CN205528823U - Magnetic frame - Google Patents
Magnetic frame Download PDFInfo
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- CN205528823U CN205528823U CN201620175922.0U CN201620175922U CN205528823U CN 205528823 U CN205528823 U CN 205528823U CN 201620175922 U CN201620175922 U CN 201620175922U CN 205528823 U CN205528823 U CN 205528823U
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- bar magnet
- magnetic
- reaction tube
- magnetic frame
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Abstract
The utility model provides a magnetic frame, magnetic frame are used for carrying out magnetism to magnetic substance in the reaction tube and inhale, and magnetic frame includes bar magnet unable adjustment base and evenly sets up on bar magnet unable adjustment base the bar magnet, the bar magnet distributes around the reaction tube, and the side of bar magnet is tangent with the reaction tube pipe wall. The utility model provides a magnetic frame evenly sets up a plurality of bar magnets around the reaction tube, because the all -round of magnetic force provides for the magnetic force that magnetism is inhaled strengthens greatly, does not attenuate along with the magnetic bead enrichment to the adsorption affinity of magnetic bead, makes the magnetic bead have stronger adhesive force, thus the adaptability that the reinforcing magnetic bead was collected. Simultaneously, magnetic bead magnetism absorption speed is accelerated to all -round magnetic force to put forward the processing speed of high automation equipment, practice thrift operating time, improve paramagnetic particle method nucleic acid extraction's efficiency. Further, this magnetic frame can realize the absorption of porous while according to the quantity of bar magnet and reaction tube, and the liquid automation of being convenient for is drawed the instrument and is carried out the magnetic separation to further improve magnetism and inhale efficiency.
Description
Technical field
This utility model relates to a kind of biological device field, particularly relates to a kind of magnetic frame.
Background technology
Along with the universal and biological field of the detections such as gene test, Personalized Drug Administration, prenatal diagnosis, Therapeutic Method is automatic
The realization changed, the magnetic separation technique with biomagnetic beads method as representative is in cell separation, protein purification, immunology and micro-life
The fields such as thing detection are extensively applied.Nucleic acid, albumen etc. can quickly be divided by magnetic separation technique with other materials in cell
From, meanwhile, can have the features such as automatization, simple to operate and used time be short, with extraction process, the sedimentation method, centrifuging
Comparing Deng traditional separation method, the advantage of magnetic separation technique is the most obvious.
Magnetic separation technique is to adsorb the enrichment with magnetic bead being specifically bound to magnetic-particle surface a certain under the action of a magnetic field
Position, makes magnetic bead separate with other materials, reaches the purpose of purification.Magnetic bead is main with the separation method of other materials at present
Being to be positioned on magnetic frame by reaction tube, the fixed position of magnetic frame is provided with bar magnet, by the magnetic force of bar magnet by reaction tube
Beads enrichment.Generally, bar magnet, between two row's reaction tubes, provides the magnetic force of a side to carry out magnetic for reaction tube.
But, above method is to magnetic bead adsorption time length and makes outer layer magnetic force decline due to enrichment with magnetic bead, thus Magneto separate
Self adaptation is poor.Additionally magnetic suck needs to complete by row, and the time property planned as a whole is not strong, and cost requirement is high.
Utility model content
This utility model provides a kind of magnetic frame, to solve the problem that in prior art, magnetic frame magnetic force is the strongest.
This utility model provides a kind of magnetic frame, and described magnetic frame is for carrying out magnetic to magnetisable material in reaction tube, described
Magnetic frame includes bar magnet firm banking and the described bar magnet being uniformly arranged on bar magnet firm banking, and described bar magnet is distributed in institute
State around reaction tube, and the side of described bar magnet is tangent with described reaction tube tube wall.
Preferably, the quantity of the described bar magnet around described reaction tube is 4, and described 4 bar magnets are at described reaction tube
Surrounding equidistantly distributes.
Preferably, described bar magnet firm banking also includes base plate and the bar magnet installing plate being buckled on described base plate, described magnetic
It is uniformly provided with bar magnet installing hole on rod installing plate, and described bar magnet is assigned in described bar magnet installing hole.
Preferably, relative to described bar magnet installing plate top surface edge line, the cross section of described bar magnet installing hole is rhombus.
Preferably, described magnetic frame also includes the fixing post of pad and location, and wherein, described location is fixed post and included that first is fixed
The fixing post of the fixing post in position and the second location, the described first fixing post in location is arranged at the edge of described bar magnet installing plate upper surface,
The described second fixing post in location is arranged at the edge of the upper surface of described pad；The lower surface edge of described pad is provided with location
Fixing hole, it is relative and cooperate that described location fixing hole fixes post position with described location.
The technical scheme that embodiment of the present utility model provides can include following beneficial effect:
This utility model provides a kind of magnetic frame, and described magnetic frame is for carrying out magnetic to magnetisable material in reaction tube, described
Magnetic frame includes bar magnet firm banking and the described bar magnet being uniformly arranged on bar magnet firm banking, and described bar magnet is distributed in institute
State around reaction tube, and the side of described bar magnet is tangent with described reaction tube tube wall.The magnetic frame that this utility model provides
Multiple bar magnet it is uniformly arranged around reaction tube, due to the comprehensive offer of magnetic force so that the magnetic force of magnetic is greatly enhanced,
The absorption affinity of magnetic bead is not decayed with enrichment with magnetic bead so that magnetic bead has stronger adhesive force, thus strengthens magnetic bead and collect
Adaptability, it is to avoid bar magnet magnetic is too small and causes magnetic bead reunion, magnetic time length, the halfway phenomenon of magnetic.Meanwhile,
Comprehensive magnetic force accelerates magnetic bead magnetic suck speed, thus improves adaptivity and the place of automation equipment paramagnetic particle method nucleic acid extraction
Reason speed, saves the operating time, improves the efficiency of paramagnetic particle method nucleic acid extraction.Further, this magnetic frame can according to bar magnet with
And the quantity of reaction tube realizes porous and adsorbs simultaneously, it is simple to liquid automatization extracts instrument and carries out Magneto separate, thus further
Improve magnetic efficiency.
It should be appreciated that it is only exemplary and explanatory that above general description and details hereinafter describe, can not
Limit this utility model.
Accompanying drawing explanation
Fig. 1 is the overall structure schematic diagram of a kind of magnetic frame provided in this utility model embodiment；
Fig. 2 is the sectional drawing of the magnetic frame A-A tangent plane provided in this utility model embodiment；
Fig. 3 is the exploded view of a kind of magnetic frame provided in this utility model embodiment；
Symbol represents:
1-bar magnet firm banking, 11-base plate, 12-bar magnet installing plate, 13-bar magnet installing hole, 2-bar magnet, 3-pad,
31-positions fixing hole, the fixing post in 4-location, and 41-first positions fixing post, and 42-second positions fixing post, 20-reaction tube.
Detailed description of the invention
Here will illustrate exemplary embodiment in detail, its example represents in the accompanying drawings.Explained below relates to attached
During figure, unless otherwise indicated, the same numbers in different accompanying drawings represents same or analogous key element.Following exemplary is implemented
Embodiment described in example does not represent all embodiments consistent with this utility model.On the contrary, they are only
Example with device consistent in terms of that described in detail in appended claims, more of the present utility model.
Refer to Fig. 1 and Fig. 2, show in this utility model embodiment provide magnetic frame overall structure schematic diagram with
And the sectional drawing of the magnetic frame A-A tangent plane provided in this utility model embodiment.
From combining Fig. 1 and Fig. 2, this utility model provides a kind of magnetic frame, and described magnetic frame is for reaction tube 20
Interior magnetisable material carries out magnetic, and described magnetic frame includes bar magnet firm banking 1 and is uniformly arranged on bar magnet firm banking 1
Described bar magnet 2, described bar magnet 2 is distributed in described reaction tube 20 around, and the side of described bar magnet 2 with described instead
Should pipe 20 tube wall tangent.
The gap that in the magnetic frame that this utility model provides, equally distributed multiple bar magnets 2 surround is reaction tube position 21, is entering
During the reaction of row magnetic, being positioned in reaction tube position 21 by reaction tube 20, the side of the bar magnet 2 around reaction tube 20 is with anti-
Should the tube wall of pipe 20 tangent, then the reactant liquor within reaction tube 20 is by the magneticaction of bar magnets 2 multiple on different directions,
Magneticaction is strong and uniform, thus ensures that magnetic reacts quickly, carries out thoroughly.
Around reaction tube 20 described in the present embodiment, the quantity of equally distributed bar magnet 2 can be 4, it is also possible to is 6
Individual, 8 etc., and be arranged in the way of symmetrical around reaction tube 20.If uniformly dividing around described reaction tube 20
The quantity of the bar magnet 2 of cloth is 4, then relative to described bar magnet installing plate 12 top surface edge line, described bar magnet installing hole
The cross section of 13 can be square, it is also possible to for rhombus.Even with bar magnet installing plate 12 top surface edge line as level
Line or vertical line, then the cross section of bar magnet installing hole 13 is square or rhombus.The cross section of bar magnet installing hole 13 is
During rhombus, be conducive to saving the area occupied of bar magnet installing hole 13, i.e. bar magnet installing hole 13 quantity around reaction tube 20
Time identical, when the cross section of bar magnet installing hole 13 is rhombus, the area taking bar magnet installing plate 12 is less.
The magnetic frame that this utility model provides is uniformly arranged multiple bar magnet 2 around reaction tube 20, comprehensive due to magnetic force
There is provided so that the magnetic force of magnetic is greatly enhanced, and does not decays the absorption affinity of magnetic bead with enrichment with magnetic bead so that magnetic bead has
Stronger adhesive force, thus strengthen the adaptability that magnetic bead is collected, it is to avoid bar magnet 2 magnetic is too small and causes magnetic bead reunion, magnetic
Suction time length, the halfway phenomenon of magnetic.Meanwhile, comprehensive magnetic force accelerates magnetic bead magnetic suck speed, thus improves automatically
The adaptivity of change equipment paramagnetic particle method nucleic acid extraction and processing speed, save the operating time, improves paramagnetic particle method nucleic acid extraction
Efficiency.Further, this magnetic frame can realize porous according to the quantity of bar magnet and reaction tube and adsorbs simultaneously, it is simple to liquid from
Dynamicization is extracted instrument and is carried out Magneto separate, thus improves magnetic efficiency further.It addition, when removing waste liquid due to four sides magnetic
Power provides and makes enrichment with magnetic bead uniform, and magnetic bead is attached on deep-well plates hole wall more firm, makes magnetic bead be difficult to adsorbed taking away, from
And avoid magnetic bead to waste, it is beneficial to improve quality of experiments.
Refer to Fig. 3, the exploded view of a kind of magnetic frame provided is provided in this utility model embodiment.
Understanding in conjunction with Fig. 2 and Fig. 3, described bar magnet firm banking 1 also includes base plate 11 and is buckled on described base plate 11
Bar magnet installing plate 12, described bar magnet installing plate 12 is uniformly provided with bar magnet installing hole 13, and described bar magnet 2 assign in
In described bar magnet installing hole 13.Base plate 11 be bar magnet install location-plate, with keep bar magnet 2 top in same level,
And then ensure the accuracy of experiment.Further, bar magnet installing hole 13 can run through bar magnet installing plate 12, and bar magnet 2
In use, may be inserted into bar magnet installing hole 13, owing to bar magnet installing hole 13 runs through bar magnet installing plate 12, therefore, magnetic
Rod 2 is the most firm in fixing of bar magnet installing plate 12.When experiment completes, or according to reaction tube quantity and other realities
Test needs (such as the detection etc. of bar magnet magnetic), bar magnet 2 can be pulled away bar magnet installing hole 13, it is simple to experimental implementation and
The maintenance of device.
Further, described magnetic frame also includes the fixing post 4 of pad 3 and location, and wherein, described location is fixed post 4 and included
The first fixing post 42 of the fixing post in location 41 and the second location, the described first fixing post 41 in location is arranged at described bar magnet and installs
The edge of plate 12 upper surface, the described second fixing post 42 in location is arranged at the edge of the upper surface of described pad 3；Described
The lower surface edge of pad 3 is provided with location fixing hole 31, and post 4 position is fixed in described location fixing hole 31 and described location
Relatively and engage each other.
When magnetic reacts, the biggest the closer to bar magnet 2 top magnetic adsorbability, the present embodiment regulates reaction tube by pad 3
20 with the relative altitude of bar magnet 2 so that bar magnet 2 top is close to the liquid level of reaction tube 20, thus provides maximum magnetic flux
Power, and then ensure that magnetic reacts quickly, completes thoroughly, strengthen the magnetic frame adaptivity to Magneto separate.
In the present embodiment, the edge of bar magnet installing plate 12 upper surface is uniformly provided with 6 the first fixing posts 41 in location, with the
The one fixing post 41 in location is relative, and the lower surface edge of pad 3 is provided with 6 location fixing holes 31, the upper table of pad 3
The edge in face arranges 6 the second fixing posts 42 in location.When the liquid level of reaction tube 20 is not up to and bar magnet 2 top base
During the height originally flushed, can add one piece of pad 3 on bar magnet installing plate 12, described pad 3 passes through lower surface edge
The location fixing hole 31 arranged engages each other with the first fixing post 41 in location on bar magnet installing plate 12, thus completes pad
The superposition of 3.If after increasing by one piece of pad 3, the liquid level of reaction tube 20 is still not up to the neatest with bar magnet 2 top
Flat height, then need to add one piece of pad 3, now, original pad 3 lower surface on the basis of original pad 3 again
The location fixing hole 31 that edge is arranged engages each other with the second fixing post 42 in location of setting on newly added pad 3, thus
Complete the superposition of new pad 3, the like, the liquid level of reaction tube 20 is adjusted to basic with bar magnet 2 top the most at last
The height flushed.
The thickness of pad 3 can be multiple, in adding procedure, and can be according to the liquid level of reaction tube 20 and magnetic
The difference in height on excellent 2 tops makes corresponding selection, if the two difference is relatively big, then and the pad 3 that selection thickness is bigger, thus soon
Speed reduces the two gap, if the two difference own is the most little or makes the two significantly after with the addition of some pads 3
After reducing the two gap, the pad 3 that thickness is less the most only need to be selected can to adjust the height of the two.
It should be noted that in this article, such as the relational terms of " first " and " second " or the like be used merely to by
One entity or operation separate with another entity or operating space, and not necessarily require or imply these entities or behaviour
Relation or the order of any this reality is there is between work.And, term " includes ", " comprising " or it is any
Other variants are intended to comprising of nonexcludability so that include the process of a series of key element, method, article or
Equipment not only includes those key elements, but also includes other key elements being not expressly set out, or also includes for this mistake
The key element that journey, method, article or equipment are intrinsic.In the case of there is no more restriction, statement " include one
It is individual ... " key element that limits, it is not excluded that there is also in including the process of described key element, method, article or equipment
Other identical element.
Each embodiment in this specification all uses the mode gone forward one by one to describe, identical similar part between each embodiment
Seeing mutually, what each embodiment stressed is the difference with other embodiments.
Above-described this utility model embodiment, is not intended that the restriction to this utility model protection domain.Any
Amendment, equivalent and the improvement etc. made within spirit of the present utility model and principle, should be included in this utility model
Protection domain within.
Claims (5)
1. a magnetic frame, described magnetic frame is for carrying out magnetic to magnetisable material in reaction tube, it is characterised in that described
Magnetic frame includes bar magnet firm banking (1) and the bar magnet (2) being uniformly arranged on described bar magnet firm banking (1), institute
State bar magnet (2) to be distributed in around described reaction tube, and the side of described bar magnet (2) is tangent with described reaction tube tube wall.
Magnetic frame the most according to claim 1, it is characterised in that the described bar magnet (2) around described reaction tube
Quantity be 4, and described 4 bar magnets (2) are symmetrically distributed in described reaction tube surrounding.
Magnetic frame the most according to claim 1, it is characterised in that described bar magnet firm banking (1) also includes the end
Plate (11) and the bar magnet installing plate (12) being buckled on described base plate (11), described bar magnet installing plate (12) is upper uniformly
It is provided with bar magnet installing hole (13), and described bar magnet (2) is assigned in described bar magnet installing hole (13).
Magnetic frame the most according to claim 3, it is characterised in that relative to the upper table of described bar magnet installing plate (12)
Face edge line, the cross section of described bar magnet installing hole (13) is rhombus.
Magnetic frame the most according to claim 3, it is characterised in that described magnetic frame also includes pad (3) and determines
The fixing post in position (4), wherein,
Described location is fixed post (4) and is included that post (41) and the second fixing post (42) in location are fixed in the first location, and described the
The one fixing post (41) in location is arranged at the edge of described bar magnet installing plate (12) upper surface, the described second fixing post in location
(42) edge of the upper surface of described pad (3) it is arranged at；
The lower surface edge of described pad (3) is provided with location fixing hole (31), and described location fixing hole (31) is with described
Fixing post (4) position, location relatively and engages each other.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620175922.0U CN205528823U (en) | 2016-03-08 | 2016-03-08 | Magnetic frame |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620175922.0U CN205528823U (en) | 2016-03-08 | 2016-03-08 | Magnetic frame |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205528823U true CN205528823U (en) | 2016-08-31 |
Family
ID=56780955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620175922.0U Active CN205528823U (en) | 2016-03-08 | 2016-03-08 | Magnetic frame |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205528823U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106675991A (en) * | 2017-01-13 | 2017-05-17 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Magnetic bead transfer device and nucleic acid extraction equipment comprising same |
| CN108220160A (en) * | 2016-12-21 | 2018-06-29 | 广州康昕瑞基因健康科技有限公司 | Magnetic frame |
| WO2023241597A1 (en) * | 2022-06-14 | 2023-12-21 | 南京金斯瑞生物科技有限公司 | Pipeline system for cell sorting, cell sorting device, and control method |
-
2016
- 2016-03-08 CN CN201620175922.0U patent/CN205528823U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108220160A (en) * | 2016-12-21 | 2018-06-29 | 广州康昕瑞基因健康科技有限公司 | Magnetic frame |
| CN106675991A (en) * | 2017-01-13 | 2017-05-17 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Magnetic bead transfer device and nucleic acid extraction equipment comprising same |
| WO2023241597A1 (en) * | 2022-06-14 | 2023-12-21 | 南京金斯瑞生物科技有限公司 | Pipeline system for cell sorting, cell sorting device, and control method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Magnetic frame Effective date of registration: 20170711 Granted publication date: 20160831 Pledgee: Ningbo free trade zone Terry with equity investment partnership (limited partnership)|Suzhou equity equity investment center (limited partnership)|Ningbo Meishan Bonded Port District, Jun and equity investment partnership (limited partnership)|Chen Bang Pledgor: Hunan Gene Technology Co.|Hunan San Xiang Biological Technology Co. Ltd. Registration number: 2017430000042 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| CP03 | Change of name, title or address |
Address after: 410205 Changsha province high and New Technology Industrial Development Zone, Lu Pine Road, No. 680, Hunan Patentee after: Shengxiang Biotechnology Co., Ltd Address before: 410205 No. 680, Lu Song Road, hi tech Industrial Development Zone, Hunan, Changsha Patentee before: Sansure Biotech Inc. |
|
| CP03 | Change of name, title or address | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200217 Granted publication date: 20160831 Pledgee: Suzhou Lirui equity investment center (limited partnership)|Triton equity investment partnership (limited partnership)|JUNHE Tongrui equity investment partnership (limited partnership)|Chenbang Pledgor: SANSURE BIOTECH Inc. Registration number: 2017430000042 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |