CN111848755A - 突变的免疫球蛋白结合多肽 - Google Patents

突变的免疫球蛋白结合多肽 Download PDF

Info

Publication number
CN111848755A
CN111848755A CN202010728898.XA CN202010728898A CN111848755A CN 111848755 A CN111848755 A CN 111848755A CN 202010728898 A CN202010728898 A CN 202010728898A CN 111848755 A CN111848755 A CN 111848755A
Authority
CN
China
Prior art keywords
ala
polypeptide
amino acid
lys
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010728898.XA
Other languages
English (en)
Chinese (zh)
Inventor
G.罗德里戈
M.安德
G.鲍伦
T.布杰克曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
Original Assignee
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Bio Sciences Corp filed Critical GE Healthcare Bio Sciences Corp
Publication of CN111848755A publication Critical patent/CN111848755A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CN202010728898.XA 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽 Pending CN111848755A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1350859-3 2013-07-10
SE1350860 2013-07-10
SE1350859 2013-07-10
SE1350860-1 2013-07-10
CN201480039292.8A CN105377880B (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480039292.8A Division CN105377880B (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽

Publications (1)

Publication Number Publication Date
CN111848755A true CN111848755A (zh) 2020-10-30

Family

ID=52280382

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202010728898.XA Pending CN111848755A (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽
CN201480039292.8A Active CN105377880B (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽
CN201480039299.XA Active CN105377881B (zh) 2013-07-10 2014-07-10 突变的免疫球蛋白结合多肽

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201480039292.8A Active CN105377880B (zh) 2013-07-10 2014-07-08 突变的免疫球蛋白结合多肽
CN201480039299.XA Active CN105377881B (zh) 2013-07-10 2014-07-10 突变的免疫球蛋白结合多肽

Country Status (5)

Country Link
US (5) US9896486B2 (https=)
EP (2) EP3019520B1 (https=)
JP (3) JP6544808B2 (https=)
CN (3) CN111848755A (https=)
WO (2) WO2015005859A1 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114149495A (zh) * 2021-12-17 2022-03-08 博格隆(上海)生物技术有限公司 突变的蛋白a结构域c及其应用
CN116333056A (zh) * 2023-02-09 2023-06-27 西宝生物科技（上海）股份有限公司 一种高结合容量的耐碱重组Protein A及其制备方法和应用
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12352734B2 (en) 2020-09-24 2025-07-08 Waters Technologies Corporation Chromatographic hardware improvements for separation of reactive molecules

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
EP3019520B1 (en) 2013-07-10 2019-12-11 GE Healthcare BioProcess R&D AB Mutated immunoglobulin-binding polypeptides
EP3060527B1 (en) 2013-10-22 2019-04-10 Nuvoda LLC Reduction of substances in contaminated fluids using a naturally occurring biological growth media
US11566082B2 (en) * 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
JP6705806B2 (ja) * 2015-03-26 2020-06-03 Jsr株式会社 イムノグロブリン結合タンパク質およびそれを用いたアフィニティー担体
RU2017134828A (ru) * 2015-04-13 2019-04-04 Фуджифилм Корпорэйшн Способ получения носителя, иммобилизованного на короткоцепочечном пептиде, и носитель, иммобилизованный на короткоцепочечном пептиде
WO2017014261A1 (ja) * 2015-07-22 2017-01-26 株式会社カネカ 抗体様タンパク質の精製方法
WO2017014257A1 (ja) * 2015-07-22 2017-01-26 株式会社カネカ 酸性ｐＨ領域での抗体結合能が低下した抗体結合性タンパク質
US10766924B2 (en) 2015-07-28 2020-09-08 Jsr Corporation Affinity support and method for isolating immunoglobulin
JPWO2017022672A1 (ja) * 2015-07-31 2018-07-05 株式会社カネカ 免疫グロブリン結合性改変型タンパク質
EP3333262A4 (en) * 2015-08-04 2019-04-03 Kaneka Corporation IMMUNOGLOBULIN BINDING MODIFIED PROTEINS
GB201515339D0 (en) * 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
US10513537B2 (en) 2016-05-11 2019-12-24 Ge Healthcare Bioprocess R&D Ab Separation matrix
WO2017194593A1 (en) * 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Method of cleaning and/or sanitizing a separation matrix
WO2017194594A1 (en) * 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Separation method
WO2017194592A1 (en) * 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Method of storing a separation matrix
DK3455244T3 (da) * 2016-05-11 2022-06-07 Cytiva Bioprocess R & D Ab Muterede immunoglobulin-bindende polypeptider
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
CN109963864B (zh) * 2016-08-11 2024-01-02 瑞普利金公司 用于亲和色谱的碱性稳定性fc结合蛋白
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
CN110799521A (zh) * 2017-02-15 2020-02-14 拜奥普罗塞亚科技有限责任公司 具有温和洗脱pH的亲和色谱配体
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
EP3592759A1 (en) * 2017-03-07 2020-01-15 JMVA Biotech AB Modified adsorptive surfaces
GB201708277D0 (en) 2017-05-24 2017-07-05 Ge Healthcare A Recombinant protein
EP3546476A1 (en) * 2018-03-26 2019-10-02 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
EP3521304B9 (en) * 2018-02-01 2023-10-04 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
US11779860B2 (en) 2017-08-07 2023-10-10 Repligen Corporation Fc binding proteins with cysteine in the C-terminal helical region
EP3842536A4 (en) * 2018-08-24 2023-01-18 JSR Corporation IMMUNOGLOBULIN-BINDING PROTEIN AND AFFINITY CARRIER WITH IT
GB201904125D0 (en) 2019-03-26 2019-05-08 Ge Healthcare Bio Sciences Ab Method for sanitization of a chromatography column
JP6927247B2 (ja) * 2019-04-08 2021-08-25 昭和電工マテリアルズ株式会社 抗体の精製方法
JP7432813B2 (ja) * 2019-09-10 2024-02-19 東ソー株式会社 免疫グロブリン結合性タンパク質
CN111057153B (zh) 2019-12-06 2021-09-07 广州康盛生物科技股份有限公司 一种免疫球蛋白结合蛋白及其制备方法和应用
CN111732642B (zh) * 2020-07-30 2020-12-04 苏州纳微科技股份有限公司 免疫球蛋白结合蛋白及其应用
WO2022081779A1 (en) 2020-10-13 2022-04-21 Avitide LLC Affinity ligand libraries of three-helix bundle proteins and uses thereof
US20240043478A1 (en) * 2020-12-22 2024-02-08 Protenova Co., Ltd. Immunoglobulin-binding polypeptide
EP4294542A1 (en) 2021-02-19 2023-12-27 Avitide LLC Aav2 affinity agents
GB202113626D0 (en) 2021-09-24 2021-11-10 Cytiva Bioprocess R & D Ab FC binding polypeptides
CN114315996B (zh) * 2021-12-31 2023-01-17 博格隆(浙江)生物技术有限公司 一种重组ProteinA蛋白及亲和层析介质的制备方法
CN114409748A (zh) * 2022-01-28 2022-04-29 博格隆(浙江)生物技术有限公司 蛋白a的b结构域和z结构域突变体及其应用
GB202203478D0 (en) 2022-03-14 2022-04-27 Cytiva Bioprocess R & D Ab Vh3 binding polypeptides
CN115850408A (zh) * 2022-09-01 2023-03-28 西安蓝晓科技新材料股份有限公司 一种多肽、融合型多聚体蛋白质及其用途
CN117700501A (zh) * 2022-09-13 2024-03-15 普米斯生物技术(珠海)有限公司 免疫球蛋白结合蛋白及其应用
CN116217680B (zh) * 2023-01-10 2024-02-02 珠海冀百康生物科技有限公司 碱稳定性高的免疫球蛋白结合蛋白及其应用
WO2026057420A1 (en) 2024-09-10 2026-03-19 Cytiva Bioprocess R&D Ab Affinity ligand for purification of antibodies of isotype iga
CN119708176B (zh) * 2024-12-05 2026-01-06 武汉瑞法医疗器械有限公司 一种多肽、多聚体及其在免疫球蛋白亲和配体中的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063243A1 (en) * 1999-04-19 2000-10-26 Biovitrum Ab Derivatives of the b or z domain from staphylococcal protein a (spa) interacting with at least one domain of human factor viii
CN1642976A (zh) * 2002-03-25 2005-07-20 阿默森生物科学有限公司 一种突变的免疫球蛋白－结合蛋白
CN101775069A (zh) * 2008-12-24 2010-07-14 米利波尔公司 腐蚀稳定性色谱分析用配体
WO2012074463A1 (en) * 2010-11-29 2012-06-07 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
US20120149875A1 (en) * 2009-01-12 2012-06-14 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN105377881B (zh) * 2013-07-10 2020-08-07 通用电气医疗集团生物工艺研发股份公司 突变的免疫球蛋白结合多肽

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8505922D0 (sv) 1985-12-13 1985-12-13 Kabigen Ab Construction of an igg binding protein to facilitate downstream processing using protein engineering
US6602977B1 (en) * 1999-04-19 2003-08-05 Biovitrum Ab Receptor structures
US7709209B2 (en) 2002-03-25 2010-05-04 Ge Healthcare Bio-Sciences Ab Protein ligands
CA2531238C (en) * 2003-07-04 2015-02-24 Affibody Ab Polypeptides having binding affinity for her2
JP2006304633A (ja) 2005-04-26 2006-11-09 Apro Life Science Institute Inc イムノグロブリン結合タンパク質
CN101287503A (zh) * 2005-08-03 2008-10-15 Rq生物科技有限公司 用于诊断IgA和IgM介导的肾脏疾病的方法和组合物
WO2007097361A1 (ja) 2006-02-21 2007-08-30 Protenova Co., Ltd. イムノグロブリン親和性リガンド
WO2008039141A1 (en) 2006-09-29 2008-04-03 Ge Healthcare Bio-Sciences Ab Chromatography ligand comprising domain c from staphyloccocus aureus protein a for antibody isolation
JP5229888B2 (ja) * 2008-09-30 2013-07-03 独立行政法人産業技術総合研究所 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤
JPWO2010110288A1 (ja) 2009-03-24 2012-09-27 株式会社カネカ 免疫グロブリンに親和性を有するタンパク質および免疫グロブリン結合性アフィニティーリガンド
HUE026855T2 (en) 2009-04-03 2016-07-28 Univ Chicago Compositions and methods related to protein a (spa) variants
CN103269762B (zh) 2010-12-20 2016-01-27 通用电气健康护理生物科学股份公司 亲和色谱基质
WO2012083425A1 (en) 2010-12-21 2012-06-28 The University Of Western Ontario Novel alkali-resistant variants of protein a and their use in affinity chromatography
US9040661B2 (en) 2010-12-21 2015-05-26 Jsr Corporation Support for affinity chromatography and method for isolating immunoglobulin
EP2728000B1 (en) * 2011-06-03 2018-12-05 National Institute of Advanced Industrial Science And Technology Protein a mutant protein having reduced affinity in acidic region, and antibody capture agent
SG186552A1 (en) * 2011-06-08 2013-01-30 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
DE102013212062B4 (de) 2013-06-25 2017-05-11 Pantrac Gmbh Vorrichtung zur Ableitung von Erdungsströmen, insbesondere in Windkraftanlagen
US9454196B2 (en) * 2013-06-27 2016-09-27 Apple Inc. Active peak power management of a high performance embedded microprocessor cluster

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063243A1 (en) * 1999-04-19 2000-10-26 Biovitrum Ab Derivatives of the b or z domain from staphylococcal protein a (spa) interacting with at least one domain of human factor viii
CN1642976A (zh) * 2002-03-25 2005-07-20 阿默森生物科学有限公司 一种突变的免疫球蛋白－结合蛋白
CN101775069A (zh) * 2008-12-24 2010-07-14 米利波尔公司 腐蚀稳定性色谱分析用配体
US20120149875A1 (en) * 2009-01-12 2012-06-14 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
WO2012074463A1 (en) * 2010-11-29 2012-06-07 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN105377881B (zh) * 2013-07-10 2020-08-07 通用电气医疗集团生物工艺研发股份公司 突变的免疫球蛋白结合多肽
CN105377880B (zh) * 2013-07-10 2020-08-07 通用电气医疗集团生物工艺研发股份公司 突变的免疫球蛋白结合多肽

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12416607B2 (en) 2017-09-18 2025-09-16 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12510520B2 (en) 2017-09-18 2025-12-30 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
US12352734B2 (en) 2020-09-24 2025-07-08 Waters Technologies Corporation Chromatographic hardware improvements for separation of reactive molecules
CN114149495A (zh) * 2021-12-17 2022-03-08 博格隆(上海)生物技术有限公司 突变的蛋白a结构域c及其应用
CN116333056A (zh) * 2023-02-09 2023-06-27 西宝生物科技（上海）股份有限公司 一种高结合容量的耐碱重组Protein A及其制备方法和应用

Also Published As

Publication number Publication date
US10112980B2 (en) 2018-10-30
US11136359B2 (en) 2021-10-05
WO2015005862A1 (en) 2015-01-15
US20180244729A1 (en) 2018-08-30
US20170320922A1 (en) 2017-11-09
JP2019165747A (ja) 2019-10-03
WO2015005859A1 (en) 2015-01-15
US9663558B2 (en) 2017-05-30
JP2016523959A (ja) 2016-08-12
CN105377880B (zh) 2020-08-07
US9896486B2 (en) 2018-02-20
US20160207966A1 (en) 2016-07-21
JP6862008B2 (ja) 2021-04-21
EP3019520B1 (en) 2019-12-11
CN105377881A (zh) 2016-03-02
US20160159855A1 (en) 2016-06-09
JP6544809B2 (ja) 2019-07-17
EP3019519A4 (en) 2017-03-08
EP3019520A4 (en) 2017-03-08
CN105377880A (zh) 2016-03-02
JP2016525100A (ja) 2016-08-22
EP3019520A1 (en) 2016-05-18
JP6544808B2 (ja) 2019-07-17
CN105377881B (zh) 2020-08-07
EP3019519A1 (en) 2016-05-18
EP3019519B1 (en) 2019-04-03
US10308690B2 (en) 2019-06-04
US20160159857A1 (en) 2016-06-09

Similar Documents

Publication Publication Date Title
CN105377880B (zh) 突变的免疫球蛋白结合多肽
KR102697609B1 (ko) 돌연변이된 이뮤노글로불린-결합 폴리펩티드
CN109071612B (zh) 突变的免疫球蛋白结合多肽
CN107108700B (zh) 修饰的κ轻链-结合多肽
CN116615433A (zh) 分离基质

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination