WO2015095535A1 - Angiotensin ii alone or in combination for the treatment of hypotension - Google Patents

Angiotensin ii alone or in combination for the treatment of hypotension Download PDF

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Publication number
WO2015095535A1
WO2015095535A1 PCT/US2014/071186 US2014071186W WO2015095535A1 WO 2015095535 A1 WO2015095535 A1 WO 2015095535A1 US 2014071186 W US2014071186 W US 2014071186W WO 2015095535 A1 WO2015095535 A1 WO 2015095535A1
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Prior art keywords
dose
angiotensin
catecholamine
norepinephrine
mcg
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PCT/US2014/071186
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English (en)
French (fr)
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WO2015095535A9 (en
Inventor
Lakhmir Chawla
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George Washington University
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George Washington University
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Priority to ES14872684T priority Critical patent/ES2771749T3/es
Priority to PL14872684T priority patent/PL2986308T3/pl
Priority to EA201691258A priority patent/EA037823B1/ru
Priority to RS20200021A priority patent/RS59804B1/sr
Priority to EP19197866.7A priority patent/EP3607962B1/en
Priority to JP2016539318A priority patent/JP6824739B2/ja
Priority to KR1020227004084A priority patent/KR20220028125A/ko
Priority to SM20200018T priority patent/SMT202000018T1/it
Priority to KR1020167019427A priority patent/KR102399383B1/ko
Priority to NZ721089A priority patent/NZ721089A/en
Priority to DK14872684.7T priority patent/DK2986308T3/da
Priority to KR1020237012136A priority patent/KR20230051721A/ko
Priority to LTEP14872684.7T priority patent/LT2986308T/lt
Priority to KR1020247034828A priority patent/KR20240154702A/ko
Priority to BR112016013961A priority patent/BR112016013961A2/pt
Priority to CA2933601A priority patent/CA2933601A1/en
Priority to AU2014364528A priority patent/AU2014364528C1/en
Application filed by George Washington University filed Critical George Washington University
Priority to HRP20200009TT priority patent/HRP20200009T1/hr
Priority to CN202411722811.2A priority patent/CN119700926A/zh
Priority to SI201431450T priority patent/SI2986308T1/sl
Priority to EP14872684.7A priority patent/EP2986308B1/en
Priority to CN201480075899.1A priority patent/CN106061493A/zh
Priority to MX2016008108A priority patent/MX380968B/es
Publication of WO2015095535A1 publication Critical patent/WO2015095535A1/en
Priority to IL246162A priority patent/IL246162B/en
Anticipated expiration legal-status Critical
Publication of WO2015095535A9 publication Critical patent/WO2015095535A9/en
Priority to CY20201100026T priority patent/CY1122604T1/el
Priority to AU2020277230A priority patent/AU2020277230A1/en
Priority to AU2024219851A priority patent/AU2024219851A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/085—Angiotensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Definitions

  • Angiotensin II (sometimes referred to herein as ATII) is a naturally occurring peptide hormone with endocrine, autocrine, paracrine, and intracrine hormonal effects. It is a potent direct vasoconstrictor, constricting both arteries and veins and increasing blood pressure [6]. It has a half-life in circulation of approximately 30 seconds, but while in tissue, its half-life may be as long as 15-30 minutes. ATII increases secretion of ADH and ACTH, and may potentiate sympathetic effects by direct action on postganglionic sympathetic fibers. It also acts on the adrenal cortex, causing it to release aldosterone [6,7]. High doses of angiotensin II have been reported to induce adverse side effects, including for example, mesenteric ischemia and bronchospasm.
  • angiotensin II and/or precursor peptides having amino acid substitutions, deletions, additions, the substitutions and additions including the standard D and L amino acids and modified amino acids, such as, for example, amidated and acetylated amino acids, wherein the therapeutic activity of the base peptide sequence is maintained at a pharmacologically useful level.
  • the preparation also may be a sterile injectable solution or suspension in a diluent or solvent, for example as a solution in 1,3-butanediol, water, Ringer's solution, and isotonic sodium chloride solution, which are exemplary acceptable diluents.
  • a diluent or solvent for example as a solution in 1,3-butanediol, water, Ringer's solution, and isotonic sodium chloride solution, which are exemplary acceptable diluents.
  • Sterile, fixed oils may be employed as a solvent or suspending medium.
  • Bland fixed oils, including synthetic mono or di-glycerides, and fatty acids, such as oleic acid, may also be used. Most of the agents described herein are commercially available and can be obtained readily from commercial sources. Excipients
  • a buffer may include one or more of the following: Tris, Tris HCl, potassium phosphate, sodium phosphate, sodium citrate, sodium ascorbate, combinations of sodium and potassium phosphate, Tris/Tris HCl, sodium bicarbonate, arginine phosphate, arginine hydrochloride, histidine hydrochloride, cacodylate, succinate, 2-(N- morpholino)ethanesulfonic acid (MES), maleate, bis-tris, phosphate, carbonate, and any pharmaceutically acceptable salts and/or combinations thereof.
  • Tris Tris HCl, potassium phosphate, sodium phosphate, sodium citrate, sodium ascorbate, combinations of sodium and potassium phosphate, Tris/Tris HCl, sodium bicarbonate, arginine phosphate, arginine hydrochloride, histidine hydrochloride, cacodylate, succinate, 2-(N- morpholino)ethanesulfonic acid (MES), maleate,
  • ATII resulted in a reduction in norepinephrine dosing in all patients (Figure 3).
  • AKI acute kidney injury
  • agents such as angiotensin II and vasopressin causes efferent arteriole vasoconstriction, thereby mitigating this effect.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/US2014/071186 2013-12-18 2014-12-18 Angiotensin ii alone or in combination for the treatment of hypotension Ceased WO2015095535A1 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
MX2016008108A MX380968B (es) 2013-12-18 2014-12-18 Angiotensina ii sola o en combinacion para usarse en el tratamiento de hipotension.
BR112016013961A BR112016013961A2 (pt) 2013-12-18 2014-12-18 angiotensina ii sozinha ou em combinação para o tratamento da hipotensão
EA201691258A EA037823B1 (ru) 2013-12-18 2014-12-18 Способ лечения субъекта, испытывающего интенсивный шок и получающего лечение катехоламином или вазопрессином
RS20200021A RS59804B1 (sr) 2013-12-18 2014-12-18 Angiotenzin ii u kombinaciji za lečenje hipotenzije
EP19197866.7A EP3607962B1 (en) 2013-12-18 2014-12-18 Angiotensin ii alone or in combination for the treatment of hypotension
JP2016539318A JP6824739B2 (ja) 2013-12-18 2014-12-18 低血圧治療のための単独または併用使用されるアンギオテンシンｉｉ
KR1020227004084A KR20220028125A (ko) 2013-12-18 2014-12-18 저혈압의 치료를 위한 안지오텐신 ii 단독 또는 조합
SM20200018T SMT202000018T1 (it) 2013-12-18 2014-12-18 Angiotensina ii in combinazione per il trattamento dell’ipotensione
AU2014364528A AU2014364528C1 (en) 2013-12-18 2014-12-18 Angiotensin ll alone or in combination for the treatment of hypotension
NZ721089A NZ721089A (en) 2013-12-18 2014-12-18 Angiotensin ii alone or in combination for the treatment of hypotension
DK14872684.7T DK2986308T3 (en) 2013-12-18 2014-12-18 Angiotensin ii i kombination til behandlingen af hypotension
KR1020237012136A KR20230051721A (ko) 2013-12-18 2014-12-18 저혈압의 치료를 위한 안지오텐신 ii 단독 또는 조합
LTEP14872684.7T LT2986308T (lt) 2013-12-18 2014-12-18 Angiotenzino ii derinys hipotenzijai gydyti
KR1020247034828A KR20240154702A (ko) 2013-12-18 2014-12-18 저혈압의 치료를 위한 안지오텐신 ii 단독 또는 조합
CA2933601A CA2933601A1 (en) 2013-12-18 2014-12-18 Angiotensin ii alone or in combination for the treatment of hypotension
ES14872684T ES2771749T3 (es) 2013-12-18 2014-12-18 Angiotensina II en combinación para el tratamiento de hipotensión
KR1020167019427A KR102399383B1 (ko) 2013-12-18 2014-12-18 저혈압의 치료를 위한 안지오텐신 ii 단독 또는 조합
PL14872684T PL2986308T3 (pl) 2013-12-18 2014-12-18 Angiotensyna ii w połączeniu do leczenia niedociśnienia
HRP20200009TT HRP20200009T1 (hr) 2013-12-18 2014-12-18 Angiotenzin ii u kombinaciji za liječenje hipotenzije
CN202411722811.2A CN119700926A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压
SI201431450T SI2986308T1 (sl) 2013-12-18 2014-12-18 Angiotenzin II v kombinaciji za zdravljenje hipotenzije
EP14872684.7A EP2986308B1 (en) 2013-12-18 2014-12-18 Angiotensin ii in combination for the treatment of hypotension
CN201480075899.1A CN106061493A (zh) 2013-12-18 2014-12-18 血管紧张素ii单独或以组合方式用于治疗低血压
IL246162A IL246162B (en) 2013-12-18 2016-06-09 Angiotensin II, alone or in combination, to treat low blood pressure
CY20201100026T CY1122604T1 (el) 2013-12-18 2020-01-13 Αγγειοτασινη ii σε συνδυασμο για την αντιμετωπιση υποτασης
AU2020277230A AU2020277230A1 (en) 2013-12-18 2020-11-26 Angiotensin ll alone or in combination for the treatment of hypotension
AU2024219851A AU2024219851A1 (en) 2013-12-18 2024-09-18 Angiotensin II Alone or in Combination for the Treatment of Hypotension

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361917576P 2013-12-18 2013-12-18
US61/917,576 2013-12-18
US201461955706P 2014-03-19 2014-03-19
US61/955,706 2014-03-19

Publications (2)

Publication Number Publication Date
WO2015095535A1 true WO2015095535A1 (en) 2015-06-25
WO2015095535A9 WO2015095535A9 (en) 2016-07-14

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PCT/US2014/071186 Ceased WO2015095535A1 (en) 2013-12-18 2014-12-18 Angiotensin ii alone or in combination for the treatment of hypotension

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US (7) US9220745B2 (enExample)
EP (2) EP2986308B1 (enExample)
JP (4) JP6824739B2 (enExample)
KR (4) KR102399383B1 (enExample)
CN (4) CN119700926A (enExample)
AU (3) AU2014364528C1 (enExample)
BR (1) BR112016013961A2 (enExample)
CA (1) CA2933601A1 (enExample)
CY (1) CY1122604T1 (enExample)
DK (2) DK3607962T3 (enExample)
EA (1) EA037823B1 (enExample)
ES (1) ES2771749T3 (enExample)
FI (1) FI3607962T3 (enExample)
HR (1) HRP20200009T1 (enExample)
HU (1) HUE047062T2 (enExample)
IL (1) IL246162B (enExample)
LT (1) LT2986308T (enExample)
MX (2) MX380968B (enExample)
NZ (1) NZ721089A (enExample)
PL (1) PL2986308T3 (enExample)
PT (2) PT2986308T (enExample)
RS (1) RS59804B1 (enExample)
SI (1) SI2986308T1 (enExample)
SM (1) SMT202000018T1 (enExample)
WO (1) WO2015095535A1 (enExample)

Cited By (5)

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Publication number Priority date Publication date Assignee Title
EP3007722A4 (en) * 2014-07-08 2016-05-25 Jolla Pharma METHOD FOR THE TREATMENT OF HYPOTONIA
US9572856B2 (en) 2009-12-16 2017-02-21 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
US10028995B2 (en) 2013-12-18 2018-07-24 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Angiotensin II alone or in combination for the treatment of hypotension
US10406201B2 (en) 2016-01-07 2019-09-10 La Jolla Pharma, Llc Methods for administering angiotensin II
US11583568B2 (en) 2017-04-14 2023-02-21 La Jolla Pharma, Llc Methods for administering angiotensin II

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WO2016153558A1 (en) 2015-03-20 2016-09-29 Atkinson Arthur J Use of angiotensin ii (aii) receptor agonists to prevent or reduce hemodialysis-associated skeletal muscle cramps
BR112018013852A2 (pt) * 2016-01-07 2018-12-18 La Jolla Pharmaceutical Company métodos de administração de vasopressores
TW201927331A (zh) * 2017-12-15 2019-07-16 美商拉荷亞製藥公司 血管收縮素組合物及與其相關之方法
WO2023244552A1 (en) * 2022-06-15 2023-12-21 Virginia Commonwealth University Methods for fluid resuscitation of an organ donor
WO2024129057A1 (en) * 2022-12-12 2024-06-20 Proletariat Therapeutics, Inc. Methods of treating cardiac injury

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US10335451B2 (en) 2009-12-16 2019-07-02 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
US9572856B2 (en) 2009-12-16 2017-02-21 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
US9867863B2 (en) 2009-12-16 2018-01-16 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
US10548943B2 (en) 2009-12-16 2020-02-04 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
US10500247B2 (en) 2009-12-16 2019-12-10 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
US10322160B2 (en) 2009-12-16 2019-06-18 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
US11096983B2 (en) 2013-12-18 2021-08-24 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Angiotensin II alone or in combination for the treatment of hypotension
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