CN212943472U

CN212943472U - Magnetic separation frame

Info

Publication number: CN212943472U
Application number: CN202020545091.8U
Authority: CN
Inventors: 姜冉; 潘鸿; 吴晓进
Original assignee: Suzhou Yujia Biomedical Technology Co ltd
Current assignee: Suzhou Yujia Biomedical Technology Co ltd
Priority date: 2020-04-14
Filing date: 2020-04-14
Publication date: 2021-04-13
Anticipated expiration: 2030-04-14

Abstract

The utility model relates to a magnetic separation frame, including first base and with the detachable magnetic part of first pedestal connection, a plurality of stands of first base fixedly connected with, detachable magnetic part include the second base and with the second base can be dismantled at least a set of magnetic unit of connection, the second base is just right first base sets up and with first base is parallel to each other, the stand with the connection can be dismantled to the second base, first base is equipped with the hole body that a plurality of confession centrifuging tubes passed, and every magnetic unit of group includes two magnetic boards that are parallel to each other, magnetic board with second base mutually perpendicular, be equipped with a plurality of depressed parts on the magnetic board, the depressed part is the arc setting and follows the direction of height of magnetic board extends.

Description

Magnetic separation frame

Technical Field

The utility model relates to a magnetic separation device especially relates to a magnetic separation frame.

Background

Magnetic separation techniques are increasingly used in cell biology, immunology, therapeutics, diagnostics, and pharmaceutical separations, such as protein and enzyme immobilization, immunoassays, RNA and DNA purification, cell separation, and drug carriers, among others. The magnetic separation frame is a magnetic separation device with simple structure and convenient use. In application, the biomagnetic separation technology of the nano magnetic particles is required to adsorb biomolecules with magnetic labels through an external magnetic field. When the centrifugal tube is used, a centrifugal tube containing a sample and magnetic materials is usually placed in a sample hole of a magnetic separation frame, the magnetic materials in the sample can be enriched on the tube wall close to one side of the magnetic separation frame under the action of an external magnetic field, and then liquid is sucked away by a liquid transfer device or an air suction pump to realize the separation of the magnetic materials and the liquid sample.

The magnetic separation plate of the existing magnetic separation rack product is generally connected with the separation rack, so that when an experimenter conducts separation of a plurality of samples at the same time, the experimenter needs to wash for a plurality of times after magnetic separation is finished every time, and the operation of moving a centrifuge tube to other test tube racks from the magnetic separation rack is continuously repeated during the operation of elution and the like, so that the inconvenience and the operation time of the operation process are increased. In addition, when the content of the magnetic substance in the sample to be separated is large, a large amount of magnetic material is concentrated on the tube wall close to one of the magnetic separation racks, so that the attraction force between part of the magnetic material and the tube wall is weak, and the loss of the magnetic material is easily caused in the process of removing the non-magnetic sample.

SUMMERY OF THE UTILITY MODEL

In order to solve the technical problem, the utility model aims at providing a magnetic separation frame, the utility model discloses a magnetic sheet in the magnetic separation frame can be dismantled, has increased the area of contact of magnetic sheet with the centrifuging tube, has reduced magnetic material's loss rate.

The utility model discloses a magnetic separation frame, including first base and the detachable magnetic part of being connected with first base, a plurality of stands of first base fixedly connected with, detachable magnetic part includes the second base and can dismantle at least a set of magnetic unit of being connected with the second base, the second base just sets up and is parallel to each other with first base to first base, the stand can be dismantled with the second base and be connected, first base is equipped with the hole body that a plurality of confession centrifuging tubes passed, every magnetic unit of group includes two magnetic boards that are parallel to each other, two magnetic boards are located the both sides of centrifuging tube respectively, magnetic board and second base mutually perpendicular, be equipped with a plurality of depressed parts on the magnetic board, the depressed part is coaxial with the centrifuging tube, the depressed part is the arc setting and extends along the direction of height of magnetic board.

Further, first base and second base are equipped with a plurality of spacing grooves respectively, and the magnetic board includes spacing groove connecting portion and panel portion, and spacing groove connecting portion are used for dismantling with the spacing groove and are connected, and panel portion's thickness is greater than the thickness of spacing groove connecting portion, and the depressed part is located panel portion.

Furthermore, the limiting groove is long-strip-shaped, and the connecting part of the limiting groove is matched with the limiting groove in shape.

Furthermore, the second base is provided with a plurality of upright post sleeves, the upright post sleeves are matched with the upright posts, and the upright post sleeves are arranged on the outer sides of the upright posts.

Furthermore, the upright post sleeve is in a barrel shape with a bottom and no cover.

Further, the second base is provided with a plurality of grooves which are just opposite to the hole body, and the grooves are used for abutting against the bottom of the centrifugal tube and are matched with the shape of the bottom of the centrifugal tube.

Further, a buffer pad is arranged in the groove.

Further, the number of the upright posts is 4.

Furthermore, the magnetic unit further comprises a connecting plate, and the two magnetic plates are connected through the connecting plate, and the connecting plate is perpendicular to the magnetic plate and the second base respectively.

Further, the magnetic unit is U-shaped.

Borrow by above-mentioned scheme, the utility model discloses at least, have following advantage:

the utility model discloses a set up a set of magnetic cell at least, including two magnetic boards that are parallel to each other in the magnetic cell, in the magnetic separation process, arrange the centrifuge tube in between two magnetic boards, and through set up the depressed part on the magnetic board, curved depressed part can be more around in the surface of centrifuge tube, increased the area of contact of magnetic plate and centrifuge tube for magnetic material is enriched firmly on being close to the pipe wall of magnetic board, has reduced magnetic material's loss rate. The above description is only an overview of the technical solution of the present invention, and in order to make the technical means of the present invention clearer and can be implemented according to the content of the description, the following detailed description is made with reference to the preferred embodiments of the present invention and accompanying drawings.

Drawings

Fig. 1 is a schematic structural view of a first base of the present invention;

fig. 2 is a schematic structural view of a second base of the present invention;

fig. 3 is a schematic structural diagram of the magnetic unit of the present invention;

1-a first base 1; 2-a limiting groove 2; 4-a second base 4; 10-a porous body 10; 11-upright 11; 30-connecting plate 30; 31- magnetic panel 31; 40-groove 40; 41-column sleeve 41; 310-limiting groove connection 310; 311-panel section 311; 312-recess 312.

Detailed Description

The following detailed description of the embodiments of the present invention is provided with reference to the accompanying drawings and examples. The following examples are intended to illustrate the invention, but are not intended to limit the scope of the invention.

Examples

Referring to the drawings, the present invention provides a magnetic separation rack, including a first base 1 and a detachable magnetic member connected to the first base 1, wherein 1 stand 11 is fixedly connected to four corners of the first base 1, the detachable magnetic member includes a second base 4 and at least one set of magnetic units detachably connected to the second base 4, the second base 4 is disposed over the first base 1 and parallel to the first base 1, and the stand 11 is detachably connected to the second base 4. Four corners of the second base 4 are respectively provided with 1 upright post sleeve 41, the upright post sleeve 41 is in a barrel shape with a bottom and without a cover, the upright post sleeve 41 is matched with the upright post 11, the upright post sleeve 41 is sleeved outside one end of the upright post 11, and the two are detachably connected.

First base 1 is equipped with a plurality of hole bodies 10 that supply the centrifuging tube to pass, and second base 4 is equipped with a plurality of recesses 40 that just set up hole body 10, is equipped with the blotter in the recess 40, and recess 40 is used for conflicting and the shape looks adaptation with the bottom of centrifuging tube.

Each group of magnetic units is U-shaped and specifically comprises two magnetic plates 31 and a connecting plate 30 which are parallel to each other, the two magnetic plates 31 are connected through the connecting plate 30, and the connecting plate 30 is perpendicular to the magnetic plate 31 and the second base 4 respectively. Two magnetic boards 31 are located the both sides of centrifuging tube respectively, magnetic board 31 and second base 4 mutually perpendicular, are equipped with a plurality of depressed parts 312 on the magnetic board 31, and depressed part 312 is coaxial with the centrifuging tube, and depressed part 312 is the arc setting and extends along the direction of height of magnetic board 31. First base 1 and second base 4 are equipped with a plurality of spacing grooves 2 respectively, and magnetic board 31 includes spacing groove connecting portion 310 and panel portion 311, and spacing groove connecting portion 310 is used for dismantling with spacing groove 2 and is connected, and panel portion 311's thickness is greater than the thickness of spacing groove connecting portion 310, and depressed part 312 is located panel portion 311. The limiting groove 2 is in a long strip shape, and the limiting groove connecting part 310 is matched with the limiting groove 2 in shape.

Use the utility model discloses the time, slide spacing groove connecting portion 310 with the magnetic unit lower part along spacing groove 2 on second base 4, make the magnetic unit install on second base 4, install stand 11 of first base 1 in stand cover 41 of second base 4 again, guarantee spacing groove 2 of first base 1 and spacing groove connecting portion 310 joint on magnetic unit upper portion simultaneously, accomplish the equipment of magnetic separation frame. When magnetic separation is performed, the centrifuge tube is inserted into the porous body 10 to make the bottom of the centrifuge tube abut against the groove 40, two magnetic plates 31 in the magnetic unit are respectively located at two sides of the centrifuge tube, and the recess 312 on the magnetic plate 31 is coaxial with the centrifuge tube. Magnetic substances in a sample to be separated in the centrifugal tube are enriched on the inner wall of the centrifugal tube close to the magnetic plate 31 under the action of magnetic force, and then a non-magnetic sample is sucked by a suction tube, so that the magnetic separation of the sample is completed. Then, the upright post 11 is taken out from the upright post sleeve 41 along the height direction, and the centrifuge tube on the first base 1 is supported by the upright post 11, so that subsequent washing and other operations can be performed.

The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, it should be noted that, for those skilled in the art, a plurality of modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.

Claims

1. A magnetic separation rack, characterized in that: including first base and with the detachable magnetic part that first base is connected, a plurality of stands of first base fixedly connected with, detachable magnetic part include the second base and with the second base can dismantle at least a set of magnetic unit of connection, the second base is just right first base sets up and with first base is parallel to each other, the stand with the connection can be dismantled to the second base, first base is equipped with the hole body that a plurality of confession centrifuging tubes passed, and every magnetic unit of group includes two magnetic boards that are parallel to each other, magnetic board with second base mutually perpendicular, be equipped with a plurality of depressed parts on the magnetic board, the depressed part is the arc setting and follows the direction of height of magnetic board extends.

2. The magnetic separation rack of claim 1, wherein: first base and second base are equipped with a plurality of spacing grooves respectively, the magnetic board includes spacing groove connecting portion and panel portion, spacing groove connecting portion be used for with the connection can be dismantled in the spacing groove, the thickness of panel portion is greater than the thickness of spacing groove connecting portion, the depressed part is located on the panel portion.

3. The magnetic separation rack of claim 2, wherein: the limiting groove is long-strip-shaped, and the limiting groove connecting part is matched with the limiting groove in shape.

4. The magnetic separation rack of claim 1, wherein: the second base is provided with a plurality of upright post sleeves, the upright post sleeves are matched with the upright posts, and the upright post sleeves are arranged on the outer sides of the upright posts.

5. The magnetic separation rack of claim 4, wherein: the upright post sleeve is in a barrel shape with a bottom and no cover.

6. The magnetic separation rack of claim 1, wherein: the second base is provided with a plurality of grooves which are right opposite to the hole body, and the grooves are used for abutting against the bottom of the centrifugal tube and are matched with the shape of the bottom of the centrifugal tube.

7. The magnetic separation rack of claim 6, wherein: and a buffer pad is arranged in the groove.

8. The magnetic separation rack of claim 1, wherein: the number of the upright posts is 4.

9. The magnetic separation rack of claim 1, wherein: the magnetic unit further comprises a connecting plate through which the two magnetic plates are connected, the connecting plate being perpendicular to the magnetic plate and the second base, respectively.

10. A magnetic separation rack according to claim 9 wherein: the magnetic unit is U-shaped.