CN111989311A - 抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用 - Google Patents

抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用 Download PDF

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CN111989311A
CN111989311A CN202080002090.1A CN202080002090A CN111989311A CN 111989311 A CN111989311 A CN 111989311A CN 202080002090 A CN202080002090 A CN 202080002090A CN 111989311 A CN111989311 A CN 111989311A
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alkoxy
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cycloalkyl
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CN111989311B (zh
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邓永奇
孙健
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Kaifu Suzhou Biomedical Co ltd
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Abstract

一种通式(I)所示的化合物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂，特别是作为PGE2/EP4信号传导抑制剂的用途以及用于治疗癌症、急性或慢性疼痛、偏头痛、骨关节炎、类风湿性关节炎、痛风、粘液囊炎、强直性脊柱炎、原发性痛经、癌症或动脉硬化症的用途。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080002090.1A 2019-01-22 2020-01-16 抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用 Active CN111989311B (zh)

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CN2019100575552 2019-01-22
CN201910057555 2019-01-22
PCT/CN2020/072487 WO2020151566A1 (zh) 2019-01-22 2020-01-16 抑制pge2/ep4信号传导的化合物、其制备方法及其在医药上的应用

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US (1) US20220064113A1 (zh)
EP (1) EP3889134B1 (zh)
JP (1) JP7488269B2 (zh)
KR (1) KR20210117280A (zh)
CN (1) CN111989311B (zh)
AU (1) AU2020212111A1 (zh)
CA (1) CA3126484A1 (zh)
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JPWO2022102731A1 (zh) 2020-11-13 2022-05-19
CN112608271A (zh) * 2020-11-26 2021-04-06 安润医药科技（苏州）有限公司 酰胺衍生物及其在制备ep4受体拮抗剂中的应用
CN117377471A (zh) * 2021-05-28 2024-01-09 凯复(苏州)生物医药有限公司 治疗肿瘤的联合疗法
WO2022257961A1 (zh) * 2021-06-08 2022-12-15 武汉人福创新药物研发中心有限公司 用于治疗ep2、ep4受体介导的疾病的苯并杂环化合物
EP4393906A1 (en) * 2021-08-27 2024-07-03 Keythera (Suzhou) Bio-Pharmaceuticals Co., Limited Solid form of indole compound, preparation method therefor and use thereof
KR20230123004A (ko) * 2022-02-15 2023-08-22 주식회사 카나프테라퓨틱스 프로스타글란딘 e2 수용체에 대한 저해 활성을 갖는 신규 화합물 및 항암제를 포함하는 암 치료용 약학 조성물
WO2023160569A1 (en) * 2022-02-24 2023-08-31 Guangdong Newopp Biopharmaceuticals Co., Ltd. Carboxamide compounds as pge2 receptor antagonists
CN114591137B (zh) * 2022-05-10 2022-09-09 上海赛默罗生物科技有限公司 螺桨烷类衍生物的合成方法

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WO2018195123A1 (en) * 2017-04-18 2018-10-25 Tempest Therapeutics, Inc. Bicyclic compounds and their use in the treatment of cancer

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CA3126484A1 (en) 2020-07-30
EP3889134A4 (en) 2022-02-16
KR20210117280A (ko) 2021-09-28
CN111989311B (zh) 2022-03-22
JP7488269B2 (ja) 2024-05-21
EP3889134A1 (en) 2021-10-06
EP3889134B1 (en) 2024-09-25
AU2020212111A1 (en) 2021-08-05
TW202041498A (zh) 2020-11-16
JP2022522993A (ja) 2022-04-21
US20220064113A1 (en) 2022-03-03
WO2020151566A1 (zh) 2020-07-30

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