CN111925906A - Be used for gene diagnosis to use sample separator - Google Patents
Be used for gene diagnosis to use sample separator Download PDFInfo
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- CN111925906A CN111925906A CN202010591509.3A CN202010591509A CN111925906A CN 111925906 A CN111925906 A CN 111925906A CN 202010591509 A CN202010591509 A CN 202010591509A CN 111925906 A CN111925906 A CN 111925906A
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- magnetic
- supporting plate
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- holes
- sample
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- 238000003745 diagnosis Methods 0.000 title claims abstract description 16
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 14
- 238000000926 separation method Methods 0.000 claims abstract description 49
- 238000010521 absorption reaction Methods 0.000 claims abstract description 10
- 238000001179 sorption measurement Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 8
- 239000011324 bead Substances 0.000 abstract description 39
- 238000000034 method Methods 0.000 abstract description 24
- 239000000523 sample Substances 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 18
- 238000000605 extraction Methods 0.000 abstract description 6
- 239000006228 supernatant Substances 0.000 abstract description 4
- 239000012472 biological sample Substances 0.000 abstract description 2
- 239000012141 concentrate Substances 0.000 abstract description 2
- 230000005389 magnetism Effects 0.000 description 10
- 210000002381 plasma Anatomy 0.000 description 10
- 206010028980 Neoplasm Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 230000000087 stabilizing effect Effects 0.000 description 3
- 238000007400 DNA extraction Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
Abstract
The invention provides a sample separation device for gene diagnosis, and relates to the technical field of biological sample extraction devices. The sample separation device for gene diagnosis comprises a magnetic frame, wherein the magnetic frame comprises a support frame, and the upper end of the support frame is connected with a support plate; a plurality of separation pipe holes vertically penetrate through the supporting plate; a bottom supporting plate is arranged below the supporting plate, bottom holes which vertically correspond to the separating tube holes are formed in the bottom supporting plate, and a magnetic absorption layer is arranged in the bottom holes. Above-mentioned magnetic frame has overcome the drawback that only magnetic frame one side adsorbs the magnetic bead among the prior art, can be adsorbed better behind the messenger magnetic bead enrichment DNA and concentrate, has avoided because the too much problem of free magnetic bead that unilateral absorption caused, conveniently abandons the supernatant, avoids sample DNA to lose, improves the effect that the magnetic bead method drawed DNA.
Description
Technical Field
The invention relates to the technical field of biological sample extraction devices, in particular to a sample separation device for gene diagnosis.
Background
Free nucleic acids in peripheral blood have long been used for tumor diagnosis, but have not been appreciated for reasons such as technical limitations and cognitive limitations. In recent years, with the rapid development of molecular biology technology, people develop changes of plasma free DNA which can reflect the biological characteristics and clinical characteristics of tumors and are expected to become a new generation of plasma tumor markers, and the separated plasma free DNA can be used as a gene diagnosis sample for tumor diagnosis and prognosis monitoring.
The plasma free DNA has the characteristics of trace and small fragment, and the separation of the plasma free DNA is mainly extracted and separated by a magnetic bead method at present. The device used in the extraction process by the magnetic bead method generally comprises a magnetic frame and a separation tube, wherein the magnetic frame can adsorb magnetic particles in the biomagnetic separation operation, so that the target molecules in the mixture can be rapidly separated and purified. But often only be provided with the adsorption part that adsorbs the magnetic bead in one side of separator tube in the magnetic frame that uses at present, often adsorption effect is not good to the magnetic bead that is located the separator tube bottom and adsorbs the opposite, and then influences the effect that the magnetic bead method drawed.
Disclosure of Invention
In view of the above, the present invention is directed to a sample separation device for gene diagnosis, comprising a magnetic rack, the magnetic rack comprising a support frame, a support plate connected to the upper end of the support frame; a plurality of separation pipe holes vertically penetrate through the supporting plate; a bottom supporting plate is arranged below the supporting plate, bottom holes which vertically correspond to the separating tube holes are formed in the bottom supporting plate, and a magnetic absorption layer is arranged in the bottom holes.
By adopting the above scheme, when adopting the magnetic bead method to extract the free DNA of plasma, place the DNA sample that has the magnetic bead in the separator tube after, insert the separator tube in the separator tube hole of magnetic frame, the bottom of separator tube inserts downthehole bottom this moment, so magnetism is inhaled the layer and can be fully adsorbed the downthehole magnetic bead of separator tube, makes the magnetic bead enrich in the separator tube bottom, conveniently discards the supernatant. By the design, the defect that only one side of the magnetic rack adsorbs magnetic beads in the prior art is overcome, the magnetic beads can be better adsorbed and concentrated after DNA enrichment, the problem that free magnetic beads are too many due to unilateral adsorption is avoided, supernatant is convenient to absorb and discard, sample DNA loss is avoided, and the effect of extracting DNA by a magnetic bead method is improved.
The shape of the bottom hole is matched with that of the bottom end of the separation tube, the bottom of the separation tube is often in a tip shape, and the height of the bottom hole is not higher than that of the tip shape of the bottom of the separation tube, so that the separation tube is inserted into the separation tube and cannot shake.
Further, on the basis of the technical scheme provided by the invention, the bottom supporting plate is provided with a magnetic attraction column wrapping the bottom of the separation tube, the bottom surface of the magnetic attraction column is connected with the periphery of the top surface of the bottom end hole, and the top surface of the magnetic attraction column protrudes out of the bottom supporting plate.
Through adopting above-mentioned scheme, magnetism is inhaled layer cooperation and is used in post and the downthehole magnetism of bottom and can be big at the sample extraction volume, and the magnetic bead is too much time, and the area of increase magnetism absorption, and then increase the magnetism adsorption effect of magnetic force frame.
Further, on the basis of the technical scheme provided by the invention, the bottom bracing plate can be detachably connected to the support frame, 3 pairs of sliding rails with different heights are arranged on two inner side surfaces of the support frame, and the bottom bracing plate is connected to the support frame in a sliding manner.
Through adopting above-mentioned scheme, when using the separator tube operation of high difference, can adjust the height of bottom fagging correspondingly to guarantee that the separator tube bottom still can insert the magnetism and inhale the layer in magnetism that post and bottom hole are inhaled to the magnetism, make magnetic frame can be applicable to the separator tube of high difference.
Further, on the basis of the technical scheme provided by the invention, one end of the slide rail is provided with a baffle.
Through adopting above-mentioned scheme, the dog can prevent to deviate from when the bottom supporting plate slides on the support frame, controls the sliding position of bottom supporting plate better, conveniently adjusts the operation of bottom supporting plate height.
Further, on the basis of the technical scheme provided by the invention, 3 groups of separation holes are arranged on the support plate, and can accommodate separation tubes with the capacities of 1.5mL, 5mL and 15mL in sequence; the height of the slide rail corresponds to the height of the separating tubes with different capacities in sequence.
By adopting the scheme, the volumes of the separation tubes commonly used in the DNA extraction operation process are 1.5mL, 5mL and 15mL, and the separation tube holes with corresponding volumes are arranged on the magnetic frame, so that an experiment operator can use the separation tube more conveniently and the universality is stronger.
Further, on the basis of the technical scheme provided by the invention, the height of the adsorption column is not lower than the bottom tip part of the separation tube.
By adopting the scheme, the separating tube with the capacities of 1.5mL, 5mL and 15mL is used in the DNA extraction process, the bottom of the separating tube is always in a tip shape, the magnetic attraction layer in the bottom hole can only adsorb magnetic beads distributed at the tip of the bottom of the separating tube, the bottom tip of the separating tube with the height not lower than that of the adsorption column can adsorb the magnetic beads at the upper part of the tip shape, and the magnetic frame is suitable for the conditions of large sample capacity and wide magnetic bead dispersion, and the adsorption effect of the magnetic frame is improved.
Further, on the basis of the technical scheme provided by the invention, the bottom end of the support frame is connected with a stable base.
Through adopting above-mentioned scheme, firm base can increase magnetic frame and place planar area of contact, and increase frictional resistance increases the steadiness ability of magnetic frame better, reduces the problem that the magnetic frame emptys to appear in the experimentation. And anti-skid grains can be further arranged on the bottom surface of the stabilizing base, so that the friction force is further increased, and the stabilizing effect is enhanced.
Further, on the basis of the technical scheme provided by the invention, a sealed cavity layer is arranged at the bottom of the bottom supporting plate, and a heat-insulating gel material is filled in the cavity layer.
By adopting the scheme, in the process of extracting the free DNA in the blood plasma by adopting the magnetic bead method, low-temperature operation or certain constant temperature is sometimes needed, and the cavity layer filled with the heat-preservation gel material can be preheated or precooled at a certain temperature in advance, so that a sample in the separation tube can be at the temperature in the operation process, and the experiment effect is improved.
Furthermore, on the basis of the technical scheme provided by the invention, small vibration parts are respectively arranged on the outer sides of the two surfaces of the bottom bracing plate, and the bottom ends of the vibration parts are arranged on the stable base.
Through adopting above-mentioned scheme, adopt the in-process of the free DNA of magnetic bead method extraction plasma, in order to avoid extracting in-process magnetic bead gathering influence enrichment effect, need regularly shake and impel the magnetic bead dispersion, current operation often is artifical with the finger bullet or rock the separator tube, is unfavorable for the homogeneity of vibrations. The vibration piece on the magnetic frame can set timing vibration and vibration amplitude, so that the vibration effect is better, and the use effect of the magnetic frame is further improved.
The invention adopts the technical scheme and has the following beneficial effects:
(1) the sample separation device for gene diagnosis is a magnetic frame, overcomes the defect that only one side of the magnetic frame adsorbs magnetic beads in the prior art, and avoids the problem of excessive free magnetic beads caused by unilateral adsorption, so that the magnetic beads can be better adsorbed and concentrated after being enriched with DNA, the supernatant is convenient to suck and discard, the loss of sample DNA is avoided, and the effect of extracting the DNA by a magnetic bead method is improved;
(2) the sample separation device for gene diagnosis can correspondingly adjust the height of the bottom supporting plate, thereby ensuring that the bottom end of the separation tube can still be inserted into the magnetic attraction layer of the magnetic attraction column and the bottom end hole, and ensuring that the magnetic frame can be suitable for separation tubes with different heights;
(3) according to the sample separation device for gene diagnosis, the cavity layer filled with the heat-preservation gel material can be preheated or precooled at a certain temperature in advance, so that the sample in the separation tube can be kept at the temperature in the operation process, and the experiment effect is improved.
Drawings
Fig. 1 is a schematic structural diagram of embodiment 1 of the present invention.
Fig. 2 is a schematic cross-sectional view of embodiment 1 of the present invention.
Fig. 3 is a schematic structural diagram of embodiment 2 and embodiment 3 of the present invention.
Reference numerals: 1. a support frame; 11. a slide rail; 111. a baffle plate; 12. a stable base; 13. a vibrating member; 2. a support plate; 21. a separator tube aperture; 3. a bottom supporting plate; 31. a bottom end hole; 311. a magnetic absorption layer; 32. a magnetic attraction column; 33. a cavity layer.
Detailed Description
Unless defined otherwise, all scientific and technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Materials, reagents and the like used in the following examples are commercially available unless otherwise specified.
The invention is described in detail below with reference to specific examples, which are intended to be illustrative, but not limiting, of the invention.
Example 1
A magnetic rack for gene diagnosis is shown in figure 1, and comprises two vertically arranged support frames 1, wherein the top ends of the support frames 1 are connected with a support plate 2, and the support plate 2 is provided with a separation tube hole 21; a bottom supporting plate 3 is arranged below the supporting plate 2, bottom holes 31 corresponding to the separation tube holes 21 up and down are arranged on the bottom supporting plate 3, and a magnetic absorption layer 311 (not shown in the drawing) is arranged in the bottom holes 31.
As shown in figure 1, two support frames 1 are cuboid plate-shaped structures, the size and the dimension are the same, the length direction is vertically arranged, and two support plates 2 are arranged in parallel. The inner side surfaces of the two supporting plates 2 are provided with 3 pairs of sliding rails 11 with different heights. The slide rail 11 is a strip-shaped groove, each pair of slide rails 11 is horizontally arranged on the two support plates 2 in parallel, the length direction of the slide rail 11 is perpendicular to the length direction of the support plates 2, and a baffle 111 is arranged at one end of each slide rail 11.
The bottom surface of the supporting plate 2 is provided with a stabilizing base 12. The stable base 12 is a cuboid plate-shaped structure, is horizontally arranged in the length direction, and the bottom surface of the stable base is in contact with the desktop.
The top surfaces of the two support frames 1 are connected with a support plate 2. The supporting plate 2 is of a cuboid plate-shaped structure, is horizontally arranged in the length direction, and is fixedly connected with the bottom surfaces of the two supporting plates 2. The support plate 2 is provided with 3 groups of separation tube holes 21, each group of 6-12 separation tube holes 21 are the separation tube holes 21 containing the volumes of 1.5mL, 5mL and 15mL from right to left.
A bottom support plate 3 is provided below the support plate 2. Bottom fagging 3 is cuboid platelike structure, and the level sets up, and length direction is the same with the length direction of backup pad 2. The size of end fagging 3 slightly is less than the size of backup pad 2, and the both ends inlay card of end fagging 3 is in above-mentioned slide rail 11, and can follow 11 horizontal slip of slide rail and the not slide rail 11 of co-altitude of change are drawn out to the pull, and the separation of 11 one end baffles 111 of slide rail makes end fagging 3 can only follow the one side pull of keeping away from baffle 111 and go out.
The bottom end hole 31 corresponding to the upper and lower positions of the separation tube hole 21 is arranged on the bottom support plate 3, and the shape and the size of the bottom end hole 31 are matched with the shape and the size of the bottom of the separation tube, such as the shape of a tip or a round bottom, and the shape can also be adjusted according to the shape of the bottom of the separation tube. The inner side surface of the bottom hole 31 is provided with a magnetic attraction layer 311, and the magnetic attraction layer 311 can be made of a permanent magnet material and is used for adsorbing magnetic beads at the bottom of the separation tube.
The height of the slide rail 11 is corresponding to the bottom height of the separating tubes with the capacities of 1.5mL, 5mL and 15mL from top to bottom in sequence, so that the bottom ends of the separating tubes are inserted into the bottom end holes 31, and the separating tubes are ensured not to shake randomly.
As shown in fig. 2, a sealed cavity layer 33 is provided on the bottom surface of the bottom gusset 3. The shape and size of the cavity layer 33 are the same as those of the support plate 2, the top surface is fixedly connected to the bottom surface of the support plate 2, a rectangular hollow structure is formed inside the cavity layer, and the cavity layer is filled with heat-preservation gel materials.
The using process of the embodiment is as follows: when adopting the magnetic bead method to draw free DNA of plasma, place the DNA sample that has the magnetic bead behind the separator tube, insert the separator tube in the separator tube hole 21 of magnetic frame according to the capacity difference, the height of backup pad 3 is adjusted through slide rail 11 of difference simultaneously, make the bottom of separator tube insert in bottom hole 31, make the magnetic bead of bottom hole 31 interior magnetic absorption layer 311 absorption separator tube bottom, can be better adsorbed behind the messenger magnetic bead enrichment DNA and concentrate, the too much problem of free magnetic bead because unilateral adsorbs the cause has been avoided, improve the effect that the magnetic bead method draws DNA.
Example 2
A magnetic force frame for gene diagnosis, as shown in FIG. 3, is different from the embodiment 1 in that a magnetic attraction column 32 is further provided on a bottom stay plate 3. The magnetic column 32 is a cylindrical structure, the inner diameter is the same as the maximum inner diameter of the bottom hole 31, the outer diameter is slightly larger than the inner diameter, the axis of the magnetic column coincides with the axis of the bottom hole 31, the bottom surface of the magnetic column is fixedly connected with the top surface of the supporting plate 2, and the height of the magnetic column is not lower than the bottom tip of the separation tube. The magnetic attraction column 32 may be made of a permanent magnet material.
The using process of the embodiment is as follows: place the DNA sample that will have the magnetic bead behind the separator tube, insert the separator tube according to the capacity difference in the separator tube hole 21 of magnetic frame, through the height of fagging 3 at the bottom of the 11 adjustment of slide rail of difference simultaneously, make the bottom of separator tube insert in adsorption column and bottom hole 31, adsorption column and bottom hole 31 parcel separator tube bottom, the area of increase magnetism absorption increases the magnetism adsorption effect of magnetic frame.
Example 3
A magnetic force frame for gene diagnosis, as shown in figure 3, is different from embodiment 2 in that small vibration pieces 13 are respectively arranged on the outer sides of two sides of a bottom bracing plate 3, the bottom ends of the vibration pieces 13 are arranged on a stable base 12, the amplitude of timing vibration and vibration can be set, the vibration effect is better, and the using effect of the magnetic force frame is improved.
The using process of the embodiment is as follows: adopt the in-process of the free DNA of magnetic bead method extraction plasma, can set up vibrations piece 13 into the amplitude of regularly shaking and adjustment vibrations, make the effect of vibrations better, avoid extracting in-process magnetic bead gathering influence DNA enrichment effect, further improve the result of use of magnetic frame.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and the like that are within the spirit and principle of the present invention are included in the present invention.
Claims (8)
1. A sample separation device for gene diagnosis is characterized by comprising a magnetic frame, wherein the magnetic frame comprises a support frame, and the upper end of the support frame is connected with a support plate; a plurality of separation pipe holes vertically penetrate through the supporting plate; a bottom supporting plate is arranged below the supporting plate, bottom holes which vertically correspond to the separating tube holes are formed in the bottom supporting plate, and a magnetic absorption layer is arranged in the bottom holes.
2. The sample separating device of claim 1, wherein the bottom supporting plate is provided with a magnetic column wrapping the bottom of the separating tube, the bottom surface of the magnetic column is connected with the periphery of the top surface of the bottom hole, and the top surface of the magnetic column protrudes out of the bottom supporting plate.
3. The sample separating device of claim 2, wherein the bottom supporting plate is detachably connected to the supporting frame, two inner sides of the supporting frame are provided with 3 pairs of sliding rails with different heights, and the bottom supporting plate is slidably connected to the supporting frame.
4. The sample separation apparatus of claim 3, wherein one end of the slide is provided with a baffle.
5. The sample separation device according to claim 3, wherein the separation holes on the support plate are arranged in 3 groups, and can accommodate separation tubes with capacities of 1.5mL, 5mL and 15mL in sequence; the height of the slide rail corresponds to the height of the separating tubes with different capacities in sequence.
6. The sample separation apparatus of claim 5, wherein the height of the adsorption column is not higher than the bottom tip portion of the separation tube.
7. The sample separation apparatus of claim 1, wherein a securing base is attached to a bottom end of the support frame.
8. The sample separation device according to claim 1, wherein the bottom of the bottom supporting plate is provided with a sealed cavity layer, and the cavity layer is filled with an insulating gel material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010591509.3A CN111925906A (en) | 2020-06-24 | 2020-06-24 | Be used for gene diagnosis to use sample separator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010591509.3A CN111925906A (en) | 2020-06-24 | 2020-06-24 | Be used for gene diagnosis to use sample separator |
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| Publication Number | Publication Date |
|---|---|
| CN111925906A true CN111925906A (en) | 2020-11-13 |
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|---|---|---|---|
| CN202010591509.3A Pending CN111925906A (en) | 2020-06-24 | 2020-06-24 | Be used for gene diagnosis to use sample separator |
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| CN110257217A (en) * | 2019-04-29 | 2019-09-20 | 柳州市妇幼保健院 | A kind of magnetic frame |
| CN209508225U (en) * | 2018-12-28 | 2019-10-18 | 苏州英芮诚生化科技有限公司 | A kind of large volume magnetic frame |
| CN210048744U (en) * | 2019-04-29 | 2020-02-11 | 柳州市妇幼保健院 | Magnetic rack |
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2020
- 2020-06-24 CN CN202010591509.3A patent/CN111925906A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040157224A1 (en) * | 2003-01-29 | 2004-08-12 | Roh Hee Joun | Kit for separating and purifying nucleic acids or various biological materials, and system for automatically performing separation or purification of biological materials using the same |
| CN204958894U (en) * | 2015-08-15 | 2016-01-13 | 济南齐鲁医学检验有限公司 | A test tube rocks observes frame for genetic test |
| CN208449384U (en) * | 2018-04-26 | 2019-02-01 | 耿梅云 | A kind of laboratory medicine rack for test tube |
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Application publication date: 20201113 |
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