CN111868037B - 作为crhr2拮抗剂的稠合环状脲衍生物 - Google Patents

作为crhr2拮抗剂的稠合环状脲衍生物 Download PDF

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CN111868037B
CN111868037B CN201980019725.6A CN201980019725A CN111868037B CN 111868037 B CN111868037 B CN 111868037B CN 201980019725 A CN201980019725 A CN 201980019725A CN 111868037 B CN111868037 B CN 111868037B
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methyl
oxo
chloro
cyclohexyl
dihydro
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CN111868037A (zh
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大见仁
松下岳史
安藤一男
山口龙一
福元豊
真柄良平
山岸龙也
竹藤干人
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Raqualia Pharma Inc
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    • A61P9/06—Antiarrhythmics
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Ink Jet (AREA)
CN201980019725.6A 2018-04-09 2019-04-09 作为crhr2拮抗剂的稠合环状脲衍生物 Active CN111868037B (zh)

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US201862654628P 2018-04-09 2018-04-09
US62/654,628 2018-04-09
PCT/JP2019/015392 WO2019198692A1 (en) 2018-04-09 2019-04-09 Fused cyclic urea derivatives as crhr2 antagonist

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US (1) US11802120B2 (enExample)
EP (1) EP3774739B1 (enExample)
JP (1) JP7357932B2 (enExample)
KR (1) KR102590854B1 (enExample)
CN (1) CN111868037B (enExample)
BR (1) BR112020020708A8 (enExample)
CA (1) CA3094609A1 (enExample)
ES (1) ES2917634T3 (enExample)
MX (1) MX2020010568A (enExample)
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ES2865330T3 (es) 2015-04-29 2021-10-15 Janssen Pharmaceutica Nv Azabenzimidazoles y su uso como moduladores del receptor AMPA
TW202140480A (zh) * 2020-01-15 2021-11-01 日商拉夸里亞創藥股份有限公司 作為crhr2拮抗劑之螺雜環衍生物
EP3901152A1 (en) * 2020-04-23 2021-10-27 F. Hoffmann-La Roche AG Kv3 enhancers for the treatment of cognitive disorders
CR20220565A (es) 2020-05-06 2023-01-13 Merck Sharp & Dohme Llc Inhibidores de il4i1 y métodos de uso
JP2023545256A (ja) 2020-09-30 2023-10-27 ラクオリア創薬株式会社 Ｃｒｈｒ２拮抗薬としての３－ヒドロキシオキシインドール誘導体
JP7607799B2 (ja) * 2021-04-27 2024-12-27 メッドシャイン ディスカバリー インコーポレイテッド ６員芳香族ヘテロ尿素環の誘導体及びその使用
TW202540088A (zh) * 2024-01-17 2025-10-16 南韓商Ｌｇ化學股份有限公司 作為ＣＢＰ／ｐ３００抑制劑之新穎化合物和含有彼作為活性成分以預防或治療癌症、發炎病症或自體免疫疾病之醫藥組成物

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WO2002100863A1 (en) * 2001-06-12 2002-12-19 Glaxo Group Limited Corticotropin releasing factor antagonists
WO2006044821A1 (en) * 2004-10-19 2006-04-27 Sb Pharmco Puerto Rico Inc. Crf receptor antagonists and methods relating thereto
CN101696208A (zh) * 2004-06-25 2010-04-21 大正制药株式会社 环氨基取代的吡咯并嘧啶和吡咯并吡啶衍生物作为crf受体拮抗剂
CN102143940A (zh) * 2008-08-07 2011-08-03 诺瓦提斯公司 用作crf-1受体拮抗剂的环己基酰胺衍生物及其用途
WO2011092293A2 (en) * 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
CN102753527A (zh) * 2010-02-02 2012-10-24 诺瓦提斯公司 用作crf受体拮抗剂的环己基酰胺衍生物
WO2013160317A2 (en) * 2012-04-23 2013-10-31 Holsboermaschmeyer Neurochemie Gmbh Crhr1 antagonists for use in the treatment of patients having crh overactivity

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DE60225127T2 (de) 2001-04-30 2009-02-19 Glaxo Group Ltd., Greenford Kondensierte pyrimidine als antagonisten des corticotropin releasing factor (crf)
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WO2002100863A1 (en) * 2001-06-12 2002-12-19 Glaxo Group Limited Corticotropin releasing factor antagonists
CN101696208A (zh) * 2004-06-25 2010-04-21 大正制药株式会社 环氨基取代的吡咯并嘧啶和吡咯并吡啶衍生物作为crf受体拮抗剂
WO2006044821A1 (en) * 2004-10-19 2006-04-27 Sb Pharmco Puerto Rico Inc. Crf receptor antagonists and methods relating thereto
CN102143940A (zh) * 2008-08-07 2011-08-03 诺瓦提斯公司 用作crf-1受体拮抗剂的环己基酰胺衍生物及其用途
WO2011092293A2 (en) * 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
CN102753527A (zh) * 2010-02-02 2012-10-24 诺瓦提斯公司 用作crf受体拮抗剂的环己基酰胺衍生物
WO2013160317A2 (en) * 2012-04-23 2013-10-31 Holsboermaschmeyer Neurochemie Gmbh Crhr1 antagonists for use in the treatment of patients having crh overactivity

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MX2020010568A (es) 2020-10-22
WO2019198692A1 (en) 2019-10-17
JP2021521142A (ja) 2021-08-26
KR20200135834A (ko) 2020-12-03
JP7357932B2 (ja) 2023-10-10
TWI822754B (zh) 2023-11-21
TW201945355A (zh) 2019-12-01
CA3094609A1 (en) 2019-10-17
EP3774739A4 (en) 2021-08-25
CN111868037A (zh) 2020-10-30
EP3774739A1 (en) 2021-02-17
KR102590854B1 (ko) 2023-10-18
BR112020020708A2 (pt) 2021-01-12
ES2917634T3 (es) 2022-07-11
BR112020020708A8 (pt) 2022-10-18
US11802120B2 (en) 2023-10-31
EP3774739B1 (en) 2022-05-11
US20210078975A1 (en) 2021-03-18

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