CN111920939A - 血管紧张素ii单独或以组合方式用于治疗低血压 - Google Patents

血管紧张素ii单独或以组合方式用于治疗低血压 Download PDF

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Publication number
CN111920939A
CN111920939A CN202010824424.5A CN202010824424A CN111920939A CN 111920939 A CN111920939 A CN 111920939A CN 202010824424 A CN202010824424 A CN 202010824424A CN 111920939 A CN111920939 A CN 111920939A
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Prior art keywords
dose
angiotensin
norepinephrine
catecholamines
map
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CN202010824424.5A
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English (en)
Chinese (zh)
Inventor
拉克米尔·乔拉
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George Washington University
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George Washington University
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53367119&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN111920939(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by George Washington University filed Critical George Washington University
Publication of CN111920939A publication Critical patent/CN111920939A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/085Angiotensins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202010824424.5A 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压 Pending CN111920939A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361917576P 2013-12-18 2013-12-18
US61/917,576 2013-12-18
US201461955706P 2014-03-19 2014-03-19
US61/955,706 2014-03-19
CN201480075899.1A CN106061493A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480075899.1A Division CN106061493A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压

Publications (1)

Publication Number Publication Date
CN111920939A true CN111920939A (zh) 2020-11-13

Family

ID=53367119

Family Applications (4)

Application Number Title Priority Date Filing Date
CN202010824424.5A Pending CN111920939A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压
CN202011494632.XA Pending CN112546197A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压
CN202411722811.2A Pending CN119700926A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压
CN201480075899.1A Pending CN106061493A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN202011494632.XA Pending CN112546197A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压
CN202411722811.2A Pending CN119700926A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压
CN201480075899.1A Pending CN106061493A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压

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US (7) US9220745B2 (enExample)
EP (2) EP2986308B1 (enExample)
JP (4) JP6824739B2 (enExample)
KR (4) KR20230051721A (enExample)
CN (4) CN111920939A (enExample)
AU (3) AU2014364528C1 (enExample)
BR (1) BR112016013961A2 (enExample)
CA (1) CA2933601A1 (enExample)
CY (1) CY1122604T1 (enExample)
DK (2) DK2986308T3 (enExample)
EA (1) EA037823B1 (enExample)
ES (2) ES3055611T3 (enExample)
FI (1) FI3607962T3 (enExample)
HR (2) HRP20251406T1 (enExample)
HU (1) HUE047062T2 (enExample)
IL (1) IL246162B (enExample)
LT (2) LT2986308T (enExample)
MX (2) MX380968B (enExample)
NZ (1) NZ721089A (enExample)
PL (2) PL3607962T3 (enExample)
PT (2) PT3607962T (enExample)
RS (2) RS59804B1 (enExample)
SI (2) SI2986308T1 (enExample)
SM (2) SMT202000018T1 (enExample)
WO (1) WO2015095535A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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US9572856B2 (en) 2009-12-16 2017-02-21 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
LT2986308T (lt) 2013-12-18 2020-03-25 The George Washington University, A Congressionally Chartered Not-For-Profit Corporation Angiotenzino ii derinys hipotenzijai gydyti
EP3381465A1 (en) * 2014-07-08 2018-10-03 La Jolla Pharmaceutical Company Methods for treating hypotension
WO2016153558A1 (en) 2015-03-20 2016-09-29 Atkinson Arthur J Use of angiotensin ii (aii) receptor agonists to prevent or reduce hemodialysis-associated skeletal muscle cramps
PL3400000T3 (pl) 2016-01-07 2024-04-22 La Jolla Pharma, Llc Sposoby podawania angiotensyny ii
WO2017120440A1 (en) * 2016-01-07 2017-07-13 La Jolla Pharmaceutical Company Methods of administering vasopressors
WO2018191678A1 (en) * 2017-04-14 2018-10-18 La Jolla Pharmaceutical Company Methods for administering angiotensin ii
TW201927331A (zh) * 2017-12-15 2019-07-16 美商拉荷亞製藥公司 血管收縮素組合物及與其相關之方法
US20250366467A1 (en) * 2022-06-15 2025-12-04 Virginia Commonwealth University Methods for fluid resuscitation of an organ donor
JP2025538841A (ja) * 2022-12-12 2025-11-28 プロレタリアート セラピューティクス, インコーポレイテッド 心損傷を処置する方法

Citations (4)

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CN101351215A (zh) * 2005-12-30 2009-01-21 霍华德·弗洛里实验生理学及医学研究所 治疗方法
WO2009009907A1 (en) * 2007-07-18 2009-01-22 The University Of British Columbia Use of vasopressin-receptor agonists for the treatment of septic shock
US20110144026A1 (en) * 2009-12-16 2011-06-16 Lakhmir Chawla Method of Treating Low Blood Pressure
US20110269666A1 (en) * 2010-04-30 2011-11-03 Quintin Luc Method and drug composition for treating septic shock hypotension

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HU181008B (en) 1980-01-18 1983-05-30 Richter Gedeon Vegyeszet Process for producing angiotenzin-ii analogues of antagonistic activity containing sarcosyl-group at the 1-positon,and an alpha-hydroxy-carboxylic acid at the 8-position
US5216025A (en) 1989-09-13 1993-06-01 Board Of Regents, The University Of Texas System Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients
US5444067A (en) 1993-08-30 1995-08-22 Merck & Co., Inc. Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety
CA2448051A1 (en) 2001-06-04 2002-12-12 Human Genome Sciences, Inc. Methods and compositions for modulating ace-2 activity
US7115266B2 (en) 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
NO20034952D0 (no) 2003-11-06 2003-11-06 Amersham Health As Farmasöytiske forbindelser
JP2007510643A (ja) 2003-11-06 2007-04-26 ジーイー・ヘルスケア・アクスイェ・セルスカプ 医薬化合物
FR2880807B1 (fr) * 2005-01-19 2007-04-13 Aguettant Sa Lab Composition pharmaceutique injectable
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WO2008130217A1 (en) * 2006-08-08 2008-10-30 Applied Nanosystems B.V. Cyclic angiotensin analogs
CA2678131A1 (en) 2006-11-17 2008-05-22 Antoine Andremont Colonic delivery using zn/pectin beads with a eudragit coating.
EP2161030A1 (en) * 2008-09-09 2010-03-10 Rijksuniversiteit te Groningen Oxytocin formulations and uses thereof
AU2009319856A1 (en) 2008-11-28 2010-06-03 Abbvie Inc. Stable antibody compositions and methods for stabilizing same
BR112013000744A2 (pt) 2010-07-14 2020-07-14 Cumberland Emerging Technologies, Inc uso de um antagonista de receptor de tromboxana a2 para prevenção ou tratamento de síndrome hepatorrenal,encefalopatia hepática,e doenças associadas
JP6522584B2 (ja) 2013-04-26 2019-05-29 ラ ホヤ ファーマシューティカル カンパニーLa Jolla Pharmaceutical Company 腎不全を処置するための組成物及び方法
LT2986308T (lt) 2013-12-18 2020-03-25 The George Washington University, A Congressionally Chartered Not-For-Profit Corporation Angiotenzino ii derinys hipotenzijai gydyti
US20150286797A1 (en) 2014-04-02 2015-10-08 David R. Ratto System and method for administering medication
EP3381465A1 (en) 2014-07-08 2018-10-03 La Jolla Pharmaceutical Company Methods for treating hypotension
WO2017120440A1 (en) 2016-01-07 2017-07-13 La Jolla Pharmaceutical Company Methods of administering vasopressors
PL3400000T3 (pl) 2016-01-07 2024-04-22 La Jolla Pharma, Llc Sposoby podawania angiotensyny ii
WO2018191678A1 (en) 2017-04-14 2018-10-18 La Jolla Pharmaceutical Company Methods for administering angiotensin ii
TW201927331A (zh) 2017-12-15 2019-07-16 美商拉荷亞製藥公司 血管收縮素組合物及與其相關之方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101351215A (zh) * 2005-12-30 2009-01-21 霍华德·弗洛里实验生理学及医学研究所 治疗方法
WO2009009907A1 (en) * 2007-07-18 2009-01-22 The University Of British Columbia Use of vasopressin-receptor agonists for the treatment of septic shock
US20110144026A1 (en) * 2009-12-16 2011-06-16 Lakhmir Chawla Method of Treating Low Blood Pressure
US20110269666A1 (en) * 2010-04-30 2011-11-03 Quintin Luc Method and drug composition for treating septic shock hypotension

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G M WRAY等: "Severe septic shock unresponsive to noradrenaline", LANCET, vol. 346, no. 8990, 16 December 1995 (1995-12-16), pages 1604, XP002111951, DOI: 10.1016/S0140-6736(95)91933-3 *

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SMT202000018T1 (it) 2020-03-13
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DK2986308T3 (en) 2020-01-27
JP2022137224A (ja) 2022-09-21
EP3607962A1 (en) 2020-02-12
MX380968B (es) 2025-03-12
US9220745B2 (en) 2015-12-29
ES3055611T3 (en) 2026-02-13
NZ721089A (en) 2022-10-28
CN112546197A (zh) 2021-03-26
KR20240154702A (ko) 2024-10-25
FI3607962T3 (fi) 2025-11-24
US11559559B2 (en) 2023-01-24
JP2025114753A (ja) 2025-08-05
US20150164980A1 (en) 2015-06-18
HRP20200009T1 (hr) 2020-03-20
LT3607962T (lt) 2026-01-12
MX2020011190A (es) 2020-11-13
WO2015095535A9 (en) 2016-07-14
EP2986308B1 (en) 2019-10-16
US10493124B2 (en) 2019-12-03
AU2014364528A1 (en) 2016-06-30
SMT202500427T1 (it) 2026-01-12
JP2017501154A (ja) 2017-01-12
WO2015095535A1 (en) 2015-06-25
RS67626B1 (sr) 2026-02-27
EP2986308A1 (en) 2016-02-24
PT3607962T (pt) 2025-11-18
IL246162B (en) 2020-03-31
EA201691258A1 (ru) 2016-11-30
DK3607962T3 (da) 2025-11-17
KR20160117437A (ko) 2016-10-10
US20230226141A1 (en) 2023-07-20
IL246162A0 (en) 2016-07-31
EP3607962B1 (en) 2025-08-13
US20220047669A1 (en) 2022-02-17
PL2986308T3 (pl) 2020-05-18
US20160129072A1 (en) 2016-05-12
AU2020277230A1 (en) 2020-12-24
SI3607962T1 (sl) 2026-02-27
EA037823B1 (ru) 2021-05-25
AU2024219851A1 (en) 2024-10-10
JP7175506B2 (ja) 2022-11-21
CA2933601A1 (en) 2015-06-25
CY1122604T1 (el) 2021-03-12
US10765722B2 (en) 2020-09-08
US20180193407A1 (en) 2018-07-12
MX2016008108A (es) 2017-03-09
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AU2014364528C1 (en) 2021-01-07
JP6824739B2 (ja) 2021-02-03
US11096983B2 (en) 2021-08-24
US10028995B2 (en) 2018-07-24
KR20230051721A (ko) 2023-04-18
RS59804B1 (sr) 2020-02-28
HRP20251406T1 (hr) 2026-02-27
AU2014364528A9 (en) 2016-07-28
CN106061493A (zh) 2016-10-26
ES2771749T3 (es) 2020-07-07
LT2986308T (lt) 2020-03-25
JP2019214610A (ja) 2019-12-19
CN119700926A (zh) 2025-03-28
US20190070250A1 (en) 2019-03-07
KR102399383B1 (ko) 2022-05-19
AU2014364528B2 (en) 2020-08-27
US20190328827A1 (en) 2019-10-31
SI2986308T1 (sl) 2020-03-31
BR112016013961A2 (pt) 2017-10-10
HUE047062T2 (hu) 2020-04-28

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