CN220300742U - Adjustable magnetic frame - Google Patents
Adjustable magnetic frame Download PDFInfo
- Publication number
- CN220300742U CN220300742U CN202320624439.6U CN202320624439U CN220300742U CN 220300742 U CN220300742 U CN 220300742U CN 202320624439 U CN202320624439 U CN 202320624439U CN 220300742 U CN220300742 U CN 220300742U
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- China
- Prior art keywords
- magnet plate
- channel
- support frame
- adjustable magnetic
- vertical
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- 230000001154 acute effect Effects 0.000 claims abstract description 6
- 239000011324 bead Substances 0.000 description 6
- 238000007885 magnetic separation Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 5
- 238000010828 elution Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 1
- 238000011091 antibody purification Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Landscapes
- Centrifugal Separators (AREA)
Abstract
The utility model discloses an adjustable magnetic frame, which comprises: the centrifugal tube rack comprises a support frame and a magnet plate, wherein the support frame can be used for placing a plurality of centrifugal tubes, and the magnet plate can be arranged in a plurality of magnet plate channels in the support frame; at least one vertical magnet plate channel and at least one inclined magnet plate channel which forms an acute angle with the vertical magnet plate channel are arranged in the support frame. According to the utility model, the use requirements of different sample sizes are ensured by arranging the channels of the 3 different magnet plates, the inclined channels can solve the problem that the magnet of the vertical channel is too far away from the sample when the sample size is less than 20ul, and the device is suitable for fully separating different sample sizes and has wider application range.
Description
Technical Field
The utility model relates to the field of biological experimental equipment, in particular to an adjustable magnetic rack.
Background
The magnetic rack is matched with the magnetic beads for use, the magnetic beads can be efficiently separated, a 1.5-2m l centrifuge tube is placed on the magnetic rack, and the magnetic separation process can be completed in 30 seconds on average, so that the purposes of rapidly separating and purifying substances such as cells, proteins or nucleic acids are achieved, and the magnetic separation device is suitable for sequencing, antibody purification, immunoprecipitation, immune co-precipitation, cell separation, nucleic acid separation and other operations. The magnetic core can adsorb the magnetic bead to one side of the centrifugal tube wall to be gathered into a point, so that the supernatant can be conveniently removed in the later stage. The existing magnetic rack is mostly designed as a vertical magnet plate. When the sample size is smaller than 20u l, the vertical magnetic core is far away from the sample at the bottom of the centrifuge tube, and the purpose of effective magnetic separation cannot be achieved.
Disclosure of Invention
Aiming at the defects of the adjustability of the existing magnetic rack, the limitation of the applicable sample range and the magnetic separation problem of small sample size, the utility model provides an adjustable magnetic rack which is used for improving the existing fixed magnetic rack and assisting the magnetic bead sorting experiment.
The specific scheme of the utility model is as follows: an adjustable magnetic rack comprises a support frame and a magnet plate, wherein the support frame can be used for placing a plurality of centrifuge tubes, and the magnet plate can be arranged in a plurality of magnet plate channels in the support frame; at least one vertical magnet plate channel and at least one inclined magnet plate channel which forms an acute angle with the vertical magnet plate channel are arranged in the support frame.
Further, the magnet plate channel is composed of a top channel and a bottom channel, and the top channel and the bottom channel are respectively arranged at the top and the bottom of the support frame.
Further, the support frame comprises a vertical magnet plate channel and 2 inclined magnet plate channels, and the 2 inclined magnet plate channels are respectively arranged on two sides of the vertical magnet plate channel.
Further, the acute angle between the inclined magnet plate channel and the vertical magnet plate channel is 15-30 degrees.
Further, the inclined magnet plate channel and the vertical magnet plate channel have a common top channel therebetween.
Further, the magnet plate is provided with 4 equally spaced circular cores.
The support frame contains top, bottom and support side, and the support side is provided with magnet board spacing groove.
Further, the top of support frame is equipped with a plurality of circular fretwork top round hole, the bottom of support frame be equipped with a plurality of little circular fretwork bottom round hole that the top round hole corresponds perpendicularly, the support frame can place the centrifuging tube of fixed a plurality of 1.5m l-2m l simultaneously.
Further, the length of the supporting frame is 100mm, the height of the supporting frame is 50mm, and the width of the supporting frame is 50mm; the diameter of the top round hole is 15mm, the diameter of the bottom round hole is 2mm, the length of the vertical magnet plate channel is 100mm, the width of the vertical magnet plate channel is 5mm, and the height of the vertical magnet plate channel is 35mm; the inclined magnet plate channel is 100mm long, 5mm wide and 45mm high; the length of the magnet plate is 110mm, the thickness of the magnet plate is 5mm, and the height of the magnet plate is 35mm.
Further, when the magnet plate is placed in the vertical magnet plate channel, the magnetic core is positioned at the position of 20uL-100uL of the centrifugal pipe body, and the magnetic core is completely attached, so that the elution of the lowest 20u l samples can be performed. When the magnet plate is placed in the inclined magnet plate channel, the magnetic core is close to the bottom of the centrifuge tube, and elution of the sample <20u l can be completed.
Further, the supporting frame and the magnet plate are made of polypropylene materials.
Further, the support frame is integrally formed.
The utility model has the following advantages: through the placement channels of 3 different magnet plates, the purpose of flexibly adjusting the magnet plates is realized.
1) Reasonable in design, the simple operation. Humanized channel inclination designs, selectable channel designs for the centrifuging tube can hug closely the magnetic force frame, and the separation process of the little sample of convenience more, application scope is extensive.
2) The magnetic field intensity is high, and the separation is quick. The average magnetic separation time is 30 seconds, and the separation process is rapid and efficient. The magnetic core is specially designed, and magnetic beads can be adsorbed on the side wall of the pipe wall to be gathered into a point, so that the supernatant can be conveniently removed in the later stage.
3) Small, light and durable. The unique material makes the magnetic rack light and durable.
Drawings
FIG. 1 is a schematic diagram of an adjustable magnetic rack according to the present utility model;
FIG. 2 is a three-view of an adjustable magnetic stand according to the present utility model;
FIG. 3 is a schematic view illustrating the use of an inclined channel of an adjustable magnetic rack according to the present utility model;
FIG. 4 is a perspective view of an inclined chute of an adjustable magnetic rack according to the present utility model;
reference numerals: 1-supporting frame, 2-supporting frame top, 21-top round hole, 3-supporting frame bottom, 31-bottom round hole, 4-magnet plate channel, 41-vertical channel, 42-inclined channel, 5-magnet plate and 51-magnetic core.
Detailed Description
In order to make the technical problems, technical schemes and beneficial effects solved by the utility model more clear, the utility model is further described in detail below with reference to the accompanying drawings and embodiments. In order to provide a thorough understanding of the present utility model, detailed steps and detailed structures will be presented in the following description in order to explain the technical solution of the present utility model. Preferred embodiments of the present utility model are described in detail below, however, the present utility model may have other embodiments in addition to these detailed descriptions.
In the description of the present utility model, it should be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, merely to facilitate describing the present utility model and simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present utility model.
As shown in fig. 1 and 3, the utility model provides an adjustable magnetic rack, which comprises a support frame 1, wherein 8 centrifuge tubes can be placed on the top 2 of the support frame, 3 magnet plate channels 4 with different angles are arranged on the side edges of the support frame, and magnet plates 5 can be placed in the magnet plate channels 4 according to requirements.
The support frame top 2 is equipped with 8 circular fretwork top round holes 21, and support frame bottom 3 is equipped with 8 little circular fretwork bottom round holes 31 that correspond perpendicularly with top round hole 21, and support frame 1 can place fixed 8 centrifuging tube of 1.5ml-2ml simultaneously. The side surface and the bottom of the support frame form 3 magnet plate channels 4 with different angles, each magnet plate channel comprises a vertical magnet plate channel 41 and 2 inclined magnet plate channels 42 inclined to one side, and the magnet plate 5 can be selectively placed in one channel according to the requirement of the sample size. The magnet plate 5 is provided with 4 equally spaced circular cores 51.
The acute angle between the inclined magnet plate channel 42 and the perpendicular magnet plate channel 41 is 15 ° to 30 °.
The inclined magnet plate channel 42 and the vertical magnet plate channel 41 have a common top channel therebetween.
When the magnet plate 5 is placed in the vertical channel 41, the magnetic core 51 is positioned at the position of 20uL-100uL of the centrifugal tube body, and is completely attached, so that the lowest 20u l samples can be eluted. When the magnet plate 5 is placed in the inclined channel 42, the magnetic core 51 is close to the bottom of the centrifuge tube, and elution of <20u l samples can be completed.
According to the utility model, the use requirements of different sample sizes are ensured by arranging the channels of the 3 different magnet plates, the inclined channel 42 can solve the problem that the magnetic core 51 of the vertical channel 41 is too far away from the sample when the sample size is less than 20u l, and the application is wider.
As shown in fig. 2 and 4, the length of the support frame 1 is 100mm, the height is 50mm, and the width is 50mm; the diameter of the top round hole 21 is 15mm; the diameter of the bottom round hole 31 is 2mm; the vertical channel 41 has a length of 100mm, a width of 5mm and a height of 35mm; the inclined groove 42 has a length of 100mm, a width of 5mm and a height of 45mm; the magnet plate 5 has a length of 110mm, a thickness of 5mm and a height of 35mm.
The application process of the utility model is as follows:
1) Placing the combined centrifuge tube containing the magnetic bead-target object mixed solution to be separated on a magnetic frame
2) Selecting a magnet plate channel according to the amount of the mixed liquid
>20u l alternative vertical channels
An optional inclined channel of 20 and 20u l
Inserting magnet plates in selected channels
3) Rest for 30 seconds until the beads are attracted to the centrifuge tube wall.
4) Carefully pour off the liquid, or aspirate the liquid with a pipette.
5) And taking the centrifuge tube out of the magnetic frame, and returning the centrifuge tube to the common centrifuge tube rack, thus completing the magnetic separation operation.
The foregoing is only a preferred embodiment of the present utility model, but the scope of the present utility model is not limited thereto, and any person skilled in the art, who is within the scope of the present utility model, should make equivalent substitutions or modifications according to the technical scheme of the present utility model and the inventive concept thereof, and should be covered by the scope of the present utility model.
Claims (10)
1. The adjustable magnetic rack is characterized by comprising a support frame and a magnet plate, wherein the support frame can be used for placing a plurality of centrifuge tubes, and the magnet plate can be arranged in a plurality of magnet plate channels in the support frame;
at least one vertical magnet plate channel and at least one inclined magnet plate channel which forms an acute angle with the vertical magnet plate channel are arranged in the support frame.
2. The adjustable magnetic rack of claim 1, wherein the magnet plate channel is comprised of a top channel and a bottom channel, disposed at the top and bottom of the support frame, respectively.
3. The adjustable magnetic rack of claim 1, wherein the support frame comprises a vertical magnet plate channel and 2 sloped magnet plate channels, the 2 sloped magnet plate channels being disposed on opposite sides of the vertical magnet plate channel.
4. The adjustable magnetic rack of claim 1, wherein the acute angle between the angled magnet plate channel and the perpendicular magnet plate channel is 15 ° to 30 °.
5. The adjustable magnetic rack of any one of claims 1-4, wherein the angled magnet plate channel and the perpendicular magnet plate channel have a common top channel therebetween.
6. The adjustable magnetic rack of claim 1 wherein the magnet plate is provided with 4 equally spaced circular cores.
7. The adjustable magnetic rack of claim 1, wherein the support frame comprises a top, a bottom, and a support side, the support side being provided with a magnet plate limit slot.
8. The adjustable magnetic rack of claim 7, wherein the top of the support frame is provided with a plurality of round hollow top round holes, the bottom of the support frame is provided with a plurality of small round hollow bottom round holes vertically corresponding to the top round holes, and the support frame can simultaneously hold and fix a plurality of centrifuge tubes with volume ranging from 1.5ml to 2 ml.
9. The adjustable magnetic rack of claim 1, wherein the support frame is integrally formed.
10. The adjustable magnetic rack of claim 1, wherein the support frame has a length of 100mm, a height of 50mm, and a width of 50mm; the diameter of the top round hole is 15mm, the diameter of the bottom round hole is 2mm, the length of the vertical magnet plate channel is 100mm, the width of the vertical magnet plate channel is 5mm, and the height of the vertical magnet plate channel is 35mm; the inclined magnet plate channel is 100mm long, 5mm wide and 45mm high; the length of the magnet plate is 110mm, the thickness of the magnet plate is 5mm, and the height of the magnet plate is 35mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320624439.6U CN220300742U (en) | 2023-03-27 | 2023-03-27 | Adjustable magnetic frame |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320624439.6U CN220300742U (en) | 2023-03-27 | 2023-03-27 | Adjustable magnetic frame |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220300742U true CN220300742U (en) | 2024-01-05 |
Family
ID=89373941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320624439.6U Active CN220300742U (en) | 2023-03-27 | 2023-03-27 | Adjustable magnetic frame |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220300742U (en) |
-
2023
- 2023-03-27 CN CN202320624439.6U patent/CN220300742U/en active Active
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