CN220597414U

CN220597414U - Magnetic rack

Info

Publication number: CN220597414U
Application number: CN202321360134.5U
Authority: CN
Inventors: 陈君娇; 王佳敏; 李猛; 夏龚杰
Original assignee: Shanghai Wanzijian Biotechnology Co ltd
Current assignee: Shanghai Wanzijian Biotechnology Co ltd
Priority date: 2023-05-31
Filing date: 2023-05-31
Publication date: 2024-03-15
Anticipated expiration: 2033-05-31

Abstract

The utility model relates to the technical field of in-vitro diagnosis, in particular to a magnetic frame, which comprises: the main frame body is provided with a front side surface and a rear side surface which are opposite; the elastic clamping piece is arranged at the upper end part of the front side surface of the main frame body and can clamp and fix a plurality of reagent tubes with different specifications; the first magnetic force absorbing part is arranged on the front side surface of the main frame body and is positioned below the elastic clamping part; the first magnetic force adsorption piece provides a magnetic field, so that magnetic beads in the reagent tube can be adsorbed on the tube wall of the reagent tube. The reagent tube is fixed by adopting the elastic clamping piece, the reagent tubes with different specifications can be effectively fixed by the elastic clamping of the elastic clamping piece, the operation is convenient, the problem that a single magnetic rack can only be adapted to a single specification reagent tube in the prior art is effectively solved, and the suitability of the single magnetic rack to the reagent tubes with different specifications is improved.

Description

Magnetic rack

Technical Field

The utility model relates to the technical field of in-vitro diagnosis, in particular to a magnetic frame.

Background

Magnetic beads have unique advantages in biological analysis and separation of proteins, nucleic acids, antibodies and cells, and have been widely used in the field of In Vitro Diagnostics (IVD), magnetic separation being one of the important links. The magnetic separation technology is to make the magnetic beads separate from the non-magnetic substances by means of the magnetic field to make the magnetic beads gather and adsorb the specific substances on the surfaces of the particles under the action of the external magnetic field, so as to capture the substances specifically combined on the surfaces of the magnetic beads and achieve the aim of purification. The magnetic separation method mainly comprises the steps of placing a reagent tube on a magnetic rack, arranging a magnetic absorption part on a main body rack of the magnetic rack, separating magnetic beads in the reagent tube from other sample solutions through the magnetic force of the magnetic absorption part, and then sucking away the liquid by using a pipette.

The existing magnetic rack is used for separating biological small samples, the magnetic rack is relatively simple for large-volume samples of 10mL, 15mL and 50mL, the problem that the separation effect is reduced due to insufficient adaptation precision of a reagent tube placement position and limited adsorption capacity of a single adsorption plate strip to the bottom is solved, and particularly, the single magnetic rack is limited by magnet arrangement and non-uniform shape of the bottom of the reagent tube, and only adaptation of the reagent tube with single specification can be realized, so that a plurality of magnetic racks with different specifications are needed to be prepared for completing experiments in some practical operations.

Disclosure of Invention

In view of the above-mentioned drawbacks of the prior art, the present utility model is to provide a magnetic rack capable of adapting to a plurality of reagent tubes with different specifications.

In order to solve the technical problems, the utility model adopts the following technical scheme:

the utility model provides a magnetic frame, comprising: the main frame body is provided with a front side surface and a rear side surface which are opposite; the elastic clamping piece is arranged at the upper end part of the front side surface of the main frame body and can clamp and fix a plurality of reagent tubes with different specifications; the first magnetic force absorbing part is arranged on the front side surface of the main frame body and is positioned below the elastic clamping part; the first magnetic force adsorption piece provides a magnetic field, so that magnetic beads in the reagent tube can be adsorbed on the tube wall of the reagent tube.

Preferably, the method further comprises: a base extending forward from a lower end of a front side of the main frame; the second magnetic force absorbing part is arranged on the upper surface of the base and is positioned below the elastic clamping part; the second magnetic force absorbing part provides a magnetic field to enable the magnetic beads in the reagent tube to be absorbed at the bottom of the reagent tube.

Preferably, a plurality of elastic clamping pieces are arranged on the front side surface of the main frame body along the left-right direction, and a first magnetic force absorbing piece and a second magnetic force absorbing piece are correspondingly arranged below each elastic clamping piece.

Preferably, the front end of the second magnetic force absorbing part is provided with an elastic telescopic part, and the elastic telescopic part is used for elastically pressing and fixing the lower end part of the reagent tube.

Preferably, the elastic clamping piece comprises a connecting piece, elastic clamping pieces and anti-slip rollers, the connecting piece is attached to the front side face of the main frame body, the left side and the right side of the connecting piece are respectively provided with the elastic clamping pieces in a forward extending mode, the front ends of the two elastic clamping pieces are respectively provided with the anti-slip rollers, and the two elastic clamping pieces and the two anti-slip rollers jointly clamp and fix the reagent tube and support the reagent tube to the first magnetic absorption piece.

Preferably, the elastic clamping member is detachably connected with the main frame body.

Preferably, the left side surface and the right side surface of the main frame body are respectively provided with a clamping groove and a clamping block, and the clamping groove on one main frame body is matched with the clamping block on the other main frame body in a clamping way.

Preferably, a bracket is provided on the rear side of the main frame body, and the bracket is used for supporting the main frame body when the main frame body is inclined backward.

Preferably, the bracket is hinged to the rear side of the main frame body and is swingable in the front-rear direction with respect to the main frame body.

Preferably, the maximum inclination angle of the stand supporting the main frame body to be inclined backward is 60 °.

Compared with the prior art, the utility model has obvious progress:

according to the magnetic rack, the reagent tubes are clamped and fixed by the elastic clamping pieces, and the reagent tubes with different specifications can be effectively fixed by the elastic clamping pieces.

Drawings

Fig. 1 is a schematic structural view of a first implementation of a magnetic stand according to an embodiment of the present utility model.

Fig. 2 is a rear view of the magnetic stand shown in fig. 1.

Fig. 3 is a schematic structural view of a second implementation of the magnetic stand according to the embodiment of the present utility model.

Fig. 4 is a schematic structural view of a third implementation of the magnetic stand according to the embodiment of the present utility model.

Fig. 5 is a schematic structural view of a fourth implementation of the magnetic stand according to the embodiment of the present utility model.

Wherein reference numerals are as follows:

1. main frame body

2. Elastic clamping piece

21. Connecting sheet

22. Elastic clamping piece

23. Anti-skid roller

3. First magnetic force absorbing piece

4. Base seat

5. Second magnetic force absorbing piece

6. Clamping groove

7. Clamping block

8. Support frame

9. Screw bolt

10. Reagent tube

Detailed Description

The following describes embodiments of the present utility model in further detail with reference to fig. 1 to 5. These embodiments are merely illustrative of the present utility model and are not intended to be limiting.

In the description of the present utility model, it should be noted that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present utility model and simplifying the description, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

Furthermore, in the description of the present utility model, unless otherwise indicated, the meaning of "a plurality" is two or more.

In the description of the present utility model, the "front" side is defined as the inner side of the paper of fig. 2, the "rear" side is defined as the outer side of the paper of fig. 2, the "left" side is defined as the right side of the paper of fig. 2, the "right" side is defined as the left side of the paper of fig. 2, the "upper" side is defined as the upper side of the paper of fig. 2, and the "lower" side is defined as the lower side of the paper of fig. 2.

Referring to fig. 1 to 5, the magnetic stand of the embodiment of the present utility model includes a main stand body 1, an elastic clamping member 2, and a first magnetic adsorbing member 3. The main frame body 1 has opposite front and rear sides. The elastic clamping piece 2 is arranged at the upper end part of the front side surface of the main frame body 1, and the elastic clamping piece 2 can clamp and fix the reagent tubes 10 with various different specifications. The first magnetic force absorbing part 3 is fixedly arranged on the front side surface of the main frame body 1, and the first magnetic force absorbing part 3 is positioned below the elastic clamping part 2. The reagent vessel 10 containing the magnetic beads and the reagent to be separated is held and fixed on the front side of the first magnetic adsorbing member 3 by the elastic clamping member 2. The first magnetic force absorbing part 3 provides a magnetic field, so that magnetic beads in the reagent tube 10 can be absorbed on the wall of the reagent tube 10, and the separation of the magnetic beads is realized.

The magnetic force frame of this embodiment adopts the fixed reagent pipe 10 of elastic clamping piece 2 centre gripping, through the elastic clamping of elastic clamping piece 2, can realize effectively fixing the reagent pipe 10 of different specifications, and convenient operation has effectively solved the problem that single magnetic force frame only can adapt to single specification reagent pipe among the prior art, has improved the suitability of single magnetic force frame to multiple different specification type reagent pipe 10.

The magnetic field provided by the first magnetic force absorbing member 3 absorbs magnetic beads around the wall of the reagent tube 10, and the magnetic bead absorbing capacity of the tube bottom of the reagent tube 10 is limited, so as to ensure that the magnetic force frame of the embodiment can absorb magnetic beads of the tube bottom of reagent tubes 10 with different shapes when being applicable to a plurality of reagent tubes 10 with different specifications, preferably, the magnetic force frame of the embodiment further comprises a base 4 and a second magnetic force absorbing member 5. The base 4 extends forward from the lower end of the front side of the main frame 1, and in this embodiment, the base 4 extends forward from the lower end of the front side of the main frame 1 and forms an L-shape with the main frame 1. Preferably, the base 4 is an integral piece with the main frame 1. The second magnetic force absorbing member 5 is fixedly arranged on the upper surface of the base 4, and the second magnetic force absorbing member 5 is positioned below the elastic clamping member 2. Thus, when the reagent vessel 10 is held and fixed by the elastic clamping member 2, the vessel wall of the reagent vessel 10 is positioned at the front side of the first magnetic adsorbing member 3, and the vessel bottom of the reagent vessel 10 is positioned above the second magnetic adsorbing member 5. The second magnetic force absorbing member 5 provides a magnetic field so that the magnetic beads in the reagent vessel 10 can be absorbed at the bottom of the reagent vessel 10. The magnetic beads at the bottom of the reagent tube 10 are adsorbed by the second magnetic adsorption piece 5, so that the magnetic bead adsorption loss caused by different shapes of the bottom of the reagent tube 10 of different specifications can be effectively reduced, and the optimal magnetic separation effect can be achieved by the first magnetic adsorption piece 3 and the second magnetic adsorption piece 5 which are matched to jointly adsorb the magnetic beads.

In this embodiment, the first magnetic force absorbing member 3 and the second magnetic force absorbing member 5 preferably use N52 permanent magnets.

Further, the front end of the second magnetic force absorbing member 5 is provided with an elastic telescopic member (not shown in the figure) for elastically pressing and fixing the lower end of the reagent vessel 10 to further fix the lower end of the reagent vessel 10. The form of the elastic expansion member is not limited, and preferably the elastic expansion member is elastically expandable and contractible in the front-rear direction, so that elastic pressure can be applied to the front side of the reagent vessel 10 toward the lower end portion of the reagent vessel 10, and the lower end portion of the reagent vessel 10 is pressed and fixed toward the first magnetic adsorbing member 3.

Preferably, in the magnetic stand of the present embodiment, a plurality of elastic clamping members 2 are arranged on the front side surface of the main stand body 1 along the left-right direction, and a first magnetic absorption member 3 and a second magnetic absorption member 5 are correspondingly arranged below each elastic clamping member 2. Whereby magnetic separation of the magnetic beads of the plurality of reagent tubes 10 can be performed simultaneously. The number of the elastic clamping members 2 provided on the single main frame body 1 is not limited, and for example, as shown in fig. 1 and 5, in one embodiment, two elastic clamping members 2 are provided on the single main frame body 1, and accordingly, the first magnetic force absorbing member 3 and the second magnetic force absorbing member 5 are provided two and are provided in one-to-one correspondence with the two elastic clamping members 2; as shown in fig. 3, in another embodiment, four elastic clamping pieces 2 are provided on a single main frame body 1, and correspondingly, four first magnetic force absorbing pieces 3 and four second magnetic force absorbing pieces 5 are provided and are arranged in a one-to-one correspondence with the four elastic clamping pieces 2; as shown in fig. 4, in still another embodiment, eight elastic clamping members 2 are provided on a single main frame body 1, and accordingly, the first magnetic force absorbing member 3 and the second magnetic force absorbing member 5 are provided with eight and are disposed in one-to-one correspondence with the eight elastic clamping members 2.

In this embodiment, preferably, the elastic clamping member 2 includes a connecting piece 21, elastic clamping pieces 22 and anti-slip rollers 23, the connecting piece 21 is attached to the front side of the main frame 1, the left and right sides of the connecting piece 21 respectively extend forward to form an elastic clamping piece 22, the front ends of the two elastic clamping pieces 22 are respectively provided with an anti-slip roller 23, and the two elastic clamping pieces 22 and the two anti-slip rollers 23 jointly clamp and fix the reagent tube 10 and support against the first magnetic adsorption member 3. The anti-slip roller 23 is preferably an anti-slip pulsator roller. Through the combined action of the elastic clamping piece 22 and the anti-slip roller 23, the reagent tube 10 with different specifications can be effectively clamped and fixed, and the reagent tube 10 with multiple specifications can be more firmly adapted. Meanwhile, the front end of the elastic clamping piece 22 is provided with an anti-skid roller 23, so that the scratch on the outer surface of the reagent tube 10 can be reduced.

In this embodiment, preferably, the elastic clamping member 2 is detachably connected with the main frame body 1. Preferably, the connecting piece 21 of the elastic clamping piece 2 is detachably connected with the main frame body 1 through the screw 9. Therefore, the magnetic rack of the embodiment can be matched with elastic clamping pieces 2 with various specifications, the elastic clamping pieces 2 with different specifications can clamp and fix the reagent tube 10 with different specifications, for example, the elastic clamping piece 2 with one specification can clamp and fix the reagent tube 10 with the diameter within the range of 15cm-30cm, and can better adapt to the reagent tube 10 with larger specification; the elastic clamping piece 2 with the other specification can clamp the fixed reagent tube 10 with the diameter ranging from 10cm to 15cm, and can be better matched with the reagent tube 10 with the smaller specification. Thus, the magnetic rack of the present embodiment can be well adapted to various specifications of reagent tubes 10.

Referring to fig. 5, in a preferred embodiment, the left and right sides of the main frame 1 are respectively provided with a clamping groove 6 and a clamping block 7, and the clamping groove 6 on one main frame 1 is matched with the clamping block 7 on the other main frame 1 in a clamping manner, so that the two main frames 1 are engaged and fixed. Therefore, the plurality of main frame bodies 1 can be spliced or split in sequence, and the length of the magnetic frame can be adjusted according to actual requirements.

In the magnetic stand of the present embodiment, preferably, a bracket 8 is provided on the rear side of the main stand 1, the bracket 8 being for supporting the main stand 1 when the main stand 1 is tilted backward. Therefore, the magnetic frame of the embodiment can humanized incline the main frame body 1 when in use, and the main frame body 1 is inclined backwards in the magnetic separation stage, so that the reagent tube 10 is inclined towards the direction of being attached to the first magnetic absorption piece 3, and the separation efficiency can be effectively improved.

Further, the bracket 8 is hinged to the rear side surface of the main frame body 1 and is swingable in the front-rear direction with respect to the main frame body 1. Therefore, the bracket 8 can be optionally retracted and released according to the experimental operation requirement, the operation is very simple and convenient, and in the magnetic separation stage, the bracket 8 swings backwards relative to the main frame body 1 so as to support the main frame body 1 to incline backwards; during the washing stage, the support 8 swings forward and retracts relative to the main frame body 1 so as to facilitate the sample adding of the reagent tube 10.

In the present embodiment, the maximum inclination angle at which the stand 8 supports the main frame body 1 to be inclined rearward is preferably 60 °.

The foregoing is merely a preferred embodiment of the present utility model, and it should be noted that modifications and substitutions can be made by those skilled in the art without departing from the technical principles of the present utility model, and these modifications and substitutions should also be considered as being within the scope of the present utility model.

Claims

1. A magnetic stand, comprising:

a main frame body (1) having opposite front and rear sides;

the elastic clamping piece (2) is arranged at the upper end part of the front side surface of the main frame body (1), and the elastic clamping piece (2) can clamp and fix a plurality of reagent tubes (10) with different specifications;

the first magnetic force absorbing part (3) is arranged on the front side surface of the main frame body (1) and is positioned below the elastic clamping part (2);

the first magnetic force absorbing part (3) provides a magnetic field, so that magnetic beads in the reagent tube (10) can be absorbed on the tube wall of the reagent tube (10).

2. The magnetic rack of claim 1, further comprising:

a base (4) extending forward from the lower end of the front side of the main frame (1);

the second magnetic force absorbing part (5) is arranged on the upper surface of the base (4) and is positioned below the elastic clamping part (2);

the second magnetic force absorption part (5) provides a magnetic field, so that magnetic beads in the reagent tube (10) can be absorbed at the bottom of the reagent tube (10).

3. The magnetic rack according to claim 2, wherein a plurality of elastic clamping pieces (2) are arranged on the front side surface of the main rack body (1) along the left-right direction, and one first magnetic absorption piece (3) and one second magnetic absorption piece (5) are correspondingly arranged below each elastic clamping piece (2).

4. The magnetic rack according to claim 2, wherein the front end of the second magnetic force absorbing member (5) is provided with an elastic telescopic member for elastically pressing and fixing the lower end of the reagent tube (10).

5. The magnetic rack according to claim 1, wherein the elastic clamping piece (2) comprises a connecting piece (21), an elastic clamping piece (22) and an anti-slip roller (23), the connecting piece (21) is attached to the front side surface of the main rack body (1), the left side and the right side of the connecting piece (21) are respectively extended forward to form one elastic clamping piece (22), the front ends of the two elastic clamping pieces (22) are respectively provided with the anti-slip roller (23), and the two elastic clamping pieces (22) and the two anti-slip rollers (23) jointly clamp and fix the reagent tube (10) and support against the first magnetic absorption piece (3).

6. A magnetic stand according to claim 1, characterized in that the elastic clamping member (2) is detachably connected with the main frame body (1).

7. The magnetic frame according to claim 1, wherein the left and right sides of the main frame body (1) are respectively provided with a clamping groove (6) and a clamping block (7), and the clamping groove (6) on one main frame body (1) is in clamping fit with the clamping block (7) on the other main frame body (1).

8. A magnetic stand according to claim 1, characterized in that a bracket (8) is provided on the rear side of the main stand (1), the bracket (8) being adapted to support the main stand (1) when the main stand (1) is tilted backwards.

9. A magnetic stand according to claim 8, characterized in that the bracket (8) is hinged to the rear side of the main frame body (1) and can swing in the front-rear direction relative to the main frame body (1).

10. A magnetic stand according to claim 9, characterized in that the maximum inclination angle of the stand (8) supporting the main frame body (1) is 60 °.