CN111971090B - 双特异性egfr/cd16抗原结合蛋白 - Google Patents
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Classifications
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
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- Mycology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
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- Molecular Biology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP18161871 | 2018-03-14 | ||
| EP18161871.1 | 2018-03-14 | ||
| PCT/EP2019/056516 WO2019175368A1 (en) | 2018-03-14 | 2019-03-14 | Bispecific egfr/cd16 antigen-binding protein |
Publications (2)
| Publication Number | Publication Date |
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| CN111971090A CN111971090A (zh) | 2020-11-20 |
| CN111971090B true CN111971090B (zh) | 2024-02-23 |
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| CN201980018525.9A Active CN111971090B (zh) | 2018-03-14 | 2019-03-14 | 双特异性egfr/cd16抗原结合蛋白 |
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| Country | Link |
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| US (2) | US11510972B2 (ko) |
| EP (1) | EP3765157A1 (ko) |
| JP (1) | JP7288913B2 (ko) |
| KR (1) | KR20200132919A (ko) |
| CN (1) | CN111971090B (ko) |
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| BR (1) | BR112020018492A2 (ko) |
| CA (1) | CA3090464A1 (ko) |
| IL (1) | IL276903A (ko) |
| MX (1) | MX2020009445A (ko) |
| SG (1) | SG11202007664WA (ko) |
| WO (1) | WO2019175368A1 (ko) |
| ZA (1) | ZA202006247B (ko) |
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| EP4081554A1 (en) | 2019-12-27 | 2022-11-02 | Affimed GmbH | Method for the production of bispecific fcyriii x cd30 antibody construct |
| CA3233696A1 (en) * | 2021-11-03 | 2023-05-11 | Joachim Koch | Bispecific cd16a binders |
| CA3237018A1 (en) * | 2021-11-03 | 2023-05-11 | Joachim Koch | Bispecific cd16a binders |
Citations (3)
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| CN105367660A (zh) * | 2015-12-22 | 2016-03-02 | 深圳市北科生物科技有限公司 | 一种抗cd16a抗原和抗muc1抗原的双特异性抗体 |
| CN105555804A (zh) * | 2013-08-07 | 2016-05-04 | 阿菲姆德股份有限公司 | 对EGFRvIII有特异性的抗体结合位点 |
| CN106661108A (zh) * | 2014-04-13 | 2017-05-10 | 阿菲姆德股份有限公司 | 三功能抗原结合分子 |
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| GB0510790D0 (en) | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
| KR101930964B1 (ko) | 2010-04-20 | 2018-12-19 | 젠맵 에이/에스 | 이종이량체 항체 ｆｃ-함유 단백질 및 그의 생산 방법 |
| CA2798273A1 (en) * | 2010-05-04 | 2011-11-10 | Merrimack Pharmaceuticals, Inc. | Antibodies against epidermal growth factor receptor (egfr) and uses thereof |
| SI2794658T1 (sl) | 2011-12-19 | 2017-05-31 | Synimmune Gmbh | Bispecifična molekula protitelesa |
| CN104736174B (zh) | 2012-07-06 | 2019-06-14 | 根马布私人有限公司 | 具有三重突变的二聚体蛋白质 |
| CA2903056A1 (en) * | 2013-03-15 | 2014-09-18 | Merck Patent Gmbh | Tetravalent bispecific antibodies |
| CA3219372A1 (en) | 2015-05-04 | 2016-11-10 | Affimed Gmbh | Combination of a cd30xcd16 antibody with a pd-1 antagonist for therapy |
| EP3156417A1 (en) | 2015-10-13 | 2017-04-19 | Affimed GmbH | Multivalent fv antibodies |
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2019
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105555804A (zh) * | 2013-08-07 | 2016-05-04 | 阿菲姆德股份有限公司 | 对EGFRvIII有特异性的抗体结合位点 |
| CN106661108A (zh) * | 2014-04-13 | 2017-05-10 | 阿菲姆德股份有限公司 | 三功能抗原结合分子 |
| CN105367660A (zh) * | 2015-12-22 | 2016-03-02 | 深圳市北科生物科技有限公司 | 一种抗cd16a抗原和抗muc1抗原的双特异性抗体 |
Also Published As
| Publication number | Publication date |
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| WO2019175368A1 (en) | 2019-09-19 |
| RU2020131234A (ru) | 2022-03-22 |
| US11510972B2 (en) | 2022-11-29 |
| KR20200132919A (ko) | 2020-11-25 |
| SG11202007664WA (en) | 2020-09-29 |
| ZA202006247B (en) | 2021-09-29 |
| CA3090464A1 (en) | 2019-09-19 |
| EP3765157A1 (en) | 2021-01-20 |
| US20230190900A1 (en) | 2023-06-22 |
| JP7288913B2 (ja) | 2023-06-08 |
| BR112020018492A2 (pt) | 2020-12-29 |
| AU2019235433A1 (en) | 2020-08-27 |
| US20200405833A1 (en) | 2020-12-31 |
| JP2021515798A (ja) | 2021-06-24 |
| IL276903A (en) | 2020-10-29 |
| MX2020009445A (es) | 2020-10-08 |
| CN111971090A (zh) | 2020-11-20 |
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