CN202277894U - Combined type magnetic separation device - Google Patents
Combined type magnetic separation device Download PDFInfo
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- CN202277894U CN202277894U CN2011202720742U CN201120272074U CN202277894U CN 202277894 U CN202277894 U CN 202277894U CN 2011202720742 U CN2011202720742 U CN 2011202720742U CN 201120272074 U CN201120272074 U CN 201120272074U CN 202277894 U CN202277894 U CN 202277894U
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- centrifuge tube
- magnet
- jack
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Abstract
The utility model discloses a combined type magnetic separation device. The device comprises seven ferromagnetic permanent magnets, an underframe, 1.5mL and 2mL centrifuge tube insertion holes, grooves, a 50mL centrifuge tube insertion holes, a 15mL centrifuge tube insertion hole and a lining plate with a 0.5mL centrifuge tube insertion hole. The front upper surface of the underframe is provided with seven grooves matched with the seven ferromagnetic permanent magnets; the magnetic permanent magnets are inserted into the grooves to form a platform suitable for a 96-pore plate; through the seven ferromagnetic permanent magnets, all holes of the 96-pore plate can be closely attached to a magnet after moving for a pore position; and multiple insertion holes suitable for 1.5mL and 2mL centrifuge tubes are arranged among the grooves. The combined type magnetic separation device disclosed by the utility model can use the tube rack thereof or be conveniently matched with an external tube rack, is convenient to use, has a simple structure and can be applied to the magnetic bead separation of different quantities of macromolecules and cells in various biological or medical laboratories.
Description
Technical field
The utility model belongs to bio-separation device technique field, more specifically, relates to a kind of magnetic of utilizing and carries out biological sample separator technical field.
Background technology
It is to add sample separation with the nanoscale magnetic bead of sample specific bond that paramagnetic particle method separates; Magnetic bead is combined with sample; Under the effect of magnetic field, be adsorbed on chamber wall or the bar magnet then; Can be very simply and solution separating, with specific elute soln target molecule is eluted to from magnetic bead again and promptly obtains product solution the solution.The paramagnetic particle method isolation technics is tending towards extensive and universal in the application of purifying biological molecule, cell drug molecule etc.Compare with centrifugal process, ion-exchange, chemical purification method commonly used, simple, convenient, and non-corrosiveness and toxic agent, safer.
Present equipment for magnetic separation is divided into craft and automation is used.It is main that the equipment for magnetic separation that automation is used is suitable for 96 orifice plates; Manual operations is main with various centrifuge tube shelfs.Main mode is that the permanent magnet fixed packet is embedded in the pipe support.Most equipment for magnetic separation only are applicable to a kind of centrifuge tube of specification, also have the minority pipe support to adopt the Combination Design that is fit to several kinds of centrifuge tubes.But, can not realize high flux experiment use not with the design of various centrifuge tube shelfs and the integration of 96 orifice plates.Automation magnetic force separator also can be used for 96 orifice plates hand-manipulated, but costs an arm and a leg, and the well-to-do inadequately laboratory of funds can not adopted usually.If if use the non-centrifuge tube shelf that carries in addition, need be between pipe support and underframe the repeated moving centrifuge tube, complex operation.The separable pipe support that has design to be used with magnetic force base, but also need the pipe support of particular design.
Summary of the invention
Only be applicable to a kind of centrifuge tube of or minority specification or the defective of porous plate to existing equipment for magnetic separation; The utility model provides a kind of combined type magnetic separator; Simple in structure, be applicable to from the equipment for magnetic separation of 0.5 to the 50mL various centrifuge tubes, 96 orifice plates and the non-external pipe support that do not wait simultaneously, realize that the high flux experiment uses.
The utility model takes following technical scheme to realize: around permanent magnet, the centrifuge tube of different size, the jack and the grillage of 96 orifice plates are incorporated on the separator frame; Reserve the space that cooperates with external pipe support simultaneously, and permanent magnet can be dismantled simply and easily also, and the pipe support arbitrary combination of processing with magnetisable material, to reach the purpose that is used with external pipe support.
The utility model provides a kind of combined type magnetic separator, comprises that the liner plate of seven strong magnetic permanent-magnet, underframe, 1.5mL, 2mL centrifuge tube jack, groove, 50mL centrifuge tube jack, 15mL centrifuge tube jack and band 0.5mL centrifuge tube jack is formed.Wherein, underframe just above be provided with the grooves that seven roads and seven strong magnetic permanent-magnet are fit to, after the magnetic permanent magnet inserts groove, constitute the platform that is applicable to 96 orifice plates; Seven strong magnetic permanent-magnet can make 96 orifice plates at mobile Kong Weihou all holes all are close on the magnet; It between the groove jack of a plurality of suitable 1.5mL, 2mL centrifuge tube; The little jack of bottom portion of groove is when putting into 1.5mL, 2mL centrifuge tube; Can be used as the bottom jack of centrifuge tube, be applicable to the 0.5mL centrifuge tube simultaneously, separator is inverted is used the 0.5mL centrifuge tube; 1.5mL, the position of 2mL centrifuge tube and 0.5mL centrifuge tube jack is in the middle of two grooves, but presses close to the 1st, 3,5,7 road grooves; Two sides of separator are respectively the jacks of a plurality of suitable 15mL and 50mL centrifuge tube, and liner plate is close in the position of jack, and the magnetic field intensity of each centrifuge tube both sides has maximum difference like this, is convenient to separate magnetic bead.
In the utility model, two sides of separator are respectively the jacks of a plurality of suitable 15mL and 50mL centrifuge tube, and liner plate is close in the position of jack, with to greatest extent near magnet; Also can be apart from the distance of a magnet thickness of liner plate, can take off magnet and be attached on the liner plate this moment from slot, make centrifuge tube more closely touch magnet.
In the utility model, every magnet itself also can be spliced by the littler magnet absorption of polylith, and this can increase application flexibility, and underframe can adopt iron or other magnetisable material.
Use the beneficial effect of the utility model:
The combined type magnetic separator that uses the utility model to provide; Simple in structure, be applicable to the equipment for magnetic separation of various centrifuge tubes, 96 orifice plates and non-external pipe support simultaneously; Realize that magnet freely takes out, reduce acquisition cost, easily with different size pipe support independent assortment; With the design of various centrifuge tube shelfs and the integration of 96 orifice plates, realize high flux experiment use.
Description of drawings
Fig. 1 is the utility model equipment for magnetic separation structural representation.
Fig. 2 is the occupation mode figure that the utility model cooperates 96 orifice plates.
Fig. 3 is the occupation mode figure that the utility model cooperates 15mL and 50mL centrifuge tube.
Fig. 4 is the occupation mode figure that the utility model cooperates 1.5mL and 0.5mL centrifuge tube.
Fig. 5 is first kind of mode figure that the utility model and external centrifuge tube shelf are used.
Fig. 6 is the second way figure that the utility model and external centrifuge tube shelf are used.
Among Fig. 1 to Fig. 6,1-ferromagnetism permanent magnet; 2-is a underframe; 3-groove (magnet slot); 4-1.5mL, 2mL centrifuge tube jack; The 5-liner plate; 6-0.5mL centrifuge tube jack; 7-50mL centrifuge tube jack; 8-15mL centrifuge tube jack; The 9-96 orifice plate; The 10-15mL centrifuge tube; The 11-50mL centrifuge tube; 12-1.5mL centrifuge tube; 13-0.5mL centrifuge tube; 14-is inserting the external centrifuge tube shelf of centrifuge tube; 15-is inserted with the external pipe support of centrifuge tube.
The specific embodiment
Below in conjunction with accompanying drawing and embodiment, the utility model is done detailed description further.
Shown in accompanying drawing 1; The utility model provides a kind of combined type magnetic separator, comprises that the liner plate (5) of seven strong magnetic permanent-magnet (1), underframe (2), 1.5mL, 2mL centrifuge tube jack (4), groove (3), 50mL centrifuge tube jack (7), 15mL centrifuge tube jack (8) and band 0.5mL centrifuge tube jack (6) is formed.Wherein, underframe (2) just above be provided with the groove (3) that seven roads and seven strong magnetic permanent-magnet (1) are fit to, after strong magnetic permanent-magnet (1) is inserted groove (3), constitute the platform that is applicable to 96 orifice plates (9); Seven strong magnetic permanent-magnet (1) can make 96 orifice plates (9) mobile hole position successor all holes all are close on the magnet; Between the groove (3) a plurality of suitable 1.5mL, 2mL centrifuge tube jack (4); The little jack of groove (3) bottom is when putting into 1.5mL, 2mL centrifuge tube; Can be used as the bottom jack of centrifuge tube, be applicable to the 0.5mL centrifuge tube simultaneously, separator is inverted is used the 0.5mL centrifuge tube; 1.5mL, the position of 2mL centrifuge tube jack (4) and 0.5mL centrifuge tube jack (6) is in the middle of two grooves (3), but presses close to the 1st, 3,5,7 road grooves (3); Two sides of separator are respectively the jacks (7,8) of a plurality of suitable 15mL and 50mL centrifuge tube, and liner plate (5) is close in the position of jack, and the magnetic field intensity of each centrifuge tube both sides has maximum difference like this, is convenient to separate magnetic bead.
In the utility model, two sides of separator are respectively the jacks (7,8) of a plurality of suitable 15mL and 50mL centrifuge tube, and liner plate (5) is close in the position of jack, with to greatest extent near magnet; Also can be apart from the distance of (5) magnet thicknesses of liner plate, can take off magnet and be attached on the liner plate (5) this moment from slot, make centrifuge tube more closely touch magnet.
In the utility model, every magnet itself also can be spliced by the littler magnet absorption of polylith, and this can increase application flexibility, and underframe can adopt iron or other magnetisable material.
Referring to accompanying drawing 2, the utility model cooperates the occupation mode of 96 orifice plates (9): underframe (2) just above be the groove (3) that seven roads and strong magnetic permanent-magnet (1) are fit to, after strong magnetic permanent-magnet (1) is inserted groove (3), constitute the platform that is applicable to 96 orifice plates (9); 96 orifice plates (9) place on the platform, and each hole wall closely contacts with a strong magnetic permanent-magnet (1), and contact point forms high-intensity magnetic field, and magnetic bead is adsorbed on sidewall, be convenient to pipette to conveniently remove solution.When needs cleaned magnetic bead, 96 orifice plates (9) moved back and forth to the left or to the right, and each hole contacts with magnet in the both sides of hole wall in succession, and magnetic bead reaches the purpose of cleaning magnetic bead because of changes of magnetic field moves back and forth between relative hole wall.Another kind of cleaning way is: magnet is taken out in groove (3), move in the above and below of 96 orifice plates (9), magnetic bead is moved up and down in liquid, also can reach the purpose of cleaning.
Referring to accompanying drawing 3; The utility model cooperates the occupation mode of 15mL and 50mL centrifuge tube (10,11): with underframe (2) side; The direction that has a required jack upwards, will corresponding 50 or 15mL centrifuge tube (10,11) insert jack (7,8), tube wall can be close on the interior strong magnetic permanent-magnet (1) of slot; Thereby magnetic bead is adsorbed onto sidewall, makes things convenient for removing of liquid.
Referring to accompanying drawing 4, the utility model cooperates the occupation mode of 1.5mL and 0.5mL centrifuge tube (12,13): underframe (2) is just put, whenever inserted a strong magnetic permanent-magnet (1) at a distance from a groove (3); 1.5mL, 2mL centrifuge tube jack (4) are inserted jack 4, can make magnetic bead be adsorbed on sidewall, with separating liquid.During magnetic bead in needs clean a plurality of centrifuge tubes, can take off strong magnetic permanent-magnet (1), move, magnetic bead is moved up and down in pipe, reach the purpose of cleaning, and need centrifuge tube not shaken one by one in the above and below of centrifuge tube.Above-mentioned underframe (2) is inverted, can 0.5mL centrifuge tube (13) be inserted the jack of liner plate (5), all the other operate same 1.5mL, 2mL centrifuge tube jack (4).
Referring to accompanying drawing 5; First kind of mode that the utility model and external centrifuge tube shelf (14) are used: underframe (2) is inverted; Strong magnetic permanent-magnet (1) is adsorbed on the inboard or the outside of sidewall, and external centrifuge tube shelf (14) is placed on the position of being close to strong magnetic permanent-magnet (1).In this mode, the position of strong magnetic permanent-magnet (1) can be adjusted arbitrarily, to reach optimum adsorption effect.Adsorb strong magnetic permanent-magnet (1) respectively at two sidewalls, can centrifuge tube shelf be moved back and forth between two sidewalls, can clean the magnetic bead in a plurality of centrifuge tubes so simultaneously and need not shake centrifuge tube.
Referring to accompanying drawing 6; The second way that the utility model and external centrifuge tube shelf (15) are used: with underframe (2) side; The strong magnetic permanent-magnet (1) that be inserted in the groove (3) this moment is edge-on; Place the outside of underframe or position that inboard be close to strong magnetic permanent-magnet (1) with centrifuge tube shelf (15) this moment, and the magnetic bead in the pipe can be adsorbed onto tube wall, arrives the purpose of separating liquid.
As stated, can realize the utility model preferably.
Claims (1)
1. combined type magnetic separator; The liner plate that comprises seven strong magnetic permanent-magnet, underframe, 1.5mL, 2mL centrifuge tube jack, groove, 50mL centrifuge tube jack, 15mL centrifuge tube jack and band 0.5mL centrifuge tube jack is formed; It is characterized in that; Described underframe just above be provided with the grooves that seven roads and seven strong magnetic permanent-magnet are fit to, after the magnetic permanent magnet inserts groove, constitute the platform that is applicable to 96 orifice plates; Seven strong magnetic permanent-magnet can make 96 orifice plates at mobile Kong Weihou all holes all are close on the magnet; It between the groove jack of a plurality of suitable 1.5mL, 2mL centrifuge tube; The little jack of bottom portion of groove is when putting into 1.5mL, 2mL centrifuge tube; Can be used as the bottom jack of centrifuge tube, be applicable to the 0.5mL centrifuge tube simultaneously, separator is inverted is used the 0.5mL centrifuge tube; 1.5mL, the position of 2mL centrifuge tube and 0.5mL centrifuge tube jack is in the middle of two grooves, but presses close to the 1st, 3,5,7 road grooves; Two sides of separator are respectively the jacks of a plurality of suitable 15mL and 50mL centrifuge tube, and liner plate is close in the position of jack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202720742U CN202277894U (en) | 2011-07-29 | 2011-07-29 | Combined type magnetic separation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202720742U CN202277894U (en) | 2011-07-29 | 2011-07-29 | Combined type magnetic separation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202277894U true CN202277894U (en) | 2012-06-20 |
Family
ID=46224080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011202720742U Expired - Fee Related CN202277894U (en) | 2011-07-29 | 2011-07-29 | Combined type magnetic separation device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202277894U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104043491A (en) * | 2013-03-13 | 2014-09-17 | 精浚科技股份有限公司 | Suction/injection pipe and nucleic acid purification device |
| CN106190827A (en) * | 2015-05-07 | 2016-12-07 | 深圳华大基因科技服务有限公司 | For separating magnetic frame and the centrifuge tube of biological sample and separating apparatus |
| CN106399093A (en) * | 2016-12-02 | 2017-02-15 | 上海默里科基因科技有限公司 | Method and device for extracting biological molecules by virtue of magnetic beads |
| CN108818419A (en) * | 2018-08-06 | 2018-11-16 | 东晶电子金华有限公司 | Magnet dismounts tooling |
-
2011
- 2011-07-29 CN CN2011202720742U patent/CN202277894U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104043491A (en) * | 2013-03-13 | 2014-09-17 | 精浚科技股份有限公司 | Suction/injection pipe and nucleic acid purification device |
| CN104043491B (en) * | 2013-03-13 | 2016-08-10 | 精浚科技股份有限公司 | Suction pipe fitting |
| CN106190827A (en) * | 2015-05-07 | 2016-12-07 | 深圳华大基因科技服务有限公司 | For separating magnetic frame and the centrifuge tube of biological sample and separating apparatus |
| CN106399093A (en) * | 2016-12-02 | 2017-02-15 | 上海默里科基因科技有限公司 | Method and device for extracting biological molecules by virtue of magnetic beads |
| CN108818419A (en) * | 2018-08-06 | 2018-11-16 | 东晶电子金华有限公司 | Magnet dismounts tooling |
| CN108818419B (en) * | 2018-08-06 | 2023-12-01 | 东晶电子金华有限公司 | Magnet disassembly and assembly tool |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120620 Termination date: 20200729 |