriostatic effect, with good cleaning effect.
  • the body wash is a cleanser and foaming agent, supplemented with other auxiliaries and additives. It is a cleansing product that moisturizes the skin, removes dirt, and improves human odor. Children's skin is relatively tender, and it is easy to breed bacteria, make the skin swollen and painful, sores, and long boils. It has low resistance to external stimuli, and is vulnerable to mechanical damage and susceptible to skin diseases.
  • the invention provides a children's bath liquid, which comprises (by weight): atractylodes oil 1.0% -1.5%, cinnamon twig oil 0.8% -1.2%, sodium citrate 0.1% -0.2%, and alkyl polyglucose 15 % -18%, glycerin 2% -3%, mint 1% -1.5%, acacia powder 1.0% -2.0%, wormwood extract 1.5-2.0%, honeysuckle extract 2.0-3.0%, pure water balance.
  • the bath liquid produced according to the present invention can remove dampness and moisturizing, and has both antibacterial and anti-inflammatory effects, safe decontamination, green environmental protection, and no irritation and side effects on children's body.
  • the bath liquid produced according to the present invention has excellent performance, and the activity of the extract obtained after the above-mentioned two-step supercritical separation of vulnerable honeysuckle and wormwood leaves is particularly stable.
  • FIG. 3 shows the extraction process of wormwood extract and / or honeysuckle extract according to the present invention: crushing honeysuckle and / or wormwood leaves into medicinal powder and filling them into an extraction kettle; cooling the CO 2 gas flowing from the CO 2 steel cylinder into The liquid is input to a pressure pump for compression; the CO 2 flowing from the pressure pump is preheated by a preheater and enters the extraction kettle to reach a supercritical fluid state; the CO 2 supercritical fluid is in direct contact with the medicinal powder for mass transfer; The CO 2 supercritical fluid flowing out of the extraction kettle is depressurized and then sequentially entered into the separation kettle I and the separation kettle II, wherein: the temperature in the separation kettle I is maintained at 60 ° C. and the pressure is 6 MPa; the temperature in the separation kettle II is maintained at 55 ° C. and the pressure to 5 MPa; and flowing out from the separation tank flows II with CO 2 in CO 2 from CO 2 cylinder merge to repeat the above steps.
  • the production method of the children's bath liquid is:
  • Stirring adopts mechanical stirring at normal temperature, the time is 15-20 minutes, and the speed is about 200 rpm.
  • the evaluation criteria are: full effect: children have no moisture, no mules, strong decontamination ability, smooth skin, and no side effects;
  • Bath lotion is also called shower gel, and its effective substance is a liquid body-care skin-care bath article made of various surfactants.
  • medicinal baths for curing diseases and strengthening the body. It has a long history and left a lot of valuable historical materials for the modern health care and beauty industry. Combined with modern advanced extraction and preparation technology, the traditional Chinese medicine bathing products are more widely available. Consumer favor.
  • body wash is required to be low-irritating to the skin and mild. Putting cleansing and skin care on equal footing.
  • the present invention provides a bath liquid, which comprises (by weight): mint extract 1% -1.5%, Gesanghua extract 2.0-3.0%, atractylodes oil: 1.0% -1.5%, twig oil: 1.0% -1.2%, cocoamide DEA: 0.5% -1.0%, TEA sodium lauryl sulfate: 2.0% -3.0%, CP-920 pearlescent pulp 1.0% -2.0%, glycerol 0.5% -0.8%, flavor 0.1% -0.3%, purified water: balance.
  • DEA diethylamino
  • TEA stands for triethylamine.
  • the natural plant bath liquid produced according to the present invention can quickly remove mites and sterilize, has a good cleaning effect, and can also cleanse, soften and moisturize the skin.
  • the bath liquid produced according to the present invention has excellent performance, and the activity of the extract obtained from the easily affected Gesanghua after the above two-step supercritical separation is particularly stable.
  • FIG. 3 shows the extraction process of the Gesanghua extract according to the present invention: the Gesanghua is pulverized into a medicinal powder and loaded into an extraction kettle; the CO 2 gas flowing from the CO 2 steel bottle is cooled to a liquid state and input to a pressure pump Compressing; CO 2 flowing from the pressurized pump is preheated by the preheater and enters the extraction kettle to reach a supercritical fluid state; the CO 2 supercritical fluid is in direct contact with the medicinal powder for mass transfer; the CO 2 flowing from the extraction kettle After the supercritical fluid is decompressed, it enters the separation kettle I and the separation kettle II in sequence, wherein: the temperature in the separation kettle I is maintained at 60 ° C and the pressure is 6 MPa; the temperature in the separation kettle II is maintained at 55 ° C and the pressure is 5 MPa; II flowing out of separation vessel and CO 2 from CO 2 cylinder flows CO 2 to repeat the above steps confluent.
  • the mint extract of the present invention is obtained by physically squeezing fresh mint leaves and taking fresh juice, centrifuging with a high-speed filter (4000 rpm), discarding the precipitated mint liquid, and putting the mint liquid in -80. Refrigerate at °C until the liquid is completely solid, and then put the solid in a freeze dryer for 48 hours to obtain peppermint extract powder.
  • the production method of the bath liquid of the present invention is:
  • cocoamide DEA, TEA sodium lauryl sulfate, peppermint extract, Gesanghua extract, CP-920 pearlescent pulp, glycerol, and flavor into purified water, and stir to fully dissolve;
  • Stirring adopts mechanical stirring at normal temperature, the time is 15-20 minutes, and the speed is about 200 rpm.
  • the evaluation criteria are: full effect: routine inspection without mites, smooth skin, and no side effects;
  • Routine inspection shows a small amount of mites, smooth skin, and no side effects
  • Routine inspection shows a large number of mites, rough skin, and no side effects.
  • Test 2 quantitative suspension sterilization test
  • the logarithmic value of killing (KL) the logarithmic value of the average live bacteria concentration of the control group (No)-the logarithmic value of the live bacteria concentration of the test group (Nx).
  • KL the logarithmic value of killing
  • No the logarithmic value of the average live bacteria concentration of the control group
  • Nx the logarithmic value of the live bacteria concentration of the test group
  • the natural plant essential oil bath liquid of the present invention has good cleaning effect, can also cleanse, soften, moisturize and kill conceal, has multiple effects, and has simple product configuration and low cost.
  • the traditional Chinese medicine ingredients in the formula have the effects of removing rheumatism, soothing bones, and moisturizing the skin. They also have the functions of antibacterial and slowing the skin's keratinization and softening the skin. At the same time, it has a significant effect on removing mites.
  • the invention provides a shampoo whose composition (weight) is: atractylodes oil: 1.0% -1.5%, twig oil: 1.0% -1.2%, cocoamide DEA: 0.5% -1.0%, TEA dodecane Sodium sulfate: 2.0% -3.0%, Polygonum multiflorum extract 1.0% -2.0%, saponin powder 1.0-2.0%, sodium citrate 0.5-0.8%, table salt 0.5% -0.8%, flavor 0.1% -0.3% Pure water: the balance.
  • DEA diethylamino
  • TEA stands for triethylamine.
  • the method for producing the shampoo includes:
  • cocoamide DEA, TEA sodium lauryl sulfate, table salt and flavor stir and fully dissolve
  • Atractylodes oil (volatile) oil and / or twig (volatile) oil can be prepared by steam distillation.
  • the saponin powder is preferably obtained in the following manner to ensure its stable sterilization effect:
  • the Shouwu extract is preferably obtained with stable activity by drying and pulverizing the Shouwu extract three times with 10 times the amount of water and cold soaking for 4 hours each time, filtering, combining the filtrate, and the residue. Percolate until the liquid has no obvious color. Combine the filtrate and percolate, concentrate to a relative density of about 1.15-1.20, and dry it with a freeze dryer.
  • the shampoo produced according to the invention has no irritation and side effects on the human body, can quickly remove dandruff and sterilize, and can also produce hair, black hair, and make the hair supple.
  • the shampoo produced according to the present invention has excellent performance, and the active ingredients are stable for a long time.
  • Saponin powder 1.0%, Shouwu extract 1.0%, Atractylodes volatile oil: 1.5%, Guizhi volatile oil: 1.2%, cocoamide DEA: 1.0%, TEA sodium lauryl sulfate: 3.0%, sodium citrate 0.8%, table salt 0.8%, essence 0.3%, purified water: balance.
  • Saponin powder 2.0%, Polygonum multiflorum extract 2.0%, Atractylodes volatile oil: 1.5%, Guizhi volatile oil: 1.2%, cocoamide DEA: 1.0%, TEA sodium lauryl sulfate: 3.0%, sodium citrate 0.8%, table salt 0.8%, essence 0.3%, purified water: balance.
  • Saponin powder 2.0%, Atractylodes volatile oil: 1.5%, Guizhi volatile oil: 1.2%, cocoamide DEA: 1.0%, TEA sodium lauryl sulfate: 3.0%, sodium citrate 0.8%, table salt 0.8%, flavor 0.3 %, Purified water: balance.
  • the evaluation criteria are: full effect: the hair is supple, no dandruff is visible to the naked eye, the itching phenomenon completely disappears, and the hair is significantly darkened;
  • the shampoo of the present invention in the 1-2 group corresponding to Example 1-2 has a more significant effect, which fully demonstrates that the shampoo of the present invention can quickly remove dandruff and sterilize hair, make hair, black hair, and make hair Quality and suppleness.

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Abstract

一种苍术油和/或桂枝油、生产方法及其应用,其中苍术油和/或桂枝油是通过下述工艺连续制备:将苍术根茎粉末和/或桂枝粉末加入安装有螺旋输送器的提取器;加热装有纯净水的第一储液罐以产生水蒸气;将水蒸气经冷却器冷凝成液态水后通入提取器以浸没苍术根茎粉末和/或桂枝粉末;停止加热第一储液罐并同时启动第二储液罐以继续上述步骤;以及分离第一储液罐中的提取液以获得苍术油和/或桂枝油。苍术挥发油中的主要活性成分苍术醇等和桂枝挥发油中的主要活性成分桂皮醛等具有协同杀菌作用,可以应用于多种卫生和日化用品。

Description

一种苍术油和/或桂枝油、生产方法及其应用
本申请要求以下中国发明专利申请的优先权:
1、2018年9月17日提交的申请号为201811078923.3、名称为“空气清新喷雾剂”;
2、2018年9月17日提交的申请号为201811079020.7、名称为“绿色缓释消毒泡腾片及其制备方法”;
3、2018年9月17日提交的申请号为201811078894.0、名称为“植物漱口水”;
4、2018年9月19日提交的申请号为201811095048.X、名称为“儿童湿纸巾”;
5、2018年9月19日提交的申请号为201811093829.5、名称为“儿童植物沐浴液”;
6、2018年9月19日提交的申请号为201811094187.0、名称为“天然植物沐浴液”;
7、2018年9月19日提交的申请号为201811094481.1、名称为“天然植物洗发液”。
技术领域
本发明属于杀菌、消毒、防腐技术领域,具体涉及天然植物精油的提取和应用。
背景技术
苍术挥发油主要含有β-桉油醇、苍术素、苍术酮、苍术醇、榄香油醇等挥发性物质。不仅能够对空气中的结核分枝杆菌、铜绿假单胞菌等有一定的杀灭作用,还对大肠杆菌和金黄色葡萄球菌有很强的杀灭作用。桂枝(挥发)油主要含有苯甲醛、苯丙醛、反式桂皮醛、桂皮醛等挥发性物质,具有显著的抗菌、镇静、镇痛等效果。
发明内容
本发明的目的是提供一种苍术油和/或桂枝油、生产方法及其应用。
根据本发明的第一方面,提供一种苍术油和/或桂枝油的生产方法,其中苍术油和/或桂枝油是通过下述工艺连续制备:
将苍术根茎粉末和/或桂枝粉末加入安装有螺旋输送器的提取器;
加热装有纯净水的第一储液罐以产生水蒸气;
将水蒸气经冷却器冷凝成液态水后通入提取器以浸没苍术根茎粉末和/或桂枝粉末;
当提取器中的液位高于连接提取器与第一储液罐的虹吸管的最高点时,提取器中的提取液自动通过虹吸管进入第一储液罐;
当提取器中的提取液变为无色时,启动提取器中的螺旋输送器以将苍术根茎湿粉和/或桂枝湿粉排出提取器,同时再向提取器中加入苍术根茎粉末和/或桂枝粉末;
停止加热第一储液罐并同时启动第二储液罐以继续上述步骤;以及
分离第一储液罐中的提取液以获得苍术油和/或桂枝油。
根据本发明的优选实施例,将苍术根茎粉末和桂枝粉末按比例混合后再执行植物油提取过程。这种情况下,由于各活性植物成分之间在提取时经历了高温反应结合过程,故而能够形成更强的协同杀菌作用。
根据本发明的第二方面,提供一种苍术油和/或桂枝油的提取系统,包括:
具有加料口和排料口的提取器,其中设置有螺旋输送器;
第一储液罐,分别通过第一气液部分回路以及第一虹吸部分回路与提取器选择性连通;
第二储液罐,分别通过第二气液部分回路以及第二虹吸部分回路与提取器选择性连通;
冷却器,靠近提取器设置在第一气液部分回路和第二气液部分回路上。
根据本发明的提取系统,其中第一气液部分回路包括与第一储液罐的顶部连通的第一竖向管路、与提取器的顶部连通的共用竖向管路、以及连通二者且设置有阀门的水平管路;第二气液部分回路包括与第二储液罐的顶部连通的第二竖向管路、与提取器的顶部连通的共用竖向管路、以及连通二者且设置有阀门的水平管路;并且第一虹吸部分回路和第二虹吸部分回路分别设置有阀门。
根据本发明的提取系统,第一虹吸部分回路和第二虹吸部分回路分别具有向上弯折部分且其最高点低于提取器的顶部。
根据本发明的第三方面,提供由上述生产方法制得的苍术油和/或桂枝油。
发明人在实践过程中发现,苍术挥发油中的主要活性成分苍术醇等和桂枝挥发油中的主要活性成分桂皮醛等具有协同杀菌作用,二者以特定配比合用,在降低总用量的同时能对表皮葡萄球菌、链球菌及厌氧链球菌具有明显的杀灭抑制作用,其机理或为苍术醇和桂皮醛协同抑制细菌细胞壁合成,即抑制胞壁粘肽合成酶(包括转肽酶、羧胎酶、内肽酶)的合成,从而阻碍细胞壁肽聚糖的合成,使细胞壁缺损,菌体破裂死亡。
根据本发明的第四方面,提供一种空气清新喷雾剂,其组成为:苍术油:1.0%-1.5%、桂枝油:0.8%-1.2%、椰油酰胺DEA:0.5%-1.0%、月桂基醚硫酸钠:3%-4%、TEA十二烷基硫酸钠:2.0%-3.0%、甘油:5%-8%、冰片:0.2%-0.3%、纳米级二氧化钛1.0-2.0%、纯净水余量。
根据本发明的第五方面,提供一种消毒泡腾片,包含(以重量比计):苍术挥发油1.0%-1.5%、桂枝挥发油0.8%-1.2%、β-环糊精5.0%-10.0%、碳酸氢钠2.0%-4.0%、柠檬酸9.0%-10.0%、十二烷基磺酸钠5.0%-8.0%、硫酸钙2.0%-4.0%、羟丙基纤维素16.0%-40.0%、HPMC-多元醇复合物10%-20%、硬脂酸钠余量。
根据本发明的第六方面,提供一种漱口水,其组成为:苍术挥发 油:1.0%-1.5%、桂枝挥发油:1.0%-1.5%、椰油酰胺DEA:0.5%-1.0%、月桂基醚硫酸钠:3%-4%、TEA十二烷基硫酸钠:2.0%-3.0%、纯净水:余量。
根据本发明的第七方面,提供一种儿童湿纸巾,由无尘纸和湿巾液构成,其中湿巾液的组成为:薄荷提取物1%-1.5%、金银花提取物2.0-3.0%、黄菊花提取物1.5-2.0%、苍术油1.0%-1.5%、桂枝油0.8%-1.2%、柠檬酸钠0.1%-0.2%、烷基聚葡萄糖甘15%-18%、甘油2%-3%、纯净水余量。
根据本发明的第八方面,提供一种沐浴液,包含:薄荷提取物1%-1.5%、格桑花提取物2.0-3.0%、苍术油:1.0%-1.5%、桂枝油:1.0%-1.2%、椰油酰胺DEA:0.5%-1.0%、TEA十二烷基硫酸钠:2.0%-3.0%、CP-920珠光浆1.0%-2.0%、丙三醇0.5%-0.8%、香精0.1%-0.3%、纯净水:余量。
根据本发明的第九方面,提供一种儿童沐浴液,包含:苍术油1.0%-1.5%、桂枝油0.8%-1.2%、柠檬酸钠0.1%-0.2%、烷基聚葡萄糖甘15%-18%、甘油2%-3%、薄荷1%-1.5%、皂荚粉1.0%-2.0%、艾叶提取物1.5-2.0%、金银花提取物2.0-3.0%、纯净水余量。
根据本发明的第十方面,提供一种洗发液,其组成为:苍术油1.0%-1.5%、桂枝油1.0%-1.2%、椰油酰胺DEA 0.5%-1.0%、TEA十二烷基硫酸钠2.0%-3.0%、制首乌提取物1.0%-2.0%、皂角粉1.0-2.0%、柠檬酸钠0.5-0.8%、食盐0.5%-0.8%、香精0.1%-0.3%、纯净水余量。
附图说明
图1是根据本发明的植物油提取系统(装置)的示意图。
图2为应用例二制备的常用消毒泡腾片的水中杀菌成分溶出释放曲线。
图3为应用例五中艾叶提取物和/或金银花提取物以及应用例六中格桑花提取物的提取流程示意图。
具体实施方式
植物油提取
本发明设计了快速(不间断)植物油提取系统,以满足工业化生产漱口水时所需植物油原料。本发明中,植物油、精油及挥发油所指相同,均为下面提及的相应植物的提取液。
参见图1,本发明的植物油提取系统包括第一储液罐10和第二储液罐20、冷却器30以及提取器40。
第一储液罐10的底部设有其上安装了阀门12的排液管11,顶部通过第一气液部分回路与提取器40的顶部连通,上侧部则通过第一虹吸部分回路50与提取器40的底部连通。第一气液部分回路包括与第一储液罐10的顶部连通的第一竖向管路13、与提取器40的顶部连通的共用竖向管路33、以及连通二者 且设置有阀门14的水平管路。第一虹吸部分回路50设置有阀门51。如图1所示,第一虹吸部分回路50具有向上弯折部分且其最高点低于提取器40的顶部。
类似地,第二储液罐20的底部设有其上安装了阀门22的排液管21,顶部通过第二气液部分回路与提取器40的顶部连通,上侧部则通过第二虹吸部分回路60与提取器40的底部连通。第二气液部分回路包括与第二储液罐20的顶部连通的第二竖向管路23、与提取器40的顶部连通的共用竖向管路33、以及连通二者且设置有阀门24的水平管路。第二虹吸部分回路60设置有阀门61。如图1所示,第一虹吸部分回路60也具有向上弯折部分且其最高点低于提取器40的顶部。
在图1中,所示第一气液部分回路与第二气液部分回路具有共用竖向管路33,共用竖向管路33穿过冷却器30。在替代实施例中,第一气液部分回路与第二气液部分回路也可以不具有共用竖向管路33,而是各自具有穿过冷却器30的竖向管路,这种情况下可以省略阀门14以及阀门24。
提取器40中安装有螺旋输送器44,以将从提取器40的顶部加料口41加入的(干燥)植物颗粒或粉末沿提取器长度方向(图示为水平方向)传送,直至提取器排料口42附近。螺旋输送器44中的粉末颗粒将与提取器40中的液体直接接触。
下面简要描述上述提取系统的工作原理。
首先,通过提取器40的加料口41加入植物颗粒或粉末例如苍术根茎颗粒或桂枝颗粒,并启动螺旋输送器44使植物颗粒沿提取器40水平方向铺至提取器40的排料口42附近。
关闭阀门12和阀门22,然后分别在第一储液罐10和第二储液罐20中加入约占罐体积三分之二左右的纯净水。
关闭阀门24和阀门61;打开阀门14和51。
启动冷却器30。
加热第一储液罐10直至并保持其中的纯净水持续沸腾以不断形成水蒸气。
第一储液罐10中形成的水蒸气向上通过第一竖向管路13以及水平管路后向下通过共用竖向管路33,并在经由冷却器30时变成冷凝水通入提取器40。
在提取器40中的液位高度超过第一虹吸部分回路50的最高点时,其中的提取液将通过第一虹吸部分回路50而返回第一储液罐10。
当通过第一虹吸部分回路50的提取液基本变为无色时,停止加热第一储液罐10,并启动螺旋输送器44以将其中的植物湿粉经由排出口42排出提取器40。
与上述螺旋输送器44的排出动作同时或紧接着,再通过提取器40的加料口41加入(新鲜)植物颗粒,仍然通过螺旋输送器44直至提取器40的排料口42附近。
关闭阀门14和阀门51;打开阀门24和61。
加热第二储液罐20以执行同样提取过程。
打开阀门12以通过排液管11将第一储液罐10中的提取液排出,并随后分离成蒸馏水和植物(提取)油。
如上所述,第一储液罐10和第二储液罐20交替工作,并配合以螺旋输送器44的快速输送/排出,从而实现了植物油的(不间断)快速工业化规模提取。
应用例一:空气清新喷雾剂
空气是我们赖以生存的条件之一,清新的空气会给人带来愉悦的心情,空气也是病菌传播的主要媒介之一,随着城市的不断发展,人口规模不断的增加,人口密度大,空气质量差环境日益恶化,空气中有害物质增多,异味、空气传染影响人的情绪、健康、工作效率。为了杀灭空气中的有害微生物并除去异味,现代家庭、医院、宾馆、饭店及其他一些公共场合,经常向空气中使用空气清新喷雾剂。空气清新喷雾剂又称“环境香水”,顾名思义,指可以使空气更加清新的药剂。
常见的空气清新喷雾剂由乙醇、香精、去离子水等成分组成,通过散发香味来掩盖异味,减轻人们对异味的不舒服感,是从20世纪开始应用于环境卫生领域的一种化工产品。目前市场上销售的空气清新喷雾剂,大多含有人工合成的化学灭菌剂,经常暴露于这种含有化学制品的空气中,可能会对人体会造成一定的伤害。因此,为净化室内空气,研制安全有效的天然空气清新消毒产品,显得尤为重要。
一种空气清新喷雾剂,其组成为:苍术挥发油:1.0%-1.5%、桂枝挥发油:0.8%-1.2%、椰油酰胺DEA:0.5%-1.0%、月桂基醚硫酸钠:3%-4%、TEA十二烷基硫酸钠:2.0%-3.0%、甘油:5%-8%、冰片:0.2%-0.3%、纳米级二氧化钛1.0-2.0%、纯净水余量。
根据本发明的优选实施例,其中纳米级二氧化钛为粒径100nm以下的锐钛型二氧化钛。这种二氧化钛具有显著的催化功能,会产生类似光合作用的光催化反应,使喷雾剂中苍术和桂枝挥发油的成分产生出氧化能力极强的自由氢氧基和活性氧,该类成分具有很强的光氧化还原功能,可氧化分解各种有机化合物和部分无机物,高效去除室内残留的甲醛。
上述空气清新喷雾剂的具体生产方法,包括:
将纯净水和甘油混合均匀;
然后分别加入椰油酰胺DEA、月桂基醚硫酸钠、TEA十二烷基硫酸钠,机械搅拌15分钟,搅拌速度200转/分钟;
再加入苍术油和桂枝油以及纳米级二氧化钛,并机械搅拌20分钟,搅拌速度200转/分钟;
最后加入冰片,灌装即可。
上述助剂中,DEA代表二乙胺基,TEA代表三乙胺基。
实施例1(喷雾剂重量配比组成,下同)
苍术挥发油:1.0%、桂枝挥发油:0.8%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、甘油:5%、冰片:0.2%、纳米锐钛型二氧化钛1.0%、纯净水余量。
实施例2
苍术挥发油:1.0%、桂枝挥发油:1.0%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、甘油:5%、冰片:0.2%、纳米锐钛型二氧化钛1.0%、纯净水余量。
实施例3
苍术挥发油:1.5%、桂枝挥发油:0.8%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、甘油:5%、冰片:0.2%、纳米锐钛型二氧化钛1.0%、纯净水余量。
实施例4
苍术挥发油:1.5%、桂枝挥发油:1.0%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、甘油:5%、冰片:0.2%、纳米锐钛型二氧化钛1.0%、纯净水余量。
实施例5
苍术挥发油:1.5%、桂枝挥发油:1.2%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、甘油:5%、冰片:0.2%、纳米锐钛型二氧化钛1.0%、纯净水余量。
试验1——除味试验
选取不同试验场所,卫生间、地下室、实验室、厨房、空调房、垃圾房、装修房作为试验场所。将上述场所分别使用实施例1~5所得空气清新喷雾剂,对比例使用不含苍术和桂枝提取物成分的喷雾剂作为对照(常规用量,喷雾使用1-3次,持续5分钟后进行跟踪测评,结果见表1。
测评标准为:√√√—无异味;√√—异味较弱;√—有明显异味
表1不同喷雾剂测评结果
  实施例1 实施例2 实施例3 实施例4 实施例5 对比例
卫生间 √√√ √√√ √√√ √√√ √√√
地下室 √√√ √√√ √√√ √√√ √√
实验室 √√√ √√ √√√ √√√ √√√ √√
厨房 √√√ √√√ √√ √√√ √√
空调房 √√√ √√√ √√√ √√ √√√
垃圾房 √√√ √√√ √√√ √√√ √√√
装修房 √√√ √√√ √√√ √√√ √√√
结果表明:上述各实施例喷雾剂具有明显的吸附异味的作用且具有明显的除甲醛作用。
试验2——悬液定量杀菌试验
(1)选择金黄色葡萄球菌、链球菌、厌氧链球菌三种菌株分别按消毒技术规范配制实验用菌悬液,浓度为1×108cfu/ml~5×108cfu/ml。
(2)取消毒试验用无菌大试管,先加入0.5ml试验用菌悬液,再加入0.5ml有机干扰物质,
混匀,置20℃±1℃水浴中5min后,用无菌吸管吸取各实施例制备的空气清新液4.0ml样品,注入其中,迅速混匀并立即记时。
(3)待试验菌与空气喷雾剂相互作用至各预定时间,分别吸取0.5ml试验菌与空气喷雾剂混合液加于4.5ml经灭菌的中和剂中,混匀。
(4)各管试验菌与空气喷雾剂混合液经加中和剂作用10min后,分别吸取1.0ml样液,按活菌培养计数方法测定存活菌数,每管样液接种2个平皿即可。如平板上生长的菌落数较多时,可进行系列10倍稀释后,再进行活菌培养计数。
(5)同时用稀释液代替空气喷雾剂,进行平行试验,作为阳性对照。
(6)所有试验样本均在37℃温箱中培养,对细菌繁殖体培养48h观察最终结果;对细菌芽孢需培养72h观察最终结果。
(7)试验重复3次,计算各组的活菌浓度(cfu/ml),并换算为对数值(N),然后按下式计算杀灭对数值:
杀灭对数值(KL)=对照组平均活菌浓度的对数值(No)-试验组活菌浓度对数值(Nx)试验结果如表1所示。
表2不同实施例杀菌试验测评结果(作用时间<10min)
Figure PCTCN2019099838-appb-000001
与市场类似产品相比,本发明组建了一种天然绿色空气清新喷雾剂,有抗高温,抗氧化,长时间保湿的特性,既能够除去空气中的一些异味物质又能够长时间保持室内香味;同时苍术和桂枝两种精油结合相辅相承具有协同作用,再借助二氧化钛的催化氧化作用,能够显著高效去除室内甲醛且对常见菌革兰氏阳性菌、革兰氏阴性菌、真菌、酵母菌等具有快速、持久的杀菌而非抑菌作用,具有良好的空气净化效果。
应用例二:绿色缓释消毒泡腾片
泡腾片是含有泡腾崩解剂的一种片剂。泡腾崩解剂通常是有机酸和碳酸钠、碳酸氢钠(小苏打)的混合物。泡腾片本身干燥不含水分,泡腾崩解剂中的两种物质未电离不能发生反应。当泡腾片放入水中之后,两种物质发生酸碱反应,产生大量二氧化碳,使片剂迅速崩解和融化,有时崩解产生的气泡还会使药片在水中上下翻滚,加速其崩解和融化。随着人们生活水平的提高,越来越多的家庭对生活环境卫生要求越来越高,因此亟需开发方便使用、高效、环保的消毒产品。
本发明提供了一种消毒泡腾片,包含(以重量比计):苍术挥发油1.0%-1.5%、桂枝挥发油0.8%-1.2%、β-环糊精5.0%-10.0%、碳酸氢钠2.0%-4.0%、柠檬酸9.0%-10.0%、十二烷基磺酸钠5.0%-8.0%、硫酸钙2.0%-4.0%、羟丙基纤维素16.0%-40.0%、HPMC-多元醇复合物10%-20%、硬脂酸钠余量。其中,HPMC代表羟丙基甲基纤维素。
根据本发明的具体实施例,HPMC-多元醇复合物中的多元醇包括但不限于以下多元醇:乳糖、蔗糖、葡萄糖、果糖、山梨醇、甘露醇、木糖醇中的一种或几种的组合。HPMC和多元醇的重量比优选在1/0.1~1/10之间。
根据本发明的进一步优选实施例,消毒泡腾片可以包含:苍术挥发油1.0%-1.2%、桂枝挥发油0.8%-1.0%、β-环糊精5.0%-10.0%、碳酸氢钠2.0%-3.0%、柠檬酸9.0%-10.0%、十二烷基磺酸钠5.0%-7.0%、硫酸钙2.0%-3.0%、羟丙基纤维素20.0%-40.0%、HPMC-多元醇复合物10%-20%、硬脂酸钠余量。
上述消毒泡腾片的生产方法,包括:
将苍术挥发油和桂枝挥发油与等体积量的95%乙醇混合进行稀释;
再分别加入β-环糊精、十二烷基磺酸钠以及HPMC-多元醇复合物;
然后再加入蒸馏水混合均匀;
用胶体磨研磨成糊状物;
再减压抽滤获得沉淀物;
用无水乙醇洗涤沉淀物;
干燥沉淀物制得精油微囊;
将精油微囊、碳酸氢钠、柠檬酸、硫酸钙、羟丙基纤维素按比例混合均匀;
然后用70%的乙醇润湿造粒,并在60℃下干燥挥发除去乙醇;以及
最后加入硬脂酸钠并压片处理,从而制得消毒泡腾片。
本发明的消毒泡腾片的形状优选制成扁平型,为长5cm,宽2cm,厚0.1cm的薄片,该片剂与水接触面积大,有利于片剂的崩解和杀菌成分释放,1分钟内可迅速崩解。
本发明的消毒泡腾片采用缓控释制剂工艺,能够控制杀菌成分的缓慢释放,能持续保持一定的杀菌成分浓度达72小时。制成的缓控释片在时间上比普通片释放持久,不会像普通片那样一到水中就完全释放,在单位时间内有着比较恒定的释放剂量,以维持水中杀菌成分浓度恒定,杀菌效力更持久。
本发明的消毒泡腾片能够杀菌消毒、无毒无害,绿色环保,且易于计量、易于溶解、携带且使用方便。本发明与市场同类产品相比优点在于组建了一种纯天然绿色消毒泡腾片,无毒无害,绿色环保;同时两种精油结合相辅相承具有协同作用,对常见有害菌:金黄色葡萄球菌、白念珠菌、大肠杆菌、链球菌等具有快速、持久的杀灭作用。
根据本发明所制备的消毒泡腾片使用效果好,对人体无刺激和副作用,杀菌消毒效果显著,安全可靠。
本发明通过使用HPMC-多元醇复合物,从而可以避免:湿法制粒过筛困难;湿法制粒片重不稳定;湿法制粒释放行为不稳定;粉末压片存在的流动性问题;粉末压片涩冲的问题;片重不稳定的问题。
实施例1(加湿器杀菌泡腾片)
苍术挥发油1.5%、桂枝挥发油0.8%、β-环糊精10.0%、碳酸氢钠4.0%、柠檬酸10.0%、十二烷基磺酸钠8.0%、硫酸钙4.0%、羟丙基纤维素30.0%、HPMC-乳糖复合物(重量比1:1)10%、硬脂酸钠余量。按制备工艺制成泡腾片,使用时放于家用加湿器中,1分钟内迅速崩解,家用加湿器采用超声波方式将水雾化,并通过风机将雾化的水汽吹出壳体,杀菌成分可随水雾弥漫,达到室内空间消毒杀菌目的。
实施例2(常用杀菌泡腾片)
苍术挥发油1.5%、桂枝挥发油0.8%、β-环糊精8.0%、碳酸氢钠2.0%、柠檬酸9.0%、十二烷基磺酸钠5.0%、硫酸钙2.0%、羟丙基纤维素30.0%、HPMC-乳糖复合物(重量比2:1)20%、硬脂酸钠余量。按制备工艺制成泡腾片,使用时放入水中,迅速崩解得到消毒杀菌液,用于环境物品的杀菌消毒,能持续保持一定的杀菌成分浓度达72小时,持续杀菌。
实施例3(常用杀菌泡腾片)
苍术挥发油1.0%、桂枝挥发油1.0%、β-环糊精10.0%、碳酸氢钠3.0%、柠檬酸9.0%、十二烷基磺酸钠6.0%、硫酸钙3.0%、羟丙基纤维素30.0%、HPMC-蔗糖复合物(重量比1:2)10%、硬脂酸钠余量。按制备工艺制成泡腾片,使用时放入水中,迅速崩解得到消毒杀菌液,用于环境物品的杀菌消毒,能持续保持一定的杀菌成分浓度达72小时,持续杀菌。
实施例4(常用杀菌泡腾片)
苍术挥发油1.0%、桂枝挥发油1.2%、β-环糊精10.0%、碳酸氢钠2.0%、柠檬酸9.0%、十二烷基磺酸钠5.0%、硫酸钙2.0%、羟丙基纤维素30.0%、HPMC-甘露醇和木糖醇复合物(重量比1:1:1)20%、硬脂酸钠余量。按制备工艺制成泡腾片,使用时放入水中,迅速崩解得到消毒杀菌液,用于环境物品的杀菌消毒,能持续保持一定的杀菌成分浓度达72小时,持续杀菌。
悬液定量杀菌试验
(1)选择金黄色葡萄球菌、链球菌、厌氧链球菌三种菌株分别按消毒技术规范配制实验用菌悬液,浓度为1×108cfu/ml~5×108cfu/ml。
(2)取消毒试验用无菌大试管,先加入0.5ml试验用菌悬液,再加入0.5ml有机干扰物质,混匀,置20℃±1℃水浴中5min后,用无菌吸管吸取各实施例和对比例制备的泡腾液4.0ml样品,注入其中,迅速混匀并立即记时。
(3)待试验菌与消毒泡腾片水溶液相互作用至各预定时间,分别吸取0.5ml试验菌与消毒泡腾片水溶液加于4.5ml经灭菌的中和剂中,混匀。
(4)各管试验菌与消毒泡腾片水溶液经加中和剂作用10min后,分别吸取1.0ml样液,按活菌培养计数方法测定存活菌数,每管样液接种2个平皿即可。如平板上生长的菌落数较多时,可进行系列10倍稀释后,再进行活菌培养计数。
(5)同时用稀释液代替消毒泡腾片水溶液,进行平行试验,作为阳性对照。
(6)所有试验样本均在37℃温箱中培养,对细菌繁殖体培养48h观察最终结果;对细菌芽孢需培养72h观察最终结果。
(7)试验重复3次,计算各组的活菌浓度(cfu/ml),并换算为对数值(N),然后按下式计算杀灭对数值:
杀灭对数值(KL)=对照组平均活菌浓度的对数值(No)-试验组活菌浓度对数值(Nx)试验结果如表1所示。
表3消毒泡腾片水溶液抗菌活性
Figure PCTCN2019099838-appb-000002
消毒泡腾片崩解试验
按2015年版《中华人民共和国药典》通则0921规定的崩解时限检查方法进行。取实施例1制取的1片泡腾片,置250ml烧杯(内有200ml温度为20℃±5℃的水)中,即有许多气泡放出,当片剂或碎片周围的气体停止逸出时,片剂应溶解或分散在水中,无聚集的颗粒剩留。取实施例2-4制取的泡腾片各2片,结果6片(同一实施例的2片为一批)消毒泡腾片全部在1min内崩解,3批的崩解时限分别为0.95、0.87和0.90min。
消毒泡腾片杀菌成分溶出释放试验
图2为根据本发明实施例2-4所制备的消毒泡腾片的水中杀菌成分溶出释放曲线。如图2所示,根据本发明制成的缓控释片在时间上比普通片释放持久,不会像普通片那样一到水中就完全释放,在单位时间内有着比较恒定的释放剂量,以维持水中杀菌成分浓度恒定,杀菌效力更持久。
本发明将具有杀菌作用的苍术和桂枝两种纯天然植物精油相互结协同杀菌,并进一步采用缓控释材料进行包合,使该泡腾片在溶解后对常见菌革兰氏阳性菌、革兰氏阴性菌、真菌、酵母菌等具有快速、持久的杀菌作用,具有良好的杀菌消毒效果。本发明解决了传统消毒剂的杀菌时间短、刺激皮肤和污染环境等缺点,具有持久杀菌消毒作用、不刺激皮肤、绿色环保,且易于计量、易于溶解、携带且使用方便等优点。
应用例三:植物漱口水
口腔健康状态是反映生命健康质量的一面镜子。近年来,口腔问题越来越得到重视,口腔异味在交谈中容易给人留下不礼貌的印象。口腔卫生的重点在于控制菌斑,消除污垢和食物残渣,增强生理刺激,使口腔有一个清洁健康的良好环境,从而发挥其生理功能,维护口腔健康,口腔平时尤其在食过有刺激性味道的食物和饭后不方便刷牙的情况下,容易引起口腔有害腔细菌的大量繁殖,同时产生不良口气。
近些年来,使用的口腔漱口水较多,目前市面上存在的口腔漱口水品类繁多,多是有化学合成杀菌成分,有一定毒副作用和环境污染。而只含纯天然植物提取物的口腔漱口水通常只能起到抗菌和抑菌作用,无法有效杀灭口腔有害菌(杀菌效果达到5个对数值的卫生消毒剂的国家标准)。
本发明提供一种可以快速杀菌的天然植物漱口水。其组成为(重量比):苍术油:1.0%-1.5%、桂枝油:1.0%-1.5%、椰油酰胺DEA:0.5%-1.0%、月桂基醚硫酸钠:3%-4%、TEA十二烷基硫酸钠:2.0%-3.0%、纯净水:余量。其中,DEA代表二乙胺基、TEA代表三乙胺。
上述漱口水的生产方法,包括:
在纯净水中分别加入椰油酰胺DEA、月桂基醚硫酸钠、TEA十二烷基硫酸钠,并搅拌使其充分溶解;
再分别加入苍术油及桂枝油,并搅拌均匀。
上述搅拌采用常温机械搅拌,时间15-20分钟,搅拌速度200转/分钟左右。
本发明的漱口水制备简单,环保无污染,原料易得且设备投资少,便于操作。本发明的漱口水能够快速杀菌、抑制口腔微生物滋生,保持口腔清洁无口气,对人体无刺激和副作用。
以下漱口水的对比例及实施例均为重量比组成。
对比例1
苍术挥发油:1.0%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、纯净水:余量。
对比例2
桂枝挥发油:1.0%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、纯净水:余量。
实施例3
苍术挥发油:1.0%、桂枝挥发油:1.5%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、纯净水:余量。
实施例4
苍术挥发油:1.2%、桂枝挥发油:1.2%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、纯净水:余量。
实施例5
苍术挥发油:1.5%、桂枝挥发油:1.0%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、纯净水:余量。
实施例6
苍术挥发油:1.5%、桂枝挥发油:1.2%、椰油酰胺DEA:0.5%、月桂基醚硫酸钠:3%、TEA十二烷基硫酸钠:2.0%、纯净水:余量。
悬液定量杀菌试验:
(1)选择表皮葡萄球菌、链球菌、乳酸杆菌三种菌株分别按消毒技术规范配制实验用菌悬液,浓度为1×108cfu/ml~5×108cfu/ml。
(2)取消毒试验用无菌大试管,先加入0.5ml试验用菌悬液,再加入0.5ml有机干扰物质,混匀,置20℃±1℃水浴中5min后,用无菌吸管吸取各实施例和对比例制备的天然植物漱口水4.0ml样品注入其中,迅速混匀并立即记时。
(3)待试验菌与漱口液相互作用至各预定时间,分别吸取0.5ml试验菌与漱口液混合液加于4.5ml经灭菌的中和剂中,混匀。
(4)各管试验菌与漱口液经加中和剂作用10min后,分别吸取1.0ml样液,按活菌培养计数方法测定存活菌数,每管样液接种2个平皿即可。如平板上生长的菌落数较多时,可进行系列10倍稀释后,再进行活菌培养计数。
(5)同时用稀释液代替口腔漱口液,进行平行试验,作为阳性对照。
(6)所有试验样本均在37℃温箱中培养,对细菌繁殖体培养48h观察最终结果;对细菌芽孢需培养72h观察最终结果。
(7)试验重复3次,计算各组的活菌浓度(cfu/ml),并换算为对数值(N),然后按下式计算杀灭对数值:
杀灭对数值(KL)=对照组平均活菌浓度的对数值(No)-试验组活菌浓度对数值(Nx)试验结果如表1所示。
表4:悬液定量杀菌试验结果
Figure PCTCN2019099838-appb-000003
从以上杀菌试验结果表明:
单独使用苍术油和桂枝油对表皮葡萄球菌具有较强的杀灭作用,杀灭对数值(KL)>5.0,但对链球菌和乳酸杆菌的杀灭对数值达不到使用效果。两者合用后从实例3-6的筛选结果来看,主要活性成分产生了协同作用,降低用量的同时能对表皮葡萄球菌、链球菌、乳酸杆菌具有明显的抑制作用,综合平均杀灭对数值分别为6.06、5.93、5.90和6.05。
本发明的纯天然植物口腔杀菌漱口水不含化学合成杀菌成分,其杀菌成分为复方植物精油,对口腔常见细菌如表皮葡萄球菌、甲型和厌氧链球菌、乳酸杆菌等细菌专一性较强,效果显著,作用效果可以达到且高于5个对数值的卫生消毒剂的国家标准。
应用例四:儿童湿纸巾
湿纸巾是由纯水、保湿剂、防腐剂、抗菌剂制成的一种用于清洁擦试人体的清洁用品。儿童皮肤较嫩,容易滋生细菌,对来自外界环境的刺激性抵抗力低。现有的湿纸巾所使用的保湿剂、防腐剂、抗菌剂是化学成分,这些对儿童的皮肤有一定伤害,对皮肤刺激较大,容易引起过敏反应。
针对上述问题,有必要提供一种具有优良的防腐、抗菌、清洁和温和滋润的效果,无刺激性和致敏性的儿童湿纸巾。
本发明提供了一种儿童湿纸巾,由无尘纸和湿巾液构成,其中湿巾液的组成为(重量百分比):薄荷提取物1%-1.5%、金银花提取物2.0-3.0%、黄菊花提取物1.5-2.0%、苍术油1.0%-1.5%、桂枝油0.8%-1.2%、柠檬酸钠0.1%-0.2%、烷基聚葡萄糖甘15%-18%、甘油2%-3%、纯净水余量。
上述儿童湿纸巾的生产方法,包括:
制备湿巾液以及用湿巾液浸湿无尘纸,其中制备湿巾液包括:
先将纯净水和柠檬酸钠混合均匀;
然后分别加入烷基聚葡萄糖甘、薄荷、黄菊花和金银花提取物、甘油,搅拌并使其充分溶解;
最后再加入苍术油和桂枝油,搅拌均匀。
本发明的无尘纸采用市售无尘纸即可。
根据本发明的生产方法,黄菊花提取物和/或金银花提取物优选通过下述方式获得以保证提取物的稳定性和抗菌消炎效果:
首先获得黄菊花和/或金银花水提取液;
再将上述水提取液减压浓缩至相对密度为1.20-1.40(相对密度为相对于水的密度)的浓缩液;
然后将上述浓缩液冷却至室温,加入乙醇搅拌,静置6-48小时,过滤,滤液回收乙醇,残渣用乙醇洗涤,洗涤液回收乙醇,然后将洗涤液与滤液合并,浓缩至60℃热测时,相对密度为1.15-1.20;
随后再加入中性水,搅拌使其完全溶解后加入等体积的石油醚萃取3次,弃去石油醚层,水层减压浓缩至60℃热测时,相对密度为1.15-1.20;
然后加水稀释(稀释至相当于生药材1g/mL),用例如D101型大孔吸附树脂吸附,再用水或质量浓度为1-15%的乙醇洗脱至洗脱液近无色,弃去洗脱液,最后分别用质量浓度为50%、70%、80%、95%的乙醇洗脱,收集洗脱液检测,合并绿原酸含量大于30%的洗脱液低温浓缩干燥即得。
根据本发明的生产方法,薄荷提取物优选通过下述方式获得:将新鲜薄荷叶物理压榨后取新鲜汁液,用高速滤心机离心(4000转/S),弃去沉淀得薄荷液,再将薄荷液放入-80℃冰箱冷冻至液体完全成固体,固体再放入冷冻干燥机冷冻干燥48小时后即得薄荷提取物(粉末)。
根据本发明生产的儿童湿纸巾无刺激和副作用,杀菌消毒效果显著,安全可靠,绿色环保。本发明的儿童湿纸巾在方便去除人体皮肤污渍的同时,还能在正常使用时间内实现有效杀菌,滋润、护肤,无残留,而且迅速干燥。
此外,根据本发明所生产的儿童湿纸巾性能优异,活性组分长期稳定。
以下实施例分别给出了不同组成(重量份)的湿巾液。
实施例1
薄荷提取物1%、金银花提取物2.0%、黄菊花提取物1.5%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖甘15%、甘油2%、纯净水余量。
实施例2
薄荷提取物1.2%、金银花提取物2.5%、黄菊花提取物1.5%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖甘15%、甘油2%、纯净水余量。
实施例3
薄荷提取物1.5%、金银花提取物2.0%、黄菊花提取物2.0%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖甘15%、甘油2%、纯净水余量。
实施例4
薄荷提取物1.5%、金银花提取物2.5%、黄菊花提取物2.0%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖甘15%、甘油2%、纯净水余量。
实施例5
薄荷提取物1.5%、金银花提取物3.0%、黄菊花提取物2.0%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖甘15%、甘油2%、纯净水余量。
试验1皮肤刺激性试验
采用动物活体试验进行湿纸巾原液刺激性测试,选取健康小白鼠50只,分为五组,每组10只,采用同体左右侧自身对比法,用电剃须刀将小白鼠背部脊椎两侧毛法剃去,剃去面积为2cm*2cm,分别取实施例1-5项下制备的湿巾液(原液)抹于小白鼠背部左侧已去毛的皮肤上作为实验组,右侧不加处理作自身空白对照组,每隔一小组观察实验组皮肤周围是否有红肿过敏等现象,24小时用温水洗去湿纸巾原液,观察结果。
表5:不同儿童湿纸巾原液皮肤刺激性测评结果
  红肿 过敏 与右侧相比异常
第一组 0 0 0
第二组 0 0 0
第三组 0 0 0
第四组 0 0 0
第五组 0 0 0
表5结果清楚表明:小白鼠受试部位的皮肤无红斑和水肿过敏等现象,与右侧对照组皮肤外观与色泽等一致,说明本发明实施例1-5制备项下的湿纸巾原液对皮肤无任何刺激作用。
试验2:悬液定量杀菌试验
(1)选择金黄色葡萄球菌、链球菌、厌氧链球菌三种菌株分别按消毒技术规范配制实验用菌悬液,浓度为1×108cfu/ml~5×108cfu/ml。
(2)取消毒试验用无菌大试管,先加入0.5ml试验用菌悬液,再加入0.5ml有机干扰物质,混匀,置20℃±1℃水浴中5min后,用无菌吸管吸取各实施例制 备的湿巾液(实施例1-5)4.0ml样品注入其中,迅速混匀并立即记时。
(3)待试验菌与原液相互作用至各预定时间,分别吸取0.5ml试验菌与原液加于4.5ml经灭菌的中和剂中,混匀。
(4)各管试验菌与原液混合液经加中和剂作用10min后,分别吸取1.0ml样液,按活菌培养计数方法测定存活菌数,每管样液接种2个平皿即可。如平板上生长的菌落数较多时,可进行系列10倍稀释后,再进行活菌培养计数。
(5)同时用稀释液代替原液,进行平行试验,作为阳性对照。
(6)所有试验样本均在37℃温箱中培养,对细菌繁殖体培养48h观察最终结果;对细菌芽孢需培养72h观察最终结果。
(7)试验重复3次,计算各组的活菌浓度(cfu/ml),并换算为对数值(N),然后按下式计算杀灭对数值:
杀灭对数值(KL)=对照组平均活菌浓度的对数值(No)-试验组活菌浓度对数值(Nx)试验结果如表2所示。
表6:不同儿童湿纸巾原液杀菌试验测评结果(作用时间<10min)
Figure PCTCN2019099838-appb-000004
由上可知,本发明制备的儿童湿纸巾具有高保护性、高安全性、低刺激性,能够安全去污;对常见菌革兰氏阳性菌、革兰氏阴性菌、真菌、酵母菌等具有快速、持久的杀菌而非抑菌作用,具有良好的清洁效果。
应用例五:儿童植物沐浴液
沐浴液是以清洁剂和起泡剂为主,辅以其它助剂和添加剂制成的具有滋润皮肤,去除污垢,改善人体气味等作用的清洁产品。儿童皮肤较嫩,容易滋生细菌,使皮肤肿痛、生疮、长痱子,对来自外界环境的刺激性抵抗力低,又容易受到机械性的损伤,易感染皮肤疾病。
现有儿童沐浴液基本都含化学制品,这些沐浴液对儿童的皮肤有一定伤害,并且所含部分化学成分可以通过皮肤渗入人体血液中,长期使用造成诸多不良影响。因此,亟需开发安全去污的儿童沐浴液。
本发明提供了一种儿童沐浴液,包含(以重量比计):苍术油1.0%-1.5%、桂枝油0.8%-1.2%、柠檬酸钠0.1%-0.2%、烷基聚葡萄糖甘15%-18%、甘油2%-3%、薄荷1%-1.5%、皂荚粉1.0%-2.0%、艾叶提取物1.5-2.0%、金银花提取 物2.0-3.0%、纯净水余量。
根据本发明生产的沐浴液能够祛湿除痱并兼具抗菌消炎功效,安全去污,绿色环保,对儿童身体无任何刺激和副作用。
此外,根据本发明所生产的沐浴液性能优异,其中易受影响的金银花和艾叶经上述二步超临界分离后所获得的提取物活性尤其稳定。
图3示出了本发明的艾叶提取物和/或金银花提取物的提取过程:将金银花和/或艾叶粉碎成药材粉末后装入萃取釜中;将从CO 2钢瓶流出的CO 2气体冷却成液态后输入加压泵进行压缩;从加压泵流出的CO 2经预热器预热后进入萃取釜达到超临界流体状态;使CO 2超临界流体与药材粉末直接接触进行传质;使从萃取釜流出的CO 2超临界流体减压后依次进入分离釜I和分离釜II,其中:在分离釜I中保持温度为60℃、压力为6MPa;分离釜II中保持温度为55℃、压力为5MPa;以及使从分离釜II中流出的CO 2与从CO 2钢瓶流出的CO 2汇合以重复上述步骤。
其它生产原料市购即可,在此不再详细描述。
本发明的儿童沐浴液的生产方法为:
将纯净水和柠檬酸钠混合均匀;
再分别加入烷基聚葡萄糖甘、薄荷、甘油,皂荚粉、艾叶提取物和金银花提取物,搅拌使其充分溶解;
最后再加入苍术油和桂枝油,搅拌均匀后灌装即可。
搅拌采用常温机械搅拌,时间15-20分钟,速度200转/分钟左右。
以下实施例分别给出了不同组成(重量份)的儿童沐浴液。
实施例1
皂荚粉1.0%、艾叶提取物1.5%、金银花提取物2.0%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖苷15%、甘油2%、薄荷1%、纯净水余量。
实施例2
皂荚粉1.5%、艾叶提取物2.0%、金银花提取物2.5%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖苷15%、甘油2%、薄荷1%、纯净水余量。
实施例3
皂荚粉1.0%、艾叶提取物1.5%、金银花提取物2.0%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖苷15%、甘油2%、薄荷1%、纯净水余量。
实施例4
皂荚粉1.0%、艾叶提取物1.5%、金银花提取物2.5%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖苷15%、甘油2%、薄荷1%、 纯净水余量。
实施例5
皂荚粉1.5%、艾叶提取物2.0%、金银花提取物3.0%、苍术挥发油1.0%、桂枝挥发油0.8%、柠檬酸钠0.1%、烷基聚葡萄糖苷15%、甘油2%、薄荷1%、纯净水余量。
效果评测
选择60名志愿者,男女不限,年龄2~16岁。将其随机分为5组,第1-5组分别使用实施例1~5所得沐浴液,第6组使用不含皂荚粉、艾叶提取物和金银花提取物成分的沐浴液作为对照(常规用量,每周使用1-3次,持续使用6个月后进行跟踪测评,结果见表1。
测评标准为:全效:儿童无湿气、不长痱子、去污能力强、皮肤滑润、无副作用;
有效:儿童湿气较轻、基本不长痱子、去污能力较强、皮肤较滑润、无副作用;
无效:儿童湿气较重、经常会长痱子、去污能力较弱、皮肤较粗糙、无副作用。
表7不同儿童沐浴液测评结果
  全效/人 有效/人 无效/人
第一组 8 2 0
第二组 7 3 0
第三组 7 3 0
第四组 8 2 0
第五组 10 0 0
第六组 4 3 3
由表7可见,使用本发明儿童沐浴液的第1-5组有效率均在100%以上,较作为对照的第6组提高30%以上,证明在该天然儿童沐浴中具有去祛湿除痱、安全去污、温润、无副作用的效果。
应用例六:天然植物沐浴液
沐浴液又称沐浴露,其有效物是由各类表面活性剂复配而成的一种液状洁身护肤沐浴用品。我国古代就有浸泡药浴,用以治病强身,其历史源远流长,为现代保健美容业留下许多宝贵的史料,而与现代先进的提取和配制技术结合,制成的中药沐浴产品更得到广大消费者的青睐。近年来,随着消费观念的转变和化妆品工业的发展,消费者对于沐浴液的要求已有变化,人们愈来愈重视皮肤的护理作用,首先要求沐浴液对皮肤是低刺激的,作用温和,而将洗净与护 理皮肤放在同等地位。
目前的沐浴液大多只有单一的清洁功能,除螨润肤效果并不理想,个别有一定杀螨效果的,多为有机化学合成杀菌成分,长期使用会对人体造成一定的伤害。
本发明提供一种沐浴液,包含(以重量比计):薄荷提取物1%-1.5%、格桑花提取物2.0-3.0%、苍术油:1.0%-1.5%、桂枝油:1.0%-1.2%、椰油酰胺DEA:0.5%-1.0%、TEA十二烷基硫酸钠:2.0%-3.0%、CP-920珠光浆1.0%-2.0%、丙三醇0.5%-0.8%、香精0.1%-0.3%、纯净水:余量。其中,DEA代表二乙胺基、TEA代表三乙胺。
根据本发明生产的天然植物沐浴液能够快速除螨杀菌、清洁效果好,还能净肤、柔肤、润肤。
此外,根据本发明所生产的沐浴液性能优异,其中易受影响的格桑花经上述二步超临界分离后所获得的提取物活性尤其稳定。
图3示出了本发明的格桑花提取物的提取过程:将格桑花粉碎成药材粉末后装入萃取釜中;将从CO 2钢瓶流出的CO 2气体冷却成液态后输入加压泵进行压缩;从加压泵流出的CO 2经预热器预热后进入萃取釜达到超临界流体状态;使CO 2超临界流体与药材粉末直接接触进行传质;使从萃取釜流出的CO 2超临界流体减压后依次进入分离釜I和分离釜II,其中:在分离釜I中保持温度为60℃、压力为6MPa;分离釜II中保持温度为55℃、压力为5MPa;以及使从分离釜II中流出的CO 2与从CO 2钢瓶流出的CO 2汇合以重复上述步骤。
本发明的薄荷提取物通过下述方式获得:将新鲜薄荷叶物理压榨后取新鲜汁液,用高速滤心机离心(4000转/s),弃去沉淀得薄荷液,再将薄荷液放入-80℃冰箱冷冻至液体完全成固体,固体再放入冷冻干燥机冷冻干燥48小时后即得薄荷提取物粉末。
其它生产原料市购即可,在此不再详细描述。
本发明的沐浴液的生产方法为:
在纯净水中分别加入椰油酰胺DEA、TEA十二烷基硫酸钠、薄荷提取物、格桑花提取物、CP-920珠光浆、丙三醇以及香精,搅拌使其充分溶解;
最后再加入苍术油和桂枝油,搅拌均匀后灌装即可。
搅拌采用常温机械搅拌,时间15-20分钟,速度200转/分钟左右。
以下实施例分别给出了不同组成(重量份)的沐浴液。
实施例1
薄荷提取物1.0%、格桑花提取物2.0%、苍术挥发油:1.0%、桂枝挥发油:1.0%、椰油酰胺DEA:0.5%、TEA十二烷基硫酸钠:2.0%、CP-920珠光浆1.0%、丙三醇0.5%、香精0.1%、纯净水:余量。
实施例2
薄荷提取物1.0%、格桑花提取物2.5%、苍术挥发油:1.0%、桂枝挥发油:1.0%、 椰油酰胺DEA:0.5%、TEA十二烷基硫酸钠:2.0%、CP-920珠光浆1.0%、丙三醇0.5%、香精0.1%、纯净水:余量。
实施例3
薄荷提取物1.0%、格桑花提取物3.0%、苍术挥发油:1.0%、桂枝挥发油:1.0%、椰油酰胺DEA:0.5%、TEA十二烷基硫酸钠:2.0%、CP-920珠光浆1.0%、丙三醇0.5%、香精0.1%、纯净水:余量。
实施例4
薄荷提取物1.5%、格桑花提取物2.5%、苍术挥发油:1.0%、桂枝挥发油:1.0%、椰油酰胺DEA:0.5%、TEA十二烷基硫酸钠:2.0%、CP-920珠光浆1.0%、丙三醇0.5%、香精0.1%、纯净水:余量。
实施例5
薄荷提取物1.5%、格桑花提取物3.0%、苍术挥发油:1.0%、桂枝挥发油:1.0%、椰油酰胺DEA:0.5%、TEA十二烷基硫酸钠:2.0%、CP-920珠光浆1.0%、丙三醇0.5%、香精0.1%、纯净水:余量。
试验1除螨试验
选择60名志愿者,男女不限,年龄18~65岁。将其随机分为5组,第1-5组分别使用实施例1~5所得沐浴液,第6组使用不含薄荷提取物和格桑花提取物成分的沐浴液作为对照(常规用量,每周使用1-3次,持续使用2个月后进行跟踪测评,结果见表1。
测评标准为:全效:常规检识无螨虫、皮肤滑润、无副作用;
有效:常规检识可见少量螨虫、皮肤较滑润、无副作用;
无效:常规检识可见大量螨虫、皮肤较粗糙、无副作用。
表8不同沐浴液测评结果
  全效/人 有效/人 无效/人
第一组 7 2 1
第二组 7 3 0
第三组 7 3 0
第四组 8 2 0
第五组 9 1 0
第六组 4 4 2
由表8可见,使用本发明沐浴液的第1-5组有效率均在90%以上,较作为对照的第6组提高20%以上,证明在该天然沐浴中具有除螨、清洁效果好,还能净肤、柔肤、润肤的效果。
试验2:悬液定量杀菌试验
(1)选择金黄色葡萄球菌、大肠杆菌、白色念珠菌三种菌株分别按消毒技术规范配制实验用菌悬液,浓度为1×108cfu/ml~5×108cfu/ml。
(2)取消毒试验用无菌大试管,先加入0.5ml试验用菌悬液,再加入0.5ml有机干扰物质,混匀,置20℃±1℃水浴中5min后,用无菌吸管吸取各实施例制备的天然植物沐浴液4.0ml样品注入其中,迅速混匀并立即记时。
(3)待试验菌与沐浴液相互作用至各预定时间,分别吸取0.5ml试验菌与沐浴液混合液加于4.5ml经灭菌的中和剂中,混匀。
(4)各管试验菌与沐浴液经加中和剂作用10min后,分别吸取1.0ml样液,按活菌培养计数方法测定存活菌数,每管样液接种2个平皿即可。如平板上生长的菌落数较多时,可进行系列10倍稀释后,再进行活菌培养计数。
(5)同时用稀释液代替沐浴液,进行平行试验,作为阳性对照。
(6)所有试验样本均在37℃温箱中培养,对细菌繁殖体培养48h观察最终结果;对细菌芽孢需培养72h观察最终结果。
(7)试验重复3次,计算各组的活菌浓度(cfu/ml),并换算为对数值(N),然后按下式计算杀灭对数值:
杀灭对数值(KL)=对照组平均活菌浓度的对数值(No)-试验组活菌浓度对数值(Nx)试验结果如表1所示。
表9不同实施例沐浴液杀菌试验测评结果(作用时间<10min)
Figure PCTCN2019099838-appb-000005
由上可知,本发明的天然植物精油沐浴液清洁效果好,还能净肤、柔肤、润肤和杀瞒,具有多重效果,并且产品配置简单,成本低。配方中的中药成分具有祛风湿、舒筋骨、滋润皮肤的功效的同时,还具有抗菌和减缓皮肤角质化、软化皮肤的作用,同时除螨功效显著。
应用例七:天然植物洗发液
随着生活水平的提高,人们对仪容仪表十分关注,头发的整洁干净与健康越来越受到人们的关心与注重。在洗头发时通常需使用洗发液,达到清洁、护法、去头皮屑等作用。然而洗发液种类繁多,针对的功效也是各有不同。特别上市场上大部分的洗发产品过分追求头发柔顺、闪亮而在洗发液里添加了伤害 头发发质的化学合成成分,长期使用对人身体健康造成极大的隐患。另外,化学合成成分除毒副作用外且不容易被分解代谢,还对自然环境产生污染。另外,目前的洗发液大多只关注头发清洁柔顺功能,对头皮中滋生的细菌缺乏有效杀灭。
本发明提供一种洗发液,其组成(重量)为:苍术油:1.0%-1.5%、桂枝油:1.0%-1.2%、椰油酰胺DEA:0.5%-1.0%、TEA十二烷基硫酸钠:2.0%-3.0%、制首乌提取物1.0%-2.0%、皂角粉1.0-2.0%、柠檬酸钠0.5-0.8%、食盐0.5%-0.8%、香精0.1%-0.3%、纯净水:余量。其中,DEA代表二乙胺基、TEA代表三乙胺。
上述洗发液的生产方法,包括:
将皂角粉和制首乌提取物溶解于纯净水中,加入柠檬酸钠调节pH值为6.5-7.0;
再分别加入椰油酰胺DEA、TEA十二烷基硫酸钠、食盐和香精,搅拌并使其充分溶解;
最后再加入苍术油和桂枝油,搅拌均匀。
根据本发明的生产方法,苍术(挥发)油和/或桂枝(挥发)油可以采用水蒸气蒸馏法制得。
根据本发明的生产方法,皂角粉优选通过下述方式获得以保证其稳定杀菌效果:
将干燥的皂角粉碎成粉末后加6倍量水煎煮2次,每次2小时,过滤,合并煎液,煎液浓缩至相对密度1.1-1.2左右,再将浓缩后的煎液经喷雾干燥即得。
根据本发明的生产方法,制首乌提取物优选通过下述方式获得以稳定活性:将制首乌干燥粉碎后用10倍量水冷浸3次,每次4小时左右,过滤、合并滤液,残渣渗漉至液体无明显颜色,合并滤液和渗漉液,浓缩至相对密度1.15-1.20左右,经冷冻干燥机干燥即得。
根据本发明生产的洗发液对人体无刺激和副作用,可以快速去屑杀菌,还能生发、黑发、使发质柔顺。
此外,根据本发明所生产的洗发液性能优异,活性组分长期稳定。
以下实施例和对比例分别给出了不同组成(重量份)的洗发液。
实施例1
皂角粉1.0%、制首乌提取物1.0%、苍术挥发油:1.5%、桂枝挥发油:1.2%、椰油酰胺DEA:1.0%、TEA十二烷基硫酸钠:3.0%、、柠檬酸钠0.8%、食盐0.8%、香精0.3%、纯净水:余量。
实施例2
皂角粉2.0%、制首乌提取物2.0%、苍术挥发油:1.5%、桂枝挥发油:1.2%、椰油酰胺DEA:1.0%、TEA十二烷基硫酸钠:3.0%、、柠檬酸钠0.8%、食盐0.8%、香精0.3%、纯净水:余量。
对比例3
制首乌提取物2.0%、苍术挥发油:1.5%、桂枝挥发油:1.2%、椰油酰胺DEA:1.0%、TEA十二烷基硫酸钠:3.0%、、柠檬酸钠0.8%、食盐0.8%、香精0.3%、纯净水:余量。
对比例4
皂角粉2.0%、苍术挥发油:1.5%、桂枝挥发油:1.2%、椰油酰胺DEA:1.0%、TEA十二烷基硫酸钠:3.0%、柠檬酸钠0.8%、食盐0.8%、香精0.3%、纯净水:余量。
效果测评
选择100名志愿者,男女不限,年龄15~55岁,有不同程度的头发干燥、头屑、瘙痒、白发等现象。将其随机分为4组,第1-2组分别使用实施例1~2所得洗发液,第3-4组分别使用不含皂角粉或何首乌提取物成分的对比例3~4洗发液作为对照。每周使用3次,持续使用1个月后进行测评,结果见表1。
测评标准为:全效:发质柔顺,肉眼无可见头屑,瘙痒现象完全消失,发质明显变黑;
有效:头发不打结,肉眼有零星头屑,无明显头痒感觉,发质有一定变黑;
无效:使用前后无变化。
表10不同洗发液测评结果
  全效/人 有效/人 无效/人
第一组 8 16 1
第二组 10 15 0
第三组 3 7 15
第四组 4 8 13
由表10可见,与实施例1-2对应的第1-2组的本发明的洗发液效果更加显著,充分说明本发明的洗发液能够快速去屑杀菌,生发、黑发、使发质柔顺等。

Claims (10)

  1. 一种苍术油和/或桂枝油的生产方法,其中苍术油和/或桂枝油是通过下述工艺连续制备:
    将苍术根茎粉末和/或桂枝粉末加入安装有螺旋输送器的提取器;
    加热装有纯净水的第一储液罐以产生水蒸气;
    将水蒸气经冷却器冷凝成液态水后通入提取器以浸没苍术根茎粉末和/或桂枝粉末;
    当提取器中的液位高于连接提取器与第一储液罐的虹吸管的最高点时,提取器中的提取液自动通过虹吸管进入第一储液罐;
    当提取器中的提取液变为无色时,启动提取器中的螺旋输送器以将苍术根茎湿粉和/或桂枝湿粉排出提取器,同时再向提取器中加入苍术根茎粉末和/或桂枝粉末;
    停止加热第一储液罐并同时启动第二储液罐以继续上述步骤;以及
    分离第一储液罐中的提取液以获得苍术油和/或桂枝油。
  2. 一种苍术油和/或桂枝油的提取系统,包括:
    具有加料口和排料口的提取器,其中设置有螺旋输送器;
    第一储液罐,分别通过第一气液部分回路以及第一虹吸部分回路与提取器选择性连通;
    第二储液罐,分别通过第二气液部分回路以及第二虹吸部分回路与提取器选择性连通;
    冷却器,靠近提取器设置在第一气液部分回路和第二气液部分回路上。
  3. 一种根据权利要求1所述的生产方法制得的苍术油和/或桂枝油。
  4. 利用权利要求3的苍术油和桂枝油制得的空气清新喷雾剂,其组成为:苍术油:1.0%-1.5%、桂枝油:0.8%-1.2%、椰油酰胺DEA:0.5%-1.0%、月桂基醚硫酸钠:3%-4%、TEA十二烷基硫酸钠:2.0%-3.0%、甘油:5%-8%、冰片:0.2%-0.3%、纳米级二氧化钛1.0-2.0%、纯净水余量。
  5. 利用权利要求3的苍术油和桂枝油制得的消毒泡腾片,包含(以重量比计):苍术挥发油1.0%-1.5%、桂枝挥发油0.8%-1.2%、β-环糊精5.0%-10.0%、碳酸氢钠2.0%-4.0%、柠檬酸9.0%-10.0%、十二烷基磺酸钠5.0%-8.0%、硫酸钙2.0%-4.0%、羟丙基纤维素16.0%-40.0%、HPMC-多元醇复合物10%-20%、硬脂酸钠余量。
  6. 利用权利要求3的苍术油和桂枝油制得的漱口水,其组成为:苍术挥发油:1.0%-1.5%、桂枝挥发油:1.0%-1.5%、椰油酰胺DEA:0.5%-1.0%、月桂基醚硫酸钠:3%-4%、TEA十二烷基硫酸钠:2.0%-3.0%、纯净水:余量。
  7. 利用权利要求3的苍术油和桂枝油制得的儿童湿纸巾,由无尘纸和湿巾液构成,其中湿巾液的组成为:薄荷提取物1%-1.5%、金银花提取物2.0-3.0%、黄菊花提取物1.5-2.0%、苍术油1.0%-1.5%、桂枝油0.8%-1.2%、柠檬酸钠 0.1%-0.2%、烷基聚葡萄糖甘15%-18%、甘油2%-3%、纯净水余量。
  8. 利用权利要求3的苍术油和桂枝油制得的沐浴液,包含:薄荷提取物1%-1.5%、格桑花提取物2.0-3.0%、苍术油:1.0%-1.5%、桂枝油:1.0%-1.2%、椰油酰胺DEA:0.5%-1.0%、TEA十二烷基硫酸钠:2.0%-3.0%、CP-920珠光浆1.0%-2.0%、丙三醇0.5%-0.8%、香精0.1%-0.3%、纯净水:余量。
  9. 利用权利要求3的苍术油和桂枝油制得的儿童沐浴液,包含:苍术油1.0%-1.5%、桂枝油0.8%-1.2%、柠檬酸钠0.1%-0.2%、烷基聚葡萄糖甘15%-18%、甘油2%-3%、薄荷1%-1.5%、皂荚粉1.0%-2.0%、艾叶提取物1.5-2.0%、金银花提取物2.0-3.0%、纯净水余量。
  10. 利用权利要求3的苍术油和桂枝油制得的洗发液,其组成为:苍术油1.0%-1.5%、桂枝油1.0%-1.2%、椰油酰胺DEA 0.5%-1.0%、TEA十二烷基硫酸钠2.0%-3.0%、制首乌提取物1.0%-2.0%、皂角粉1.0-2.0%、柠檬酸钠0.5-0.8%、食盐0.5%-0.8%、香精0.1%-0.3%、纯净水余量。
PCT/CN2019/099838 2018-09-17 2019-08-08 一种苍术油和/或桂枝油、生产方法及其应用 WO2020057285A1 (zh)

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CN201811078923.3A CN110326627B (zh) 2018-09-17 2018-09-17 空气清新喷雾剂
CN201811093829.5A CN110917076A (zh) 2018-09-19 2018-09-19 儿童植物沐浴液
CN201811094481.1A CN110917078B (zh) 2018-09-19 2018-09-19 天然植物洗发液
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